BMC Chemistry最新文献

{"title":"Thyrotoxicosis antidote assay along with concurrent medication; chromatographic and environmental issues","authors":"Raghda A. Emam,&nbsp;Aml A. Emam,&nbsp;Rehab M. Abdelfatah,&nbsp;Basma H. Anwar","doi":"10.1186/s13065-025-01487-1","DOIUrl":"10.1186/s13065-025-01487-1","url":null,"abstract":"<div><p>A thionamide medication, Methimazole (MTZ), is a crucial antidote of thyroid hormone in cases of toxic nodular goiter or thyrotoxicosis by decreasing thyroid hormone synthesis. Propranolol (PRP), a beta blocker, is commonly co-administered with MTZ for controlling tachycardia associated with hyperthyroidism. Quantitative determination and tracing of MTZ in plasma in the presence of its co-administered medication, like PRP, is of paramount importance due to the reported toxic manifestations related to MTZ long-term administration that include agranulocytosis, hepatitis, arthritis, and skin rashes. An environmentally benign FDA-validated TLC densitometric approach was established for the first time for simultaneous and quantitative analysis of MTZ and PRP in pure form and spiked human plasma. The work is considered a mimetic study for their co-administration. Successful resolution between them was achieved on Merck^® silica gel plates using a mixture of ethyl acetate: acetone: 33% NH₃ solution in a ratio of (9: 1: 0.05, by volume) as a developing phase and UV scanning at 254 nm. Adding hydrocortisone acetate (HCA) as an internal standard eliminated the matrix effect variation. Reasonable resolution of the developed peaks was attained, with R_f values of 0.07, 0.19, 0.67, and 0.81 for plasma, PRP, MTZ, and HCA, respectively. Four greenness and viability rating approaches were applied to check and measure the greenness aspects of the suggested method toward the eco-system, and the outcomes were convenient and satisfactory. Also, the verification domains were tested using US-FDA bio-analytical specifications where reliable and acceptable outcomes were obtained with satisfied % recoveries for the quality control samples ranging from (100.39–104.44%) and (96.01–100.72%) for MTZ and PRP, respectively, with low RSD values indicating good accuracy and precision of the proposed method.</p></div>","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"19 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bmcchem.biomedcentral.com/counter/pdf/10.1186/s13065-025-01487-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143938458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation and characterization of an algal-based magnetic biochar nanocomposite for the removal of azocarmine G2 dye from aqueous solutions","authors":"Mohamed Saad Hellal,&nbsp;Sayed K. Attia,&nbsp;Kishore Kumar Kadimpati,&nbsp;Anna Gnida,&nbsp;Ahmed M. Rashad","doi":"10.1186/s13065-025-01474-6","DOIUrl":"10.1186/s13065-025-01474-6","url":null,"abstract":"<div><p>Dyes are released into bodies of water as the textile industry expands in response to the growth of the global population. These textile dyes have severe effects on the environment, including wildlife, terrestrial species, and humans. This study explores the synthesis, characterization, and application of an algal-based magnetic biochar nanocomposite for the efficient adsorption of azocarmine G2 (ACG2) dye from aqueous solutions. The magnetic biochar (Fe₃O₄@BC) was characterized by Raman spectroscopy, scanning electron microscopy (SEM), X-ray diffraction (XRD), and Fourier transform infrared spectrometry (FTIR). Batch adsorption experiments were performed to assess the impact of the initial dye concentration (25 to 100 mg / L), contact time (up to 300 min), pH (1–3) and temperature (298 to 328 K). The nano-composite achieved a maximum adsorption capacity (q_max) of 71.3 mg/g at pH 1, with equilibrium reached within 240 min. Adsorption kinetics followed a pseudo-second-order model (R2 = 0.99), while isotherm analysis fit well with the Langmuir model (R2 = 0.98), indicating monolayer adsorption. However, the Freundlich model provided a better fit, indicating that the multilayer covered a heterogeneous surface with a chemisorption process. The nanocomposite demonstrated as &gt; 90% adsorption efficiency for ACG2 under a variety of conditions, with reusability tests showing retention of over 80% adsorption capacity after five regeneration cycles. This study focusses on the synthesis of an algae-derived biochar with magnetic properties, enhancing its efficiency in post-adsorption separation. The adsorption of Azocarmine G2 (ACG2), a hazardous azo dye, is addressed herein for the first time, establishing the novelty of this research within the domain. Furthermore, this innovative Fe₃O₄@BC adsorbent compound effectively resolves the issue of recyclability. The results highlight that the algal-based magnetic biochar nanocomposite is a viable and sustainable adsorbent, demonstrating exceptional dye adsorption capacity, simplified separation processes, and recyclability. Therefore, it is deemed appropriate for extensive applications in wastewater treatment processes.