Reviews in the Neurosciences最新文献

Implications of the mitochondrial CB1 receptor in the brain: from mitochondrial dysfunction to neuroprotection. 脑中线粒体CB1受体的意义：从线粒体功能障碍到神经保护。

IF 4.1 3区医学

Reviews in the Neurosciences Pub Date : 2025-10-22 DOI: 10.1515/revneuro-2025-0086

Ari Misael Martínez-Torres, Keyla Tamara Cerdán-Centeno, Crisalde Ramirez-Celis, Suly Peniche-Zamudio, Teresa de Jesús Durán-González, Camila Roa-Gutierrez, Cynthia Navarro-Mabarak, Julio Morán

{"title":"Implications of the mitochondrial CB1 receptor in the brain: from mitochondrial dysfunction to neuroprotection.","authors":"Ari Misael Martínez-Torres, Keyla Tamara Cerdán-Centeno, Crisalde Ramirez-Celis, Suly Peniche-Zamudio, Teresa de Jesús Durán-González, Camila Roa-Gutierrez, Cynthia Navarro-Mabarak, Julio Morán","doi":"10.1515/revneuro-2025-0086","DOIUrl":"https://doi.org/10.1515/revneuro-2025-0086","url":null,"abstract":"Mitochondrial activity is essential for brain function, as ATP produced by mitochondria is crucial for neuronal activity, growth, and regeneration. Bioenergetic failure is a hallmark in neurodegenerative and acquired brain diseases and converts the mitochondria into a molecular target to prevent neuronal death. Mitochondrial regulation can play a crucial role in energetic balance, calcium homeostasis, and neuronal signaling. Different molecules have been implicated in the regulation of this organelle, and recently, the endocannabinoid system (ECS) became a relevant mitochondrial regulator through the mitochondrial CB1 receptor (mtCB1R). The recent discovery of this receptor and its participation in mitochondrial homeostasis opens new insights about its role in neuronal plasticity and neurodegeneration. This review briefly describes the endocannabinoid system, with a major focus on mtCB1R and its role in mitochondrial homeostasis, learning, memory, and neuronal death. Relevant aspects of the role of mtCB1R in the brain in health and diseases remain unclear; however, exploring this topic holds promising implications in the comprehension of mitochondrial degeneration and future therapeutic advantages.","PeriodicalId":49623,"journal":{"name":"Reviews in the Neurosciences","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145338009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The involvement of HIF-1α-dependent paracrine factors in Alzheimer's disease. hif -1α依赖性旁分泌因子在阿尔茨海默病中的作用

IF 4.1 3区医学

Reviews in the Neurosciences Pub Date : 2025-10-07 DOI: 10.1515/revneuro-2025-0102

Victoria I Zhdankina, Elizaveta S Perepelitsa, Anna V Blagova, Yulia K Komleva, Tatyana I Baranich, Alla B Salmina

{"title":"The involvement of HIF-1α-dependent paracrine factors in Alzheimer's disease.","authors":"Victoria I Zhdankina, Elizaveta S Perepelitsa, Anna V Blagova, Yulia K Komleva, Tatyana I Baranich, Alla B Salmina","doi":"10.1515/revneuro-2025-0102","DOIUrl":"https://doi.org/10.1515/revneuro-2025-0102","url":null,"abstract":"Activated HIF-1α is a key regulator of various paracrine factors that influence vascular tone, angiogenesis, and cell survival, including endothelin-1, VEGF, Ang-2, erythropoietin, and SDF-1/CXCL12. These factors not only play established roles in vascular biology but are also critical in modulating neurogenesis. The intricate relationship between the brain's vascular system and its neurogenic niches underscores the importance of HIF-1 in facilitating their interactions. Angiogenesis and proper vessel perfusion are vital for the maintenance and proliferation of neural progenitor cells, especially in the context of neurodegenerative diseases such as Alzheimer's disease (AD). In AD, impaired angiogenesis can negatively impact neurogenesis, exacerbating cognitive decline. Recent transcriptomic and proteomic studies have revealed significant upregulation of HIF-1α expression in AD patients, indicating its potential involvement in the pathophysiology of this disease. This review aims to elucidate the role of HIF-1α and related hypoxia-inducible factors in AD, focusing on their diagnostic and therapeutic implications. We specifically examine two critical neurogenic niches in the adult brain: the subventricular zone (SVZ) and the subgranular zone (SGZ). Understanding how HIF-1α affects neurogenesis in these regions may offer novel insights into potential therapeutic strategies for AD, highlighting the need for further research into the intersection of hypoxia, angiogenesis, and neurogenesis in the context of neurodegeneration. By exploring these connections, we hope to contribute to a better understanding of AD pathophysiology and identify new avenues for intervention.","PeriodicalId":49623,"journal":{"name":"Reviews in the Neurosciences","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145233904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prefrontal cortex cytosolic and synaptosome proteome reveal molecular signatures of resilience to chronic social isolation stress in rats. 大鼠前额叶皮层细胞质和突触体蛋白质组揭示了慢性社会隔离应激恢复的分子特征。

