Physiology最新文献_第5页

Physiology in Perspective. 透视生理学

IF 5.3 2区医学

Physiology Pub Date : 2024-03-01 DOI: 10.1152/physiol.00002.2024

Nikki Forrester

引用次数: 0

Microglia in Central Control of Metabolism. 中枢控制代谢的小胶质细胞。

IF 5.3 2区医学

Physiology Pub Date : 2024-01-01 Epub Date: 2023-11-14 DOI: 10.1152/physiol.00021.2023

Jung Dae Kim, Francesca Copperi, Sabrina Diano

引用次数: 0

Physiology in Perspective. 透视生理学。

IF 5.3 2区医学

Physiology Pub Date : 2024-01-01 DOI: 10.1152/physiol.00027.2023

Christopher England

引用次数: 0

Endothelium-Derived Dopamine and 6-Nitrodopamine in the Cardiovascular System. 内皮源性多巴胺和6-硝基多巴胺在心血管系统中的作用。

IF 5.3 2区医学

Physiology Pub Date : 2024-01-01 Epub Date: 2023-10-24 DOI: 10.1152/physiol.00020.2023

Roberto Zatz, Gilberto De Nucci

{"title":"Endothelium-Derived Dopamine and 6-Nitrodopamine in the Cardiovascular System.","authors":"Roberto Zatz, Gilberto De Nucci","doi":"10.1152/physiol.00020.2023","DOIUrl":"10.1152/physiol.00020.2023","url":null,"abstract":"The review deals with the release of endothelium-derived dopamine and 6-nitrodopamine (6-ND) and its effects on isolated vascular tissues and isolated hearts. Basal release of both dopamine and 6-ND is present in human isolated umbilical cord vessels, human popliteal vessels, nonhuman primate vessels, and reptilia aortas. The 6-ND basal release was significantly reduced when the tissues were treated with Nω-nitro-l-arginine methyl ester and virtually abolished when the endothelium was mechanically removed. 6-Nitrodopamine is a potent vasodilator, and the mechanism of action responsible for this effect is the antagonism of dopamine D2-like receptors. As a vasodilator, 6-ND constitutes a novel mechanism by which nitric oxide modulates vascular tone. The basal release of 6-ND was substantially decreased in endothelial nitric oxide synthase knockout (eNOS-/-) mice and not altered in neuronal nitric oxide synthase knockout (nNOS-/-) mice, indicating a nonneurogenic source for 6-ND in the heart. Indeed, in rat isolated right atrium, the release of 6-ND was not affected when the atria were treated with tetrodotoxin. In the rat isolated right atrium, 6-ND is the most potent endogenous positive chronotropic agent, and in Langendorff's heart preparation, it is the most potent endogenous positive inotropic agent. The positive chronotropic and inotropic effects of 6-ND are antagonized by β1-adrenoceptor antagonists at concentrations that do not affect the effects induced by noradrenaline, adrenaline, and dopamine, indicating that blockade of the 6-ND receptor is the major modulator of heart chronotropism and inotropism. The review proposes that endothelium-derived catecholamines may constitute a major mechanism for control of vascular tone and heart functions, in contrast to the overrated role attributed to the autonomic nervous system.","PeriodicalId":49694,"journal":{"name":"Physiology","volume":" ","pages":"44-59"},"PeriodicalIF":5.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11283902/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50159157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Physiological Functions of the Ubiquitin Ligases Nedd4-1 and Nedd4-2. 泛素连接酶nedd4-1和nedd4-2的生理功能。

IF 5.3 2区医学

Physiology Pub Date : 2024-01-01 Epub Date: 2023-11-14 DOI: 10.1152/physiol.00023.2023

Daniela Rotin, Gali Prag

引用次数: 0

Reflecting Back, Looking Ahead. 回顾过去，展望未来。

IF 5.3 2区医学

Physiology Pub Date : 2024-01-01 Epub Date: 2023-11-21 DOI: 10.1152/physiol.00026.2023

Willis Rick Samson, Dee Silverthorn, Timothy Musch

引用次数: 0

All Light, Everywhere? Photoreceptors at Nonconventional Sites. 到处都是光吗？非常规部位的光受体。

IF 5.3 2区医学

Physiology Pub Date : 2024-01-01 Epub Date: 2023-10-31 DOI: 10.1152/physiol.00017.2023

