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Screening and quantification of inorganic anions in Shilajit and its supplements 石拉吉特及其补品中无机阴离子的筛选与定量
IF 4.3 2区 化学
BMC Chemistry Pub Date : 2025-04-13 DOI: 10.1186/s13065-025-01473-7
Elham Kamgar, Joanna Zembrzuska, Wiktor Lorenc, Massoud Kaykhaii
{"title":"Screening and quantification of inorganic anions in Shilajit and its supplements","authors":"Elham Kamgar,&nbsp;Joanna Zembrzuska,&nbsp;Wiktor Lorenc,&nbsp;Massoud Kaykhaii","doi":"10.1186/s13065-025-01473-7","DOIUrl":"10.1186/s13065-025-01473-7","url":null,"abstract":"<div><p>Shilajit, a natural substance with ancient medicinal roots, is increasingly used in modern supplements for its purported health benefits. However, there is a lack of comprehensive chemical characterization, particularly regarding inorganic anions. This study addresses this gap by quantifying common inorganic anions in 14 raw Shilajit samples sourced from Iran, India, Nepal, Kyrgyzstan, and Russia, as well as in 6 commercially available supplements from Poland, Russia, and Kyrgyzstan. Using ion chromatography, key anions including chloride, sulphate, nitrate, hydrogen phosphate, and fluoride were analyzed. Results revealed that chloride was the most prevalent anion, with concentrations ranging from 0.102 to 9.496 mg.g<sup>− 1</sup> in raw Shilajit samples and up to 0.931 mg.g<sup>− 1</sup> in supplements. Sulphate levels were significant, with concentrations up to 12.412 mg.g<sup>− 1</sup> in raw Shilajit and 0.854 mg.g<sup>− 1</sup> in supplements. Nitrate was detected in lower concentrations, peaking at 9.504 mg.g<sup>− 1</sup> in raw Shilajit. Fluoride was quantifiable in only one sample at 0.064 mg.g<sup>− 1</sup>. The study concludes that Shilajit’s geographical origin significantly influences its anion composition, leading to variability in its potential health effects. These findings highlight the necessity for standardized formulations and stringent quality control measures in Shilajit supplement production to ensure consumer safety and product efficacy.</p></div>","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"19 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bmcchem.biomedcentral.com/counter/pdf/10.1186/s13065-025-01473-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143826585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Accidents involving lithium-ion batteries in non-application stages: incident characteristics, environmental impacts, and response strategies 非应用阶段涉及锂离子电池的事故:事件特征、环境影响和应对策略
IF 4.3 2区 化学
BMC Chemistry Pub Date : 2025-04-13 DOI: 10.1186/s13065-025-01445-x
Ziyu Wang, Guohe Huang, Zhikun Chen, Chunjiang An
{"title":"Accidents involving lithium-ion batteries in non-application stages: incident characteristics, environmental impacts, and response strategies","authors":"Ziyu Wang,&nbsp;Guohe Huang,&nbsp;Zhikun Chen,&nbsp;Chunjiang An","doi":"10.1186/s13065-025-01445-x","DOIUrl":"10.1186/s13065-025-01445-x","url":null,"abstract":"<div><p>With the rapid growth of electric vehicle adoption, the demand for lithium-ion batteries has surged, highlighting the importance of understanding the associated risks, particularly in non-application stages such as transportation, storage, assembly, and disposal. This review explores the types and causes of lithium-ion battery accidents, categorizing them into leakage, fire, and explosion, often resulting from electrical, thermal, and mechanical abuses. It examines the environmental impacts of such incidents, including the release of toxic substances that threaten public health and ecological systems. The research also outlines the need for effective risk assessment methods and compliance with safety standards. Furthermore, it evaluates current emergency response strategies, advocating for a unified approach to managing these incidents. By delving into the complexities of lithium-ion battery safety, this study aims to contribute to improved practices and regulatory frameworks, ultimately enhancing related accident responses.</p></div>","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"19 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bmcchem.biomedcentral.com/counter/pdf/10.1186/s13065-025-01445-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143826583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antioxidant capacities and in vitro anti-microbial activities of rice (Oryza sativa var Bajong) from Borneo 婆罗洲稻(Oryza sativa var Bajong)的抗氧化能力和体外抑菌活性