</p></div>","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"19 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bmcchem.biomedcentral.com/counter/pdf/10.1186/s13065-025-01474-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143932310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Theoretical study on the structures and pharmacokinetic evaluation of verticillane-type diterpenes from soft coral Heteroxenia ghardaqensis","authors":"Jiangmei Pang,&nbsp;Qinzhe Yu,&nbsp;Huining Wei,&nbsp;Xiaoyun Xia,&nbsp;Zishan Lin,&nbsp;Xiandong Du,&nbsp;Chaojie Wang","doi":"10.1186/s13065-025-01499-x","DOIUrl":"10.1186/s13065-025-01499-x","url":null,"abstract":"<div><p>The density functional theory (DFT) method ωB97XD/6-311++G(2d, p) was applied to calculate and analyze the geometric structures, spectral properties, frontier molecular orbitals, and molecular electrostatic potentials of 14 novel verticillane-type diterpenoids isolated from the soft coral <i>Heteroxenia ghardaqensis</i>. Additionally, reaction index analysis was conducted using conceptual density functional theory, and the drug-likeness of these compounds was evaluated using two different pharmacokinetic prediction platforms. The results showed that the hydroxyl hydrogen, secondary amine hydrogen, carbonyl oxygen, and hydroxyl oxygen in the molecules of these compounds have relatively high reactivity. Compounds <b>5</b>, <b>8</b>, and <b>9</b> exhibit significant anti-inflammatory activity and have similar electronic delocalization distribution characteristics, showing good stability and excellent biological activity, among which compound <b>5</b> demonstrates more significant drug potential. For compounds <b>2</b>, <b>8</b>, and <b>12</b> with hepatoprotective activity, through the analysis of comprehensive pharmacokinetic parameters and molecular docking data, compound <b>12</b> is considered more suitable as a potential hepatoprotective drug.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"19 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bmcchem.biomedcentral.com/counter/pdf/10.1186/s13065-025-01499-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143932311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Introducing the carbon footprint reduction index (CaFRI) as a software-supported tool for greener laboratories in chemical analysis","authors":"Fotouh R. Mansour,&nbsp;Paweł Mateusz Nowak","doi":"10.1186/s13065-025-01486-2","DOIUrl":"10.1186/s13065-025-01486-2","url":null,"abstract":"<div><p>Carbon Footprint Reduction Index (CaFRI) has been presented as a newly developed web tool designed to assess and enhance the sustainability of analytical methods, with a focus on estimating greenhouse gas emissions (available at bit.ly/CaFRI). While many tools exist for evaluating greenness, none specifically address the carbon footprint of laboratory procedures. CaFRI fills this gap by providing a standardized approach that predicts the effectiveness of carbon footprint reduction strategies. It assigns a numerical rating based on direct CO₂ emission factors such as energy efficiency and indirect factors like sample storage, transportation, waste management, and reagent use. By implementing CaFRI, laboratories can optimize resource use, minimize environmental hazards, ensure compliance with eco-friendly regulations, and target specific areas for improvement. Case studies using techniques such as spectrophotometry for polidocanol in ampoules, dispersive solid phase microextraction with HPLC/UV for ritonavir in human plasma, carbon quantum dots for molnupiravir in capsules, and homogenous liquid-liquid microextraction with HPLC/UV for favipiravir in human plasma demonstrated CaFRI’s applicability in evaluating the carbon footprint across diverse analytical methods and matrices. These case studies illustrated that energy consumption and CO₂ emissions are key criteria for CaFRI scores, with higher scores indicating more sustainable methods.