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New chemometrics-assisted spectrophotometric methods for simultaneous determination of co-formulated drugs montelukast, rupatadine, and desloratadine in their different dosage combinations 化学计量学辅助分光光度计新方法,用于同时测定不同剂量组合中的复方药物孟鲁司特、鲁帕他定和地氯雷他定
IF 4.3 2区 化学
BMC Chemistry Pub Date : 2024-11-19 DOI: 10.1186/s13065-024-01345-6
Marco M. Z. Sharkawi, Nehal F. Farid, Moataz H. Hassan, Said A. Hassan
{"title":"New chemometrics-assisted spectrophotometric methods for simultaneous determination of co-formulated drugs montelukast, rupatadine, and desloratadine in their different dosage combinations","authors":"Marco M. Z. Sharkawi,&nbsp;Nehal F. Farid,&nbsp;Moataz H. Hassan,&nbsp;Said A. Hassan","doi":"10.1186/s13065-024-01345-6","DOIUrl":"10.1186/s13065-024-01345-6","url":null,"abstract":"<div><p>Two accurate, precise and robust multivariate chemometric methods were developed for the simultaneous determination of montelukast sodium (MON), rupatadine fumarate (RUP) and desloratadine (DES). These methods provide a cost-effective alternative to chromatographic techniques by utilizing spectrophotometry in pharmaceutical quality control. The proposed approaches, partial least squares-1 (PLS-1) and artificial neural network (ANN), were optimized using genetic algorithm (GA) to select the most influential wavelengths, enhancing model performance. A five-level, three-factor design was employed to construct a calibration set with 25 mixtures, utilizing concentration ranges of 3–19, 5–25, and 4–20 µg.mL<sup>−1</sup> for MON, RUP, and DES, respectively. An independent validation set was employed to assess the performance of the models. GA significantly improved the PLS-1 and ANN models for RUP and DES, though minimal enhancement was observed for MON. These methods were successfully applied to the simultaneous quantification of the compounds in pharmaceutical formulations and proved useful as stability-indicating assays for RUP, given that DES is a known degradation product. The developed methods offer a valuable tool for impurity profiling and quality control in pharmaceutical analysis.</p></div>","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"18 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bmcchem.biomedcentral.com/counter/pdf/10.1186/s13065-024-01345-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142672390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
AQbD-enhanced green RP-UPLC-PDA methodology for quantification and forced degradation studies for omeprazole, amoxicillin, and rifabutin 用于奥美拉唑、阿莫西林和利福布汀定量和强制降解研究的 AQbD 增强绿色 RP-UPLC-PDA 方法。
IF 4.3 2区 化学
BMC Chemistry Pub Date : 2024-11-18 DOI: 10.1186/s13065-024-01337-6
S. P. Ashnah Baffinsha, Vijayageetha Ragupathi, Hemanth Kumar Chanduluru
{"title":"AQbD-enhanced green RP-UPLC-PDA methodology for quantification and forced degradation studies for omeprazole, amoxicillin, and rifabutin","authors":"S. P. Ashnah Baffinsha,&nbsp;Vijayageetha Ragupathi,&nbsp;Hemanth Kumar Chanduluru","doi":"10.1186/s13065-024-01337-6","DOIUrl":"10.1186/s13065-024-01337-6","url":null,"abstract":"<div><p>The ternary combination like omeprazole (OMP), amoxicillin (AMX), and rifabutin (RFB) was approved by the FDA in November 2019 for combating Helicobacter pylori infections and ulcers caused by this infection. This study aims to develop and authenticate a robust and eco-friendly RP-UPLC technique aimed at the concurrent analysis of OMP, AMX, and RFB, following ICH guidelines, Analytical Quality by Design (AQbD), and green analytical chemistry (GAC) principles. The analysis used the Thermo C18 column (100 mm × 2.1 mm, 1.7 µm), ethanol, and formic acid solution (43:57) as mobile phase