BMC Chemistry最新文献

{"title":"Electrochemical evaluation of stainless steel alloy as a ureteral stent in synthetic urine solution in-vitro with Candida urinary tract infection.","authors":"Salma Mamdouh, Renad S El-Kamel, Amany M Fekry, Magda A Ameer","doi":"10.1186/s13065-025-01586-z","DOIUrl":"10.1186/s13065-025-01586-z","url":null,"abstract":"","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"19 1","pages":"224"},"PeriodicalIF":4.3,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12297752/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144717222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Streamlined analytical strategy using resonance Rayleigh scattering signal amplification for nanoscale quantification of rasagiline in tablets with content assessment.","authors":"Ahmed A Abu-Hassan","doi":"10.1186/s13065-025-01585-0","DOIUrl":"10.1186/s13065-025-01585-0","url":null,"abstract":"<p><p>Rasagiline (RSG), a prevalent drug for Parkinson's disease, is classified as a monoamine oxidase inhibitor. These drugs operate by elevating dopamine levels in the brain, with the objective of alleviating symptoms related to the illness. This work utilized a sensitive and feasible experimental approach to assess the amount of RSG. An experiment in a single pot, which is compatible with green chemistry, was used. The fundamental premise of this approach was the molecular-size-dependent resonance Rayleigh scattering phenomenon, arising from an association between the dual complex of Erythrosine and RSG. The combination of RSG medicine and Erythrosine in an acidic environment resulted in the formation of an association complex, which amplified the resonance Rayleigh scattering (RRS) signal. The increase in signal was directly associated with the concentration of RSG, particularly within the range of 50-1400 ng/mL. The amplification of the RRS signal was observed at a wavelength of 354 nm. Determining the limit of detection at 15.18 ng/mL and the limit of quantitation at 46 ng/mL demonstrated the method's sensitivity. The method's attributes were meticulously examined and refined. The methodological approach was validated in compliance with the International Council for Harmonisation (ICH) requirements to verify its dependability. Moreover, the approach was effectively utilized to assess RSG in its designated dose form. The utilization of existing RRS innovation to assess the target drug was extend to estimate content homogeneity was an impressive accomplishment. Clinical trial number: Not applicable.</p>","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"19 1","pages":"225"},"PeriodicalIF":4.3,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12297670/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144717223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis of ultra-high molecular weight poly(methyl methacrylate) initiated by the combination of copper nanopowder with organic halides.","authors":"Ming Yuan, Xiaofang Han, Zekai Zhang, Ruijia Wang, Shengrong Guo","doi":"10.1186/s13065-025-01597-w","DOIUrl":"10.1186/s13065-025-01597-w","url":null,"abstract":"<p><p>In this study, organic halides, such as 2-bromobutane (C₄H₉Br), ethyl α-bromophenylacetate (BPA), ethyl 2-bromoisobutyrate (EBiB), and ethyl 2-bromopropionate (EBP) are utilized in conjunction with copper nanopowder (Nano-Cu) to initiate the polymerization of methyl methacrylate (MMA). Among these, BPA combined with nano-Cu exhibits the highest reactivity, resulting in the production of poly(methyl methacrylate) (PMMA) with a number-average molecular weight (M_n) of 1.91 × 10⁶ Da, a weight-average molecular weight (M_w) of 3.46 × 10⁶ Da, and a polydispersity index (PDI) of 1.81. A kinetic analysis of the polymerization reveals that the reaction orders for MMA, BPA, and nano-Cu concentration are 0.76, 0.49, and 0.77, respectively. The activation energy of the polymerization of MMA initiated by BPA is calculated to be 59.6 kJ/mol. The molecular weight of PMMA product is determined using gel permeation chromatography (GPC), while the structure of the synthesized PMMA is characterized through proton nuclear magnetic resonance (¹H NMR). Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF) is employed to analyze the precise structure and molecular weight of PMMA. Additionally, the nano-Cu recovered after the polymerization is examined using X-ray photoelectron spectroscopy (XPS). An electron paramagnetic resonance (EPR) spectrometer is employed to detect the reaction intermediate formed during the polymerization. Results from MALDI-TOF, XPS and EPR reveal that the polymerization of MMA proceeds via a radical mechanism, with the combination of nano-Cu and BPA leading to the formation of BPA residual radicals that initiate the polymerization of MMA.</p>","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"19 1","pages":"223"},"PeriodicalIF":4.3,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12297669/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144717224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of activated charcoal and graphite on growth parameters and production of secondary metabolites of Plantago maritima through in vitro culture.","authors":"Fatemeh Najafi, Samin Mohammadi, Parina Asgharian, Morteza Kosari-Nasab","doi":"10.1186/s13065-025-01589-w","DOIUrl":"10.1186/s13065-025-01589-w","url":null,"abstract":"<p><p>Plantago maritima L. is a highly adaptable species recognized for producing valuable secondary metabolites with significant medicinal properties and a broad geographical distribution. This study explored the effects of various Graphite (G) and Activated Charcoal (AC) concentrations on the growth parameters and secondary metabolite production of P. maritima during the propagation stage. Concentrations of G and AC (0, 2, 4, and 8 g/L) were tested individually, and total phenolic and flavonoid contents were measured using folin-ciocalteu and aluminum chloride reagents, respectively. Antioxidant activity was evaluated using the DPPH assay. Spectroscopic techniques were employed to assess pigment composition, phenolic acid profiles, and n-hexane extracts, utilizing GC-MS and LC-MS/MS. The results indicated that high concentrations of G (4 and 8 g/L) and low concentrations of AC (2 and 4 g/L) significantly influenced growth parameters. A low G concentration (2 g/L) notably enhanced pigment production, while AC treatments at 4 and 8 g/L maximized phenolic content, antioxidant activity, and terpenoid levels. Application of 4 g/L of AC resulted in the production of biologically active rosmarinic acid, a compound not observed in other treatment conditions or the control sample. Overall, the cultivation of P. maritima demonstrates considerable potential for the biosynthesis of bioactive metabolites and promoting growth. However, further investigation into the elicitors' role and underlying mechanisms is critical to optimize production efficiency.</p>","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"19 1","pages":"222"},"PeriodicalIF":4.3,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12297822/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144717225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In situ decoration of Ag@exfoliated graphite composite catalyst for Fenton-like oxidation of methylene blue dye: kinetic and thermodynamic studies.","authors":"Somia M Abbas, Khadiga M Abas","doi":"10.1186/s13065-025-01584-1","DOIUrl":"10.1186/s13065-025-01584-1","url":null,"abstract":"<p><p>Amendable nanomaterials are preferred for wastewater remediation. Silver (Ag) and graphene materials have drawn significant consideration for wastewater treatment due to their good dispersibility in aqueous systems, biocompatibility, and catalytic activity. For this purpose, an easy-to-follow procedure has been developed to prepare exfoliated graphite (EG) involving a binary-component system composed of concentrated H₂SO₄ and (NH₄)₂S₂O₈. Afterwards, Ag@EG composite catalysts were prepared by in-situ decoration of silver nanoparticles (AgNPs) over EG by sonication. The prepared catalysts were investigated for methylene blue (MB) dye removal from wastewater using a homogeneous Fenton-like oxidation process (H₂O₂/Ag⁺). Process-controlling factors like H₂O₂ dose, solution pH, and dye concentrations were explored. The results showed that MB dye degradation in the Fenton-like oxidation process can be clarified by a pseudo-first-order kinetic model. The highest dye degradation efficiency (99.8%) was achieved using Ag@EG (1:1). The morphology and structural characteristics of the prepared catalysts were evaluated by SEM, TEM, EDX, XRD, Raman spectroscopy, FTIR, and UV-Vis analyses. The activation energy, enthalpy, and entropy of the catalytic degradation of the MB dye in the presence of prepared catalysts were established. The data elucidated that most MB dye degraded within 120 min when using mesoporous Ag@EG (1:1) catalyst. Ag@EG (1:1), with a high S_BET (87 m²/g), functioned as a Fenton-like oxidation catalyst, exhibiting high degradation efficiency compared to other cited catalysts.