BMC Chemistry最新文献

Eco-Friendly electrochemical sensor for vildagliptin detection in human plasma: green approach using ZnO nanoparticles and graphene oxide. 用于人体血浆中维格列汀检测的环保电化学传感器：使用ZnO纳米颗粒和氧化石墨烯的绿色方法。

IF 4.3 2区化学

BMC Chemistry Pub Date : 2025-07-18 DOI: 10.1186/s13065-025-01582-3

Bassant Samy, Mokhtar M Mabrouk, Mohamed A Abdel Hamid, Hytham M Ahmed

引用次数: 0

Sulfonic acid functionalized porous organic polymer as a heterogeneous catalyst for efficient pseudo four-component synthesis of dihydro-2-oxypyrroles. 磺酸功能化多孔有机聚合物作为伪四组分合成二氢-2-氧吡咯的多相催化剂。

IF 4.3 2区化学

BMC Chemistry Pub Date : 2025-07-17 DOI: 10.1186/s13065-025-01583-2

Saba Daliran, Seyedeh Fatemeh Hosseini, Ali Reza Oveisi, Esmael Sanchooli, Enrique Rodríguez-Castellón, Daniel Ballesteros-Plata

引用次数: 0

Total synthesis and biological evaluation of Koshidacin B, TAN-1746, and Ac-TAN-1746. Koshidacin B、TAN-1746、Ac-TAN-1746的全合成及生物学评价。

IF 4.3 2区化学

BMC Chemistry Pub Date : 2025-07-16 DOI: 10.1186/s13065-025-01581-4

Xiong-En Long, Hailiang Xing, Yixin He, Xuanli Meng, Yanling Ma, Chang Liu, Xi Cao, Huiru Nan, Min-Jing Cheng, Jia-Lei Yan, Junyang Liu

{"title":"Total synthesis and biological evaluation of Koshidacin B, TAN-1746, and Ac-TAN-1746.","authors":"Xiong-En Long, Hailiang Xing, Yixin He, Xuanli Meng, Yanling Ma, Chang Liu, Xi Cao, Huiru Nan, Min-Jing Cheng, Jia-Lei Yan, Junyang Liu","doi":"10.1186/s13065-025-01581-4","DOIUrl":"10.1186/s13065-025-01581-4","url":null,"abstract":"Analogues of chlamydocin derivatives consistently demonstrate multifaceted bioactivities, particularly through HDAC inhibition mechanisms, oncolytic efficacy, and neuronal preservation capacities. These activities primarily originate from their unique cyclic tetrapeptide scaffold and functional groups within the side chains that enable specific interactions with biomacromolecules. We herein report the total syntheses of three naturally occurring chlamydocin analogues-koshidacin B, TAN-1746, and Ac-TAN-1746. The synthetic strategy employed a modular approach that involved modifying a common intermediate via late-stage olefin cross-metathesis to install the requisite side-chain fragments. This versatile approach enabled an efficient and divergent total synthesis of the target compounds, completing the syntheses in a longest linear sequence of 9-10 steps. Remarkably, TAN-1746 and Ac-TAN-1746 demonstrated significant anti-osteosarcoma activity that exceeded the potency of clinically employed cisplatin-an observation not previously documented. These results strongly validate the utility of the chlamydocin scaffold as a platform for the development of potent inhibitors with promising therapeutic potential.","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"19 1","pages":"213"},"PeriodicalIF":4.3,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12265328/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spectroscopic approaches for structural analysis of extracted chitosan generated from chitin deacetylated for escalated periods. 几丁质逐步去乙酰化提取壳聚糖的光谱分析方法。

