BMC Chemistry最新文献

{"title":"β-cyclodextrin cross-linked metal organic frameworks as a new sensing candidate for donepezil hydrochloride potentiometric sensors.","authors":"Rehab O El-Attar, Reda M Abdelhameed, Elmorsy Khaled","doi":"10.1186/s13065-025-01521-2","DOIUrl":"10.1186/s13065-025-01521-2","url":null,"abstract":"<p><p>Screen-printing is a well-established promising technology for large scale production of planner disposable electrochemical sensors. The present study aims to fabricate a novel donepezil hydrochloride (DPH) screen-printed sensor integrated with the cross-linked β-cyclodextrin-functionalized aluminum metal organic framework-multiwall carbon nanotubes nanocomposites (β-CD/MOF/MWCNTs) as a novel sensing element. The fabricated disposable sensors exhibit theoretical Nernstian compliance value of 60.7 ± 1.5 mV decade^-1 within a linear dynamic concentration range from 10^-6 to 10^-2 mol L^-1 and limit of detection 7.0 × 10 ^-7 molL^-1. The DPH disposable sensors show high potential stability with a prolonged operational lifetime and the fast response time of 6 s. The presented electrochemical sensors represent an efficient analytical tool for fast and sensitive assay of DPH residues in the marketed pharmaceutical tablets and biological samples with acceptable average recoveries under direct potentiometric measurements, flow injection analysis (FIA), and potentiometric titration. Moreover, the dissolution and degradation studies of DPH can be monitored by the presented disposable sensors.</p>","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"19 1","pages":"150"},"PeriodicalIF":4.3,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12121035/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144179478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computational and experimental insights into the spectroscopy, electronic states, and molecular docking of (2S)-2,6-diaminohexanoic acid [DAHA].","authors":"T Amna Sherin, P V Abdul Nazar, Sandhya Savita, Mudassar Shahid, Nazia Siddiqui, Saleem Javed","doi":"10.1186/s13065-025-01511-4","DOIUrl":"10.1186/s13065-025-01511-4","url":null,"abstract":"<p><p>This paper presents a theoretical analysis of the L-Lysine molecule using the DFT (density functional theory) method with a 6-311+ + G(d,p) basis set, a quantum-mechanical atomistic simulation method. The research encompasses the analysis of optimized chemical structure, vibrations, FMO, ELF, NLO, RDG, etc., to study the molecule's intensive properties, stability, and other biological activities. IR and UV spectra were analysed for the spectrochemical study, and the VEDA program was used to determine the PED values. The chemical reactivity of the molecule was identified through analysis of the Frontier molecular orbitals, Fukui, and molecular electrostatic potential. The electron localization function and reduced density gradient were determined to understand bonding and electronic structure. The temperature dependence on the properties of the molecule was estimated. The optical properties of the molecule were discussed by analyzing the non-linear optical property. The feasibility of the molecule as a therapeutic drug was examined using the drug likeness concept. Molecular docking analysis was conducted to acquire the best ligand-receptor complex and to study the molecule's biological activity.</p>","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"19 1","pages":"151"},"PeriodicalIF":4.3,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12123746/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144179591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on the law and mechanism by which oxalic acid dissolves tungstic acid.","authors":"Zanhong Chen, Yinliang Liu, Yong Liang, Ting Pu, Wei Lai","doi":"10.1186/s13065-025-01510-5","DOIUrl":"10.1186/s13065-025-01510-5","url":null,"abstract":"<p><p>The traditional alkali autoclaving tungsten smelting process has several disadvantages, such as high production costs, high water consumption and prominent \"three wastes\" problem, all of which seriously hinder the sustainable development of the tungsten smelting industry. We found that tungstic acid (H₂WO₄) can be dissolved in oxalic acid and that H₂WO₄ can be easily precipitated from a solution at relatively high temperatures. Thus, traditional ammonium para-tungstate (APT) can potentially be replaced by H₂WO₄ as the smelting intermediate, which is expected to overcome the problems associated with the alkali autoclaving process, and solve the problem of ammonia/ammonium pollution at the source. To provide theoretical guidance for the development of novel tungsten smelting processes, the law and mechanism of H₂WO₄ dissolution in oxalic acid are urgently needed. These results indicate that when H₂WO₄ is dissolved in an oxalic acid solution, H₂C₂O₄ and H₂WO₄ can ionize C₂O^2-₄ and WO^2-₄, respectively. Then, some of the oxygen atoms bonded with W in WO^2-₄ are replaced by free C₂O^2-₄ to form [WO₃(C₂O₄)·H₂O]^2-. H₂[WO₃(C₂O₄)·H₂O] is subsequently formed by combining [WO₃(C₂O₄)·H₂O]^2- with H⁺ in solution. Under the conditions of an oxalic acid concentration of 0.05-0.4 mol/L, a reaction temperature of 25-65 ℃ and a liquid-solid ratio of 2:1-10:1 mL/g, the dissolution efficiency of H₂WO₄ in oxalic acid increases with increasing oxalic acid concentration or liquid-solid ratio; a low temperature (25 ℃-35 ℃) is more conducive to the dissolution of H₂WO₄ than a high temperature (45 ℃-65 ℃).