with a flow rate of 0.2 ml/min at 272 nm. The method was developed based on the ICH Q14 and validated according to ICH Q2(R1) followed by Forced degradation studies under various conditions. The method showed good linearity for OMP, AMX, and RFB, with coefficient of determination (r2) of 0.9995, 0.9993, and 0.9997, respectively. Precision studies indicated low %RSD values, confirming high reproducibility. Forced degradation studies confirmed the stability of the drugs for 30 min in acid, base, and redox reactions, and they were also stable for 6 h at 105 °C in dry conditions. GAPI assessment depicted a green and yellow pictogram, AGREE scored 0.85, BAGI scored 80, and RGB12 Whiteness Assessment Tool scored 97.5%. The developed RP-UPLC-PDA technique is robust and reliable for the concurrent quantification of the triple combination. It aligns with sustainability goals, enhancing the efficiency and environmental sustainability of pharmaceutical analysis, and setting a benchmark for future analytical methods.</p></div>","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"18 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bmcchem.biomedcentral.com/counter/pdf/10.1186/s13065-024-01337-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142666579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chromatographic assay of recently approved co-formulation of Vonoprazan fumarate with low dose Aspirin: AGREE, Complex MoGAPI, and RGB 12-model assessments 最近批准的富马酸伏诺普拉赞与低剂量阿司匹林联合制剂的色谱分析:AGREE、Complex MoGAPI 和 RGB 12 模型评估。
IF 4.3 2区 化学
BMC Chemistry Pub Date : 2024-11-16 DOI: 10.1186/s13065-024-01344-7
Mona M. Abdel Moneim, Mohamed M. A. Hamdy
{"title":"Chromatographic assay of recently approved co-formulation of Vonoprazan fumarate with low dose Aspirin: AGREE, Complex MoGAPI, and RGB 12-model assessments","authors":"Mona M. Abdel Moneim,&nbsp;Mohamed M. A. Hamdy","doi":"10.1186/s13065-024-01344-7","DOIUrl":"10.1186/s13065-024-01344-7","url":null,"abstract":"<div><p>Two simple, valid and green chromatographic based techniques are developed in the present work for first time to simultaneously analyze the recently approved combination of Aspirin (ASP) with the novel gastro-protective agent Vonoprazan (VON). First method is an HPLC-DAD “diode array detection”, where separation was successful using C18 (250 × 4.6 mm) column with isocratic elution of phosphate buffer-pH 6.8 and acetonitrile in ratio of 63:37 with detection at 230 nm. Second method is an HPTLC method on HPTLC silica plates using ethyl acetate: ethanol (75%): ammonia (5:5:0.05 v/v) mobile phase followed by densitometric scanning at 230 nm. The methods were applied successfully for analysis of VON and ASP mixture in laboratory-prepared tablets and the methods were validated in regards to linearity, precision, accuracy and selectivity. The proposed methods are assessed for their greenness and whiteness as well using the “Analytical GREEnness Metric Approach”, “Complementary Modified Green Analytical Procedure Index” and the new algorithm “RGB 12 model” (Red-Green-Blue) and proved the greenness and the sustainability of the methods in the routine assay of the newly marketed formulation.</p></div>","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"18 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bmcchem.biomedcentral.com/counter/pdf/10.1186/s13065-024-01344-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142643462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New thiophene derivatives: chemoselective synthesis, antitumor effectiveness, structural characterization, DFT calculations, Hirshfeld surface, and Fukui function analysis 新噻吩衍生物:化学选择性合成、抗肿瘤效果、结构特征、DFT 计算、Hirshfeld 表面和 Fukui 函数分析。