IF 4.1 3区医学

Reviews in the Neurosciences Pub Date : 2025-09-26 DOI: 10.1515/revneuro-2025-0081

Dragana Filipović, Christoph W Turck

{"title":"Prefrontal cortex cytosolic and synaptosome proteome reveal molecular signatures of resilience to chronic social isolation stress in rats.","authors":"Dragana Filipović, Christoph W Turck","doi":"10.1515/revneuro-2025-0081","DOIUrl":"https://doi.org/10.1515/revneuro-2025-0081","url":null,"abstract":"Chronic social isolation stress (CSIS) is a well-established preclinical model for studying stress-induced neurobiological changes and their effects on behavior and brain function in depression. The prefrontal cortex (PFC), a brain region essential for emotional regulation, cognitive control, and social interactions, is particularly susceptible to stress. While CSIS exposure triggers molecular and behavioral changes characteristic of depression-like behavior, a subset of animals displays a resilient phenotype, maintaining normal neurobiological and behavioral function despite experiencing adverse conditions. Understanding the molecular differences between resilient and susceptible phenotypes is crucial for identifying biomarkers and developing novel therapeutic targets for depression. Mass spectrometry-based proteomics, combined with bioinformatics approaches, provides a powerful tool for exploring these complex cellular processes. This review focuses on proteomic changes in cytosolic and synaptosome-enriched fractions of the PFC in adult male rats following CSIS exposure, with particular emphasis on differences between resilient and susceptible animals. We summarize findings of differential protein expression across multiple biological systems, including energy metabolism, cytoskeletal organization, cellular stress defense mechanisms, neurotransmitter regulation, and synaptic function. Additionally, we present protein predictors of resilience to CSIS identified through machine learning-based analyses, highlighting potential pathways for preventing and mitigating depression-like outcomes following CSIS.","PeriodicalId":49623,"journal":{"name":"Reviews in the Neurosciences","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145139217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Visual rating scales of brain atrophy in dementia: a systematic review of reliability and diagnostic accuracy. 痴呆患者脑萎缩的视觉评定量表：可靠性和诊断准确性的系统评价。

IF 4.1 3区医学

Reviews in the Neurosciences Pub Date : 2025-09-17 DOI: 10.1515/revneuro-2025-0066

Chiara Fornari, Giorgio G Fumagalli

{"title":"Visual rating scales of brain atrophy in dementia: a systematic review of reliability and diagnostic accuracy.","authors":"Chiara Fornari, Giorgio G Fumagalli","doi":"10.1515/revneuro-2025-0066","DOIUrl":"https://doi.org/10.1515/revneuro-2025-0066","url":null,"abstract":"Visual rating scales of brain atrophy allow to quantify brain regional atrophy and could be used as a diagnostic marker for differentiating neurodegenerative diseases. This paper aims to review the visual rating scales for dementia, focusing on their reliability, the correlation with volumetric imaging measures, and their predictive accuracy. Following the PRISMA guidelines, we systematically searched in Pubmed, Web of Science, Scopus, and MEDLINE databases until November 4, 2024. Of the 441 articles extracted, we included in the review 28 papers. All the scales reached a fair to excellent level of inter and intra rater agreement. Furthermore, negative correlations were found between the rating in each scale and brain volumetric measures. Lastly, the discriminative abilities exhibited variability according to the scale and the population comparisons. Visual rating scales of atrophy provide a reliable method for distinguishing physiological aging from pathological conditions, and among neurodegenerative forms. For an accurate differential diagnosis, it is essential to employ scales with the highest diagnostic precision.","PeriodicalId":49623,"journal":{"name":"Reviews in the Neurosciences","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145087910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Data fusion of medical imaging in neurological disorders. 神经系统疾病医学影像的数据融合。

IF 4.1 3区医学

Reviews in the Neurosciences Pub Date : 2025-09-16 DOI: 10.1515/revneuro-2025-0062

Golrokh Mirzaei, Aaditya Gupta, Hojjat Adeli

引用次数: 0

From lactate to lactylation: potential targets for the treatment of neurodegenerative diseases. 从乳酸到乳酸化：治疗神经退行性疾病的潜在靶点。

IF 4.1 3区医学

Reviews in the Neurosciences Pub Date : 2025-07-31 DOI: 10.1515/revneuro-2025-0068

Bingbing Wang, Shenghao Qian, Caizhen Shi, Li Dan, Tianyu Zhai, Can Zhang, Juan Shen, Yanling Yang, Lin Zhao