IF 4.3 2区化学

BMC Chemistry Pub Date : 2025-07-16 DOI: 10.1186/s13065-025-01558-3

S N Ghanem, M I Marzouk, M E Tawfik, S B Eskander

{"title":"Spectroscopic approaches for structural analysis of extracted chitosan generated from chitin deacetylated for escalated periods.","authors":"S N Ghanem, M I Marzouk, M E Tawfik, S B Eskander","doi":"10.1186/s13065-025-01558-3","DOIUrl":"10.1186/s13065-025-01558-3","url":null,"abstract":"A conventional chemical method was applied for the extraction of chitosan (CH) from shrimp shell wastes (SSWs) in three stages: (1) Demineralization: SSWs were treated with HCl to remove minerals. (2) Deproteinization: NaOH was used to eliminate proteins from the demineralization shells. 3: Deacetylation: The chitin (CT) obtained from stage 2 was converted to chitosan in alkaline medium using NaOH. This study aims to demonstrate the impact of varying deacetylation times on chitosan surface morphology, elemental composition, thermal resistance, structural configuration, and deacetylation degree (DD). Variable techniques including UV-visible spectroscopy, Fourier Transformed Infra-Red (FTIR-ATR), Thermogravimetry (TG/DTG), Scanning Electron Microscopy (SEM), and Energy-dispersive X-ray spectroscopy (EDX) analyses were employed to analyze how increased deacetylation periods affect the characterization of the products. The FTIR spectra showed a notable similarity between all extracted chitosan processed with increasing deacetylation time and the commercial one. Moreover, the results revealed that all the extracted chitosan samples acquired DD values, based on FTIR-ATR analysis, are comparable to that of commercial ones i.e. 79.54%, 78.23%, 74.81%, and 76.56% for deacetylated times of 22 h, 30 h, 36 h, and 40 h, respectively are comparable to that of the commercial chitosan (76.1%). Furthermore, the EDX analysis confirms that the extracted chitosan is non-toxic product, making it suitable for various applications, including biological and medical uses.","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"19 1","pages":"214"},"PeriodicalIF":4.3,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12265149/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metal chelation approach synergized with surfactant for spectrofluorimetric assay of moxifloxacin with method greenness evaluation. 表面活性剂协同金属螯合法测定莫西沙星的荧光光度并评价其绿色度。

IF 4.3 2区化学

BMC Chemistry Pub Date : 2025-07-15 DOI: 10.1186/s13065-025-01580-5

Sayed M Derayea, Mohamed A Hammad, Mahmoud A Omar, Yasser F Hassan

{"title":"Metal chelation approach synergized with surfactant for spectrofluorimetric assay of moxifloxacin with method greenness evaluation.","authors":"Sayed M Derayea, Mohamed A Hammad, Mahmoud A Omar, Yasser F Hassan","doi":"10.1186/s13065-025-01580-5","DOIUrl":"10.1186/s13065-025-01580-5","url":null,"abstract":"This work deals with devising a quick and easy method for moxifloxacin assay using a sensitive spectrofluorimetric technique. The method benefited from the interaction of the aforementioned drug with the aluminum cation which form a stable chelate with a high fluorescence characteristic. Further improvement in the fluorescence was achieved upon the addition of sodium lauryl sulfate. The experimental parameters of the reaction were carefully investigated. The fluorescence intensity was measured at a wavelength of 478 nm after excitation at 365 nm. A linear relationship between the intensity of fluorescence and moxifloxacin concentration was in the range of 10-200 ng mL- 1. The developed method was highly sensitive since the lower limit of detection was 2.2 ng mL- 1. Application of the suggested spectrofluorimetric method included the analysis of commercial tablet dosage forms containing the cited drug. In addition, human plasma samples spiked with the drug were analyzed, and good recovery was obtained. Moreover, the environmental friendliness of the developed procedure was confirmed through employing AGREE and GAPI approaches.","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"19 1","pages":"212"},"PeriodicalIF":4.3,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261815/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144641429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spectrophotometric approach for deconvolving overlapped spectra of antihypertensive drug mixtures using UV detection: an eco-friendly method. 紫外分光光度法测定抗高血压药物混合物重叠光谱的反卷积：一种环保方法。