</p></div>","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"19 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bmcchem.biomedcentral.com/counter/pdf/10.1186/s13065-025-01486-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143930119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Numerical simulation of stability of diffusion depth of deterrents into cylindrical nitrocellulose composite under different conditions","authors":"Hussein Riyadh Abdul Kareem Al-Hetty,&nbsp;Abdulla A. Al-dulaimi,&nbsp;Hiba Muwafaq Saleem,&nbsp;Ehsan kianfar","doi":"10.1186/s13065-025-01495-1","DOIUrl":"10.1186/s13065-025-01495-1","url":null,"abstract":"<div><p>In this study, evaluation and prediction of diffusion depth of deterrents of Butyl-NENA and Polyethylene-glycol-di-methacrylate into the propellant and the effect of different conditions on diffusion stability, such as variations of concentration, temperature and aging with time, were performed by using COMSOL Multi-physics 4.4 to lower the laboratory costs and saving time. Diagrams indicated that diffusion of deterrents occurs to a certain depth of the propellant radius and variations of concentration in allowed ranges, does not affect the final diffusion depth significantly. Also, variations in temperature and aging with time had a little effect on the diffusion depth. Results showed that substances were used for nitrocellulose propellant coating, have excellent diffusion stability. simulation results were compared torelated experimental results and showed good agreement with them. concentration profiles of Butyl-Nena at two concentrations of 10% and 20%, measured at 70˚C for 10 h. the concentration profile at 10% is shown, and a gentle increase in concentration is observed for small to medium radii. While the 20% profile shows a faster and more significant increase in concentration, reaching high values at larger radii. These results indicate a significant effect of Butyl-Nena concentration on its concentration distribution pattern with increasing radius. the concentration profiles of deterrent polymers at two concentrations of 2% and 12%, measured at 70˚C for 10 h. the deterrent concentration at 2% gradually increases and reaches significant values, while at 12%, the concentration rapidly approaches a maximum value. These results indicate a significant effect of deterrent concentration on the concentration profiles with increasing radius.The aim of the present work was predicting the influence of various conditions such as, concentration, temperature and time on deterrents diffusion stability by COMSOL Multi-physics.</p></div>","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"19 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bmcchem.biomedcentral.com/counter/pdf/10.1186/s13065-025-01495-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143930060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alendronate repositioning as potential anti-parasitic agent targeting Trichinella spiralis inorganic pyrophosphatase, in vitro supported molecular docking and molecular dynamics simulation study","authors":"Marmar A. Hanafy,&nbsp;Doaa A. Nassar,&nbsp;Fatima M. Zahran,&nbsp;Magdy M. D. Mohammed","doi":"10.1186/s13065-025-01468-4","DOIUrl":"10.1186/s13065-025-01468-4","url":null,"abstract":"<div><p>Trichinellosis represents great public health and economic problems worldwide. Moreover, the development of parasitic resistance against conventional anthelminthic treatment led to the urgent search for new therapeutic strategies, including drug repurposing. Bisphosphonates have been used to inhibit the growth of many parasites and have also emerged as promising candidates for the treatment of cryptosporidiosis and amoebic liver abscess. Alendronate is a second-generation bisphosphonate that is widely used for the treatment and prevention of osteoporosis. Till date, there is not enough data on the effect of this drug on <i>Trichinella spiralis</i> and it is unknown whether the regular use of this drug in osteoporotic patients may alter the course of the infection. ALN showed a significant lethal effect on both adult worms and juveniles, with severe tegumental damage in the form of fissures in the cuticle, widening of the hypodermal gland, and flattening of the cuticular annulation, ending with the appearance of multiple vesicles and large cauliflower masses. Molecular docking outcomes unveiled the potential inhibition of ALN against <i>T. spiralis</i> surface proteins (<i>i.e., Ts</i>-SP, <i>Ts</i>-PPase, <i>Ts</i>-MAPRC2, <i>Ts</i>-TS, <i>Ts</i>-MIF, etc.), with promising results confirmed its ability to defeat <i>T. spiralis</i> via targeting its surface proteins. Moreover, molecular dynamics simulation, through the analysis of RMSD, RMSF, RG, SASA and cluster analysis, proved the prolonged effective inhibition of ALN on <i>T. spiralis</i> inorganic pyrophosphatase, as an essential surface protein required for molting and developmental process of intestinal larval stages. Thus, ALN might be a valuable drug candidate for the treatment of trichinellosis and warrant further investigation in animal models of disease.