IF 4.3 2区 化学
BMC Chemistry Pub Date : 2024-11-14 DOI: 10.1186/s13065-024-01346-5
Abdullatif Bin Muhsinah, Mohammed M. Alharbi, Nabila A. Kheder, Saied M. Soliman, Hazem A. Ghabbour, Naglaa S. Mahmoud, Ismail A. Elhaty, Yahia N. Mabkhot
{"title":"New thiophene derivatives: chemoselective synthesis, antitumor effectiveness, structural characterization, DFT calculations, Hirshfeld surface, and Fukui function analysis","authors":"Abdullatif Bin Muhsinah,&nbsp;Mohammed M. Alharbi,&nbsp;Nabila A. Kheder,&nbsp;Saied M. Soliman,&nbsp;Hazem A. Ghabbour,&nbsp;Naglaa S. Mahmoud,&nbsp;Ismail A. Elhaty,&nbsp;Yahia N. Mabkhot","doi":"10.1186/s13065-024-01346-5","DOIUrl":"10.1186/s13065-024-01346-5","url":null,"abstract":"<div><p>In this study, the chemoselective synthesis of two new thiophene derivatives is presented. The structure of newly synthesized thiophenes derivatives; ethyl 4-acetyl-3-phenyl-5-(phenylamino)thiophene-2-carboxylate (<b>5</b>) and ethyl (E)-4-(3-(dimethylamino)acryloyl)-3-phenyl-5-(phenylamino)thiophene-2-carboxylate (<b>8</b>) were established using different FTIR and NMR spectral analyses. Compound <b>8</b> was isolated as single crystal and its 3D structure was determined using X-ray crystallographic analysis. Possible intermolecular interactions that control the molecular packing of <b>8</b> were elucidated using Hirshfeld topology analysis. The O…H (13.7%), H…H (55.3%) and C…C (2.3%) intermolecular interactions are the most significant. Fukui functions showed that C4 in thiophene <b>5</b> and C3 in thiophene 8 are the most reactive atoms for nucleophilic attack, while N9 in thiophene <b>5</b> and C1 in thiophene <b>8</b> are the most reactive atoms for electrophilic attack. Antitumor activity of thiophene <b>5</b> was assessed and the results showed higher activity against HepG-2 (7.46 µg/mL) compared to the HCT 116 (12.60 µg/mL) cell line.</p></div>","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"18 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bmcchem.biomedcentral.com/counter/pdf/10.1186/s13065-024-01346-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bio-inspired one-pot synthesis of luminescent silver nanoparticles and its significant utility as a fluorescence nano sensor for analysis of two adjunctive COVID-19 drugs 受生物启发的发光银纳米粒子的一锅合成及其作为荧光纳米传感器在分析 COVID-19 两种辅助药物中的重要作用。
IF 4.3 2区 化学
BMC Chemistry Pub Date : 2024-11-14 DOI: 10.1186/s13065-024-01335-8
Yasmeen E. Mostafa, Fawzi Elsebaei, Mohammed El-Sayed Metwally
{"title":"Bio-inspired one-pot synthesis of luminescent silver nanoparticles and its significant utility as a fluorescence nano sensor for analysis of two adjunctive COVID-19 drugs","authors":"Yasmeen E. Mostafa,&nbsp;Fawzi Elsebaei,&nbsp;Mohammed El-Sayed Metwally","doi":"10.1186/s13065-024-01335-8","DOIUrl":"10.1186/s13065-024-01335-8","url":null,"abstract":"<div><p>This study reveals one-step green synthesis of plant inspired silver nanoparticles (Ag-NPs). The synthesis procedure relies on the bio-reduction of Ag<sup>+</sup> to Ag<sup>0</sup> using orange waste (orange peel) extract as cheap, readily available, sustainable, biocompatible feedstocks as a reducing and stabilizing agent. The prepared Ag-NPs passed through a full characterization procedure for better confirmation and elucidation of optical and structural properties. The fluorescence of the prepared Ag-NPs has a quantum yield of 17.15% enabling its potential use in chemical sensing of drugs. Ag-NPs are conceived to be used as a fluorescent nano sensor for sensitive, ecofriendly, rapid spectrofluorimetric determination of two recent direct oral anticoagulants, namely, rivaroxaban (RIV) and edoxaban tosylate monohydrate (EDT); COVID-19 adjunctive drugs in