Sao Paulo Medical Journal最新文献

{"title":"Mouth Opened with Tongue Extended (MOTE) maneuver: improvement in tomographic T-staging accuracy of oral cavity cancer: a prospective cross-sectional study.","authors":"Gustavo de Francisco Campos, Ula Lindoso Passos, Renato Sartori de Carvalho, Lucimara Sonja Villela de Miranda, Antônio Marcos Coldibelli Francisco, Miriam Harumi Tsunemi, Cauê Ocaña Demarqui, Daniel Cesar Shirane, Luciana Brito Corrêa, Carlos Neutzling Lehn, Marcelo Fernando Matielo","doi":"10.1590/1516-3180.2025.0006.R1.04112025","DOIUrl":"10.1590/1516-3180.2025.0006.R1.04112025","url":null,"abstract":"<p><strong>Background: </strong>Accurate T-staging of oral squamous cell carcinoma (SCC) is essential for surgical planning and prognosis. However, conventional computed tomography (CT) may underestimate tumor extent, particularly when performed without dynamic maneuvers.</p><p><strong>Objectives: </strong>To evaluate the accuracy of CT in predicting the T-staging of primary SCC of the oral cavity by comparing scans in the neutral position and with the mouth open and tongue extended (MOTE) maneuver.</p><p><strong>Methods: </strong>This prospective cross-sectional study analyzed patients with oral SCC who underwent CT in both positions. Two blinded head-and-neck radiologists measured tumor size and depth of invasion (DOI). An anatomopathological study served as the reference. The accuracy of classifying early and advanced T-stage tumors was determined using diagnostic tests.</p><p><strong>Results: </strong>Twenty-five patients (72% male, mean age 65.6 ± 11.3 years) were included. Tumor detection sensitivity increased from 72% (95% CI: 51.9-86.9) in the neutral position to 100% (95% CI: 83.4-100) with the MOTE maneuver. Correct T-staging prediction improved from 52-56% in the neutral position to 7276% with MOTE. Accuracy for early-stage (T1/T2) classification rose from 60.0% (95% CI: 39.3-78.1) to 88.0% (95% CI: 68.7-97.4, h = 0.66). Lesion size overestimation decreased from 20.9-23.7% to 15.3-16.1% (p < 0.05), whereas DOI differences were not significant (p > 0.05).</p><p><strong>Conclusions: </strong>The MOTE maneuver significantly improved both the sensitivity and accuracy of CT in the preoperative T-staging of oral cavity SCC. Its incorporation into diagnostic protocols may enhance lesion detection and staging reliability in daily clinical practice.</p>","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":"144 1","pages":"e2025006"},"PeriodicalIF":1.2,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12795518/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145985713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of a telemedicine center on reducing the carbon footprint for primary health care: a multicenter retrospective cohort study.","authors":"Mônica Rossatti Molina, Marcus Vinicius Dutra Zuanazzi, Francisco Antônio Sousa de Araújo, Cleyton Zanardo de Oliveira, Vivian Oliveira Balan, Rafael Saad Fernandez, Camilla do Rosario Nicolino Chiorino, Eduardo Augusto Oliveira Barrozo, Dante Dianezi Gambardella, Soraya Camargo Ito Süffert","doi":"10.1590/1516-3180.2025.3299.01102025","DOIUrl":"10.1590/1516-3180.2025.3299.01102025","url":null,"abstract":"<p><strong>Background: </strong>Telemedicine can promote access to specialized care and avoid travel to referral centers.</p><p><strong>Objectives: </strong>To present the environmental impacts and the positive results for the sustainability of the Brazilian public health system after the implementation of the TeleNordeste Project developed by hospital BP - A Beneficência Portuguesa de São Paulo.</p><p><strong>Design and setting: </strong>A retrospective cohort study was developed in three states in the Brazilian Northeast, Alagoas, Maranhão, and Piauí.</p><p><strong>Methods: </strong>This study was conducted between August 2022 and December 2023. All patients participating in telemedicine care were selected for this type of care by Primary Health Care (PHC) doctors according to the need for clinical discussion. The variables analyzed were the total distance and time (round trip) saved by telemedicine care, the amount of carbon emissions not released into the environment, gasoline costs, resolution of care through teleconsultation, and evaluation of the Net Promoter Score.