</p></div>","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"19 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bmcchem.biomedcentral.com/counter/pdf/10.1186/s13065-025-01468-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143913859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility of green chemistry for spectrofluorometric and spectrophotometric analysis of vericiguat via reaction with erythrocin B","authors":"Hesham Salem,&nbsp;Amany Abdelaziz,&nbsp;Omar Saied,&nbsp;Micheal Amir,&nbsp;Maemona M. Sadik,&nbsp;Noha Khalid,&nbsp;Nadin Mohsen,&nbsp;Dina Z. Mazen","doi":"10.1186/s13065-025-01485-3","DOIUrl":"10.1186/s13065-025-01485-3","url":null,"abstract":"<div><p>Food colorant Erythrosine B (EB) is an antiviral xanthene dye with a wide range of uses as a colorant in cosmetics and medications. Its availability, affordability, quick labeling, and high sensitivity make it an excellent choice for spectrofluorometric and spectrophotometric examination of amine-based medications. Two quick and accurate spectrophotometric and spectrofluorometric methods were developed for the estimation of vericiguat in this case. To create an ion-pair complex at pH 4 using the Britton Robinson buffer, the suggested methods relied on the interaction between the amino groups of the medication under study and the phenolic group of EB. The quenching effect of the vericigaute drug of EB at excitation/emission wavelengths of 530.0/550.0 nm. This method demonstrated a limit of detection (LOD) of 0.036 µg/mL and a limit of quantification (LOQ) of 0.110 µg/mL, showing rectilinear response in the concentration range of 0.05–0.5 µg/mL. Additionally, the absorbance of the produced ion-pair complex was evaluated using the colorimetric approach at 560 nm, displaying a linearity range of 0.5–10.0 µg/mL with LOD = 0.428 µg/mL and LOQ = 1.298 µg/mL. The greenness of the developed approaches was determined by GAPT and AGREE software for evaluating the suggested methods.</p></div>","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"19 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bmcchem.biomedcentral.com/counter/pdf/10.1186/s13065-025-01485-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143908872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Greenness, blueness, and whiteness evaluation of a quantitative nuclear magnetic resonance procedure for concurrent assay of aspirin and omeprazole in their single and fixed-dose combined tablets","authors":"Amal A. El-Masry,&nbsp;Abdallah M. Zeid,&nbsp;Nora A. Abdallah","doi":"10.1186/s13065-025-01477-3","DOIUrl":"10.1186/s13065-025-01477-3","url":null,"abstract":"<div><p>The Food and Drug Administration recently approved a fixed dose combination of aspirin and omeprazole that has been introduced for the treatment of gastrointestinal disorders, as it reduces the risk of upper gastrointestinal and cardiovascular adverse events in aspirin-treated patients. Therefore, an optimized eco-friendly, simple, fast, and precise quantitative nuclear magnetic resonance spectroscopy technique was presented for the concurrent estimation of that mixture in their single and combined dosage forms. The quantitative nuclear magnetic resonance spectroscopy concurrent estimation of both drugs was achieved using phloroglucinol as the internal standard and dimethyl sulfoxide as a deuterated solvent. An ideal set of acquisition parameters was determined to be 128 scans, 10 s relaxation latency, and 90° pulse angle. The selected quantitative signal of aspirin was the doublet of doublet signal appeared at 7.945 ppm, while that of omeprazole was the singlet signal at 8.18 ppm. The singlet signal at 5.69 ppm was selected for the internal standard. The spectra were subjected to integration, baseline correction, and auto phase correction. The developed quantitative proton nuclear magnetic resonance spectroscopy method was found to be rectilinear over the range of 0.05–4.0 mg mL⁻¹ for both drugs. The detecting and quantifying limits for both drugs were approximately 0.01 and 0.03 mg mL⁻¹, respectively. Neither labelling nor pretreatment steps were needed to assay the studied drugs using our developed quantitative nuclear magnetic resonance spectroscopy method. The proposed nuclear magnetic resonance spectroscopy approach was effectively evaluated in terms of linearity (r = 0.9999), accuracy, and precision (%RSD &lt; 1.08). Furthermore, the suggested technique was investigated to analyze the studied drugs in their single and combined dosages. This work enables clinicians to simultaneously monitor aspirin and omeprazole levels in both single and fixed-dose combination tablets, ensuring precise dosing and effective treatment management. For patients, it supports safer therapy by reducing the risks associated with improper dosing or drug interactions in combination therapies. After evaluating the method's greenness, whiteness and blueness, it was determined that the suggested approach was environmentally friendly. The suggested approach was compared with the previously reported methods from both an analytical and eco-friendly perspective.