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How and Why Does Metabolism Scale with Body Mass? 代谢如何以及为什么会随着体重而变化？
IF 8.4 2区 医学
Physiology Pub Date : 2023-11-01 Epub Date: 2023-09-12 DOI: 10.1152/physiol.00015.2023
Craig R White, Dustin J Marshall
{"title":"How and Why Does Metabolism Scale with Body Mass?","authors":"Craig R White,&nbsp;Dustin J Marshall","doi":"10.1152/physiol.00015.2023","DOIUrl":"10.1152/physiol.00015.2023","url":null,"abstract":"<p><p>Most explanations for the relationship between body size and metabolism invoke physical constraints; such explanations are evolutionarily inert, limiting their predictive capacity. Contemporary approaches to metabolic rate and life history lack the pluralism of foundational work. Here, we call for reforging of the lost links between optimization approaches and physiology.</p>","PeriodicalId":49694,"journal":{"name":"Physiology","volume":" ","pages":"0"},"PeriodicalIF":8.4,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10268371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Emerging Concept of Transportome: State of the Art. 运输体的新兴概念：最新技术。
IF 8.4 2区 医学
Physiology Pub Date : 2023-11-01 Epub Date: 2023-09-05 DOI: 10.1152/physiol.00010.2023
Federico Alessandro Ruffinatti, Giorgia Scarpellino, Giorgia Chinigò, Luca Visentin, Luca Munaron
{"title":"The Emerging Concept of Transportome: State of the Art.","authors":"Federico Alessandro Ruffinatti,&nbsp;Giorgia Scarpellino,&nbsp;Giorgia Chinigò,&nbsp;Luca Visentin,&nbsp;Luca Munaron","doi":"10.1152/physiol.00010.2023","DOIUrl":"10.1152/physiol.00010.2023","url":null,"abstract":"<p><p>The array of ion channels and transporters expressed in cell membranes, collectively referred to as the transportome, is a complex and multifunctional molecular machinery; in particular, at the plasma membrane level it finely tunes the exchange of biomolecules and ions, acting as a functionally adaptive interface that accounts for dynamic plasticity in the response to environmental fluctuations and stressors. The transportome is responsible for the definition of membrane potential and its variations, participates in the transduction of extracellular signals, and acts as a filter for most of the substances entering and leaving the cell, thus enabling the homeostasis of many cellular parameters. For all these reasons, physiologists have long been interested in the expression and functionality of ion channels and transporters, in both physiological and pathological settings and across the different domains of life. Today, thanks to the high-throughput technologies of the postgenomic era, the omics approach to the study of the transportome is becoming increasingly popular in different areas of biomedical research, allowing for a more comprehensive, integrated, and functional perspective of this complex cellular apparatus. This article represents a first effort for a systematic review of the scientific literature on this topic. Here we provide a brief overview of all those studies, both primary and meta-analyses, that looked at the transportome as a whole, regardless of the biological problem or the models they used. A subsequent section is devoted to the methodological aspect by reviewing the most important public databases annotating ion channels and transporters, along with the tools they provide to retrieve such information. Before conclusions, limitations and future perspectives are also discussed.</p>","PeriodicalId":49694,"journal":{"name":"Physiology","volume":" ","pages":"0"},"PeriodicalIF":8.4,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10155817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
NAFLD: An Emerging Causal Factor for Cardiovascular Disease. NAFLD:心血管疾病的一个新出现的原因因素。
IF 8.4 2区 医学
Physiology Pub Date : 2023-11-01 Epub Date: 2023-07-11 DOI: 10.1152/physiol.00013.2023
Mei Li, Hongmin Wang, Xiao-Jing Zhang, Jingjing Cai, Hongliang Li