their raw materials and pharmaceutical tablets. The fluorescence of the prepared Ag-NPs at 333 nm <span>({(uplambda }_{text{ex}}=258 text{nm}))</span> was found to be substantially quenched in existence of increasing concentrations of each drug. The quenching mechanisms were studied and explained. The validation of the method revealed linear correlation over the ranges of 0.5–10 µg/ml with an excellent regression correlation (r = 0.9999) for both drugs with minimum detection limits of 0.14 and 0.16 µg/ml for rivaroxaban and edoxaban tosylate monohydrate, correspondingly. Three different metrics were employed for verifying the greenness profile of the presented study. The findings of the greenness assessment were congruent and compatible with the green synthesis procedure, ecofriendly analysis, and the exclusion of using organic solvents and noxious materials opening an avenue for green synthesis of nanoparticles instead of chemical and physical methods.</p></div>","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"18 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bmcchem.biomedcentral.com/counter/pdf/10.1186/s13065-024-01335-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Utilizing MEDT analysis of [3 + 2] cycloaddition reaction: x-ray crystallography of spirooxindole linked with thiophene/furan heterocycles and triazole framework 利用 MEDT 分析 [3 + 2] 环加成反应:与噻吩/呋喃杂环和三唑框架相连的螺吲哚的 X 射线晶体学。
IF 4.3 2区 化学
BMC Chemistry Pub Date : 2024-11-14 DOI: 10.1186/s13065-024-01343-8
Abdulmajeed Abdullah Alayyaf, M. Ali, Moayad Abdullah Alwehaibi, Muhanna K. Al-Muhanna, Saied M. Soliman, Mar Ríos-Gutiérrez, Matti Haukka, Assem Barakat
{"title":"Utilizing MEDT analysis of [3 + 2] cycloaddition reaction: x-ray crystallography of spirooxindole linked with thiophene/furan heterocycles and triazole framework","authors":"Abdulmajeed Abdullah Alayyaf,&nbsp;M. Ali,&nbsp;Moayad Abdullah Alwehaibi,&nbsp;Muhanna K. Al-Muhanna,&nbsp;Saied M. Soliman,&nbsp;Mar Ríos-Gutiérrez,&nbsp;Matti Haukka,&nbsp;Assem Barakat","doi":"10.1186/s13065-024-01343-8","DOIUrl":"10.1186/s13065-024-01343-8","url":null,"abstract":"<div><p>Hybridization of spirooxindole with different pharmacophores such as triazole and heterocycle such as thiophene and furan moiety was achieved by the [3 + 2] cycloaddition (32CA) reaction approach. Structural investigations of the compounds <b>4a</b> and <b>4b</b> were performed using X-ray single crystal structure determinations and Hirshfeld analysis. Both compounds crystallized in monoclinic crystal system. The space group is <i>P2</i><sub><i>1</i></sub><i>/c</i> for <b>4a</b> and <i>P2</i><sub><b><i>1</i></b></sub><i>/n</i> for <b>4b</b>. The crystal parameters are <i>a</i> = 10.2619(3) Å, <i>b</i> = 13.6776(3) Å, <i>c</i> = 10.9318(3), <i>β</i> = 116.640(4)° for the former while <i>a</i> = 13.0012(1) Å, <i>b</i> = 14.9692(1) Å, <i>c</i> = 14.1178(1) Å, <i>β</i> = 97.101(1)° for the latter. In both compounds, the aryl group and the triazole moieties are twisted from one another. The twist angle is 84.75˚for <b>4a</b> while 86.64˚ for <b>4b</b>. Based on Hirshfeld calculations, the Cl…H, O…H, N…H and C…H non-covalent interactions in <b>4a</b> while the O…H interactions in <b>4b</b> are the most important. The molecular mechanism of the key 32CA reaction between the in situ generated azomethine ylides and the corresponding chalcones has been studied within the Molecular Electron Density Theory (MEDT). The MEDT study reveals that the low activation energies and high experimental selectivity are the result of the supernucleophilic character of the ylides and the strong electrophilicity of the chalcones, which favour the process through a high polar character. This high polar character accounts for the total <i>endo</i> selectivity experimentally found.