</p><p><strong>Results: </strong>In total, 25,194 consultations were conducted via telemedicine, requiring in-person referral in 775 tele-interconsultations, representing a resolution rate of 96.92%. It saved approximately 10,737,287 miles (17,279,988.6 km) and 264,302 hours for patients and the municipal health department, and reduced carbon dioxide (CO2) emissions according to Environmental Protection Agency (EPA) parameters, estimated at 4,294,915 kg, saving US$ 1,660,068.89 (R$ 8,532,754.09) on gasoline.</p><p><strong>Conclusion: </strong>To our knowledge, in Brazil, this study is one of the first to present results on the impact of telemedicine on reducing carbon emissions in relation to the movement of patients to reference centers in healthcare networks and the resolution of care provided in health units in the context of the PROADI-SUS TeleNordeste Project developed by BP and promotes reflection on the potential benefits of telemedicine according to current evidence.</p>","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":"144 1","pages":"e20253299"},"PeriodicalIF":1.6,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12707785/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145795203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cut-off point for diagnosing thoraco-lumbo-pelvic rotation range hypomobility through the leg lateral reach test in chronic low back pain: a cross-sectional study.","authors":"André Pontes-Silva, Aldair Darlan Santos-de-Araújo, Mariana Schamas-Esposel, Aliny da Silva de Araujo, Giovanna Laura Neves Antonio Gaban, Almir Vieira Dibai Filho","doi":"10.1590/1516-3180.2024.0500.R1.08092025","DOIUrl":"10.1590/1516-3180.2024.0500.R1.08092025","url":null,"abstract":"<p><strong>Background: </strong>Studies have proposed using the leg lateral reach test (LLRT). However, they did not establish a cut-off point for testing.</p><p><strong>Objective: </strong>To establish a cut-off point for the thoraco-lumbo-pelvic rotation range using the LLRT in patients with chronic low back pain.</p><p><strong>Design and setting: </strong>Cross-sectional study conducted in Buriticupu, Maranhão, Brazil.</p><p><strong>Methods: </strong>In the chronic low back pain group (LBPG, n = 35), we included patients aged 18 to 59 years, of both sexes, with scores ≤ 4 on the Baecke Habitual Physical Activity Questionnaire, body mass indeces ≤ 26 kg/m2, disability levels ≥ 3 on the Roland-Morris Disability Questionnaire, and pain levels ≥ 3 on the Numeric Pain Rating Scale. In the healthy control group (HCG, n = 35), the patients had the same characteristics (except for pain and disability). We used receiver operating characteristic curves to check the rate of true versus false positives in different LLRT ranges of motion and found the best LLRT cut-off point using the following mathematical model: (1 - sensitivity)2 + (1 - specificity)2.</p><p><strong>Results: </strong>The sample was mainly composed of females (HCG = 65.71%; LBPG = 82.85%, P = 0.101), and 68.42% of the characteristics (13 of 19 comparisons between groups) showed a significant difference (P ≤ 0.05), with an effect size ranging from moderate to large (Cohen's d ≥ 0.5). The cut-off value for ideal sensitivity and specificity was ≤ 82.85 cm.</p><p><strong>Conclusion: </strong>Patients with chronic low back pain and an LLRT range ≤ 82.85 cm have hypomobility regarding thoraco-lumbo-pelvic rotation range.</p>","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":"144 1","pages":"e2024500"},"PeriodicalIF":1.6,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12707782/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145795285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Psychological Inflexibility in Pain Scale (PIPS) in Brazilian patients with chronic cancer pain: translation, cross-cultural adaptation, and validation study.","authors":"Sergio Paulo Mariano de Aguiar, Daniela Bassi-Dibai, Letícia Padilha Mendes, Naara Rayane Moura Cutrim, César Leonardo Ribeiro Guedes, Jocassia Silva Pinheiro, Daniel Nunes Morais, Carlos Wagner de Sousa Campos Neto, Plínio da Cunha Leal, Almir Vieira Dibai Filho","doi":"10.1590/1516-3180.2025.0018.R1.08092025","DOIUrl":"10.1590/1516-3180.2025.0018.R1.08092025","url":null,"abstract":"<p><strong>Background: </strong>The Psychological Inflexibility in Pain Scale (PIPS) was developed to measure avoidance and cognitive fusion.</p><p><strong>Objectives: </strong>To translate, cross-culturally adapt, and analyze the measurement properties of the Psychological Inflexibility in Pain Scale (PIPS) in Brazilian patients with chronic cancer pain.