IF 4.3 2区 化学
BMC Chemistry Pub Date : 2025-04-09 DOI: 10.1186/s13065-025-01453-x
Xiu Qian Lam, Heng Yen Khong, Siow Phing Tay, Isabel Lim Fong
{"title":"Antioxidant capacities and in vitro anti-microbial activities of rice (Oryza sativa var Bajong) from Borneo","authors":"Xiu Qian Lam,&nbsp;Heng Yen Khong,&nbsp;Siow Phing Tay,&nbsp;Isabel Lim Fong","doi":"10.1186/s13065-025-01453-x","DOIUrl":"10.1186/s13065-025-01453-x","url":null,"abstract":"<div><p>Rice contains antioxidants and phenolic components that exert anti-inflammatory and anticancer properties. Different geographical areas produce rice with various chemical constituents and phytochemicals, in turn these confer differential protective effects including antimicrobial and anticancer properties. Sarawak rice, <i>Oryza sativa var</i> Bajong (Bajong), a fragrant dark purple rice grain harvested from two locations in Sarawak, namely interior Lubok Nibong (LN) and coastal Sri Aman (SA), was assessed for their antioxidant properties and antimicrobial activities. The rice was extracted using methanol solvent and evaluated for total phenolic content (TPC), total flavonoid contents (TFC), as well as their antioxidant and antimicrobial activities based on the Folin–Ciocalteu assay, the aluminium calorimetric method, 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging activity and disk diffusion assay, respectively. Using dual-wavelength measurement, Bajong LN showed 2.16% higher amylose content than Bajong SA. Furthermore, 24-h extract of Bajong LN and 48-h extract of Bajong SA exhibited high antioxidant properties (34–70 µg/mL) and were rich in phenolic (46.54 ± 2.62 mg GAE/g; 25.28 ± 3.91 mg GAE/g) and flavonoid contents (5.53 ± 0.36 mg QCE/g; 7.7 ± 2.19 mg QCE/g) respectively. It is interesting to note that 72-h Bajong extract exhibited the largest zone of inhibition (9–9.3 mm) against Gram-negative <i>Pseudomonas aeruginosa</i> (<i>Ps. aeruginosa</i>), which correlated to the high TPC and TFC despite a reduction of antioxidant activity due to prolonged extraction hours. These significant results conferred added value to a staple, health-promoting Bajong had warranted it to be further investigated as a nutraceutical and pharmaceutical crop.</p></div>","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"19 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bmcchem.biomedcentral.com/counter/pdf/10.1186/s13065-025-01453-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143809134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis and in silico studies of quinoline appended acridine via conventional and green methods: photophysical analysis of novel fluorophore for picric acid detection using a ‘turn-off' fluorescence approach 通过传统方法和绿色方法合成喹啉附加吖啶并对其进行硅学研究:利用 "关闭 "荧光方法对用于苦味酸检测的新型荧光团进行光物理分析
IF 4.3 2区 化学
BMC Chemistry Pub Date : 2025-04-09 DOI: 10.1186/s13065-025-01452-y
Rebecca Susan Philip, V. Vijayakumar
{"title":"Synthesis and in silico studies of quinoline appended acridine via conventional and green methods: photophysical analysis of novel fluorophore for picric acid detection using a ‘turn-off' fluorescence approach","authors":"Rebecca Susan Philip,&nbsp;V. Vijayakumar","doi":"10.1186/s13065-025-01452-y","DOIUrl":"10.1186/s13065-025-01452-y","url":null,"abstract":"<div><p>A series of novel 4-(9-phenyl-1,2,3,4-tetrahydroacridin-2-yl)cyclohexan-1-ones and their dimers were synthesized using an efficient one-pot method with Deep Eutectic Solvents (DESs), alongside microwave-assisted and conventional techniques. Using less toxic and inexpensive DESs enhance sustainability in producing desired products. Green metrics calculations indicate a high level of greenness in the synthesis process. FT-IR, NMR, and HRMS characterized the compounds. In-silico tests involving Bovine Serum Albumin (BSA) assessed the binding affinity of the compounds toward various drugs. Furthermore, DFT studies explored theoretical spectral calculations, energy differences, and electron cloud density. Notably, among the derivatives, the fluorophore 4-(7-amino-9-phenyl-1,2,3,4-tetrahydroacridin-2-yl)cyclohexan-1-one (<b>3e</b>) can specifically detect 2,4,6-trinitrophenol (Picric acid, PA), a fatal nitro explosive. Photophysical studies confirmed <b>3e</b>'s ability as a “turn-off” fluorescence chemosensor for PA with a detection limit of 1.766 × 10<sup>–9</sup> M and a binding stoichiometric ratio of 1:1 between the probe and analyte. Structural confirmation of the probe was achieved through single-crystal XRD.</p></div>","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"19 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bmcchem.biomedcentral.com/counter/pdf/10.1186/s13065-025-01452-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143809135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effective removal of anionic dyes from aqueous solution using polyethersulfone based membrane reinforced by montmorillonite 使用蒙脱石增强的聚醚砜基膜有效去除水溶液中的阴离子染料