</p>","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"19 1","pages":"149"},"PeriodicalIF":4.3,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12121132/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144180746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mixed hemimicelle dispersive solid-phase extraction of methamphetamine from urine by ionic liquid coated silica nanoparticles.","authors":"Sepideh Boyaghchi, Arezou Taghvimi, Samin Hamidi, Siavoush Dastmalchi, Asrin Pakravan, Yousef Javadzadeh","doi":"10.1186/s13065-025-01437-x","DOIUrl":"10.1186/s13065-025-01437-x","url":null,"abstract":"<p><p>Regarding the increasing trend of methamphetamine consumption in society, identifying and measuring low levels of methamphetamine in biological matrices is of great importance for clinical and forensic laboratories. Coated ionic liquid silica nanoparticles (CILSNPs) are appropriate adsorbent candidates to extract methamphetamine with high selectivity and sensitivity from complex urine matrix using the mixed hemimicelle dispersive solid-phase extraction (MHMDSPE) method. After successful characterization of synthesized CILSNPs by various techniques such as FTIR, XRD, SEM, and Zeta potential, the one-factor-at-a-time (OFAT) method was performed to optimize effective extraction parameters. HPLC-UV method was used to detect and quantify methamphetamines. The optimized extraction parameters were as follows: 400 µL of methanol, 10 min of extraction, 5 min of desorption time, stirring rate of 2,000 rpm, urine pH of 10, 40 mg of adsorbent, and 10 mL of urine volume. The calibration curve was plotted in the 50-2000 ng/mL concentration range, and the method was validated. The method's limit of detection (LOD) was calculated as 9 ng/mL. Analysis of addicted subjects for the proposed method proves that the method could be used in clinical and analytical laboratories to detect methamphetamine efficiently.</p>","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"19 1","pages":"153"},"PeriodicalIF":4.3,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12123869/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144179605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation of a novel economically efficient and environment friendly controlled release urea from liquefied corn straw and castor oil.","authors":"Hao Lu, Yuan Chen, Canping Dun, Xi Hu, Rui Wang, Peiyuan Cui, Haipeng Zhang, Hongcheng Zhang","doi":"10.1186/s13065-025-01529-8","DOIUrl":"10.1186/s13065-025-01529-8","url":null,"abstract":"<p><p>Because of the renewable nature of castor oil, it has been widely used in the production of bio-based polyurethane (BPU) coated controlled-release fertilizer. However, although castor oil (CO) is a natural material, the polyurethane prepared from castor oil is still a product difficult to degrade. In order to further improve the degradability of castor oil-based polyurethane, six different BPU coated controlled-release urea were prepared using liquefied corn straw (LCS)-based polyols, castor oil, isocyanate as raw materials, glycerol and acrylamide as crosslinking agents. The surface morphology, hydrophobicity, thermal stability, release characteristic curve, degradation related functional groups, colony, soil micro plastic content and other indicators of controlled-release urea were determined, and then six different controlled-release urea were comprehensively evaluated. The results showed that the release time of LCS based polyurethane coated urea was shorter than that of CO based polyurethane coated urea, but the degradation was better. The crosslinking structure significantly improved the hydrophobicity of BPU and prolonged the release period of controlled-release fertilizer. When 30% castor oil was replaced by liquefied corn straw, the release period remained unchanged, but the degradability was improved, which made the content of microplastics in soil decreased. In a word, the partial replacement of castor oil with liquefied corn straw and its application in the production of coated controlled release fertilizer has high environmental benefits.