IF 4.3 2区化学

BMC Chemistry Pub Date : 2025-07-14 DOI: 10.1186/s13065-025-01565-4

Suvarna Yenduri, K Naga Prashant, H N Varalakshmi

{"title":"Spectrophotometric approach for deconvolving overlapped spectra of antihypertensive drug mixtures using UV detection: an eco-friendly method.","authors":"Suvarna Yenduri, K Naga Prashant, H N Varalakshmi","doi":"10.1186/s13065-025-01565-4","DOIUrl":"10.1186/s13065-025-01565-4","url":null,"abstract":"This study presented four simple, environmentally friendly, chemometric methods for the determination of Amlodipine besylate and Telmisartan, When analyzed together, these drugs exhibit spectral overlapping; therefore, by adopting spectral manipulation, drugs are quantified simultaneously. The methods are namely the first derivative spectrophotometric method, the ratio difference method, the first derivative ratio method and the amplitude factor method. The methods showed detection limits ranging from 0.1211 to 0.4304 µg/mL and 0.0773 to 0.5640 µg/mL for Amlodipine besylate and Telmisartan, respectively, with good adherence to International Council for Harmonization standards. The methods were compared with the reported HPLC method using the student t-test and F-test, where the results showed no significant difference. For this method, a green solvent such as propylene glycol is selected through the Green solvent selection tool with a greenness score of 7.8 and the sustainability of the solvent is evaluated using spider diagram. Methods were assessed for their eco-friendliness and sustainability using novel tools such as Blue Applicability Grade Index, Green Analytical Procedure Index and RGB model with respect to White and Green analytical chemistry principles. Using Greenness tools for this UV-spectroscopy method improves both safety and effectiveness compared to expensive and laborious HPLC techniques. Hence, this study suggests employing easy and renewable UV spectrophotometric technologies for traditional analysis.","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"19 1","pages":"211"},"PeriodicalIF":4.3,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12257698/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144635878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel 1,3,4-oxadiazole-nicotinamide hybrids as non-classical AHL mimics quorum sensing inhibitors of Pseudomonas aeruginosa: design, synthesis and biological evaluation. 新型1,3,4-恶二唑-烟酰胺杂合体作为铜绿假单胞菌非经典AHL模拟群体感应抑制剂：设计、合成和生物学评价。

IF 4.3 2区化学

BMC Chemistry Pub Date : 2025-07-11 DOI: 10.1186/s13065-025-01560-9

Mohamed M S Hamoud, Amany M Ghanim, Abdalla E A Hassan, Hanan A Abdel-Fattah, Hisham A Abbas, Noura M Seleem, Hend Kothayer, Nermine A Osman

引用次数: 0

Evaluating DNA damage in earthworms (Eisenia fetida's): toxicological insights from carbon, gold, and silver nanoparticles using enzyme and comet assays. 评估蚯蚓（Eisenia fetida's）的DNA损伤：使用酶和彗星测定从碳、金和银纳米颗粒中获得的毒理学见解。

IF 4.3 2区化学

BMC Chemistry Pub Date : 2025-07-11 DOI: 10.1186/s13065-025-01577-0

Ramsha Latif, Shazia Perveen, Sumaira Kanwal, Saima Nasreen, Fariha Latif, Mommna Khan, Sadaf Ahmad, Ali Irfan, Gamal A Shazly, Yousef A Bin Jardan

引用次数: 0

Tailoring polymethylhydrosiloxane as candidate material for vitreous humour substitution: physical properties and in vitro toxicity. 裁剪聚甲基氢硅氧烷作为玻璃体幽默替代的候选材料：物理性质和体外毒性。

IF 4.3 2区化学

BMC Chemistry Pub Date : 2025-07-11 DOI: 10.1186/s13065-025-01548-5

Diba G Auliya, Vira F Arini, Tiara Nurmadanti, Ulfa Fauziah, Soni Setiadji, Fitrilawati Fitrilawati, Risdiana Risdiana