IF 4.3 2区 化学
BMC Chemistry Pub Date : 2025-04-07 DOI: 10.1186/s13065-025-01464-8
Farnaz Mortezapour, Nasrin Shadjou, Mehdi Mahmoudian
{"title":"Effective removal of anionic dyes from aqueous solution using polyethersulfone based membrane reinforced by montmorillonite","authors":"Farnaz Mortezapour,&nbsp;Nasrin Shadjou,&nbsp;Mehdi Mahmoudian","doi":"10.1186/s13065-025-01464-8","DOIUrl":"10.1186/s13065-025-01464-8","url":null,"abstract":"<div><p>The study highlights the development and characterization of a novel polymeric membrane composed of montmorillonite (MMT) and polyethersulfone (PES) using the phase inversion process. The membrane incorporates polyethylene glycol (PEG) as a pore-forming agent and N-methyl pyrrolidone (NMP) as a solvent. The addition of MMT significantly enhances the membrane's properties, including hydrophilicity, porosity, antifouling capacity, hydraulic resistance, water uptake, and dye removal efficiency. Characterization techniques such as FT-IR spectroscopy, FE-SEM, EDX spectroscopy, water flux measurements, water uptake analysis, contact angle studies, and fouling assessments confirm the improved performance of the PES/MMT composite membrane. The presence of MMT increases the negative surface charge of the membrane, making it particularly effective in removing anionic dyes like Congo red (CR), Quinoline yellow (QY), and Methyl orange (MO). The study demonstrates that membranes with up to 5 wt% MMT exhibit high porosity (68.2%) and enhanced water flux (35 L/m<sup>2</sup>·h), achieving dye rejection rates of 99% for CR, 92% for MO, and 81% for QY. The integration of MMT into PES membranes presents a significant advancement in sustainable water purification technologies. These modified membranes demonstrate enhanced mechanical strength, improved structural stability, and an increased surface area, making them highly effective for dye adsorption. Compared to traditional materials, PES/MMT membranes exhibit superior performance in wastewater treatment and dye removal, offering a promising and eco-friendly alternative for addressing environmental challenges.</p></div>","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"19 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bmcchem.biomedcentral.com/counter/pdf/10.1186/s13065-025-01464-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143793160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis of thiazoloquinolinone derivatives: molecular docking, MD simulation, and pharmacological evaluation as VEGFR-2 inhibitors 噻唑喹啉酮衍生物的合成:分子对接、MD模拟和VEGFR-2抑制剂的药理评价
IF 4.3 2区 化学
BMC Chemistry Pub Date : 2025-04-05 DOI: 10.1186/s13065-025-01459-5
Zeinab Amiri, Mohammad Bayat, Davood Gheidari
{"title":"Synthesis of thiazoloquinolinone derivatives: molecular docking, MD simulation, and pharmacological evaluation as VEGFR-2 inhibitors","authors":"Zeinab Amiri,&nbsp;Mohammad Bayat,&nbsp;Davood Gheidari","doi":"10.1186/s13065-025-01459-5","DOIUrl":"10.1186/s13065-025-01459-5","url":null,"abstract":"<div><p>We synthesized a series of novel thiazoloquinolinone derivatives, achieving moderate to high yields ranging from 74 to 96%, and assessed their efficacy against Vascular Endothelial Growth Factor Receptor-2 (VEGFR-2) using in silico methodologies. The structures of these compounds were characterized through various spectroscopic techniques, including <sup>1</sup>H-NMR, <sup>13</sup>C-NMR, IR, and mass spectrometry. Comprehensive computational analyses, encompassing molecular docking, molecular dynamics (MD) simulations, and absorption, distribution, metabolism, excretion, and toxicity (ADMET) profiling, were conducted. Docking studies with VEGFR-2 revealed that all synthesized compounds exhibited docking scores between − 3.24 and − 6.63, indicating varying degrees of binding affinity. Notably, compound <b>(5e)</b> demonstrated the strongest binding affinity with an energy of − 6.63 kcal/mol. The MD simulations indicated that Lys868 was one of the amino acids exhibiting the highest frequency of interaction throughout the simulation. Analysis of the ADMET and physicochemical properties revealed that all inhibitor compounds possess favorable pharmacological characteristics.