BMC Chemistry最新文献

{"title":"The potential of novel arsenic nanoparticles containing metformin (MTF@As NPs): a study on their antioxidant and cytotoxic properties","authors":"Mojtaba Shakibaie,&nbsp;Seyed Soheil Hosseininasab,&nbsp;Soudabe Riahi-Madvar,&nbsp;Mahboubeh Adeli-Sardou,&nbsp;Fereshteh Jabari-Morouei,&nbsp;Hamid Forootanfar","doi":"10.1186/s13065-025-01419-z","DOIUrl":"10.1186/s13065-025-01419-z","url":null,"abstract":"<div><p>In the present research, arsenic nanoparticles containing metformin (MTF@As NPs) were synthesized by subjecting a mixture of As₂O₃ and sodium borohydride solution to microwave irradiation in the presence of metformin. The physicochemical properties of the prepared nanoparticles were analyzed using UV-visible spectroscopy, Fourier transform infrared spectroscopy (FTIR), energy-dispersive X-ray spectroscopy (EDS), and scanning electron microscopy (SEM). The nanoparticles were assessed for their antioxidant potential, hemocompatibility, and cytotoxic effects. Based on the study’s findings, it was found that MTF@As NPs have a size range of 14–38 nm. DPPH scavenging and iron-reducing assays demonstrated that MTF@As NPs exhibited significantly higher antioxidant activity than As NPs (80–1280 µg/mL). The study also revealed that nanoparticles were compatible materials that did not induce significant hemolysis in RBCs. According to the study, the concentration required for death of half of the cells (IC₅₀) treated with MTF@As NPs after 24 h was found to be 33.5 ± 2.6 µg/mL and 5.7 ± 0.3 µg/mL for MCF-7, and NIH3T3 cells, respectively. Notably, MTF@As NPs exhibited significantly higher toxicity against MCF-7 cells at higher concentrations (40–1280 µg/mL). This study provides insights into the cytotoxic properties of MTF@As NPs, additional investigation is necessary to fully understand these nanoparticles’ underlying biological mechanisms.</p></div>","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"19 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bmcchem.biomedcentral.com/counter/pdf/10.1186/s13065-025-01419-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143726661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemometric-assisted UV spectrophotometric methods for determination of miconazole nitrate and lidocaine hydrochloride along with potential impurity and dosage from preservatives","authors":"Esraa S. Ashour,&nbsp;Ghada M. El-Sayed,&nbsp;Maha A. Hegazy,&nbsp;Nermine S. Ghoniem","doi":"10.1186/s13065-025-01447-9","DOIUrl":"10.1186/s13065-025-01447-9","url":null,"abstract":"<div><p>Three accurate, simple, and precise chemometric techniques, principal component regression (PCR), partial least squares (PLS), and backward interval partial least squares (biPLS) were used to resolve the severely overlapped UV spectra of miconazole nitrate (MIC) and Lidocaine hydrochloride (LDC) along with the toxic impurity of LDC; dimethyl aniline (DMA) and the two inactive ingredients; methyl paraben (MTP) and saccharin sodium (SAC). The concentration ranges of the developed models were found to be (2.40–12.00 µg/mL) for LDC and MIC, (1.50–7.50 µg/mL) for DMA and MTP, and (2.00–6.00 µg/mL) for SAC. The proposed methods were found to be green, rapid, and were effectively used to analyze the studied compounds in both laboratory-prepared mixtures and antifungal oral gel, where no impurity was detected. The obtained results revealed that PLS algorithm was superior to PCR depending on the lowest root mean square error of prediction (RMSEP) and correlation coefficient values (r). The biPLS model, constructed with [3, 4, 5, 6, 8, and 9] subintervals, is considered the most efficient model with the lowest number of latent variables. biPLS is ideal for data analysis and enhancing model performance and robustness by focusing on the most relevant spectral regions. When compared to a reported HPLC method, the proposed methods showed non-significant difference regarding accuracy and precision. The developed models often yield faster results than HPLC. Once the model is built, it takes no time to predict multiple samples without requiring reconstruction, in addition, the proposed models minimize the costs of solvents and equipment compared to HPLC, making them a valuable option for quality control laboratories.