Physiology最新文献_第7页

Pulmonary Vascular Dysfunctions in Cystic Fibrosis. 囊性纤维化的肺血管功能障碍。

IF 5.3 2区医学

Physiology Pub Date : 2024-07-01 Epub Date: 2024-03-19 DOI: 10.1152/physiol.00024.2023

Jean-Pierre Amoakon, Goutham Mylavarapu, Raouf S Amin, Anjaparavanda P Naren

{"title":"Pulmonary Vascular Dysfunctions in Cystic Fibrosis.","authors":"Jean-Pierre Amoakon, Goutham Mylavarapu, Raouf S Amin, Anjaparavanda P Naren","doi":"10.1152/physiol.00024.2023","DOIUrl":"10.1152/physiol.00024.2023","url":null,"abstract":"Cystic fibrosis (CF) is an inherited disorder caused by a deleterious mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Given that the CFTR protein is a chloride channel expressed on a variety of cells throughout the human body, mutations in this gene impact several organs, particularly the lungs. For this very reason, research regarding CF disease and CFTR function has historically focused on the lung airway epithelium. Nevertheless, it was discovered more than two decades ago that CFTR is also expressed and functional on endothelial cells. Despite the great strides that have been made in understanding the role of CFTR in the airway epithelium, the role of CFTR in the endothelium remains unclear. Considering that the airway epithelium and endothelium work in tandem to allow gas exchange, it becomes very crucial to understand how a defective CFTR protein can impact the pulmonary vasculature and overall lung function. Fortunately, more recent research has been dedicated to elucidating the role of CFTR in the endothelium. As a result, several vascular dysfunctions associated with CF disease have come to light. Here, we summarize the current knowledge on pulmonary vascular dysfunctions in CF and discuss applicable therapies.","PeriodicalId":49694,"journal":{"name":"Physiology","volume":" ","pages":"0"},"PeriodicalIF":5.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11368519/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140159380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Burning Question: How Does Our Brain Process Positive and Negative Cues Associated with Thermosensation? 我们的大脑如何处理积极和消极的热感线索？

IF 5.3 2区医学

Physiology Pub Date : 2024-07-01 Epub Date: 2024-03-27 DOI: 10.1152/physiol.00034.2023

Jose G Grajales-Reyes, Bandy Chen, David Meseguer, Marc Schneeberger

{"title":"Burning Question: How Does Our Brain Process Positive and Negative Cues Associated with Thermosensation?","authors":"Jose G Grajales-Reyes, Bandy Chen, David Meseguer, Marc Schneeberger","doi":"10.1152/physiol.00034.2023","DOIUrl":"10.1152/physiol.00034.2023","url":null,"abstract":"Whether it is the dramatic suffocating sensation from a heat wave in the summer or the positive reinforcement arising from a hot drink on a cold day; we can certainly agree that our thermal environment underlies our daily rhythms of sensation. Extensive research has focused on deciphering the central circuits responsible for conveying the impact of thermogenesis on mammalian behavior. Here, we revise the recent literature responsible for defining the behavioral correlates that arise from thermogenic fluctuations in mammals. We transition from the physiological significance of thermosensation to the circuitry responsible for the autonomic or behavioral responses associated with it. Subsequently, we delve into the positive and negative valence encoded by thermoregulatory processes. Importantly, we emphasize the crucial junctures where reward, pain, and thermoregulation intersect, unveiling a complex interplay within these neural circuits. Finally, we briefly outline fundamental questions that are pending to be addressed in the field. Fully deciphering the thermoregulatory circuitry in mammals will have far-reaching medical implications. For instance, it may lead to the identification of novel targets to overcome thermal pain or allow the maintenance of our core temperature in prolonged surgeries.","PeriodicalId":49694,"journal":{"name":"Physiology","volume":" ","pages":"0"},"PeriodicalIF":5.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11368520/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140295108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synergism Between Hypothalamic Astrocytes and Neurons in Metabolic Control. 下丘脑星形胶质细胞和神经元在新陈代谢控制中的协同作用

IF 5.3 2区医学

Physiology Pub Date : 2024-07-01 Epub Date: 2024-03-26 DOI: 10.1152/physiol.00009.2024

Laura M Frago, Alfonso Gómez-Romero, Roberto Collado-Pérez, Jesús Argente, Julie A Chowen

引用次数: 0

Pharmacological Advances in Incretin-Based Polyagonism: What We Know and What We Don't. 基于胰岛素的多拮抗剂的药理研究进展--我们知道什么，我们不知道什么t.