</p></div>","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"18 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bmcchem.biomedcentral.com/counter/pdf/10.1186/s13065-024-01343-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New N-amino-5-cyano-6-pyridones as antimicrobial small molecules endowed with DNA gyrase a inhibitory activity: design, one-pot synthesis, biological assessment and in silico insights 具有 DNA gyrase a 抑制活性的新型 N-氨基-5-氰基-6-吡啶酮类抗菌小分子:设计、一锅合成、生物学评估和硅学研究。
IF 4.3 2区 化学
BMC Chemistry Pub Date : 2024-11-13 DOI: 10.1186/s13065-024-01342-9
Omkulthom Al Kamaly, Amel S. Younes, Marwa F. Harras, Rehab Sabour, Aisha A. Alsfouk, Mona H. Ibrahim
{"title":"New N-amino-5-cyano-6-pyridones as antimicrobial small molecules endowed with DNA gyrase a inhibitory activity: design, one-pot synthesis, biological assessment and in silico insights","authors":"Omkulthom Al Kamaly,&nbsp;Amel S. Younes,&nbsp;Marwa F. Harras,&nbsp;Rehab Sabour,&nbsp;Aisha A. Alsfouk,&nbsp;Mona H. Ibrahim","doi":"10.1186/s13065-024-01342-9","DOIUrl":"10.1186/s13065-024-01342-9","url":null,"abstract":"<div><p>A set of innovative <i>N</i>-amino-5-cyano-6-pyridones derivatives was developed and produced using one-pot three-component procedures. The evaluated molecules were examined for their antimicrobial efficacy. Based on the acquired findings, most of the investigated compounds had promising antimicrobial properties. Out of these derivatives of 3-cyanopyridine, compounds <b>3d</b> and <b>3e</b> exhibited minimum inhibitory concentrations (MIC) of 3.91 µg/mL against <i>E.coli</i>. In vitro evaluation of DNA gyrase A displayed that molecule <b>3d</b> exhibited promising potency as an inhibitor, with an IC<sub>50</sub> value of 1.68 µg/mL compared to ciprofloxacin (IC<sub>50</sub> = 0.45 µg/mL). Furthermore, it was observed that molecule <b>3e</b> exhibited a moderate inhibitory effect, as indicated by its IC<sub>50</sub> value of 3.77 µg/mL. A kinetics study conducted to assess the time required to kill <i>E. coli</i> bacteria demonstrated that gentamycin and compounds <b>3d</b> and <b>3e</b> exhibited bactericidal effects within a time frame of 90–120 min. Based on the ADME predictions, compounds <b>3d</b> and <b>3e</b> are expected to have favorable oral bioavailability and are unlikely to penetrate the blood-brain barrier. Computational mutagenicity and tumorigenicity studies were conducted on compounds <b>3d</b> and <b>3e</b>. The molecular docking investigation has conclusively demonstrated the binding of compounds <b>3d</b> and <b>3e</b> to the target DNA gyrase A enzyme, further reinforcing the existing data.</p></div>","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"18 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bmcchem.biomedcentral.com/counter/pdf/10.1186/s13065-024-01342-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Separation properties and fouling resistance of polyethersulfone membrane modified by fungal chitosan 真菌壳聚糖改性聚醚砜膜的分离性能和抗堵塞性
IF 4.3 2区 化学
BMC Chemistry Pub Date : 2024-11-11 DOI: 10.1186/s13065-024-01341-w
Hilya N. Iman, Henry Susilo, Adhi Satriyatama, Ignatius D. M. Budi, Kiki A. Kurnia, I. G. Wenten, K. Khoiruddin