</p>","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"19 1","pages":"154"},"PeriodicalIF":4.3,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12123856/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144179732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phospholipid conjugates: formation of the intramolecular π-cation complex.","authors":"Valery P Shendrikov, Erik F Kot, Kirill I Makrinsky, Abdulilah Ece, Ivan A Boldyrev","doi":"10.1186/s13065-025-01526-x","DOIUrl":"10.1186/s13065-025-01526-x","url":null,"abstract":"<p><p>Phospholipid conjugates consist of functionally different classes of molecules: phospholipid drug conjugates, fluorescent lipid probes and lipid molecular motors. All these conjugates are molecules that bear a functional group- a drug, a fluorophore or a molecular motor attached to the phospholipid. The conjugation is needed to incorporate a functional group into the lipid bilayer of liposome or lipid nanoparticle and thus, either modulate the effect of the drug or bring a new function to the liposome. Here, using NMR spectroscopy and quantum chemistry calculations, we show that phospholipid conjugates can form intramolecular π-cation complexes between quaternary ammonium group of the phosphatidylcholine and aromatic ring of the conjugated moiety. We also report on how to avoid the π-cation complex formation. If the linker between the aromatic moiety and the choline group is long enough the formation of π-cation complex is not observed.</p>","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"19 1","pages":"152"},"PeriodicalIF":4.3,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12123761/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144179634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemometrically assisted optimization and validation of the HPLC method for the analysis of alectinib and its related impurity with measurement uncertainty evaluation and whiteness, blueness, and greenness profile assessments.","authors":"Serkan Levent, Abeer Elriş, Hazal Avcı, Saniye Özcan, Nafiz Öncü Can","doi":"10.1186/s13065-025-01509-y","DOIUrl":"10.1186/s13065-025-01509-y","url":null,"abstract":"<p><p>Alectinib, the most common second-generation anaplastic lymphoma kinase inhibitor, is efficacious against various anaplastic lymphoma kinase mutations and is utilized in the treatment of non-small cell lung cancer. In this work, the determination of both alectinib and its impurity 5-trifluoroacetate at the same time was realized by developing a novel high performance liquid chromatography method. The stationary phase was an Ascentis^® Express 90 Å C₈ (10 cm × 4.6 mm, 2.7 µm) HPLC column; the separation was obtained using a gradient system with a mobile phase consisting of acetonitrile and ammonium acetate buffer, and the responses were recorded from the PDA detector at a wavelength of 269 nm. The method's optimization was carried out using the Box-Behnken design, whereas the optimized conditions were selected according to the desirability function. Validation of the method was done with the International Council for Harmonization, ICH Q2(R2) Guidelines. The limit of detection values was 0.1 and 0.3 µg/mL, and the limit of quantification values were 0.3 and 0.5 µg/mL for alectinib and its impurity, respectively. The recovery study was realized in the Alecensa^® capsule (150 mg alectinib/capsule), with high recoveries showing the perfect precision and accuracy of the method. A bottom-up approach was used to estimate the measurement uncertainty. This made it possible to find and measure the sources of uncertainty as well as the factors that affected the chromatographic responses. The resulting regression models were deemed adequate and were then used to define the operable design region using the Monte Carlo method. The eco-friendliness of the proposed methods was validated with the Complex Green Analytical Procedure Index, Analytical Greenness Metric and Blue Applicability Grade Index greenness evaluation tools. Also, the whiteness of the method was calculated with the newly developed White Analytical Chemistry tool. The method can be used to assay alectinib and its impurity agents in its formulation in quality control laboratories.</p>","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"19 1","pages":"147"},"PeriodicalIF":4.3,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12117729/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144155347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial activity, synthesis, and docking study of some novel arylazo-1,3-thiazolopyrimidine and arylazo-1,3-thiazolopyridopyrimidine derivatives.","authors":"Jihan Qurban, Sara A Alqarni, Adel I Alalawy, Nawaa Ali H Alshammari, Gadeer R S Ashour, Maryam M Alnoman, Hanadi A Katuah, Nashwa M El-Metwaly","doi":"10.1186/s13065-025-01506-1","DOIUrl":"10.1186/s13065-025-01506-1","url":null,"abstract":"<p><p>In this study, a new series of aryl azo thiazolopyrimidine and thiazolopyridopyrimidine derivatives was synthesized using novel 6-aryl-4-(2,3,6,7-tetrahydro-1H,5H-pyrido[3,2,1-ij]quinolin-9-yl)-3,4-dihydropyrimidine-2(1H)-thione and 5-aryl-7-(2,3,6,7-tetrahydro-1H,5H-pyrido[3,2,1-ij]quinolin-9-yl)-2-thioxo-2,3-dihydropyrido[2,3-d]pyrimidin-4(1H)-one scaffolds as key intermediates. Structural elucidation of all intermediates and final products was performed via IR, UV, ¹H/¹³C-NMR, and mass spectrometry. Among the forty synthesized compounds, several exhibited significant in vitro antimicrobial activities, particularly derivatives 11a, 11b, 7a, and 7b, with potent inhibition against S. aureus, E. coli, and C. albicans. Molecular docking studies using the bacterial DNA gyrase B subunit (Protein Data Bank (PDB): 1aj6) revealed favorable binding interactions, especially for 11b, which demonstrated the best docking score and strong π-H interactions. Furthermore, DFT-based molecular modeling confirmed the stability and high electronic reactivity of selected bioactive compounds, with low HOMO-LUMO energy gaps and favorable electrostatic potential profiles. Structure-activity relationship (SAR) analysis indicated that electronic effects, lipophilicity, and heteroaromatic substitution patterns critically influence antimicrobial potency. These findings support the potential of thiazolopyridopyrimidine derivatives as promising scaffolds for future antimicrobial drug development.