{"title":"From lactate to lactylation: potential targets for the treatment of neurodegenerative diseases.","authors":"Bingbing Wang, Shenghao Qian, Caizhen Shi, Li Dan, Tianyu Zhai, Can Zhang, Juan Shen, Yanling Yang, Lin Zhao","doi":"10.1515/revneuro-2025-0068","DOIUrl":"https://doi.org/10.1515/revneuro-2025-0068","url":null,"abstract":"Traditionally, lactate is regarded as a byproduct of anaerobic metabolism. With the deepening of related research, the roles of lactate in cellular energy metabolism, signal transduction, and microenvironment regulation have attracted increasing attention. Against this research background, the discovery of a novel post-translational modification - lactylation modification - has further expanded its biological functions. In the context of the increasingly aging global population, neurodegenerative diseases (ND) have become a significant challenge threatening global public health. Studies have reported that lactate metabolic disorders are common metabolic characteristics in the occurrence and development of ND. In summary, this article focuses on reviewing lactate and lactylation in the brain and their roles in ND. It comprehensively outlines the process from lactate to lactylation, highlights the close connection between brain lactate metabolism and ND, and explores potential molecular mechanisms underlying disease development - providing new perspectives for understanding ND pathogenesis. Additionally, this review systematically summarizes potential therapeutic strategies for ND based on regulating lactate metabolism, aiming to offer innovative approaches for disease prevention, diagnosis, and treatment.","PeriodicalId":49623,"journal":{"name":"Reviews in the Neurosciences","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144745825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From genetic roots to recent advancements in gene therapy targeting amyloid beta in Alzheimer's disease. 从遗传根源到针对阿尔茨海默病的β淀粉样蛋白基因治疗的最新进展。

IF 3.4 3区医学

Reviews in the Neurosciences Pub Date : 2025-05-30 DOI: 10.1515/revneuro-2025-0025

Pinar Peyvand, Pantea Allami, Nima Rezaei

{"title":"From genetic roots to recent advancements in gene therapy targeting amyloid beta in Alzheimer's disease.","authors":"Pinar Peyvand, Pantea Allami, Nima Rezaei","doi":"10.1515/revneuro-2025-0025","DOIUrl":"https://doi.org/10.1515/revneuro-2025-0025","url":null,"abstract":"Alzheimer's disease (AD) is one of the most prevalent neurodegenerative disorders. The pathological hallmarks of AD are amyloid-beta (Aβ) plaques and tau protein tangles, which cause neurodegeneration and lead to cognitive decline. The distinguished role of Aβ plaques in the onset of the disease, especially in familial AD, alongside the genetic complexity of AD, underscores the need for precise and targeted genetic interventions targeting Aβ. This review first highlights the amyloidogenic and non-amyloidogenic pathways and inflammatory mechanisms contributing to Aβ accumulation. It also introduces the role of genetic variants such as amyloid precursor protein (APP), presenilin (PSEN1), PSEN2, and Apolipoprotein E (APOE) alongside the molecular and cellular mechanisms involved in Aβ pathology. Then, gene therapy techniques are discussed for their potential to target Aβ either directly by inhibiting its production or enhancing its degradation or indirectly by targeting APOE, inflammatory pathways, and neurotrophic factors. While these approaches show significant preclinical promise, challenges such as timing, safety, and delivery across the blood-brain barrier persist and need further investigation.","PeriodicalId":49623,"journal":{"name":"Reviews in the Neurosciences","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144192432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The current approaches to modeling the brain ischemia-reperfusion and inflammation: from animal models toward vascularized and neuroimmune cerebral organoids. 目前脑缺血再灌注和炎症建模的方法：从动物模型到血管化和神经免疫脑类器官。

IF 3.4 3区医学

Reviews in the Neurosciences Pub Date : 2025-05-28 DOI: 10.1515/revneuro-2025-0015

Pavel P Tregub, Daria D Volegova, Arseniy K Berdnikov, Pavel A Chekulaev, Daniil A Bystrov, Yulia K Komleva, Natalia A Kolotyeva, Sergey N Illarioshkin, Alla B Salmina, Stanislav O Yurchenko

