BMC Chemistry最新文献

{"title":"Development and comprehensive greenness assessment of HPLC method for quality control of β-sitosterol in pharmaceutical ointments with trio-color coded evaluation","authors":"Haya I. Aljohar,&nbsp;Abdullah M. Al-Hossaini,&nbsp;Seham A. Alzammay,&nbsp;Samiah Alhabardi,&nbsp;Hadir M. Maher,&nbsp;Aya R. Ahmed","doi":"10.1186/s13065-024-01372-3","DOIUrl":"10.1186/s13065-024-01372-3","url":null,"abstract":"<div><p>A simple, rapid, and reproducible high-performance liquid chromatography (HPLC) method has been developed and validated for the determination of β-sitosterol in the pharmaceutical dosage form of moist exposed burn ointment (MEBO). This method involved an effective sample procedure for extraction of β-sitosterol from MEBO using an alkali saponification agent composed of 0.8 N ethanolic NaOH and diethyl ether. The chromatographic separation was achieved on a C18 column (50 × 3.0 mm, 2.5 μm), using a mobile phase composed of methanol and acetonitrile (70:30 v/v) pumped in an isocratic mode at a flow rate of 0.7 mL/min. The column temperature was maintained at 40 °C, the injection volume was 10 µL, and the detection wavelength was 203 nm. Employing these conditions, the retention time was found to be 2.10 min. The developed method was validated for its specificity, linearity, accuracy, precision, the limit of detection, the limit of quantification, robustness, and solution stability based on International Council for Harmonisation (ICH) guidelines Q2 (R1). Our proposed method demonstrated superior performance compared to other reported methods. It exhibited a linearity range of 30 to 500 µg/mL and improved detectability with a limit of detection (LOD) of 4.65 µg/mL, highlighting its high sensitivity. Additionally, the separation was achieved in a remarkably short analysis time of just 2.1 min, which not only enhanced throughput but also significantly minimized waste and solvent consumption, thereby making it a more sustainable and effective alternative for β-sitosterol extraction. Moreover, in the light of green and white analytical chemistry, a comprehensive ecological and sustainable tri-color coded assessment protocol was established. The proposed method has been successfully applied to quantify β-sitosterol in commercial products (MEBO^®, Avomeb^® and BISTROl^®) demonstrating its suitability for routine quality control analysis of β-sitosterol in pharmaceutical ointment dosage forms.</p></div>","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"19 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bmcchem.biomedcentral.com/counter/pdf/10.1186/s13065-024-01372-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142976414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adaptive alcohols-alcohols cross-coupling via TFA catalysis: access of unsymmetrical ethers","authors":"Chengxiu Liu,&nbsp;Jiaxin Liang,&nbsp;Yuqiu Liang,&nbsp;Lu Ouyang,&nbsp;Youchun Li","doi":"10.1186/s13065-025-01379-4","DOIUrl":"10.1186/s13065-025-01379-4","url":null,"abstract":"<div><p>Ethers are high value organic compounds widely applied in chemical industry, natural products, material, pharmaceuticals, argochemicals, as well as modern organic synthesis. Herein, we report an adaptive TFA-catalyzed cross-coupling of alcohols with various oxygen nucleophiles (nitro-, halogen-, sulfur-, nitrogen-, aryl-, and alkynyl-substituted aliphatic alcohols), delivering diverse unsymmetrical ethers under mild conditions and simple operation. This protocol features a broad range of substrate scope and high catalytic efficiency (54 examples, up to 99% yield). The decagram scale performance and one-step synthesis of drug molecules evidenced the potential industrial production and practicability of this protocol.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"19 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bmcchem.biomedcentral.com/counter/pdf/10.1186/s13065-025-01379-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142963126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Loading of anionic surfactant on eco-friendly biochar and its applications in Cr(VI) removal: adsorption, kinetics, and reusability studies","authors":"Azza M. Shaker,&nbsp;Mohamed Khedawy,&nbsp;Abeer A. Moneer,&nbsp;Nabila M. El-Mallah,&nbsp;Mohamed S. Ramadan","doi":"10.1186/s13065-024-01363-4","DOIUrl":"10.1186/s13065-024-01363-4","url":null,"abstract":"<div><p>Surfactant-modified biochar is a viable adsorbent for eliminating Cr(VI) from synthetic wastewater. The biochar obtained from the <i>zea mays</i> plant (BC) was tailored with sodium dodecyl sulfate (SDS) as an anionic surfactant forming SDS-BC adsorbent. Different controlling conditions have been evaluated including pH of the solution, biomass concentration, primary Cr(VI) concentration, time of adsorption, and temperature. Under the best controlling circumstances, the percentage of removal has attained 99%. The pseudo-second-order kinetic model best described the removal process, according to the kinetic data, while the Temkin model, one of the applicable adsorption isotherm models, well expressed the adsorption process. The thermodynamic parameters were computed, which disclosed the spontaneity and exothermic character of the Cr(VI) elimination. According to the regeneration cycles, SDS-BC was cost-effective and had a good removal capability.