</p></div>","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"19 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bmcchem.biomedcentral.com/counter/pdf/10.1186/s13065-025-01447-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143726663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adsorptive-removal of bromothymol blue & keto-bromothymol blue from wastewater using antioxidant curcumin: thermodynamic assessment, kinetic and isotherm modeling","authors":"Samia M. Ibrahim,&nbsp;Ahmed F. Al-Hossainy,&nbsp;Asmaa Y. Wahman","doi":"10.1186/s13065-025-01444-y","DOIUrl":"10.1186/s13065-025-01444-y","url":null,"abstract":"<div><p>Our research objective is using a spectrophotometer method at a wavelength of 430 nm to explore the removal of bromthymol blue (BTB) &amp; keto-bromothymol blue (KBTB) dyes utilizing curcumin (CUR) as an adsorbent. The impacts of several factors such as initial dye concentration, adsorbent dose, contact time, and temperature, were examined. The adsorption equilibrium data were assessed utilizing Langmuir and Freundlich, as well as an appropriate reaction mechanism, were put forth and discussed. CUR, (CUR -BTB) and (CUR -KBTB) dye were confirmed using Fourier Transform Infrared Spectroscopy (FTIR) and Scanning Electron Microscope (SEM) techniques. The highest percentages of curcumin elimination of BTB, KBTB were 43 &amp; 90%, respectively, at 430 nm and 25 °C, and dye adsorption by the adsorbent increased with increasing initial dye concentration but decreased with increasing adsorbent dose. First-order kinetic models in elimination of BTB and KBTB with correlation 0.97 &amp; 0.98, respectively, were fitted using the experimental data for removal of BTB &amp; KBTB by CUR. This demonstrated that chemisorption, which involves valence forces through the sharing or exchange of electrons, is the rate-limiting phase. Hence, the exothermic nature of BTB adsorption onto CUR is indicated by the negative value of ΔH°(-54.216 kJmol^− 1). Once more, the non-spontaneous nature of the adsorption process is indicated by the positive ΔG° value (+ 49.65 kJmol^− 1). Furthermore, the non-affinity of CUR for BTB dye is illustrated by the -ve of change of entropy, ΔS° (-166.78 J/mol K).</p></div>","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"19 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bmcchem.biomedcentral.com/counter/pdf/10.1186/s13065-025-01444-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143726664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a metal-organic framework-based nanosensor for determination of cyclosporine in plasma samples","authors":"Reza Moharami,&nbsp;Zahra Karimzadeh,&nbsp;Zahra Golsanamlu,&nbsp;Afshin Gharakhani,&nbsp;Elaheh Rahimpour,&nbsp;Abolghasem Jouyban","doi":"10.1186/s13065-025-01456-8","DOIUrl":"10.1186/s13065-025-01456-8","url":null,"abstract":"<div><p>According to the narrow therapeutic range and multiple adverse effects of cyclosporine and the need for its therapeutic drug monitoring (TDM), in this study, an efficient zeolitic imidazolate framework-8 metal-organic framework (ZIF-8 MOF) based nanoprobe was designed for simple, rapid and high sensitive its quantification in plasma samples. After the successful synthesis of the ZIF-8 MOF, under the optimum condition, the fluorescence emission of ZIF-8 MOF, measured at an excitation wavelength of 370 nm and an emission wavelength of 417 nm, was enhanced with increasing cyclosporine concentration, due to the specific interactions between cyclosporine and the nanoprobe, including hydrogen bonding and hydrophobic effects. The nanoprobe showed a linear correlation between the analytical response and cyclosporine concentration in the concentration range of 0.01–1.0 µg mL^− 1, with a detection limit of 0.003 µg mL^− 1. Acceptable precision was achieved, evidenced by intra-day and inter-day relative standard deviations of 0.4% and 0.5%, respectively. Recovery between 97.1% and 102.1% in plasma samples indicated the method’s reliability in practical applications.