血管稳态中的 ECM 微环境：动脉粥样硬化的新目标。

IF 5.3 2区医学 Q1 PHYSIOLOGY

Physiology Pub Date : 2024-09-01 DOI:10.1152/physiol.00028.2023

Lu Zhang, Qianqian Feng, Wei Kong

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引用次数: 0

摘要

血管细胞外基质（ECM）成分、相互作用和机械特性的改变会影响动脉粥样硬化斑块的形成和稳定性。本综述以软骨低聚基质蛋白（COMP）及其降解酶 ADAMTS7 为例，讨论了 ECM 微环境在动脉粥样硬化的血管稳态和重塑过程中的作用，并提出了未来研究的潜在途径，旨在根据 ECM 微环境确定动脉粥样硬化的新型治疗靶点。

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ECM Microenvironment in Vascular Homeostasis: New Targets for Atherosclerosis.

Alterations in vascular extracellular matrix (ECM) components, interactions, and mechanical properties influence both the formation and stability of atherosclerotic plaques. This review discusses the contribution of the ECM microenvironment in vascular homeostasis and remodeling in atherosclerosis, highlighting Cartilage oligomeric matrix protein (COMP) and its degrading enzyme ADAMTS7 as examples, and proposes potential avenues for future research aimed at identifying novel therapeutic targets for atherosclerosis based on the ECM microenvironment.

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来源期刊

Physiology 医学-生理学

CiteScore

14.50

自引率

0.00%

发文量

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