{"title":"NAFLD: An Emerging Causal Factor for Cardiovascular Disease.","authors":"Mei Li,&nbsp;Hongmin Wang,&nbsp;Xiao-Jing Zhang,&nbsp;Jingjing Cai,&nbsp;Hongliang Li","doi":"10.1152/physiol.00013.2023","DOIUrl":"10.1152/physiol.00013.2023","url":null,"abstract":"<p><p>Nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease worldwide that poses a significant threat to human health. Cardiovascular disease (CVD) is the leading cause of mortality in NAFLD patients. NAFLD and CVD share risk factors such as obesity, insulin resistance, and type 2 diabetes. However, whether NAFLD is a causal risk factor for CVD remains a matter of debate. This review summarizes the evidence from prospective clinical and Mendelian randomization studies that underscore the potential causal relationship between NAFLD and CVD. The mechanisms of NAFLD contributing to the development of CVD and the necessity of addressing CVD risk while managing NAFLD in clinical practice are also discussed.</p>","PeriodicalId":49694,"journal":{"name":"Physiology","volume":" ","pages":"0"},"PeriodicalIF":8.4,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10144328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent Advances in Senolysis for Age-Related Diseases. 衰老相关疾病的研究进展
IF 8.4 2区 医学
Physiology Pub Date : 2023-09-01 DOI: 10.1152/physiol.00003.2023
Sae Aratani, Makoto Nakanishi
{"title":"Recent Advances in Senolysis for Age-Related Diseases.","authors":"Sae Aratani,&nbsp;Makoto Nakanishi","doi":"10.1152/physiol.00003.2023","DOIUrl":"https://doi.org/10.1152/physiol.00003.2023","url":null,"abstract":"<p><p>Cellular senescence plays a central role in aging and geriatric diseases. Senolysis is a promising new strategy that selectively kills and eliminates senescent cells to control aging. To date, various senolytic drugs have been discovered and shown efficacy. This review highlights how we can benefit from senolysis.</p>","PeriodicalId":49694,"journal":{"name":"Physiology","volume":"38 5","pages":"0"},"PeriodicalIF":8.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9784275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Corrigendum for Prerau MJ, et al., Volume 32, 2017, p. 60-92. preau MJ等人的勘误表，2017年第32卷，第60-92页。
IF 8.4 2区 医学
Physiology Pub Date : 2023-09-01 DOI: 10.1152/physiol.00062.2015_COR
{"title":"Corrigendum for Prerau MJ, et al., Volume 32, 2017, p. 60-92.","authors":"","doi":"10.1152/physiol.00062.2015_COR","DOIUrl":"https://doi.org/10.1152/physiol.00062.2015_COR","url":null,"abstract":"","PeriodicalId":49694,"journal":{"name":"Physiology","volume":"38 5","pages":"0"},"PeriodicalIF":8.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9834676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Surviving in an Acidifying Ocean: Acid-Base Physiology and Energetics of the Sea Urchin Larva. 在酸化的海洋中生存:海胆幼体的酸碱生理学和能量学。
IF 8.4 2区 医学
Physiology Pub Date : 2023-09-01 DOI: 10.1152/physiol.00007.2023
Marian Y Hu, Meike Stumpp
{"title":"Surviving in an Acidifying Ocean: Acid-Base Physiology and Energetics of the Sea Urchin Larva.","authors":"Marian Y Hu,&nbsp;Meike Stumpp","doi":"10.1152/physiol.00007.2023","DOIUrl":"https://doi.org/10.1152/physiol.00007.2023","url":null,"abstract":"<p><p>The sea urchin larva has been used by biologists for more than a century to study the development and evolution of animals. Surprisingly, very little information has been generated regarding the physiology of this small planktonic organism. However, in the context of anthropogenic CO<sub>2</sub>-driven ocean acidification (OA), the membrane transport physiology and energetics of this marine model organism have received considerable attention in the past decade. This has led to the discovery of new, exciting physiological systems, including a highly alkaline digestive tract and the calcifying primary mesenchyme cells that generate the larval skeleton. These physiological systems directly relate to the energetics of the organisms when challenged by OA. Here we review the latest membrane transport physiology and energetics in the sea urchin larva, we identify emerging questions, and we point to important future directions in the field of marine physiology in times of rapid climate change.</p>","PeriodicalId":49694,"journal":{"name":"Physiology","volume":"38 5","pages":"0"},"PeriodicalIF":8.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9858340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Tissue Specificity of DNA Damage and Repair. DNA损伤与修复的组织特异性。
IF 8.4 2区 医学
Physiology Pub Date : 2023-09-01 DOI: 10.1152/physiol.00006.2023
Nicolas C Hoch
