泛素连接酶nedd4-1和nedd4-2的生理功能。

IF 5.3 2区医学 Q1 PHYSIOLOGY

Physiology Pub Date : 2024-01-01 Epub Date: 2023-11-14 DOI:10.1152/physiol.00023.2023

Daniela Rotin, Gali Prag

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引用次数: 0

摘要

E3泛素连接酶Nedd4家族由C2-WW(n)-HECT结构域组成，包括密切相关的Nedd4/Nedd4-1和Nedd4L/Nedd4-2，它们在人体生理和病理生理中发挥重要作用。本文将重点介绍这些Nedd4蛋白的酶活性调控，以及它们在调节膜和其他信号蛋白(如离子通道、离子转运体和生长因子受体)的稳定性和功能中的作用。讨论了由这种调节功能受损引起的疾病，以及针对这些酶进行治疗的机遇和挑战。

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Physiological Functions of the Ubiquitin Ligases Nedd4-1 and Nedd4-2.

The Nedd4 family of E3 ubiquitin ligases, consisting of a C2-WW(n)-HECT domain architecture, includes the closely related Nedd4/Nedd4-1 and Nedd4L/Nedd4-2, which play critical roles in human physiology and pathophysiology.This review focuses on the regulation of enzymatic activity of these Nedd4 proteins, as well as on their roles in regulating stability and function of membrane and other signaling proteins, such as ion channels, ion transporters, and growth factor receptors. The diseases caused by impairment of such regulation are discussed, as well as opportunities and challenges for targeting these enzymes for therapy.

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来源期刊

Physiology 医学-生理学

CiteScore

14.50

自引率

0.00%

发文量

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