IF 5.3 2区医学

Physiology Pub Date : 2024-05-01 Epub Date: 2024-02-14 DOI: 10.1152/physiol.00032.2023

Aaron Novikoff, Timo D Müller

{"title":"Pharmacological Advances in Incretin-Based Polyagonism: What We Know and What We Don't.","authors":"Aaron Novikoff, Timo D Müller","doi":"10.1152/physiol.00032.2023","DOIUrl":"10.1152/physiol.00032.2023","url":null,"abstract":"The prevalence of obesity continues to rise in both adolescents and adults, in parallel obesity is strongly associated with the increased incidence of type 2 diabetes, heart failure, certain types of cancer, and all-cause mortality. In relation to obesity, many pharmacological approaches of the past have tried and failed to combat the rising obesity epidemic, particularly due to insufficient efficacy or unacceptable side effects. However, while the history of antiobesity medication is plagued by failures and disappointments, we have witnessed over the last 10 years substantial progress, particularly in regard to biochemically optimized agonists at the receptor for glucagon-like peptide-1 (GLP-1R) and unimolecular coagonists at the receptors for GLP-1 and the glucose-dependent insulinotropic polypeptide (GIP). Although the GIP receptor:GLP-1R coagonists are being heralded as premier pharmacological tools for the treatment of obesity and diabetes, uncertainty remains as to why these drugs testify superiority over best-in-class GLP-1R monoagonists. Particularly with regard to GIP, there remains great uncertainty if and how GIP acts on systems metabolism and if the GIP system should be activated or inhibited to improve metabolic outcome in adjunct to GLP-1R agonism. In this review, we summarize recent advances in GLP-1- and GIP-based pharmacology and discuss recent findings and open questions related to how the GIP system affects systemic energy and glucose metabolism.","PeriodicalId":49694,"journal":{"name":"Physiology","volume":" ","pages":"142-156"},"PeriodicalIF":5.3,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11368522/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139730833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IUPS: Physiology on a Global Scale. IUPS：全球范围的生理学。

IF 5.3 2区医学

Physiology Pub Date : 2024-05-01 DOI: 10.1152/physiol.00005.2024

Susan Wray

引用次数: 0

Emerging Pathophysiological Roles of Ketone Bodies. 新出现的酮体的病理生理作用。

IF 5.3 2区医学

Physiology Pub Date : 2024-05-01 Epub Date: 2024-01-23 DOI: 10.1152/physiol.00031.2023

Hiroaki Tsuruta, Kosuke Yamahara, Mako Yasuda-Yamahara, Shinji Kume

引用次数: 0

Circadian Rhythm Regulation by Pacemaker Neuron Chloride Oscillation in Flies. 苍蝇起搏神经元氯离子振荡对昼夜节律的调节

IF 5.3 2区医学

Physiology Pub Date : 2024-05-01 Epub Date: 2024-02-27 DOI: 10.1152/physiol.00006.2024

Aylin R Rodan

引用次数: 0

Complementing Cell Taxonomies with a Multicellular Analysis of Tissues. 用组织的多细胞分析补充细胞分类法。

IF 5.3 2区医学

Physiology Pub Date : 2024-05-01 Epub Date: 2024-02-06 DOI: 10.1152/physiol.00001.2024

Ricardo Omar Ramirez Flores, Philipp Sven Lars Schäfer, Leonie Küchenhoff, Julio Saez-Rodriguez

引用次数: 0

Physiology in Perspective. 透视生理学

IF 5.3 2区医学

Physiology Pub Date : 2024-05-01 DOI: 10.1152/physiol.00016.2024

Nikki Forrester

引用次数: 0

From Beats to Metabolism: the Heart at the Core of Interorgan Metabolic Cross Talk. 从节拍到新陈代谢：器官间串联的核心是心脏。

IF 5.3 2区医学

Physiology Pub Date : 2024-03-01 Epub Date: 2023-12-05 DOI: 10.1152/physiol.00018.2023

Rafael Romero-Becera, Ayelén M Santamans, Alba C Arcones, Guadalupe Sabio

{"title":"From Beats to Metabolism: the Heart at the Core of Interorgan Metabolic Cross Talk.","authors":"Rafael Romero-Becera, Ayelén M Santamans, Alba C Arcones, Guadalupe Sabio","doi":"10.1152/physiol.00018.2023","DOIUrl":"10.1152/physiol.00018.2023","url":null,"abstract":"The heart, once considered a mere blood pump, is now recognized as a multifunctional metabolic and endocrine organ. Its function is tightly regulated by various metabolic processes, at the same time it serves as an endocrine organ, secreting bioactive molecules that impact systemic metabolism. In recent years, research has shed light on the intricate interplay between the heart and other metabolic organs, such as adipose tissue, liver, and skeletal muscle. The metabolic flexibility of the heart and its ability to switch between different energy substrates play a crucial role in maintaining cardiac function and overall metabolic homeostasis. Gaining a comprehensive understanding of how metabolic disorders disrupt cardiac metabolism is crucial, as it plays a pivotal role in the development and progression of cardiac diseases. The emerging understanding of the heart as a metabolic and endocrine organ highlights its essential contribution to whole body metabolic regulation and offers new insights into the pathogenesis of metabolic diseases, such as obesity, diabetes, and cardiovascular disorders. In this review, we provide an in-depth exploration of the heart's metabolic and endocrine functions, emphasizing its role in systemic metabolism and the interplay between the heart and other metabolic organs. Furthermore, emerging evidence suggests a correlation between heart disease and other conditions such as aging and cancer, indicating that the metabolic dysfunction observed in these conditions may share common underlying mechanisms. By unraveling the complex mechanisms underlying cardiac metabolism, we aim to contribute to the development of novel therapeutic strategies for metabolic diseases and improve overall cardiovascular health.","PeriodicalId":49694,"journal":{"name":"Physiology","volume":" ","pages":"98-125"},"PeriodicalIF":5.3,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138488893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0