</p><p><strong>Methods: </strong>Questionnaire translation, cross-cultural adaptation, and validation studies were conducted in two hospitals in northeastern Brazil. The measurement properties tested included structural validity, construct validity, reliability, and internal consistency. The following assessment instruments were used in addition to the PIPS: Pain Catastrophizing Scale (PCS), Barthel Index, Edmonton Symptom Assessment Scale (ESAS), and Hospital Anxiety and Depression Scale (HADS).</p><p><strong>Results: </strong>The study sample consisted of 122 patients, most of whom were women (65.6%) with a mean age of 49 years. Most patients had uterine cancer (23%) and leukemia (9.8%). We identified problems in the two-dimensional structure of the PIPS by presenting three inadequate fit indices. Adequate reliability was observed in both domains. Regarding the avoidance domain, there was a correlation with a magnitude > 0.30 with the depression domain of the HADS, and correlations with a magnitude < 0.30 with the anxiety domain of the HADS, the PCS domains, and the Barthel Index. The cognitive fusion domain did not correlate with any of these scales (P > 0.05). No ceiling or floor effects were observed.</p><p><strong>Conclusion: </strong>The Brazilian version of the PIPS is reliable; however, the instrument does not have a valid internal structure and the cognitive fusion domain is not a valid construct.</p>","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":"144 1","pages":"e2025018"},"PeriodicalIF":1.6,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12707784/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145794892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of music and conversation on pain and anxiety levels during transrectal ultrasound-guided prostate biopsy: a randomized-controlled prospective study.","authors":"Volkan Selmi, Mehmet Sakir Taspinar, Mehmet Caniklioglu, Sercan Sari, Mahmut Akyuz, Levent Isikay","doi":"10.1590/1516-3180.2025.3273.28072025","DOIUrl":"10.1590/1516-3180.2025.3273.28072025","url":null,"abstract":"<p><strong>Background: </strong>Prostate biopsy is the recommended diagnostic test for prostate cancer in patients with abnormal findings on digital rectal examinations (DRE) or elevated PSA (prostate-specific antigen) levels. Biopsies can cause severe anxiety and pain.</p><p><strong>Objective: </strong>To evaluate the effects of music and conversation on pain and anxiety in patients undergoing transrectal ultrasound-guided prostate biopsy.</p><p><strong>Design and setting: </strong>Prospective trial at a Tertiary University Hospital in Türkiye.</p><p><strong>Methods: </strong>A prospective randomized controlled study was conducted. Ninety patients who had abnormal findings on DRE and/or a PSA value greater than 2.5 ng/ml and were scheduled to undergo TRUS-PBx were randomly assigned to one of three groups (n = 30) via the sealed envelope randomization method: control, music, and conversation groups. VAS pain, VAS anxiety, and STAI scores were recorded before and after the procedure. Statistical analysis was performed using One-Way ANOVA and Kruskal-Wallis tests. Pairwise comparison tests were conducted for the parameters that yielded significant differences among the control, conversation, and music groups. For all statistical analyses, a P value < 0.05 was considered statistically significant.</p><p><strong>Results: </strong>Conversation reduced pain and anxiety significantly (P < 0.001 and P = 0.01 respectively). Post-Bx VAS pain and STAI-State scores were lower in the conversation group. Pairwise comparisons revealed significant differences between the music and conversation groups (VAS pain, P < 0.001; STAI-State, P = 0.006). However, pain and STAI-State scores were similar in both the groups (VAS pain P = 0.645; STAI-State P = 0.597).</p><p><strong>Conclusions: </strong>The study demonstrated that listening to music had no significant effect on pain and anxiety in patients undergoing TRUS-PBx. Conversely, the findings showed that engaging patients in conversation significantly reduced pain and anxiety during the procedure.</p><p><strong>Clinical trial or systematic review registration: </strong>The trial is registered at clinicaltrials.gov (registration number: NCT07006779) and is accessible at https://clinicaltrials.gov/ct2/show/NCT07006779.