</p></div>","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"19 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bmcchem.biomedcentral.com/counter/pdf/10.1186/s13065-025-01456-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143716869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temperature-dependent solubilization and thermodynamic characteristics of ribociclib in varied {PEG 400 + water} combinations","authors":"Faiyaz Shakeel,&nbsp;Ramadan Al-Shdefat,&nbsp;Mohammad Ali,&nbsp;Usama Ahmad","doi":"10.1186/s13065-025-01461-x","DOIUrl":"10.1186/s13065-025-01461-x","url":null,"abstract":"<div><p>The solubility and thermodynamic characteristics of ribociclib (RCB), a new anticancer medication, have been assessed in a range of {polyethylene glycol 400 (PEG 400) + water} combinations at 293.2–313.2 K and atmospheric pressure. RCB solubility was determined utilizing the saturation shake flask approach, and “van’t Hoff, Apelblat, Buchowski-Ksiazczak <i>λh</i>, Yalkowsky-Roseman, Jouyban-Acree, and Jouyban-Acree-van’t Hoff models” were utilized to validate the measured experimental data. The uncertainties for the computational predictions were less than 3.0% throughout the validation, indicating an outstanding relationship with the experimental RCB solubility data. PEG 400 mass fraction and temperature both improved the solubility of RCB in mole fraction in the compositions of {PEG 400 + water}. It was discovered that the RCB solubility in mole fraction was greatest in pure PEG 400 (1.04 × 10^− 1) at 313.2 K and lowest in neat water (1.07 × 10^− 6 at 293.2 K). All of the {PEG 400 + water} mixes under study showed “endothermic and entropy-driven” RCB dissolution, as indicated by the positive values of the estimated thermodynamic parameters. Compared to RCB-water, RCB-PEG 400 exhibited the strongest molecular interactions. PEG 400 offers a great potential for RCB solubilization in water, according to the evaluation’s findings.</p></div>","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"19 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bmcchem.biomedcentral.com/counter/pdf/10.1186/s13065-025-01461-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143706922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In silico engineering of graphitic carbon nitride nanostructures through germanium mono-doping and codoping with transition metals (Ni, Pd, Pt) as sensors for diazinon organophosphorus pesticide pollutants","authors":"Ene F. Otoh,&nbsp;Michael O. Odey,&nbsp;Osinde I. Martin,&nbsp;Daniel C. Agurokpon","doi":"10.1186/s13065-025-01436-y","DOIUrl":"10.1186/s13065-025-01436-y","url":null,"abstract":"<div><p>The extensive use of pesticides has raised concerns about environmental contamination, which poses potential health risks to humans and aquatic life. Hence, the need for a healthy and friendly ecosystem initiated this study, which was modeled through profound density functional theory (DFT) at the B3LYP-D3(BJ)/def2svp level of theory to gain insights into the electronic characteristics of germanium-doped graphitic carbon nitride (Ge@C₃N₄) engineered with nickel group transition metals (Ni, Pt, and Pd) as sensors for diazinon (DZN), an organophosphorus pesticide pollutant. To effectively sense diazinon, this research employed a variety of methodologies, beginning with the analysis of electronic properties, intermolecular investigations, adsorption studies, and sensor mechanisms. These detailed assessments revealed insightful results, as clearly indicated by their narrow energy gap and other electronic properties. Noncovalent interactions characterized by van der Waals forces were revealed predominantly by quantum atoms in molecules (QTAIM) and noncovalent interaction (NCI) analyses. Furthermore, the results of the adsorption studies, which measured the strength of the interaction between the pesticide molecules and the nanostructures, revealed favorable results characterized by negative adsorption energies of − 1.613, − 1.613, and − 1.599 eV for DZN_Ge@C₃N₄, DZN_Ni_Ge@C₃N₄, and DZN_Pd_Ge@C₃N₄, respectively. The simulated mechanism through which diazinon is sensed revealed favorable results, as observed by the negative Fermi energy and fraction of electron transfer (∆N), as well as a high dipole moment. This study also revealed that the codoping influenced the behavior of the systems, revealing that DZN_Ni_Ge@C₃N₄ was the best sensing system because of its strongest adsorption (− 1.613 eV), highest dipole moment (8.348 D), most negative Fermi energy (− 1.300 eV), lowest work function (1.300 eV), and good ∆N (− 1.558) values. This study, therefore, proposes these nanostructures for further in vitro studies seeking to sense diazinon and other pesticides to maintain healthy ecosystems.