</p>","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"19 1","pages":"221"},"PeriodicalIF":4.3,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12291263/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144706006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A convergence of synthesis and antimicrobial research: imidazolium based dicationic ionic liquids.","authors":"Hira Akram, Bushra Arshad, Menahil Imtiaz, Waqas Ahmed, Muhammad Shafiq, Zaheer Ul-Haq, Rawaiz Khan, Ali Bahadar, Bashir Ahmad, Mudassir Iqbal","doi":"10.1186/s13065-025-01574-3","DOIUrl":"10.1186/s13065-025-01574-3","url":null,"abstract":"<p><p>The rising challenge of developing effective antimicrobial agents to combat a broad spectrum of bacterial infections, while mitigating the risk of drug resistance, has prompted extensive exploration into alternative treatment strategies. This paper focuses on the synthesis and characterization of imidazolium-based dicationic ionic liquids with the aim of addressing this crucial healthcare need. A total of 16 distinct compounds were successfully synthesized and systematically characterized using Fourier-transform infrared spectroscopy (FTIR) and nuclear magnetic resonance (NMR) techniques. The investigation into the antibacterial activity of these ionic liquids showcased their potential as promising antimicrobial agents. Drawing on the advantageous properties of ionic liquids, such as reduced toxicity and outstanding antimicrobial efficacy. Our study specifically explores dicationic imidazolium-based ionic liquids with two different spacers: 1,3-dibromopropane and (E)-1,4-dibromobut-2-ene. Thorough analysis using ¹H NMR, ¹³C NMR, FTIR, and TGA techniques provided valuable insights into the molecular structures and thermal properties of the synthesized compounds. Antibacterial assays were conducted to evaluate the efficacy of various combinations of these ionic liquids against bacterial strains, including Bacillus subtilis, Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus, and Methicillin-resistant Staphylococcus aureus. Remarkably, the ionic liquids containing the bisulphate anion exhibited exceptional antibacterial results compared to other combinations. The structure-activity relationship of the most prominent ionic liquids identified in the antibacterial assays was analyzed by DFT studies. Additionally, molecular docking was employed to investigate the molecular interactions involved in the antibacterial activities. ILs can be utilized as effective candidates against infections to avoid disabilities.</p>","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"19 1","pages":"220"},"PeriodicalIF":4.3,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12285118/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Facile synthesis and characterization of nanorods Pb-MOF for toxic rodenticide detection.","authors":"Ayman S Eliwa, Magdi E A Zaki, Mostafa A Besher, Gehad G Mohamed","doi":"10.1186/s13065-025-01579-y","DOIUrl":"10.1186/s13065-025-01579-y","url":null,"abstract":"<p><p>One of the most powerful anticoagulant rodenticides is bromadiolone and its detection is essential because of its extensive application and possible environmental and health risks. Bromadiolone is a highly potent second-generation anticoagulant rodenticide that poses significant risks to both human health and the environment. Due to its high toxicity, even low levels of exposure can lead to severe poisoning in non-target species, including pets, wildlife, and humans. Furthermore, bromadiolone is known for its environmental persistence, accumulating in ecosystems and entering food chains. Therefore, the sensitive and accurate detection of bromadiolone residues is essential for monitoring contamination, ensuring public safety and guiding appropriate regulatory measures. Effective detection methods play a vital role in minimizing accidental poisoning, assessing environmental impact, and supporting forensic investigations related to toxic exposure incidents. This study presents the preparation and characterization of lead organic frameworks (Pb-MOFs) designed for the selective and sensitive detection of bromadiolone. Utilizing a combination of