</p></div>","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"19 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bmcchem.biomedcentral.com/counter/pdf/10.1186/s13065-025-01459-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143778018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A novel fabrication method of vertically aligned carbon nanotubes by single-stage floating catalyst CVD 通过单级浮动催化剂 CVD 制备垂直排列碳纳米管的新方法
IF 4.3 2区 化学
BMC Chemistry Pub Date : 2025-04-02 DOI: 10.1186/s13065-025-01460-y
B. V.N. Sewwandi, A. R. Kumarasinghe, Xing CHEN, P. M.C.J. Bandara, L. Jayarathna, Rohan Weerasooriya
{"title":"A novel fabrication method of vertically aligned carbon nanotubes by single-stage floating catalyst CVD","authors":"B. V.N. Sewwandi,&nbsp;A. R. Kumarasinghe,&nbsp;Xing CHEN,&nbsp;P. M.C.J. Bandara,&nbsp;L. Jayarathna,&nbsp;Rohan Weerasooriya","doi":"10.1186/s13065-025-01460-y","DOIUrl":"10.1186/s13065-025-01460-y","url":null,"abstract":"<div><p>The single-stage floating catalyst chemical vapor deposition (SS-FCCVD) method using the ferrocene route (e.g., ferrocene: catalyst and camphor: carbon source) offers significant but largely unexplored versatility for the production of carbon nanotubes (CNTs). Our study used the SS-FCCVD method to grow vertically aligned carbon nanotubes (VACNTs) on an alumina ceramic reactor surface at 850 °C under a nitrogen atmosphere. The experimental setup included a camphor/ferrocene ratio of 20:1 and a specific temperature gradient of 21 °C/cm. To minimize the catalyst agglomeration, we positioned the chemical sources at a distance of 15 cm from the inlet of the CVD reactor. Alumina ceramic surfaces proved highly effective for VACNT production, showing minimal agglomeration of iron particles, facilitating the formation of reactive sites essential for VACNT growth. The VACNTs grew readily on alumina ceramic surfaces, forming bundled, forest-like structures with segment lengths up to 1.2 mm and diameters around 60 nm. When compared to conventional substrates, the surface area of the reaction zone substrate increases by up to 705%, resulting in a significant boost in VACNT yield. A detailed evaluation of characterization results confirmed the growth mechanism and behavior of Fe particles such that carbon-encapsulated particles are attached to the inner and outer surfaces of the CNTs. These VACNT surfaces exhibited superhydrophobic properties, similar to the lotus leaf effect. The synthesized iron-dispersed CNTs exhibit exceptional efficiency in Chromium (VI) removal, with an impressive adsorption capacity of 0.206 mmol/m², positioning them as a promising solution for effective water treatment. This scalable SS-FCCVD method using the ferrocene route achieved the longest VACNTs reported to date.</p></div>","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"19 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bmcchem.biomedcentral.com/counter/pdf/10.1186/s13065-025-01460-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143761739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Functionalized novel carbon dots from bell pepper seeds for sustainable green Edoxaban quantification 从甜椒种子中提取的功能化新型碳点用于可持续绿色艾多沙班定量研究
IF 4.3 2区 化学
BMC Chemistry Pub Date : 2025-04-02 DOI: 10.1186/s13065-025-01427-z
Rasha Th. El-Eryan, Mona S. Elshahed, Dalia Mohamed, Azza A. Ashour, Heba T. Elbalkiny
{"title":"Functionalized novel carbon dots from bell pepper seeds for sustainable green Edoxaban quantification","authors":"Rasha Th. El-Eryan,&nbsp;Mona S. Elshahed,&nbsp;Dalia Mohamed,&nbsp;Azza A. Ashour,&nbsp;Heba T. Elbalkiny","doi":"10.1186/s13065-025-01427-z","DOIUrl":"10.1186/s13065-025-01427-z","url":null,"abstract":"<div><p>Global warming and the developed worldwide awareness have persuaded efforts to minimize the generated hazardous wastes. As a result, “green” chemical procedures are being gradually included in science for sustainable development. This concept has been extended and inspired chemists to fabricate novel green carbon dots (CDs) from natural