</p>","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":"144 1","pages":"e20253273"},"PeriodicalIF":1.6,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12707780/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145795227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knee and ankle biomechanics during recovery from primary, secondary, and bilateral anterior cruciate ligament injuries: a quasi-experimental study.","authors":"Sérgio Loureiro Nuno, Carlos Romero-Morales, Daniel López-López, Marta Elena Losa-Iglesias, Ricardo Becerro-de-Bengoa-Vallejo, Juan Gómez-Salgado, João Guerra, Miguel Ángel Saavedra-García","doi":"10.1590/1516-3180.2024.0497.R1.13072025","DOIUrl":"10.1590/1516-3180.2024.0497.R1.13072025","url":null,"abstract":"<p><strong>Background: </strong>Anterior cruciate ligament (ACL) tears are common knee injuries with a known but vague association with secondary joint injuries. The extent to which these injuries are preventable remains unclear.</p><p><strong>Objective: </strong>This study aimed to assess the functional differences in knee and ankle dorsiflexion biomechanics with full loading on one leg and to understand whether it could be a key point as a progressive method in ACL reconstruction, considering both legs and three different groups.</p><p><strong>Design and setting: </strong>A quasi-experimental study of Medical Centers in an outpatient clinic in Portugal.</p><p><strong>Methods: </strong>The Y balance test (YBT) was used to evaluate and analyze the association between ankle dorsiflexion range of motion (DF-ROM) and knee flexion. DF-ROM and knee flexion were used to compare the deficits between the operated and uninvolved limbs in all three groups (ACL-I, ACL-II, and ACL-III).</p><p><strong>Results: </strong>Ankle DF-ROM and knee flexion assessed during the YBT were associated with higher knee flexion ROM, identifying individuals who were better prepared for the next phase of the guideline. The study results provide preliminary data for future studies that use prospective longitudinal research and involve large patient populations to establish prognostic biomechanical markers for determining long-term dynamic stability after ACL reconstruction.</p><p><strong>Conclusions: </strong>In the three groups with a history of ACL injury, compensations and kinematic asymmetries in dorsal flexion and knee flexion were observed in the operated and control legs both at 6 and 8 weeks of treatment.</p>","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":"144 1","pages":"e2024497"},"PeriodicalIF":1.6,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12707781/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145794597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Organ donation in Brazil: individual autonomy versus family consent.","authors":"Gabriela Favaro Faria, Marcelo de Azevedo Granato, Paulo Manuel Pêgo-Fernandes","doi":"10.1590/1516-3180.2025.1441.17102025","DOIUrl":"10.1590/1516-3180.2025.1441.17102025","url":null,"abstract":"","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":"144 1","pages":"e20261441"},"PeriodicalIF":1.6,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12707783/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145794563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Financial sustainability and the incorporation of technologies in the Brazilian Unified Health System: advances, challenges, and perspectives.","authors":"Gabriela Favaro Faria, Paulo Manuel Pêgo-Fernandes","doi":"10.1590/1516-3180.2025.1436.15102025","DOIUrl":"10.1590/1516-3180.2025.1436.15102025","url":null,"abstract":"","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":"143 6","pages":"e20251436"},"PeriodicalIF":1.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12685275/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145726993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of thyroid volume on serum ionized calcium and PTH levels after total thyroidectomy.","authors":"Nicolas Johnson de Oliveira Vieira, Lucas Norambuena Aulicino, João Victor Marques Cruz Helene de Oliveira, Inês Nobuko Nishimoto, Rogério Aparecido Dedivitis","doi":"10.1590/1516-3180.2024.0441.13062025","DOIUrl":"10.1590/1516-3180.2024.0441.13062025","url":null,"abstract":"<p><strong>Background: </strong>The relationship between thyroid gland volume and hypoparathyroidism after total thyroidectomy remains controversial.</p><p><strong>Objective: </strong>To evaluate thyroid gland mass as a risk factor for hypoparathyroidism after total thyroidectomy.