Neuropsychology Review最新文献

{"title":"Empathy in Adults with Acquired Brain Injury: a Systematic Review and Meta-Analysis.","authors":"Emily Clements, Kristin Naragon-Gainey, Michael Weinborn, Carmela Pestell, Dawn Neumann, David Preece, Rodrigo Becerra","doi":"10.1007/s11065-025-09667-5","DOIUrl":"https://doi.org/10.1007/s11065-025-09667-5","url":null,"abstract":"<p><p>Empathy is the ability to recognise, share and understand others' emotional states. Increasing evidence suggests that empathy may be impacted by acquired brain injury (ABI), with consequences for social and emotional functioning. However, the literature has been characterised by inconsistent findings and small sample sizes. To address these limitations, we provide the first meta-analytic review of empathy in adults with ABI. Specifically, the review aimed to quantify the degree of impairment in adults with ABI across four empathy-related domains: cognitive, affective, empathic concern (e.g. sympathy) and personal distress. We also sought to estimate the prevalence of deficits in each area and explore whether demographic and injury factors moderate impairment. A systematic search yielded 29 studies measuring self-reported empathy in adults with ABI versus healthy, matched peers. A series of random-effects meta-analyses revealed moderate deficits in cognitive empathy (Hedges' g =  - 0.68, 95% CI [- 0.87, - 0.50]) and affective empathy (Hedges' g =  - 0.43, 95% CI [- 0.65, - 0.21]), as well as small-to-moderate deficits in empathic concern (Hedges' g =  - 0.38, 95% CI [- 0.63, - 0.13]). No significant difference was found for personal distress. We estimated the proportion of ABI participants scoring equal to or more than 1 SD below the normative mean to be 15.3-35.0%, depending on the empathy subcomponent. Our results highlight that empathy deficits may play an important role in functional or emotional difficulties post-brain injury. This demonstrates the need for routine clinical assessment of empathy in survivors of brain injury and the need to develop interventions which target both cognitive and affective components.</p>","PeriodicalId":49754,"journal":{"name":"Neuropsychology Review","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Level and Nature of Impairment on the Iowa Gambling Task Following Acquired Brain Injury: A Meta-analysis.","authors":"Sammy Moore, Kristin Naragon-Gainey, Carmela F Pestell, Rodrigo Becerra, Melissa T Buelow, Danielle M Fynn, Michael Weinborn","doi":"10.1007/s11065-025-09668-4","DOIUrl":"https://doi.org/10.1007/s11065-025-09668-4","url":null,"abstract":"<p><p>The Iowa Gambling Task (IGT) is a popular measure of risky decision-making, but to date, no formal quantitative reviews have been conducted, focused exclusively on IGT performance amongst individuals with acquired brain injury (ABI). Therefore, this meta-analytic study firstly explored performance differences between individuals with ABI vs controls. Second, we extended this comparison by investigating differences in IGT scoring and interpretive approaches (e.g., total score vs later block analysis). Finally, we explored potential IGT performance moderators (e.g., average age). A total of 25 studies, containing 39 samples (total n = 2188), were included. Overall findings suggested that the IGT is sensitive to the presence of ABI, particularly non-TBI and medically confirmed TBI, which becomes evident by block 2 of 5. Medium effect sizes were obtained for IGT total score, as well as indicators using later blocks only. Performance moderators such as population type and region influenced IGT performance, whilst average age, average education, and proportion of males did not. These results indicate that the IGT is sensitive to decision-making impairment following ABI, although we conclude that further research is needed to confirm the IGT's ability to detect impairment relative to specific brain regions.</p>","PeriodicalId":49754,"journal":{"name":"Neuropsychology Review","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Motor Learning in Older Adults with Mild Cognitive Impairment: A Systematic Review.","authors":"Kylie B Tomlin, Ruth Akinlosotu, Emily F Gorman, Emily Schmitt, Stephen Eaton, Kelly P Westlake","doi":"10.1007/s11065-025-09661-x","DOIUrl":"https://doi.org/10.1007/s11065-025-09661-x","url":null,"abstract":"<p><p>The purpose of this systematic review was to synthesize the current evidence on motor learning in mild cognitive impairment (MCI). A search of five databases returned a total of 6058 references, 10 of which met criteria for inclusion in this review. The existing evidence was notably variable with an overall moderate risk of bias. Eight articles compared behavioral motor learning outcomes in MCI and age matched, non-cognitively impaired (NCI) samples. In 37.5% of these studies, the degree of motor skill acquisition in the MCI group was statistically significantly less than in the NCI group. Skill retention was only compared between MCI and NCI samples in one article, which reported a relative reduction in MCI group performance following a 24-h, no-practice delay. Importantly, none of the included articles examined motor skill transfer. We discuss possible sources of heterogeneity among collective findings including variability in motor tasks, outcome measurement, and research design. Further research is needed to support a comprehensive understanding of motor learning in the early stages of age-related cognitive decline. Future investigations should emphasize functional motor tasks and clinically relevant learning outcomes, including retention and transfer of motor skills, while controlling for potentially confounding factors such as motivation and sleep performance. This systematic review was registered with PROSPERO international prospective register of systematic reviews (registration ID CRD42023417329).