transition metals and organic linkers, we developed a series of MOFs with tailored pore sizes and functional groups to enhance their interaction with bromadiolone molecules. The synthesized MOFs were characterized through multiple techniques, including X-ray diffraction (XRD), scanning electron microscope (SEM), Fourier-Transform infrared spectroscopy (FT-IR), and Brunauer-Emmett-Teller (BET) surface area analysis, to verify their crystalline structure, morphology, functional groups, surface area, and pore size. The surface area was determined to be 1304.27 m² g^- 1 according to the BET analysis. With an average pore size of 4.61 nm, the calculated total pore volume was 2.13 cm³g^- 1. An important step forward in chemical research is the utilization of the produced Pb-MOF in the electrochemical detection of the powerful anticoagulant rodenticide bromadiolone. We incorporated lead ions into the MOF structure to enhance its electrochemical sensitivity, enabling high detection of bromadiolone..</p>","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"19 1","pages":"219"},"PeriodicalIF":4.3,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12285016/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144688491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction and optimization of Rhodamine B removal from water using metal-organic frameworks: RSM-CCD, ANN, non-linear kinetics, and isotherm studies.","authors":"Simon Bbumba, John Ssekatawa, Ibrahim Karume, Emmanuel Tebandeke, Moses Kigozi, Solomon Yiga, Robert Setekera, Joseph Ssebuliba, Steven Sekitto, Ruth Mbabazi, Ivan Kiganda, Maximillian Kato, Patrick Taremwa, Moses Murungi, Chinaecherem Tochukwu Arum, Collins Yiiki Letibo, Geofrey Kaddu, Margret Namugwanya, John Kusasira, Peace Mwesigwa, Muhammad Ntale","doi":"10.1186/s13065-025-01590-3","DOIUrl":"10.1186/s13065-025-01590-3","url":null,"abstract":"<p><p>This study involved the chemical synthesis of Metal-organic Frameworks (MOFs). The synthesized MOFs were characterized using Scanning Electron Microscopy (SEM), Fourier Transform Infrared (FTIR), and Powder X-ray diffraction (PXRD). Artificial intelligence models such as Response Surface Methodology (RSM) and Artificial Neural Networks (ANN) were used to predict and optimize the adsorptive removal of Rhodamine B (RhB) from water. The adsorption process was optimized using RSM with a Central Composite Design (CCD), which predicted a maximum removal efficiency of 95.91% under the following conditions: initial dye concentration (10 mg/L), adsorbent dosage (15 mg), pH (6), and temperature (25 °C). ANN was also optimized using similar conditions and the resulting predictive removal efficiency of 97.18% was obtained. Non-linear isotherm studies strongly correlated with the Freundlich (R² = 0.9987) and Sips (R² = 0.9928) models, indicating multilayer and monolayer adsorption. Non-linear Pseudo-first-order, Pseudo-second-order, and Elovich model correlation coefficients of 0.9644, 0.9998, and 0.952 suggested that the mechanisms were by chemisorption and physisorption on energetically stable heterogeneous surfaces. The findings of this study show a dual approach based on metal-organic framework and machine learning models as efficient alternatives to understanding the removal of RhB from water.</p>","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"19 1","pages":"218"},"PeriodicalIF":4.3,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12281964/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144688492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Via entropy analysis (EA) and systematic cluster analysis (SCA), multi-index chemometric analysis of 20 amino acids, trace elements, etc., of five green teas from Guizhou, China.","authors":"Libing Zhou, Chunli Huang","doi":"10.1186/s13065-025-01588-x","DOIUrl":"10.1186/s13065-025-01588-x","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Using a stoichiometric method, this study conducted a comprehensive evaluation of tea quality and categorization based on nutritional indicators such as amino acids and trace elements. Based on multiple indicators, including amino acids, trace elements, etc., the nutritional analysis of five green teas, namely Fanjingshan green tea, Guizhou green tea, Meitan green tea, Tiangui green tea and Xixiu green tea from Guizhou, China, was performed to determine the combustion heat, combustion stability, fat, crude fiber, ash, trace elements and amino acids of five kinds of green tea.