IGF-1 信号在心脏中的新发现。

IF 5.3 2区医学 Q1 PHYSIOLOGY

Physiology Pub Date : 2024-09-01 Epub Date: 2024-05-07 DOI:10.1152/physiol.00003.2024

Wang-Soo Lee, E Dale Abel, Jaetaek Kim

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引用次数: 0

摘要

胰岛素样生长因子（IGF）-1 信号在细胞生长、新陈代谢和衰老过程中发挥着多种生理作用。心肌肥厚、细胞死亡、衰老、纤维化和电重塑是各种心脏病的标志，也是心力衰竭的诱因。本综述强调了 IGF-1 及其同源受体在心肌肥厚、衰老和重塑中的关键作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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New Insights into IGF-1 Signaling in the Heart.

Insulin-like growth factor-1 (IGF-1) signaling has multiple physiological roles in cellular growth, metabolism, and aging. Myocardial hypertrophy, cell death, senescence, fibrosis, and electrical remodeling are hallmarks of various heart diseases and contribute to the progression of heart failure. This review highlights the critical role of IGF-1 and its cognate receptor in cardiac hypertrophy, aging, and remodeling.

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来源期刊

Physiology 医学-生理学

CiteScore

14.50

自引率

0.00%

发文量

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