</p>","PeriodicalId":49754,"journal":{"name":"Neuropsychology Review","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144081634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Always Getting Lost: Defining Developmental Topographical Disorientation (DTD)-A Systematic Literature Review.","authors":"Ineke J M van der Ham, Michiel H G Claessen","doi":"10.1007/s11065-025-09664-8","DOIUrl":"https://doi.org/10.1007/s11065-025-09664-8","url":null,"abstract":"<p><p>Developmental topographical disorientation (DTD) refers to a condition of highly impaired navigation ability in healthy individuals. DTD often leads to severe consequences in daily life, affecting education and professional choices and limited everyday mobility. Since its first description in 2009, a substantial number of empirical studies on DTD have appeared, but a clear clinical definition of DTD that can be used to develop a behavioral assessment tool is not yet available. The aim of the current study was to shed more light on the precise behavioral characteristics of DTD by examining the empirical evidence available to date. Recent theoretical developments that enable the classification of navigation impairment in various populations are utilized in the current work. Through a systematic literature review, reported descriptions and criteria for DTD were identified. Furthermore, tests included and performance of people with DTD are classified in the different navigation domains relevant to navigation impairment (landmark knowledge; location knowledge, egocentric and allocentric; and path knowledge, route and survey). A total of 15 empirical papers were included in the analyses, each discussing performance of people with DTD in large-scale spatial tasks. Initial DTD descriptions focused on mental map quality, whereas later work adheres to a more general definition of impaired navigation. Performance patterns show that the navigation impairment in DTD is largely attributable to low mental map quality, as low performance is primarily found for tasks measuring allocentric location knowledge and path knowledge. In contrast, landmark knowledge remains largely unaffected and, if impaired, appears to also include face recognition impairment, suggesting a more general form of visual agnosia. Egocentric location knowledge is often not included in assessments. The outcomes support the initial focus on poor mental map quality as the key characteristic of DTD, combined with a landmark-focused navigation strategy. The current findings therefore provide relevant input to the development of a clinical characterization of DTD and the development of appropriate assessment tools.</p>","PeriodicalId":49754,"journal":{"name":"Neuropsychology Review","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comparison of Clinical Diagnostic Classification Criteria Used in Longitudinal Cohort Studies of the Alzheimer's Disease Continuum: A Systematic Review.","authors":"Juan Manuel Villalpando, Bernard-Simon Leclerc, Minh Tri Le, Carol Hudon, Aline Bolduc, Marie-Jeanne Kergoat","doi":"10.1007/s11065-025-09663-9","DOIUrl":"https://doi.org/10.1007/s11065-025-09663-9","url":null,"abstract":"<p><p>Alzheimer's is a progressive disease, with a long preclinical phase of many decades. Accurate classification within longitudinal cohort studies is crucial for understanding disease progression and for the comparability and collaboration across studies. The main objective of this systematic review was to identify and compare the diagnostic criteria used in prospective population study cohorts centering on the Alzheimer's disease clinical continuum in older adults. A review was performed of cohort studies started in the year 2000 or later, with a follow-up duration of at least 3 years among people aged between 50 and 85 years old living in the community. Original studies were searched in MEDLINE, Embase, Cochrane, PsycINFO, and Web of Science. Two independent reviewers agreed on the final selection of 28 studies covering 25 cohorts. One study was identified by three independent judges as having methodological limitations due to inadequate reporting as per the modified NIH quality assessment tool. Data was extracted from each included study using a standardized extraction form. In general, the studies followed fewer than 1500 participants. The results showed convergence in the choice of diagnostic classification criteria among the 25 cohorts studied especially for the later stages of AD, while criteria for the earliest stages showed greater variability. Only five cohorts studied were concerned with the follow-up of the full spectrum of the disease. Our study may help to put in place a unified set of clinical diagnostic criteria across the continuum of Alzheimer's disease, rather than criteria developed specifically for a given study.