目前脑缺血再灌注和炎症建模的方法:从动物模型到血管化和神经免疫脑类器官。

IF 3.4 3区 医学 Q2 NEUROSCIENCES
Pavel P Tregub, Daria D Volegova, Arseniy K Berdnikov, Pavel A Chekulaev, Daniil A Bystrov, Yulia K Komleva, Natalia A Kolotyeva, Sergey N Illarioshkin, Alla B Salmina, Stanislav O Yurchenko
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引用次数: 0

摘要

几十年来,在实验动物中建立脑疾病模型一直是研究中枢神经系统病理发病机制和寻找新的预防和治疗方法的关键组成部分之一。近年来,体外病理状态建模的新方法正在积极发展;这些方法不仅将减少动物研究的数量,而且还使我们朝着重现人类特有的脑病理机制迈出了一步。在这篇综述中,我们描述了最常见的啮齿动物脑缺血和再灌注模型,以及神经退行性疾病(特别是帕金森病)固有的神经炎症,这些模型在体内繁殖。本文综述了工程和技术方面的挑战以及体外脑病理模型的发展前景,例如血管化和含小胶质细胞/神经免疫脑类器官,这可能有助于克服目前体内模型的缺点和局限性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The current approaches to modeling the brain ischemia-reperfusion and inflammation: from animal models toward vascularized and neuroimmune cerebral organoids.

For several decades, the modeling of brain diseases in experimental animals has remained one of the key components of studying the pathogenesis of central nervous system pathology and searching for new methods of prevention and therapy. In recent years, new approaches to modeling pathological conditions in vitro have been in active development; these approaches will not only reduce the number of animal studies but also allow us to take a step toward reproducing the human-specific mechanisms of brain pathology. In this review, we characterize the most common rodent models of cerebral ischemia and reperfusion, as well as neuroinflammation inherent to neurodegeneration (in particular, Parkinson's disease), which are reproduced in vivo. This review addresses engineering and technical challenges and the prospects for the development of brain pathology models in vitro, e.g., vascularized and microglia-containing/neuroimmune cerebral organoids, which may be useful in overcoming the shortcomings and limitations of the current in vivo models.

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来源期刊
Reviews in the Neurosciences
Reviews in the Neurosciences 医学-神经科学
CiteScore
9.40
自引率
2.40%
发文量
54
审稿时长
6-12 weeks
期刊介绍: Reviews in the Neurosciences provides a forum for reviews, critical evaluations and theoretical treatment of selective topics in the neurosciences. The journal is meant to provide an authoritative reference work for those interested in the structure and functions of the nervous system at all levels of analysis, including the genetic, molecular, cellular, behavioral, cognitive and clinical neurosciences. Contributions should contain a critical appraisal of specific areas and not simply a compilation of published articles.
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