{"title":"Separation properties and fouling resistance of polyethersulfone membrane modified by fungal chitosan","authors":"Hilya N. Iman,&nbsp;Henry Susilo,&nbsp;Adhi Satriyatama,&nbsp;Ignatius D. M. Budi,&nbsp;Kiki A. Kurnia,&nbsp;I. G. Wenten,&nbsp;K. Khoiruddin","doi":"10.1186/s13065-024-01341-w","DOIUrl":"10.1186/s13065-024-01341-w","url":null,"abstract":"<div><p>This research explores the enhancement of polyethersulfone (PES) membranes through the incorporation of chitosan derived from the lignicolous fungus <i>Ganoderma sp</i>. Utilizing wet phase inversion and solution casting techniques, chitosan was successfully integrated into the PES matrix, as confirmed by Fourier Transform Infrared Spectroscopy (FT-IR), which indicated a high deacetylation degree of 75.7%. The incorporation of chitosan significantly increased the membrane hydrophilicity, as evidenced by a reduction in the water contact angle and a substantial improvement in pure water permeability, from 17.9 L m<sup>-2</sup> h<sup>-1</sup> bar<sup>-1</sup> to 27.3 L m<sup>-2</sup> h<sup>-1</sup> bar<sup>-1</sup>. The membrane anti-fouling properties were also notably enhanced, with the Flux Recovery Ratio (FRR) increasing from approximately 60–80%. Moreover, the chitosan-modified PES/CS membrane, particularly at a 5% chitosan concentration, demonstrated exceptional efficacy in pollutant removal, achieving over 90% elimination of total suspended solids, cadmium (Cd), and lead (Pb), alongside a 79% reduction in color during the treatment of textile wastewater.</p></div>","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"18 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bmcchem.biomedcentral.com/counter/pdf/10.1186/s13065-024-01341-w","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142600567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Removal of As(V) and Cr(VI) using quinoxaline chitosan schiff base: synthesis, characterization and adsorption mechanism 利用喹喔啉壳聚糖片基去除 As(V) 和 Cr(VI):合成、表征和吸附机理
IF 4.3 2区 化学
BMC Chemistry Pub Date : 2024-11-11 DOI: 10.1186/s13065-024-01328-7
Huda E. Abdelwahab, Mohammed Elhag, Mohamed M. El Sadek
{"title":"Removal of As(V) and Cr(VI) using quinoxaline chitosan schiff base: synthesis, characterization and adsorption mechanism","authors":"Huda E. Abdelwahab,&nbsp;Mohammed Elhag,&nbsp;Mohamed M. El Sadek","doi":"10.1186/s13065-024-01328-7","DOIUrl":"10.1186/s13065-024-01328-7","url":null,"abstract":"<div><p>Elevated Arsenic and Chromium levels in surface and ground waters are a significant health concern in several parts of the world. Chitosan quinoxaline Schiff base (CsQ) and cross-linked chitosan quinoxaline Schiff base (CsQG) were prepared to adsorb both Arsenate [As(V)] and Chromium [Cr(VI)] ions. The thermo-gravimetric analysis (TGA), X-ray diffraction analysis (XRD), and Fourier-transform infrared spectroscopy (FTIR) were used to investigate the prepared Schiff bases (CsQ) and (CsQG). The UV–VIS spectra showed a shift in the wavelength area of the modified polymer, indicating the reaction occurrence, besides the variation of the shape and intensity of the peaks. The XRD patterns showed the incensement of the amorphous characteristic. On the other hand, the thermal stability of the modified polymers is better according to TGA studies; also, the morphology of the modified chitosan was investigated before and after crosslinking (CsQ and CsQG) using a scanning electron microscope (SEM) where the surface was fall of wrinkles and pores, which then were decreased after cross-linking. Contact time, temperature, pH, and initial metal ion concentration were all studied as factors influencing metal ion uptake behavior. The Langmuir, Temkin, Dubinin–Radushkevich, and Freundlich isotherm models were used to describe the equilibrium data using metal concentrations of 10–1000 mg/L at pH = 7 and 1 g of adsorbent. The pseudo-first-order and pseudo-second-order kinetic parameters were evaluated. The experimental data revealed that the adsorption kinetics follow the mechanism of the pseudo-second-order equation with R<sup>2</sup> values (0.9969, 0.9061) in case of using CsQ and R<sup>2</sup> values (0.9989, 