</p>","PeriodicalId":49754,"journal":{"name":"Neuropsychology Review","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144042470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cortical Gradients Support Mental Time Travel into the Past and Future: Evidence from Activation Likelihood Estimation Meta-analysis.","authors":"Alice Teghil, Martin Wiener, Maddalena Boccia","doi":"10.1007/s11065-025-09662-w","DOIUrl":"https://doi.org/10.1007/s11065-025-09662-w","url":null,"abstract":"<p><p>A longstanding issue concerns the extent to which episodic autobiographical memory (EAM) and episodic future thinking (EFT) are the expression of the same cognitive ability and may be dissociated at the neural level. Here, we provided an updated picture of overlaps and dissociations between brain networks supporting EAM and EFT, using Activation Likelihood Estimation. Moreover, we tested the hypothesis that spatial gradients characterize the transition between activations associated with the two domains, in line with accounts positing a transition in the relative predominance of their features and process components. We showed the involvement of a core network across EAM and EFT, including midline structures, the bilateral hippocampus/parahippocampus, angular gyrus and anterior middle temporal gyrus (aMTG) and the left superior frontal gyrus (SFG). Contrast analyses highlighted a cluster in the right aMTG significantly more activated during EFT compared with EAM. Finally, gradiental transitions were found in the ventromedial prefrontal cortex, left SFG, and bilateral aMTG. Results show that differences between EAM and EFT may arise at least partially through the organization of specific regions of common activation along functional gradients, and help to advocate between different theoretical accounts.</p>","PeriodicalId":49754,"journal":{"name":"Neuropsychology Review","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144005833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of the Hayling and Brixton Tests for Detecting Dementia, Progressive Cognitive Decline, and Mild Cognitive Impairment in Middle to Older Aged Adults: A Systematic Review and Meta-analysis.","authors":"M O Palombo, A M Foran","doi":"10.1007/s11065-025-09658-6","DOIUrl":"https://doi.org/10.1007/s11065-025-09658-6","url":null,"abstract":"<p><p>The aging population is increasing the prevalence of dementia, neurodegenerative disorders, and mild cognitive impairment, which are associated with cognitive declines in executive functioning. In people with these disorders, accurate tests can aid in the early detection of executive functioning decline and facilitate access to interventions. The Hayling and Brixton tests (HBTs) are popular executive functioning tests that assess inhibitory control. The HBTs may be especially effective for detecting people with disorders that are associated with disinhibition, such as behavioral-variant frontotemporal dementia (bvFTD). However, the effectiveness of the HBTs for detecting cognitive decline in dementia, neurodegenerative disorders, and mild cognitive impairment has yet to be collated. A comprehensive search of five databases identified 50 studies that compared the HBTs performances of adults aged 40 years and over with a dementia, neurodegenerative disorder, or mild cognitive impairment (e.g., Parkinson's disease, Alzheimer's dementia, bvFTD) and cognitively-healthy controls. Hedges' g effect sizes compared groups on the five HBTs scores (Inhibition Errors, Inhibition Reaction Time (RT), Automatic RT, Inhibition minus Automatic RT, and Brixton Errors). The disorders (combined) showed negative effects on all HBTs scores (g - 0.37 to - 1.13), with dementia (combined) performing the worst (g - 0.54 to - 1.56). Automatic RT and Inhibition Errors were the most effective scores for detecting cognitive decline in dementia (g - 1.55; g - 1.34). The dementia types performed similar after outliers were removed and only studies with low risk-of-bias were analyzed. Overall, the HBTs are effective for detecting cognitive decline in middle to older aged adults, especially those with dementia. However, no score type can be recommended for differentiating the dementia types, such as AD and bvFTD.</p>","PeriodicalId":49754,"journal":{"name":"Neuropsychology Review","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Virtual Reality and Serious Videogame-Based Instruments for Assessing Spatial Navigation in Alzheimer's Disease: A Systematic Review of Psychometric Properties.","authors":"Juan Pablo Sánchez-Escudero, Ana María Galvis-Herrera, David Sánchez-Trujillo, Laura Cristina Torres-López, Cole J Kennedy, Daniel Camilo Aguirre-Acevedo, Mauricio A Garcia-Barrera, Natalia Trujillo","doi":"10.1007/s11065-024-09633-7","DOIUrl":"10.1007/s11065-024-09633-7","url":null,"abstract":"<p><p>Over the past decade, research using virtual reality and serious game-based instruments for assessing spatial navigation and spatial memory in at-risk and AD populations has risen. We systematically reviewed the literature since 2012 to identify and evaluate the methodological quality and risk of bias in the analyses of the psychometric properties of VRSG-based instruments. The search was conducted primarily in July-December 2022 and updated in November 2023 in eight major databases. The quality of instrument development and study design were analyzed in all studies. Measurement properties were defined and analyzed according to COSMIN guidelines. A total of 1078 unique records were screened, and following selection criteria, thirty-seven studies were analyzed. From these studies, 30 instruments were identified. Construct and criterion validity were the most reported measurement properties, while structural validity and internal consistency evidence were the least reported. Nineteen studies were deemed very good in construct validity, whereas 11 studies reporting diagnostic accuracy were deemed very good in quality. Limitations regarding theoretical framework and research design requirements were found in most of the studies. VRSG-based instruments are valuable additions to the current diagnostic toolkit for AD. Further research is required to establish the psychometric performance and clinical utility of VRSG-based instruments, particularly the instrument development, content validity, and diagnostic accuracy for preclinical AD screening scenarios. This review provides a straightforward synthesis of the state of the art of VRSG-based instruments and suggests future directions for research.