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The results showed that the order of combustion heat of the five types of green tea was Fanjingshan green tea &gt; Xixiu green tea &gt; Guizhou green tea &gt; Meitan green tea &gt; Tiangui green tea. The combustion heat of the five types of green tea was 3707.968-8670.937 J/g, among which the average combustion heat of Fanjingshan green tea was 8670.937 J/g and the energy was the highest. The results of gray pattern recognition were as follows: Guizhou green tea &gt; Fanjingshan green tea &gt; Tiangui green tea &gt; Meitan green tea &gt; Xixiu green tea. The crude fiber content (%) ranged from 11.13 to 14.63%, with an average content of 12.9975%, followed by Guizhou green tea, Fanjingshan green tea, Meitan green tea, Xixiu green tea, and Tiangui green tea. The fat content (%) was between 0.48% and 1.37%, with an average of 0.8635%, followed by Fanjingshan green tea &gt; Guizhou green tea &gt; Meitan green tea &gt; Xixiu green tea &gt; Tiangui green tea. The ash content (%) was between 4.83% and 5.53%, with an average content of 5.2182%, and decreased in the following order: Fanjingshan green tea &gt; Tiangui green tea &gt; Xixiu green tea &gt; Guizhou green tea &gt; Meitan green tea. Principal component analysis (PCA) revealed that the cumulative contribution ratio of the first three principal components was 88% &gt;85%, and the first three principal components were selected to represent 88% of the 13 trace elements in the five types of green tea.Factor analysis (FA) revealed that the order of the contents of 19 amino acids, namely, CySO&lt;sub&gt;3&lt;/sub&gt;H, Asp, Thr, Ser, Glu, Gly, Ala, (Cys)&lt;sub&gt;2&lt;/sub&gt;, Val, Met, Ile, Leu, Tyr, Phe, His, Lys, NH&lt;sub&gt;4&lt;/sub&gt;, Arg and Pro, in the 5 green teas was Tiangui green tea &gt; Fanjingshan green tea &gt; Meitan green tea &gt; Guizhou green tea &gt; Xixiu green tea. The ratio of essential amino acid content to total amino acid content was 10.61-18.14%, and the ratio of essential amino acid content to nonessential amino acid content was 11.87-22.15%. Tiangui green tea had the highest amino acid content. The order of comprehensive evaluation of food nutrition using the entropy method (EA) was as follows: Fanjingshan green tea &gt; Tiangui green tea &gt; Guizhou green tea &gt; Meitan green tea &gt; Xixiu green tea. According to the analysis of these indicators, the most common food source was Fanjingshan green tea. Systematic cluster analysis (SCA) of th","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"19 1","pages":"217"},"PeriodicalIF":4.3,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12278498/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144681830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eco-Friendly electrochemical sensor for vildagliptin detection in human plasma: green approach using ZnO nanoparticles and graphene oxide.","authors":"Bassant Samy, Mokhtar M Mabrouk, Mohamed A Abdel Hamid, Hytham M Ahmed","doi":"10.1186/s13065-025-01582-3","DOIUrl":"10.1186/s13065-025-01582-3","url":null,"abstract":"<p><p>A fast, sensitive, and selective voltammetric method utilizing a modified glassy carbon electrode with zinc oxide nanoparticles and graphene oxide (ZnO-NPs / GOs/ GCE) was developed for the determination of vildagliptin (VID). The electrochemical oxidative behavior of VID as well as the morphological characterization of the modified electrode were investigated by transmission electron microscopy, Fourier transform-infrared spectrum and X-ray photoelectron spectroscopy. The determination of VID using the used sensor was shown to have a linear relationship over a concentration range of (15-150 µg/ml) under optimized conditions, with an LOD of 4.9 µg/ml and an LOQ of 15 µg/ml. The used sensor demonstrated good reproducibility, repeatability, and stability. Moreover, the proposed method was successfully used for the determination of VID in pharmaceutical dosage tablets and human plasma with good recovery. The green analytical procedure index (GAPI) method was also used to assess this method's greenness.</p>","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"19 1","pages":"216"},"PeriodicalIF":4.3,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12273015/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144666766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}