0.9999) in case of using CsQG, demonstrating chemical sorption is the rate-limiting step of the adsorption mechanism. Comparing the adsorption efficiency of the synthesized Schiff base and the cross-linked one, it was found that CsQ is a better adsorbent than CsQG in both cases of As(V) and Cr(VI) removal. This means that cross-linking doesn’t enhance the efficiency as expected, but on the contrary, in some cases, it decreases the removal. In addition, the newly modified chitosan polymers work better in As(V) removal than Cr(VI); the removal is 22.33% for Cr(VI) and 98.36% for As(V) using CsQ polymer, whereas using CsQG, the values are 6.20% and 91.75% respectively. On the other hand, the maximum adsorption capacity (Qm) for As(V) and Cr(VI) are 8.811 and 3.003 mg/g, respectively, using CsQ, while in the case of using CsQG, the Qm value reaches 31.95 mg/g for As(V), and 103.09 mg/g for Cr(VI).</p></div>","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"18 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bmcchem.biomedcentral.com/counter/pdf/10.1186/s13065-024-01328-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142600568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel pyrrole based triazole moiety as therapeutic hybrid: synthesis, characterization and anti-Alzheimer potential with molecular mechanism of protein ligand profile 基于吡咯的新型三唑分子作为治疗用杂交化合物:合成、表征和抗老年痴呆潜力以及蛋白质配体的分子机制
IF 4.3 2区 化学
BMC Chemistry Pub Date : 2024-11-09 DOI: 10.1186/s13065-024-01340-x
Shoaib Khan, Tayyiaba Iqbal, Muhammad Bilal Khan, Rafaqat Hussain, Yousaf Khan, Hany W. Darwish
{"title":"Novel pyrrole based triazole moiety as therapeutic hybrid: synthesis, characterization and anti-Alzheimer potential with molecular mechanism of protein ligand profile","authors":"Shoaib Khan,&nbsp;Tayyiaba Iqbal,&nbsp;Muhammad Bilal Khan,&nbsp;Rafaqat Hussain,&nbsp;Yousaf Khan,&nbsp;Hany W. Darwish","doi":"10.1186/s13065-024-01340-x","DOIUrl":"10.1186/s13065-024-01340-x","url":null,"abstract":"<div><p>As a springboard to explore novel potent inhibitors of cholinesterase enzymes (AChE and BChE) responsible for causing Alzheimer disorder, the current study was conducted to synthesize pyrrole derived triazole based Schiff base scaffolds by facile synthetic route. These compounds were validated by <sup>1</sup>HNMR, <sup>13</sup>CNMR and HREI-MS. All these scaffolds (1–16) were examined for their inhibitory activity against AChE and BChE in contrast to Donepezil (<b>10.20 ± 0.10 and 10.80 ± 0.20 µM</b>) and Allanzanthone (<b>12.40 ± 0.10 and 13.10 ± 0.10 µM</b>). All pyrrole derived triazole based Schiff base scaffolds (1–16) showed varied range of inhibitory potentials against acetylcholinesterase and butyrylcholinesterase enzymes with lowest inhibition concentration values ranging from <b>5.10 ± 0.40–27.10 ± 0.10 µM</b> (for AChE) and <b>5.60 ± 0.30–28.40 ± 0.30 µM</b> (for BChE). SAR analysis of these derivatives revealed analog 7 as lead molecule against targeted enzyme, while analog 6 and 11 were ranked as second and third most potent scaffolds. Binding affinity and selectivity of potent molecules against targeted enzymes were examined by molecular docking and obtained results showed that potent molecule have versatile significant binding interactions with stated enzymes. Furthermore, safety profiles of potent analogues were predicted via ADMET protocols.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"18 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bmcchem.biomedcentral.com/counter/pdf/10.1186/s13065-024-01340-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142598907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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