</p></div>","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"19 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bmcchem.biomedcentral.com/counter/pdf/10.1186/s13065-025-01436-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143676476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing antibiotic detection via an aptasensor: the case of ciprofloxacin","authors":"Eva Hobeika,&nbsp;Joseph Saab,&nbsp;Souheil Hallit,&nbsp;Isaac-Aaron Morales Frias,&nbsp;Nicole Jaffrezic-Renault,&nbsp;Abdelhamid Errachid","doi":"10.1186/s13065-025-01425-1","DOIUrl":"10.1186/s13065-025-01425-1","url":null,"abstract":"<div><p>The need for fast, efficient, and cost-effective test systems for antibiotics is surging, to control resistant bacterial strains. Electrochemical biosensors offer a good alternative to routine laboratory-bound analytical methods. These biosensors are portable, suitable for in-field analysis and biocompatible for detection of small biomolecules. The aim of this work is the ciprofloxacin active pharmaceutical ingredient since resistance of bacteria to this antibiotic is reportedly increasing worldwide, especially in Lebanon where hospitalization bills are no longer affordable. So, the target is ciprofloxacin detection, a fluoroquinolone antibiotic, on screen-printed electrodes. Following diazonium salt, also known as carboxymethylaniline (CMA) deposition, a ciprofloxacin oligonucleotide was incubated on the electrode. This aptamer acts as an anchor for the ciprofloxacin molecule, allowing the latter’s attachment to the electrode and its quantification. Electrochemical characterization, through cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) allowed for deposition of molecules on electrodes and confirmation that an electrochemical change took place. Scanning Electron Microscope images are used to confirm conformational changes on the surface of electrodes. Impedance results reported a limit of detection of LOD = 3 nM, a dynamic range from 10 nM to 100 µM, and reproducibility of results between two aptasensors to be 10%. Moreover, impedimetric sensor specificity evaluation was through the effect of interfering compounds tobramycin, ofloxacin, norfloxacin and ceftriaxone, on the aptasensor’s response. Based on available literature, this LOD level reached allows for the detection of ciprofloxacin via a portable potentiostat in environmental (wastewater, food), biological (urine, saliva) and pharmaceutical samples (efficient market withdrawal of counterfeit medications from pharmaceutical storage facilities).</p></div>","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"19 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bmcchem.biomedcentral.com/counter/pdf/10.1186/s13065-025-01425-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of UV-Chemometric techniques for resolving the overlapped spectra of aspirin, caffeine and orphenadrine citrate in their combined pharmaceutical dosage form","authors":"Sobhy M. El-Adl,&nbsp;Amr A. Mattar,&nbsp;Omar M. El-Abassy,&nbsp;Mahmoud M. Sebaiy","doi":"10.1186/s13065-025-01429-x","DOIUrl":"10.1186/s13065-025-01429-x","url":null,"abstract":"<div><p>A UV-chemometric approach has been developed to analyze a ternary combination of aspirin, caffeine, and orphenadrine citrate without the need for previous separation. The method is easy, specific, accurate, and highly precise. The three medications were evaluated simultaneously utilizing CLS, PLS, and PCR, which were generated based on separate data sets that yielded superior findings. Regrettably, their accurate estimation could only be achieved using the PLS approach. In order to determine the prediction power of each chemometric approach, its validity has been tested using 8 synthetic mixes. The latent variable number varies across various models as the dataset changes. The comparison of various methodologies and the assessment of the predictive capacity of each set of data were done using the predicted residual error sum of squares (PRESS) and the root mean square error of prediction (RMSEP). The created approach was also used to statistically compare the performance of PLS in a dataset with zero absorption, as well as to compare the performance of the offered chemometric methods in various datasets. The environmental impact of the created approach was assessed to determine the overall ecological sustainability of the designed methodology. According to the new Blue Applicability Grade Index (BAGI) evaluation methodology, the suggested technique was also found to be practicable.