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"19 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bmcchem.biomedcentral.com/counter/pdf/10.1186/s13065-024-01363-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142940685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of anion exchange resin for sorption of selenium (IV) from aqueous solutions","authors":"A. El-Tantawy,&nbsp;E. M. Abu Elgoud,&nbsp;S. E. A. Sharaf El-Deen","doi":"10.1186/s13065-024-01356-3","DOIUrl":"10.1186/s13065-024-01356-3","url":null,"abstract":"<div><p>In this work, selenium (IV) ions were adsorbed from aqueous solutions by the strongly basic anion exchange resin Amberlite IRA-400. The morphology of the resin before and after Se(IV) sorption was investigated using different techniques such as energy dispersive X-ray spectroscopy (EDX), Fourier transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM). To determine the ideal sorption conditions, a batch approach was used to examine the variables affecting Se(IV) sorption performance, including pH, shaking time, adsorbent dosage, initial metal ion concentration, and temperature. The results showed the optimal parameters for the highest percentage of selenium (80.25%) at an initial concentration of 100.0 mg L⁻¹, pH 3.0, the adsorbent dosage of 10.0 mg, and the shaking time of 60.0 min. According to the experimental findings, the sorption process was satisfactorily explained by the pseudo-second-order kinetic model. The maximum adsorption capacity at pH 3.0 was 18.52 mg g⁻¹, and the adsorption rather well followed the Langmuir adsorption isotherm. Moreover, exothermic and spontaneous sorption reaction was the result of thermodynamic properties (negativity of both ΔG° and ΔH°). The adsorption phase's random distribution of the resin-solution interface is indicated by the positive value of ΔS^o. Finally, the desorption study was performed using different concentrations of desorbing agents; HNO₃, HCl, and sodium acetate. The results illustrated that the effective desorbing agent was 1.0 mol L^-1 HNO₃, with desorption efficiency reaching about 96.4%. Finally, the Amberlite IRA-400 demonstrated excellent adsorption–desorption behavior over five times, suggesting that the Amberlite IRA-400 could be an effective candidate for the sorption of Se(IV) from several metal ions that occur in fission products.</p></div>","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"19 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bmcchem.biomedcentral.com/counter/pdf/10.1186/s13065-024-01356-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142938997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eco-sustainable chromatographic method for the determination of favipiravir and nitazoxanide for COVID-19: application to human plasma","authors":"Amal B. Ahmed,&nbsp;Maha M. Abdelrahman,&nbsp;Fadwa H. Edrees","doi":"10.1186/s13065-024-01364-3","DOIUrl":"10.1186/s13065-024-01364-3","url":null,"abstract":"<div><p>Coronavirus disease 2019 (COVID-19), an extremely contagious illness, has posed enormous challenges to healthcare systems around the world. Although the evidence on COVID-19 management is growing, antiviral medication is still the first line of treatment. Therefore, it is critical that effective, safe, and tolerable antivirals be available to treat early COVID-19 and stop its progression. Recently, favipiravir (FAV) has received FDA approval as safe and effective antiviral medication for COVID-19 management. Nitazoxanide (NTZ) also possesses antiviral and immunomodulating activities. Moreover, FAV and NTZ in combination are clinically used in COVID-19 treatment with reported safety, synergistic antiviral and immunomodulating effects. Despite the availability of various clinical studies on both FAV and NTZ, no existing analytical application for the simultaneous estimation of FAV and NTZ exists. As a result, the current work goal is to establish a green HPLC method for their analysis and implementation to human plasma. The developed method utilizes isocratic elution with 0.1% aqueous formic acid: ethanol (55:45, v/v) and dantrolene as internal standard. The bioanalytical validation parameters passed the FDA acceptance criteria. NEMI, eco scale, AGREE and ComplexGAPI approaches were used for qualitative and quantitative evaluation of the method’s greenness.