</p>","PeriodicalId":49754,"journal":{"name":"Neuropsychology Review","volume":" ","pages":"77-101"},"PeriodicalIF":5.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11965194/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139974227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is There a Bias Towards Males in the Diagnosis of Autism? A Systematic Review and Meta-Analysis.","authors":"Sara Cruz, Sabela Conde-Pumpido Zubizarreta, Ana Daniela Costa, Rita Araújo, Júlia Martinho, María Tubío-Fungueiriño, Adriana Sampaio, Raquel Cruz, Angel Carracedo, Montse Fernández-Prieto","doi":"10.1007/s11065-023-09630-2","DOIUrl":"10.1007/s11065-023-09630-2","url":null,"abstract":"<p><p>Autism is more frequently diagnosed in males, with evidence suggesting that females are more likely to be misdiagnosed or underdiagnosed. Possibly, the male/female ratio imbalance relates to phenotypic and camouflaging differences between genders. Here, we performed a comprehensive approach to phenotypic and camouflaging research in autism addressed in two studies. First (Study 1 - Phenotypic Differences in Autism), we conducted a systematic review and meta-analysis of gender differences in autism phenotype. The electronic datasets Pubmed, Scopus, Web of Science, and PsychInfo were searched. We included 67 articles that compared females and males in autism core symptoms, and in cognitive, socioemotional, and behavioural phenotypes. Autistic males exhibited more severe symptoms and social interaction difficulties on standard clinical measures than females, who, in turn, exhibited more cognitive and behavioural difficulties. Considering the hypothesis of camouflaging possibly underlying these differences, we then conducted a meta-analysis of gender differences in camouflaging (Study 2 - Camouflaging Differences in Autism). The same datasets as the first study were searched. Ten studies were included. Females used more compensation and masking camouflage strategies than males. The results support the argument of a bias in clinical procedures towards males and the importance of considering a 'female autism phenotype'-potentially involving camouflaging-in the diagnostic process.</p>","PeriodicalId":49754,"journal":{"name":"Neuropsychology Review","volume":" ","pages":"153-176"},"PeriodicalIF":5.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11965184/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139571944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Neurocognitive Bases of Meaningful Intransitive Gestures: A Systematic Review and Meta-analysis of Neuropsychological Studies.","authors":"Josselin Baumard, Alice Laniepce, Mathieu Lesourd, Léna Guezouli, Virginie Beaucousin, Maureen Gehin, François Osiurak, Angela Bartolo","doi":"10.1007/s11065-024-09634-6","DOIUrl":"10.1007/s11065-024-09634-6","url":null,"abstract":"<p><p>Researchers and clinicians have long used meaningful intransitive (i.e., not tool-related; MFI) gestures to assess apraxia-a complex and frequent motor-cognitive disorder. Nevertheless, the neurocognitive bases of these gestures remain incompletely understood. Models of apraxia have assumed that meaningful intransitive gestures depend on either long-term memory (i.e., semantic memory and action lexicons) stored in the left hemisphere, or social cognition and the right hemisphere. This meta-analysis of 42 studies reports the performance of 2659 patients with either left or right hemisphere damage in tests of meaningful intransitive gestures, as compared to other gestures (i.e., MFT or meaningful transitive and MLI or meaningless intransitive) and cognitive tests. The key findings are as follows: (1) deficits of meaningful intransitive gestures are more frequent and severe after left than right hemisphere lesions, but they have been reported in both groups; (2) we found a transitivity effect in patients with lesions of the left hemisphere (i.e., meaningful transitive gestures more difficult than meaningful intransitive gestures) but a \"reverse\" transitivity effect in patients with lesions of the right hemisphere (i.e., meaningful transitive gestures easier than meaningful intransitive gestures); (3) there is a strong association between meaningful intransitive and transitive (but not meaningless) gestures; (4) isolated deficits of meaningful intransitive gestures are more frequent in cases with right than left hemisphere lesions; (5) these deficits may occur in the absence of language and semantic memory impairments; (6) meaningful intransitive gesture performance seems to vary according to the emotional content of gestures (i.e., body-centered gestures and emotional valence-intensity). These findings are partially consistent with the social cognition hypothesis. Methodological recommendations are given for future studies.</p>","PeriodicalId":49754,"journal":{"name":"Neuropsychology Review","volume":" ","pages":"177-210"},"PeriodicalIF":5.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140050843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}