</p></div>","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"19 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bmcchem.biomedcentral.com/counter/pdf/10.1186/s13065-025-01429-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143655359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eco-friendly RP-HPLC method for simultaneous determination of water-soluble and fat-soluble vitamins in nano-formula and pharmaceutical dosage forms","authors":"Safaa Hussein Salah El-Din,&nbsp;Amr M. Mahmoud,&nbsp;Amany Morsi","doi":"10.1186/s13065-025-01441-1","DOIUrl":"10.1186/s13065-025-01441-1","url":null,"abstract":"<div><p>A green method for simultaneous determination of water soluble vitamin (vitamin C) and fat soluble vitamin (vitamin A) was developed using reversed phase high performance liquid chromatography technique. The method succeed to separate the water-soluble and fat-soluble vitamins by isocratic elution using Agilent Zorbax octylsilane column (250 × 4.6 mm, 5 μm) in a short single run. The proposed mobile phase consisted of buffer (10 mM potassium dihydrogen phosphate and 3 mM hexane sulfonic acid sodium salt), pH adjusted to 2.5 using orthophosphoric acid and methanol in a ratio (8:92 v/v) with flow rate 1.0 mL.min^− 1 and UV detection 328 nm for vitamin A and 243 nm for vitamin C in concentration range (0.5–30 IU.mL^− 1) and (1–60 µg.mL^− 1), respectively. Accuracy results were 99.49% ± 1.58 for vitamin C and 100.26% ± 1.86 for vitamin A, limit of detection (L.O.D) of vitamin C is 0.3 µg.mL^− 1 while for vitamin A is 0.15 IU.mL^− 1 and limit of quantification (L.O.Q) of vitamin C is 1.0 µg.mL^− 1 while for vitamin A is 0.5 IU.mL^− 1. Analytical eco scale and green analytical procedure index showed that our proposed method is greener than the reported method. The proposed method validation was performed according to ICH guidelines and the method was applied successfully for determination of vitamin A and vitamin C simultaneously in cosmetic nano-formulation, pharmaceutical dosage form and in pure forms.</p></div>","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"19 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bmcchem.biomedcentral.com/counter/pdf/10.1186/s13065-025-01441-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A stability-indicating potentiometric platform for assaying Metoprolol succinate and felodipine in their tablets and human plasma","authors":"Haitham A. El Fiky,&nbsp;Mahmoud A. Tantawy,&nbsp;Dina A. Ahmed,&nbsp;Maha F. Abd El Ghanyd,&nbsp;Amr M. Badawey,&nbsp;Nermine V. Fares","doi":"10.1186/s13065-025-01435-z","DOIUrl":"10.1186/s13065-025-01435-z","url":null,"abstract":"<div><p>Solid contact electrodes are prevalent in analytical applications due to their superior performance compared to traditional electrodes. Nonetheless, these electrodes have been observed to develop a water layer, which compromises their stability. In this study, we introduce an innovative solid contact ion selective electrode designed to mitigate this issue by incorporating multi-walled carbon nanotubes. This system was utilized for potentiometric sensing of metoprolol and felodipine. Furthermore, molecular imprinted polymer was developed to enhance selectivity for determination of felodipine. The electrode modified with multi-walled carbon nanotubes was employed for the quantification of metoprolol, exhibiting a Nernstian slope of 55.23 mV/decade over a linear concentration range of 1.0 × 10^− 7 to 1.0 × 10^− 2 mol L^− 1, at a pH of 7.0. The molecularly imprinted polymer-modified electrode was utilized for the determination of felodipine, showing slope of 56.089 mV/decade across a linear range of 1.0 × 10^− 7 to 1.0 × 10^− 4 mol L^− 1, at a pH of 3.0. Detection limits for both sensor were less than 8.0 × 10^− 8 mol L^− 1. The developed sensors were successfully utilized for the quantification of the aforementioned drugs in pharmaceutical tablets, in human plasma samples and in the presence of their degradates. The proposed approach showed a better linearity range and a lower limit of detection for metoprolol quantification compared to its reported potentiometric methods. Moreover, it was the first one to use such an electrochemical technique for felodipine detection.</p></div>","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"19 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bmcchem.biomedcentral.com/counter/pdf/10.1186/s13065-025-01435-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143655249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}