Audrey Mat, Hong Ha Vu, Eva Wolf, Kristin Tessmar-Raible

{"title":"All Light, Everywhere? Photoreceptors at Nonconventional Sites.","authors":"Audrey Mat, Hong Ha Vu, Eva Wolf, Kristin Tessmar-Raible","doi":"10.1152/physiol.00017.2023","DOIUrl":"10.1152/physiol.00017.2023","url":null,"abstract":"One of the biggest environmental alterations we have made to our species is the change in the exposure to light. During the day, we typically sit behind glass windows illuminated by artificial light that is >400 times dimmer and has a very different spectrum than natural daylight. On the opposite end are the nights that are now lit up by several orders of magnitude. This review aims to provide food for thought as to why this matters for humans and other animals. Evidence from behavioral neuroscience, physiology, chronobiology, and molecular biology is increasingly converging on the conclusions that the biological nonvisual functions of light and photosensory molecules are highly complex. The initial work of von Frisch on extraocular photoreceptors in fish, the identification of rhodopsins as the molecular light receptors in animal eyes and eye-like structures and cryptochromes as light sensors in nonmammalian chronobiology, still allowed for the impression that light reception would be a relatively restricted, localized sense in most animals. However, light-sensitive processes and/or sensory proteins have now been localized to many different cell types and tissues. It might be necessary to consider nonlight-responding cells as the exception, rather than the rule.","PeriodicalId":49694,"journal":{"name":"Physiology","volume":" ","pages":"0"},"PeriodicalIF":5.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11283901/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71415019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How and Why Does Metabolism Scale with Body Mass? 代谢如何以及为什么会随着体重而变化？

IF 8.4 2区医学

Physiology Pub Date : 2023-11-01 Epub Date: 2023-09-12 DOI: 10.1152/physiol.00015.2023

Craig R White, Dustin J Marshall

引用次数: 0

The Emerging Concept of Transportome: State of the Art. 运输体的新兴概念：最新技术。

IF 8.4 2区医学

Physiology Pub Date : 2023-11-01 Epub Date: 2023-09-05 DOI: 10.1152/physiol.00010.2023

Federico Alessandro Ruffinatti, Giorgia Scarpellino, Giorgia Chinigò, Luca Visentin, Luca Munaron

{"title":"The Emerging Concept of Transportome: State of the Art.","authors":"Federico Alessandro Ruffinatti, Giorgia Scarpellino, Giorgia Chinigò, Luca Visentin, Luca Munaron","doi":"10.1152/physiol.00010.2023","DOIUrl":"10.1152/physiol.00010.2023","url":null,"abstract":"The array of ion channels and transporters expressed in cell membranes, collectively referred to as the transportome, is a complex and multifunctional molecular machinery; in particular, at the plasma membrane level it finely tunes the exchange of biomolecules and ions, acting as a functionally adaptive interface that accounts for dynamic plasticity in the response to environmental fluctuations and stressors. The transportome is responsible for the definition of membrane potential and its variations, participates in the transduction of extracellular signals, and acts as a filter for most of the substances entering and leaving the cell, thus enabling the homeostasis of many cellular parameters. For all these reasons, physiologists have long been interested in the expression and functionality of ion channels and transporters, in both physiological and pathological settings and across the different domains of life. Today, thanks to the high-throughput technologies of the postgenomic era, the omics approach to the study of the transportome is becoming increasingly popular in different areas of biomedical research, allowing for a more comprehensive, integrated, and functional perspective of this complex cellular apparatus. This article represents a first effort for a systematic review of the scientific literature on this topic. Here we provide a brief overview of all those studies, both primary and meta-analyses, that looked at the transportome as a whole, regardless of the biological problem or the models they used. A subsequent section is devoted to the methodological aspect by reviewing the most important public databases annotating ion channels and transporters, along with the tools they provide to retrieve such information. Before conclusions, limitations and future perspectives are also discussed.","PeriodicalId":49694,"journal":{"name":"Physiology","volume":" ","pages":"0"},"PeriodicalIF":8.4,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10155817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NAFLD: An Emerging Causal Factor for Cardiovascular Disease. NAFLD:心血管疾病的一个新出现的原因因素。

IF 8.4 2区医学

Physiology Pub Date : 2023-11-01 Epub Date: 2023-07-11 DOI: 10.1152/physiol.00013.2023

Mei Li, Hongmin Wang, Xiao-Jing Zhang, Jingjing Cai, Hongliang Li

引用次数: 0