Bassant Samy, Mokhtar M Mabrouk, Mohamed A Abdel Hamid, Hytham M Ahmed
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引用次数: 0
Abstract
A fast, sensitive, and selective voltammetric method utilizing a modified glassy carbon electrode with zinc oxide nanoparticles and graphene oxide (ZnO-NPs / GOs/ GCE) was developed for the determination of vildagliptin (VID). The electrochemical oxidative behavior of VID as well as the morphological characterization of the modified electrode were investigated by transmission electron microscopy, Fourier transform-infrared spectrum and X-ray photoelectron spectroscopy. The determination of VID using the used sensor was shown to have a linear relationship over a concentration range of (15-150 µg/ml) under optimized conditions, with an LOD of 4.9 µg/ml and an LOQ of 15 µg/ml. The used sensor demonstrated good reproducibility, repeatability, and stability. Moreover, the proposed method was successfully used for the determination of VID in pharmaceutical dosage tablets and human plasma with good recovery. The green analytical procedure index (GAPI) method was also used to assess this method's greenness.
期刊介绍：
BMC Chemistry, formerly known as Chemistry Central Journal, is now part of the BMC series journals family.
Chemistry Central Journal has served the chemistry community as a trusted open access resource for more than 10 years – and we are delighted to announce the next step on its journey. In January 2019 the journal has been renamed BMC Chemistry and now strengthens the BMC series footprint in the physical sciences by publishing quality articles and by pushing the boundaries of open chemistry.
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