{"title":"Tailoring polymethylhydrosiloxane as candidate material for vitreous humour substitution: physical properties and in vitro toxicity.","authors":"Diba G Auliya, Vira F Arini, Tiara Nurmadanti, Ulfa Fauziah, Soni Setiadji, Fitrilawati Fitrilawati, Risdiana Risdiana","doi":"10.1186/s13065-025-01548-5","DOIUrl":"10.1186/s13065-025-01548-5","url":null,"abstract":"Polymethylhydrosiloxane (PMHS) has been considered to be developed as an alternative material of polydimethylsiloxane (PDMS) for vitreous humour substitution. This polymer production begins with hydrolysis of dichloromethylsilane (DCMS), as raw material, which continues through condensation polymerization. Previous research reported the synthesis of PMHS using an acid solvent with different temperature variations and indicated that low-viscosity PMHS can be produced through condensation at 15-20 °C. However, this process requires a very long polymerization time. Meanwhile, synthesis using a higher temperature of 50 °C required a catalyst. The influence of solvents, one of the important synthesis temperatures, on the synthesis process of PMHS has not been explored. Furthermore, the toxicity of this material has not been reported. In this study, PMHS with low- and medium-viscosity were synthesized from DCMS with different solvents and additional control of the condensation temperature to accelerate the polymerization. Utilizing a basic diethyl ether (DE) solvent facilitates a higher viscosity value than an acidic dichloromethane (DCM) solvent. All PMHS samples were characterized by a viscometer, refractometer, surfgauge, UV-Vis, FTIR, and NMR spectroscopy. The in vitro hen's egg chorioallantoic membrane (HET-CAM) toxicity test of PMHS was also conducted. A low-viscosity PMHS sample had a surface tension of 20 milliN/m and a refractive index of 1.3960, while medium-viscosity had 21 milliN/m and 1.3982. All samples were ~ 100% transparent, had typical functional groups of PMHS, and did not show signs of being irritant (non-toxic). Therefore, PMHS has the potential to be developed as a new material for vitreous humour substitution.","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"19 1","pages":"210"},"PeriodicalIF":4.3,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12255143/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144615739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

4-amino-5-(trifluoromethyl)-4H-1, 2, 4-triazole-3-thiol as an effective corrosion inhibitor for low carbon steel in HCl environment: experimental and theoretical studies. 4-氨基-5-（三氟甲基）- 4h - 1,2,4 -三唑-3-硫醇作为低碳钢在盐酸环境中的有效缓蚀剂：实验和理论研究。

IF 4.3 2区化学

BMC Chemistry Pub Date : 2025-07-10 DOI: 10.1186/s13065-025-01553-8

Zehbah Ali Mohammed Al-Ahmed, Medhat M Kamel, Mostafa A A Mahmoud, Sherin A M Ali, Ahmed Z Ibrahim, Badria M Alshehri

{"title":"4-amino-5-(trifluoromethyl)-4H-1, 2, 4-triazole-3-thiol as an effective corrosion inhibitor for low carbon steel in HCl environment: experimental and theoretical studies.","authors":"Zehbah Ali Mohammed Al-Ahmed, Medhat M Kamel, Mostafa A A Mahmoud, Sherin A M Ali, Ahmed Z Ibrahim, Badria M Alshehri","doi":"10.1186/s13065-025-01553-8","DOIUrl":"10.1186/s13065-025-01553-8","url":null,"abstract":"The compound 4-amino-5-(trifluoromethyl)-4H-1,2,4-triazole-3-thiol (ATFS) was assessed for its effectiveness in preventing corrosion of low-carbon steel (LCS) in a hydrochloric acid (HCl) solution with a concentration of 0.5 mol L-1. The inhibition performance of the ATFS compound was investigated by chemical, electrochemical, and quantum studies. The surface morphology of LCS was studied by scanning electron (SEM) and atomic force (AFM) microscopes. At 298 K, the inhibitory efficiency (IE) increased from 52.27 to 89% as the inhibitor concentration increased from 50 to 300 ppm. However, at 328 K and with 300 ppm of the ATFS compound, the IE decreased to 74.51%. The Tafel plot confirmed that the ATFS compound belonged to mixed-type inhibitors. An increase in inhibitor's concentration resulted in an elevation of the activation energy of the corrosion process, indicating that the ATFS was physically adsorbed at the LCS surface. The adsorption followed the Langmuir's isotherm. The ATFS decreased the capacitance of the double layer (Cdl) and increased the charge transfer resistance (Rct). The AFM results indicated that the average roughness of LCS in the HCl solution was 7.58 nm, which reduced to 4.79 nm in the presence of 300 ppm of the ATFS compound. The high IE of the ATFS inhibitor was verified by the quantum parameters that derived from the density functional theory (DFT). The low hardness value of ATFS compound (η = 0.095) suggested its high adsorbability onto the steel surface, however, the high global softness (σ = 10.482) indicated its strong capability as an inhibitor. Monte Carlo (MC) simulations demonstrated that the adsorption energy of ATFS at the LCS surface is significantly negative (- 287.12 kJ mol-1), indicating a strong interaction between the AFTS and LCS.","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"19 1","pages":"205"},"PeriodicalIF":4.3,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12243178/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144607053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0