{"title":"Tissue Specificity of DNA Damage and Repair.","authors":"Nicolas C Hoch","doi":"10.1152/physiol.00006.2023","DOIUrl":"https://doi.org/10.1152/physiol.00006.2023","url":null,"abstract":"<p><p>DNA is a remarkable biochemical macromolecule tasked with storing the genetic information that instructs life on planet Earth. However, its inherent chemical instability within the cellular milieu is incompatible with the accurate transmission of genetic information to subsequent generations. Therefore, biochemical pathways that continuously survey and repair DNA are essential to sustain life, and the fundamental mechanisms by which different DNA lesions are repaired have remained well conserved throughout evolution. Nonetheless, the emergence of multicellular organisms led to profound differences in cellular context and physiology, leading to large variations in the predominant sources of DNA damage between different cell types and in the relative contribution of different DNA repair pathways toward genome maintenance in different tissues. While we continue to make large strides into understanding how individual DNA repair mechanisms operate on a molecular level, much less attention is given to these cell type-specific differences. This short review aims to provide a broad overview of DNA damage and repair mechanisms to nonspecialists and to highlight some fundamental open questions in tissue and cell-type-specificity of these processes, which may have profound implications for our understanding of important pathophysiological processes such as cancer, neurodegeneration, and aging.</p>","PeriodicalId":49694,"journal":{"name":"Physiology","volume":"38 5","pages":"0"},"PeriodicalIF":8.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9797766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Inflammatory Mechanisms in Heart Failure with Preserved Ejection Fraction. 射血分数保留型心力衰竭的炎症机制
IF 5.3 2区 医学
Physiology Pub Date : 2023-09-01 Epub Date: 2023-04-04 DOI: 10.1152/physiol.00004.2023
Daniel Daou, Thomas G Gillette, Joseph A Hill
{"title":"Inflammatory Mechanisms in Heart Failure with Preserved Ejection Fraction.","authors":"Daniel Daou, Thomas G Gillette, Joseph A Hill","doi":"10.1152/physiol.00004.2023","DOIUrl":"10.1152/physiol.00004.2023","url":null,"abstract":"<p><p>Heart failure with preserved ejection fraction (HFpEF) is now the most common form of heart failure and a significant public health concern for which limited effective therapies exist. Inflammation triggered by comorbidity burden is a critical element of HFpEF pathophysiology. Here, we discuss evidence for comorbidity-driven systemic and myocardial inflammation and the mechanistic role of inflammation in pathological myocardial remodeling in HFpEF.</p>","PeriodicalId":49694,"journal":{"name":"Physiology","volume":"38 5","pages":"0"},"PeriodicalIF":5.3,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10396273/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10286818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Physiology in Perspective. 透视生理学
IF 5.3 2区 医学
Physiology Pub Date : 2023-09-01 DOI: 10.1152/physiol.00016.2023
Nikki Forrester
{"title":"Physiology in Perspective.","authors":"Nikki Forrester","doi":"10.1152/physiol.00016.2023","DOIUrl":"10.1152/physiol.00016.2023","url":null,"abstract":"","PeriodicalId":49694,"journal":{"name":"Physiology","volume":"38 5","pages":"204"},"PeriodicalIF":5.3,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10234564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Physiology in Perspective. 透视生理学。
IF 8.4 2区 医学
Physiology Pub Date : 2023-07-01 DOI: 10.1152/physiol.00014.2023
Christopher England
{"title":"Physiology in Perspective.","authors":"Christopher England","doi":"10.1152/physiol.00014.2023","DOIUrl":"https://doi.org/10.1152/physiol.00014.2023","url":null,"abstract":"<p><p>This issue of <i>Physiology</i> features four excellent review articles that highlight current research and discuss untapped areas for future work across a range of topics in physiology. First, we explore the impact that the loss of the Y chromosome in white blood cells has on men's health. Next, we discuss the pathophysiological roles of the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) in chronic inflammation. Third, we discuss how certain animals remain hydrated in seawater. Finally, we present on the systemic reprogramming of endothelial cell signaling in metastasis and cachexia.</p>","PeriodicalId":49694,"journal":{"name":"Physiology","volume":"38 4","pages":"160"},"PeriodicalIF":8.4,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9691348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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