plants. Herein, we represent novel CDs synthesized by recycling seeds obtained from bell pepper as fluorescent probe for the determination of Edoxaban tosylate hydrate (EDO) a non-fluorescent drug; we exploit the advantage of the inner filter effect between the absorption peak of the drug and the emission peak of the CDs. This overlap resulted in quenching the fluorescence of CDs by increasing the concentration of EDO within the range 0.80–20.00 µg/mL with a limit of detection 0.23 and 0.22 µg/mL and a limit of quantitation 0.69 and 0.72 µg/mL for Microwave CDs and Plate CDs, respectively, at λ<sub>ex</sub>/λ<sub>em</sub> 310/409 nm. Two facile preparation techniques for the CDs were used, the microwave-assisted method and the thermal decomposition method, using a single-step approach. The fabricated CDs were characterized using various techniques, including UV-vis, fluorescence and Fourier transform infrared spectroscopies, energy-dispersive X-ray, high-resolution transmission electron microscope, X-ray Diffaction, X-Ray photoelectron spectroscopy and zeta potential. The performance of the synthesized fluorescent probe for the determination of EDO was evaluated according to ICH guidelines. The accomplished results, together with the simplicity, sensitivity, and low cost of the developed probe, recommended its appropriateness for the routine quality control assay of EDO pharmaceutical formulation, as good % recovery was obtained upon the investigation of the marketed tablets with 99.77% and 98.79% recoveries for microwave CDs and plate CDs, respectively. The method’s greenness was evaluated using three integral matrices, the Blue Applicability Grade Index, the Complementary Green Analytical Procedure Index and Analytical Eco-Scale.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"19 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bmcchem.biomedcentral.com/counter/pdf/10.1186/s13065-025-01427-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143761793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis and anti-inflammatory activity of novel 1,2,3-triazole- derivatives from 7-Oxodehydroabietic acid 7-氧脱氢枞酸新型1,2,3-三唑衍生物的合成及抗炎活性研究
IF 4.3 2区 化学
BMC Chemistry Pub Date : 2025-04-02 DOI: 10.1186/s13065-025-01449-7
Yong-Feng Lv, Fu-Cai Ren, Kang Hui, Jie Zheng, Shou-Jin Liu, Han Luo
{"title":"Synthesis and anti-inflammatory activity of novel 1,2,3-triazole- derivatives from 7-Oxodehydroabietic acid","authors":"Yong-Feng Lv,&nbsp;Fu-Cai Ren,&nbsp;Kang Hui,&nbsp;Jie Zheng,&nbsp;Shou-Jin Liu,&nbsp;Han Luo","doi":"10.1186/s13065-025-01449-7","DOIUrl":"10.1186/s13065-025-01449-7","url":null,"abstract":"<div><p>Dehydroabietic acid (DHA) is a naturally occurring diterpene with relevant biological activities. 7-Oxodehydroabietic acid as a highly oxidized state derivative from Dehydroabietic acid (DHA) showing good activities. However, the reported compounds did not include triazole derivatives. To discover novel potent anti-inflammatory diterpenoids, a series of hybrids of 7-Oxodehydroabietic acid containing 1,2,3-triazole moiety were designed and synthesized. The anti-inflammatory activity of the new compounds was assessed towards BV2 cell lines using L-NMMA (IC<sub>50</sub> = 42.36 ± 2.47 <i>µ</i>M) as a positive control. Compared with the L-NMMA, anti-inflammatory effect (NO inhibitory activities) was found in these novel molecules, especially compounds <b>9</b> (IC<sub>50</sub> = 8.00 ± 0.83 <i>µ</i>M), <b>10</b> (IC<sub>50</sub> = 8.44 ± 0.89 <i>µ</i>M), <b>15</b> (IC<sub>50</sub> = 8.13 ± 0.97 <i>µ</i>M) and <b>16</b> (IC<sub>50</sub> = 8.84 ± 1.10 <i>µ</i>M). The anti-inflammatory activity of compounds <b>9</b>, <b>10</b>, <b>15</b> and <b>16</b> in vivo are underway.</p></div>","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"19 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bmcchem.biomedcentral.com/counter/pdf/10.1186/s13065-025-01449-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143761738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Robust ternary system of corncob-derived carbon quantum dots/ ZnFe2O4/graphene oxide for wastewater treatment 玉米芯衍生的碳量子点/ ZnFe2O4/氧化石墨烯三元体系用于废水处理
IF 4.3 2区 化学
BMC Chemistry Pub Date : 2025-04-02 DOI: 10.1186/s13065-025-01462-w
Wajeeha Qayyum, Noor Tahir, Muhammad Zahid, Saima Noreen, Muhammad Yaseen, Abeer A. AlObaid, Qamar Abbas, Ghulam Mustafa
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