</p></div>","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"19 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bmcchem.biomedcentral.com/counter/pdf/10.1186/s13065-024-01364-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142938929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrochemical study of anti-platelets tirofiban HCl in dosage form using nanomaterials modified sensors: developed and green assessed by eco-scale and complex-GAPI approach","authors":"Mohamed. Rizk,&nbsp;Maha Mahmoud Abou El-Alamin,&nbsp;Ola Abd Elkhalek,&nbsp;Hassan A. M. Hendawy","doi":"10.1186/s13065-024-01358-1","DOIUrl":"10.1186/s13065-024-01358-1","url":null,"abstract":"<div><p>Tirofiban hydrochloride is used to inhibit platelet aggregation, which has a significant impact on the treatment of congestive heart failure the most common cause of death according to WHO. Therefore, its quantification in pharmaceutical dosage form is critical. In this work, an electrochemical method for the determination of tirofiban HCl in pharmaceutical dosage form was developed and validated. Carbon paste electrode modified with multi-walled carbon nanotubes (MWCNT) was utilized to examine the electrochemical response of tirofiban hydrochloride. Scanning electron microscopy and Energy-dispersive X-ray analysis was used to investigate the morphology of this electrode. A linear response was obtained within the range of (27.00–745.00 ng/mL) (5.4 × 10^–5 M–1.5 × 10⁻³ M) with a correlation coefficient of 0.9995, and a detection limit of 15.50 ng<i>/</i>mL (3.1 × 10^–5 M). The greenness profile of the method was assessed utilizing the eco-scale and the green analytical procedure Index.</p></div>","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"19 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bmcchem.biomedcentral.com/counter/pdf/10.1186/s13065-024-01358-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142939044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel ecofriendly spectrophotometric methods for the determination of six dihydropyridines calcium channel blockers through derivatization with sulfophtalein dye: application to tablet analysis","authors":"Mariana Horyn,&nbsp;Liubomyr Kryskiw,&nbsp;Tetyana Kucher,&nbsp;Nadiya Zarivna,&nbsp;Olha Poliak,&nbsp;Liliya Logoyda","doi":"10.1186/s13065-024-01378-x","DOIUrl":"10.1186/s13065-024-01378-x","url":null,"abstract":"<div><p>Novel, «green» and simple visible spectrophotometric procedures for the determination of six dihydropyridines CCBs (amlodipine besylate (AML), lacidipine (LAC), levamlodipine besylate (LAML<b>)</b>, nifedipine (NIF), nimodipine (NIM) and nitrendipine (NIT)) through derivatization with the sulfophthalein dye bromophenol blue (BPB) have been developed. The optimal parameters for CCBs spectrophotometric analysis via complex formation using BPB were as follows: detection wavelength—596 nm, reaction time—5 min, ratio of reacting components—1:1, operating temperature—25 ± 2 °C. The concentration was linearly proportional to absorbance values in the range of 3.40—17.00 μg/mL (AML), 1.14—9.11 μg/mL (LAC), 1.14—9.08 μg/mL (LAML), 4.16—12.40 μg/mL (NIF), 0.84—5.86 μg/mL (NIM), 6.52—19.60 μg/mL (NIT). The developed methods are colorimetric and therefore does not require a UV instrument to quantify these drugs. The proposed approach was more efficient in terms of time reliability, sensitivity and «greenness» than other recorded spectrophotometric methods and can be easily implemented for routine pharmaceutical analysis.</p></div>","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"19 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bmcchem.biomedcentral.com/counter/pdf/10.1186/s13065-024-01378-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142938987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A newly developed high-performance thin layer chromatographic method for determination of remdesivir, favipiravir and dexamethasone, in spiked human plasma: comparison with the published methods","authors":"Rehab M. Abdelfatah,&nbsp;Esraa H. Abdelmomen,&nbsp;Eglal A. Abdelaleem,&nbsp;Refaat H. Abdelmoety,&nbsp;Aml A. Emam","doi":"10.1186/s13065-024-01366-1","DOIUrl":"10.1186/s13065-024-01366-1","url":null,"abstract":"<div><p>Co-administration of COVID-19 RNA polymerase inhibitors, remdesivir and favipiravir, has synergistic benefits. Together they reduce viral load and inflammation more effectively than either drug used alone. Corticosteroids like dexamethasone are used alongside antivirals in multidrug combination regimens. A new HPTLC method was utilized to isolate and quantitatively determine the three medicines of the COVID-19 therapeutic protocol, remdesivir, favipiravir and dexamethasone, using the anticoagulant apixaban as an internal standard in human plasma. The mobile phase system used a solvent mixture of ethyl acetate, hexane, and acetic acid (9:1:0.3, by volume). At 254 nm, well-resolved spots with Rf values of 0.3 for remdesivir, 0.64 for dexamethasone, and 0.77 for favipiravir have been observed. To ensure compliance with FDA regulations, a validation study was conducted. Quantitation limits as low as 0.1 µg/band have been achieved with remdesivir and dexamethasone, and 0.2 µg/band with favipiravir, demonstrating excellent sensitivities. From 97.07% to 102.77%, the drugs were recovered from human plasma that had been artificially spiked. The whiteness of the method has been assessed using RGB 12 algorithm and a percentage of whiteness of 95.6% has been obtained.