</p>","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"19 1","pages":"148"},"PeriodicalIF":4.3,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12121148/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sustainable management of copper-contaminated soils using vetiver root biochar","authors":"Sameer Neve,&nbsp;Dibyendu Sarkar,&nbsp;Zhiming Zhang,&nbsp;Rupali Datta","doi":"10.1186/s13065-025-01523-0","DOIUrl":"10.1186/s13065-025-01523-0","url":null,"abstract":"<div><p>Throughout the 19th and early 20th centuries, copper mining was a predominant industry in Michigan’s Upper Peninsula, resulting in substantial environmental issues due to the generation of mining waste. This waste, referred to as stamp sands, was disposed of in Lake Superior, causing severe harm to aquatic ecosystems. Later, the stamp sands were dredged and deposited along the lake shores, causing large-scale contamination with copper. This rendered the land incapable of supporting vegetation. This study investigates the efficacy of vetiver <i>(Chrysopogon zizanioides)</i> root biochar as a soil amendment to enhance the quality of copper-contaminated stamp sands. The biochar was produced from spent vetiver roots following essential oil extraction, using a circular economy approach. Biochar was incorporated with the stamp sand at various concentrations (0%, 2.5%, 5%, 10%, 20% w/w) and incubated over a 60-day period. Comprehensive soil analysis was conducted to assess carbon, nitrogen, phosphorus, organic matter, and copper speciation due to the amendments. The results indicated significant improvements in water-holding capacity, alkalinity, electrical conductivity, nutrient content, and organic matter levels. The 20% biochar amendment had a significantly higher impact on all parameters as compared to the other amendment rates. Geochemical fractionation of amended soil showed that Cu was predominantly in bound forms, thereby reducing its bioavailability. These findings indicate that vetiver root biochar can improve soil quality and potentially facilitate vegetation growth in contaminated Superfund sites integrating principles of circular economy for sustainable management of resources.</p></div>","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"19 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bmcchem.biomedcentral.com/counter/pdf/10.1186/s13065-025-01523-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144135440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimization of HPLC methods for the development of quality control methods of combined powder formulations with paracetamol, phenylephrine hydrochloride, pheniramine maleate","authors":"Oleksandra Havrylenko,&nbsp;Yuliya Kondratova,&nbsp;Lyudmyla Ivanets,&nbsp;Ihor Berdey,&nbsp;Liliya Logoyda","doi":"10.1186/s13065-025-01488-0","DOIUrl":"10.1186/s13065-025-01488-0","url":null,"abstract":"<div><p>Our main goal was to optimize HPLC methods for the determination of a combined powder containing paracetamol, phenylephrine hydrochloride, and pheniramine maleate based on the indicators «Quantitative determination», «Uniformity of dosage units», and «4-aminophenol». Precise HPLC methods were developed for determining paracetamol, phenylephrine hydrochloride, pheniramine maleate, and the impurity of paracetamol (4-aminophenol). The method was optimized by selecting the chromatographic column and gradient elution to balance component separation and chromatographic time. Separation was achieved using a diode array detector at 273 nm («Quantitative determination», «Uniformity of dosage units») and 225 nm (4-aminophenol) with a gradient mobile phase consisting of a 1.1 g/L sodium octanesulfonate solution (pH 3.2), methanol, and a chromatographic column Zorbax SB-Aq. The method showed a linear response in the range of 160–360 µg/mL for paracetamol, 5–11 µg/mL for phenylephrine hydrochloride, and 10–22 µg/mL for pheniramine maleate. The optimized method, validated according to ICH guidelines, reduced run times to 20 min for impurity analysis and 10 min for active ingredients, which is twice as fast as the official pharmacopeial method. The developed methods were successfully applied for the quality control of this powder.</p></div>","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"19 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bmcchem.biomedcentral.com/counter/pdf/10.1186/s13065-025-01488-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144135341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}