Assessment of atrial electromechanical delay and echocardiographic parameters in patients with multiple sclerosis

IF 0.2 4区医学 Q4 CLINICAL NEUROLOGY

Neurology Asia Pub Date : 2023-12-01 DOI:10.54029/2023yjr

Derya Özdoğru, F. Salkın, Elif Banu Söker, O. Uysal

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引用次数: 0

Abstract

Objective: Data on cardiovascular dysfunction is limited in the previous literature on patients with multiple sclerosis. In this study, we aimed to elucidate the cardiovascular parameters in multiple sclerosis patients by comparing the systolic-diastolic functions and atrial electro-mechanical delay compared to the control group. Method: A total of 37 patients with a diagnosis of relapsing-remitting multiple sclerosis and had Expanded Disability Status Scale (EDSS) scores between 0 – 3, and 20 individuals in the control group were included in the study. Seventeen of the MS patients (n=17) were taking immunomodulatory drugs and the other 20 did not receive any immunomodulatory agents. Patients with a diagnosis or clinical suspicion of cardiac dysfunction and using cardiotoxic medications were excluded. The measurement of systolic and diastolic function parameters was performed via M – Mode 2D transthoracic echocardiography, and Atrial electro-mechanical delay (AEMD) measurements were performed with tissue Doppler. Results: E’ MV lateral and MV E/A values were determined to be higher in MS patients, who did not use immunomodulatory drugs, compared to the control group (p<0.001, p=0.010 respectively). E/E’ MV lateral and MV AVmax values were determined to be significantly higher in the patient group using immunomodulators compared to the other two groups (p=0.009, p=0.012 respectively). PAs, PAI, left and right intraatrial EMG values were determined to be prolonged in MS patients using and not using drugs compared to the control group, but these values were not determined to be statistically significant. Conclusion: We found that left ventricular diastolic function was impaired in MS patients compared to the control group, and right-left intra- and interatrial AEMD were similar. Based on these results, we recommend echocardiographic assessment for early detection of left ventricular diastolic dysfunction in MS patients.

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评估多发性硬化症患者的心房机电延迟和超声心动图参数

目的：以往文献中有关多发性硬化症患者心血管功能障碍的数据有限。在本研究中，我们旨在通过比较多发性硬化症患者与对照组的收缩-舒张功能和心房电子机械延迟，来阐明多发性硬化症患者的心血管参数。研究方法研究共纳入 37 名诊断为复发缓解型多发性硬化症且残疾状况扩展量表（EDSS）评分在 0 - 3 之间的患者，以及 20 名对照组患者。多发性硬化症患者中有 17 人（n=17）正在服用免疫调节药物，另外 20 人没有服用任何免疫调节药物。被诊断或临床怀疑有心功能不全以及正在使用心脏毒性药物的患者被排除在外。通过M-模式二维经胸超声心动图测量收缩和舒张功能参数，并通过组织多普勒测量心房电动力学延迟（AEMD）。结果与对照组相比，未使用免疫调节药物的多发性硬化症患者的 E' MV 侧值和 MV E/A 值均较高（分别为 p<0.001 和 p=0.010）。使用免疫调节剂的患者组的 E/E' MV lateral 值和 MV AVmax 值明显高于其他两组（分别为 p=0.009 和 p=0.012）。与对照组相比，使用和未使用药物的多发性硬化症患者的 PAs、PAI、左右心房内 EMG 值均被确定为延长，但这些值未被确定为具有统计学意义。结论我们发现，与对照组相比，多发性硬化症患者的左心室舒张功能受损，而左右心房内和心房间肌电图相似。基于这些结果，我们建议进行超声心动图评估，以便及早发现多发性硬化症患者的左心室舒张功能障碍。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurology Asia CLINICAL NEUROLOGY-

CiteScore

0.30

自引率

0.00%

发文量

审稿时长

>0 weeks

期刊介绍： Neurology Asia (ISSN 1823-6138), previously known as Neurological Journal of South East Asia (ISSN 1394-780X), is the official journal of the ASEAN Neurological Association (ASNA), Asian & Oceanian Association of Neurology (AOAN), and the Asian & Oceanian Child Neurology Association. The primary purpose is to publish the results of study and research in neurology, with emphasis to neurological diseases occurring primarily in Asia, aspects of the diseases peculiar to Asia, and practices of neurology in Asia (Asian neurology).