</p></div>","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"19 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bmcchem.biomedcentral.com/counter/pdf/10.1186/s13065-025-01477-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143904855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microwaved schiff base dialdehyde cellulose-chitosan hydrogels for sustained drug release with DFT calculations","authors":"Hebat-Allah S. Tohamy","doi":"10.1186/s13065-025-01469-3","DOIUrl":"10.1186/s13065-025-01469-3","url":null,"abstract":"<div><p>Dialdehyde cellulose (DAC) prepared from sugarcane bagasse (SC) by an eco-friendly, fast and low-cost microwave method was used for loading and sustained release of 4-aminoacetophenone (4-AAP). DAC was reacted with chitosan (Ch) and 4-AAP via a Schiff base reaction. FTIR analysis confirmed successful Schiff base formation between DAC and Ch, evidenced by the disappearance of the DAC aldehyde peak at 1716 cm⁻¹ and the appearance of the imine peak at 1631 cm⁻¹, as well as strong hydrogen bonding with incorporated 4-AAP, indicated by a shift in the O–H stretch from 3336 cm⁻¹ to 3330 cm⁻¹.Swelling studies showed increased water absorption with higher 4-AAP content, with 4-AAP@DAC/Ch2 demonstrating pseudo-second-order kinetics and non-Fickian diffusion. The DFT calculations revealed that the 4-AAP@DAC/Ch hydrogel exhibited enhanced stability and reactivity. A significantly reduced HOMO–LUMO energy gap, coupled with negative Pi values, indicated strong interactions between DAC, chitosan, and 4-AAP. The high adsorption energy further supported the observed slow drug release, validating the experimental findings.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"19 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bmcchem.biomedcentral.com/counter/pdf/10.1186/s13065-025-01469-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143900618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro biological activity and nutritional evaluation of purple potato (Solanum tuberosum L. var. Vitelotte)","authors":"Merve Sabuncu,&nbsp;Dilek Dulger Altıner,&nbsp;Yasemin Sahan","doi":"10.1186/s13065-025-01484-4","DOIUrl":"10.1186/s13065-025-01484-4","url":null,"abstract":"<div><p>This study aimed to produce functional flour from purple potatoes, which are relatively less known and have limited usage. Purple potatoes (<i>Solanum tuberosum L.</i> var<i>.</i> Vitelotte) and yellow potatoes (<i>Solanum tuberosum L</i>.) used in this study were cultivated in Türkiye. The purple potato flour (PPF) displayed higher values across various parameters, including total phenolic compounds, total flavonoids, total anthocyanins, antioxidant capacity, phenolic content, as well as <i>in-vitro</i> biological activities such as bioaccessibility, anti-diabetic activities, and anti-inflammatory properties, compared to the yellow potato flour (YPF). The mineral content ranking for both flour samples was K &gt; P &gt; Na &gt; Mg &gt; Ca &gt; Fe &gt; Zn &gt; Mn &gt; Cu &gt; Se. The predominant phenolic compounds in PPF were chlorogenic acid, D-( +) malic acid, ferulic acid, and succinic acid. The compounds from anthocyanins found in purple vegetables and fruits, including malvidin chloride, cyanidin chloride, and cyanin chloride, were identified in PPF. PPF exhibited an average <i>in-vitro</i> bioaccessibility of 60%, whereas YPF demonstrated a slightly lower value of 48%. Regarding their <i>in-vitro</i> anti-diabetic activities, PPF showcased an α-amylase inhibition rate averaging 51.67% and an α-glucosidase inhibition rate at 36.22%. As a result of the study, it was observed that purple potato flour was a rich source of total phenolic content, dietary fiber, minerals, antioxidants, and anthocyanins. Considering its gluten-free nature, this functional flour is considered a potential alternative flour source for individuals with celiac disease, opening up new possibilities for various applications in our daily nutrition.</p></div>","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"19 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bmcchem.biomedcentral.com/counter/pdf/10.1186/s13065-025-01484-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143900619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}