{"title":"The current approaches to modeling the brain ischemia-reperfusion and inflammation: from animal models toward vascularized and neuroimmune cerebral organoids.","authors":"Pavel P Tregub, Daria D Volegova, Arseniy K Berdnikov, Pavel A Chekulaev, Daniil A Bystrov, Yulia K Komleva, Natalia A Kolotyeva, Sergey N Illarioshkin, Alla B Salmina, Stanislav O Yurchenko","doi":"10.1515/revneuro-2025-0015","DOIUrl":"https://doi.org/10.1515/revneuro-2025-0015","url":null,"abstract":"For several decades, the modeling of brain diseases in experimental animals has remained one of the key components of studying the pathogenesis of central nervous system pathology and searching for new methods of prevention and therapy. In recent years, new approaches to modeling pathological conditions in vitro have been in active development; these approaches will not only reduce the number of animal studies but also allow us to take a step toward reproducing the human-specific mechanisms of brain pathology. In this review, we characterize the most common rodent models of cerebral ischemia and reperfusion, as well as neuroinflammation inherent to neurodegeneration (in particular, Parkinson's disease), which are reproduced in vivo. This review addresses engineering and technical challenges and the prospects for the development of brain pathology models in vitro, e.g., vascularized and microglia-containing/neuroimmune cerebral organoids, which may be useful in overcoming the shortcomings and limitations of the current in vivo models.","PeriodicalId":49623,"journal":{"name":"Reviews in the Neurosciences","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144182885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exercise-induced modulation of miRNAs and gut microbiome: a holistic approach to neuroprotection in Alzheimer's disease. 运动诱导的mirna和肠道微生物组的调节：阿尔茨海默病神经保护的整体方法

IF 3.4 3区医学

Reviews in the Neurosciences Pub Date : 2025-05-07 DOI: 10.1515/revneuro-2025-0013

Rui Wang, Juan Li, Xiaochen Li, Yan Guo, Pei Chen, Tian Peng

{"title":"Exercise-induced modulation of miRNAs and gut microbiome: a holistic approach to neuroprotection in Alzheimer's disease.","authors":"Rui Wang, Juan Li, Xiaochen Li, Yan Guo, Pei Chen, Tian Peng","doi":"10.1515/revneuro-2025-0013","DOIUrl":"https://doi.org/10.1515/revneuro-2025-0013","url":null,"abstract":"Alzheimer's disease (AD), a progressive neurodegenerative disorder, is marked by cognitive decline, neuroinflammation, and neuronal loss. MicroRNAs (miRNAs) have emerged as critical regulators of gene expression, influencing key pathways involved in neuroinflammation and neurodegeneration in AD. This review delves into the multifaceted role of exercise in modulating miRNA expression and its interplay with the gut microbiome, proposing a comprehensive framework for neuroprotection in AD. By synthesizing current research, we elucidate how exercise-induced changes in miRNA profiles can mitigate inflammatory responses, promote neurogenesis, and reduce amyloid-beta and tau pathologies. Additionally, we explore the gut-brain axis, highlighting how exercise-driven alterations in gut microbiota composition can further influence miRNA expression, thereby enhancing cognitive function and reducing neuroinflammatory markers. This holistic approach underscores the potential of targeting exercise-regulated miRNAs and gut microbiome interactions as a novel, noninvasive therapeutic strategy to decelerate AD progression and improve quality of life for patients. This approach aims to decelerate disease progression and improve patient outcomes, offering a promising avenue for enhancing the effectiveness of AD management.","PeriodicalId":49623,"journal":{"name":"Reviews in the Neurosciences","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144055766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A proposed role for electrical coupling in the neocortical slow oscillation. 电耦合在新皮层慢振荡中的作用。

IF 3.4 3区医学

Reviews in the Neurosciences Pub Date : 2025-05-07 DOI: 10.1515/revneuro-2025-0018

Roger D Traub, Andreas Draguhn, Diego Contreras, Mark O Cunningham

{"title":"A proposed role for electrical coupling in the neocortical slow oscillation.","authors":"Roger D Traub, Andreas Draguhn, Diego Contreras, Mark O Cunningham","doi":"10.1515/revneuro-2025-0018","DOIUrl":"https://doi.org/10.1515/revneuro-2025-0018","url":null,"abstract":"We constructed a computational thalamocortical network model for study of the neocortical slow oscillation. It incorporated a number of neuronal types, both excitatory and inhibitory, each model neuron simulated as a multicompartment entity with numerous membrane conductances. As in previous experimental and modeling studies, simulated slow oscillations primarily depended on recurrently connected deep intrinsic bursting (IB) pyramidal cells, with NMDA receptors being critical as well as intrinsic membrane conductances (e.g. persistent Na+); and with repolarization to the Down state dependent on intrinsic (slow Ca2+-dependent K+) and synaptic (GABAB receptor mediated) conductances. Furthermore, however, we now can account for additional features of the slow oscillation: the frequent occurrence of spikelets, the presence of very fast ripple-like oscillations, and the transition to so-called fast runs (10 to ∼20 Hz bursty oscillations). These latter phenomena depended in our model on electrical coupling via gap junctions between pyramidal neurons. The importance of gap junctions is supported by previous experimental data on the ripple-blocking effect of halothane, as well as by data from the in vitro hippocampus.","PeriodicalId":49623,"journal":{"name":"Reviews in the Neurosciences","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144044520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0