</p><p><strong>Design and setting: </strong>A Retrospective cross-sectional observational study was conducted at Centro Universitário Lusíada (UNILUS), Santos/SP, Brazil.</p><p><strong>Methods: </strong>Patients undergoing total thyroidectomy between January 2022 and September 2023 were retrospectively evaluated for serum levels of ionized calcium and ultrasensitive parathyroid hormone (PTH), measured preoperatively and 30-60 days postoperatively, and thyroid mass, obtained by weighing the specimen.</p><p><strong>Results: </strong>A total of 174 patients were evaluated, with a predominance of women (89.7%), a median age of 50.5 years, and a median goiter volume of 36.3 mL. A reduction in both PTH and ionized calcium levels was observed in the postoperative period compared with the preoperative period (P < 0.05). No significant changes were observed in PTH levels and volume (P = 0.481). For calcium, there was a tendency towards an association between volume measurements and its change between the pre- and postoperative periods, which was marginally significant (P = 0.051).</p><p><strong>Conclusion: </strong>There was a marginal association between volume and changes in pre- and postoperative ionized calcium levels, but no significant association with pre- and postoperative PTH measurements.</p>","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":"143 6","pages":"e2024441"},"PeriodicalIF":1.6,"publicationDate":"2025-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12646491/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145607079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The difference in hematocrit and albumin levels and the risk of sepsis for patients with acute pancreatitis: a retrospective cohort study based on the MIMIC-IV database.","authors":"Mingjie Jin, Yanmin Wu, Bin Ye","doi":"10.1590/1516-3180.2024.0401.14042025","DOIUrl":"10.1590/1516-3180.2024.0401.14042025","url":null,"abstract":"<p><strong>Background: </strong>Acute pancreatitis (AP) is a major cause of gastrointestinal hospitalization, with an annual global incidence of 3.07%. Severe AP develops in up to 20% of cases, with sepsis occurring in 40-70% of such cases, leading to higher mortality. The early detection of sepsis is crucial. Hematocrit (HCT) and albumin (ALB) levels are individually linked to sepsis. Their combined measure, HCT-ALB, indicates blood and nutritional health. HCT-ALB can predict sepsis and infection outcomes; however, its effectiveness in treating AP-related sepsis has not been investigated.</p><p><strong>Objective: </strong>This study aimed to examine the association between HCT-ALB values and sepsis risk in patients with AP.</p><p><strong>Methods: </strong>This retrospective cohort study used Medical Information Market for Intensive Care IV database data. The primary outcome was the risk of sepsis in patients with AP. The HCT-ALB value refers to the difference between HCT and ALB levels, which we categorized into three groups according to quantiles: < 0.5, 0.5-7.6, and ≥ 7.6. Logistic regression models were used to assess the association between HCT-ALB values and sepsis. The predictive value of HCT-ALB was assessed using a receiver operating characteristic curve. Subgroup analyses were conducted for different subgroups.</p><p><strong>Results: </strong>Among 565 patients with AP, 163 developed sepsis. In the multivariable model, HCT-ALB ≥ 7.60 was associated with sepsis risk for patients with AP [odds ratio (OR) 1.82, 95% confidence interval (CI) 1.06-3.14]. The area under the curve (AUC) value of HCT-ALB in predicting sepsis risk among patients with AP was 0.599 (95% CI 0.544-0.654), which was higher than that of the bedside index for severity in acute pancreatitis score (AUC 0.558, 95% CI 0.509-0.607). Subgroup analysis showed that HCT-ALB was only related to sepsis risk in male patients with acute kidney injury and Sequential Organ Failure Assessment in < 2 subgroups.</p><p><strong>Conclusion: </strong>HCT-ALB values ≥ 7.6 were associated with increased sepsis risk in patients with AP. HCTALB may contribute to identifying the risk of sepsis in patients with AP.</p>","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":"143 6","pages":"e2024401"},"PeriodicalIF":1.6,"publicationDate":"2025-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12646492/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145607074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}