</p></div>","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"19 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bmcchem.biomedcentral.com/counter/pdf/10.1186/s13065-024-01366-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142938884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fabrication of promising competitive graphene nanocomposite transducer to determine Prucalopride succinate in pharmaceutical formulation and in spiked human biological fluids","authors":"Marwa T. Saad,&nbsp;Shereen A. Boltia,&nbsp;Taghreed A. Fattah,&nbsp;Hala E. Zaazaa","doi":"10.1186/s13065-024-01368-z","DOIUrl":"10.1186/s13065-024-01368-z","url":null,"abstract":"<div><p>The development of a newly fabricated ion-selective electrode (ISE) solid-contacted type for the determination of prucalopride succinate represents a significant advancement in analytical chemistry, particularly in the context of green chemistry principles. The optimization process involved numerous trials to ensure the selection of a cation exchanger and ionophore that offer high sensitivity and selectivity for prucalopride succinate. Through these optimization trials, sodium tetrakis was identified as the most suitable cation exchanger, while calix [8] arene demonstrated the highest affinity towards prucalopride succinate as the ionophore. This careful selection of components ensures accurate and specific detection of prucalopride succinate. To enhance the electroanalytical performance of the ISE, a graphene nanocomposite layer was developed as an ion-electron transducer between the carbon and synthetic polymeric membrane. This graphene-nanocomposite layer improves the overall performance of the ISE, providing a Nernstian slope of 57.249 mV per decade, which aligns with the recommendations of the International Union of Pure and Applied Chemistry (IUPAC). The integration of these components and the utilization of green chemistry principles in the design of the fabricated ISE enable rapid and accurate determination of prucalopride succinate. This innovative approach holds great potential for applications in pharmaceutical analysis and quality control, providing a more sustainable and efficient method for the analysis of prucalopride succinate.</p></div>","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"19 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bmcchem.biomedcentral.com/counter/pdf/10.1186/s13065-024-01368-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142939174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel sustainable biodiesel production from low-grade oleic acid via esterification catalyzed by characterized crystalline ZrO2/Al2O3","authors":"Amal Alkahlawy,&nbsp;Amany Gaffer","doi":"10.1186/s13065-024-01360-7","DOIUrl":"10.1186/s13065-024-01360-7","url":null,"abstract":"<div><p>The depletion of fossil fuels and growing environmental concerns necessitate the exploration of renewable energy sources. Biodiesel, a promising alternative fuel derived from sustainable feedstock, has attracted considerable attention. This study investigates the catalytic esterification of oleic acid, a readily available fatty acid, with ethanol for biodiesel production using a novel heterogeneous catalyst, ZrO₂/Al₂O₃. Crystalline ZrO₂/Al2O₃ was successfully synthesized and characterized using X-ray diffraction (XRD), Brunauer–Emmett–Teller (BET) surface area analysis, and Fourier-transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS) and temperature programmed desorption NH₃-TPD to understand its structural and textural properties. The characterized ZrO₂/Al₂O₃ was then employed to catalyze the esterification reaction. The influence of reaction parameters, including temperature, alcohol-to-oleic acid molar ratio, and catalyst loading, was systematically evaluated. Under optimal conditions (70 °C, 10:1 alcohol-to-oleic acid molar ratio, and 4 wt% catalyst loading), a remarkable 90.5% conversion of oleic acid to biodiesel was achieved. Furthermore, the catalyst exhibited reusability, demonstrating its potential for sustainable biodiesel production from low-grade oleic acid feedstock.</p></div>","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"19 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bmcchem.biomedcentral.com/counter/pdf/10.1186/s13065-024-01360-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142925587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}