Sao Paulo Medical Journal最新文献

{"title":"Time to initiation of dialysis and length of stay in hospitalized patients with kidney damage: a cross-sectional study.","authors":"Douglas Vieira Gemente, Marcelo Rodrigues Bacci","doi":"10.1590/1516-3180.2023.0365.R1.03072024","DOIUrl":"10.1590/1516-3180.2023.0365.R1.03072024","url":null,"abstract":"<p><strong>Background: </strong>Universal healthcare is a cornerstone of Brazil's public health system. However, delayed diagnosis and treatment of chronic kidney disease (CKD) remain substantial issues. The scarcity of outpatient dialysis facilities contributes to extended hospital stays. This study aimed to examine how the time to dialysis initiation (TID) impacts mortality in patients with renal disease.</p><p><strong>Objectives: </strong>This study aimed to evaluate the correlation between variables affecting TID and mortality in hospitalized patients with renal disease.</p><p><strong>Design and setting: </strong>A cross-sectional study was conducted at Santa Marcelina Hospital in São Paulo.</p><p><strong>Methods: </strong>This cross-sectional study was conducted in a tertiary hospital, involving adults with kidney disease who were referred to the emergency department between 2014 and 2017. Primary outcomes included TID and mortality rates.</p><p><strong>Results: </strong>Among the 402 patients studied, the average age was 58.6 years, and 59.4% were men. The median hospital stay was 44.5 d. Notably, 28.1% of the patients began dialysis under emergency conditions. Diabetes and hypertension were the most prevalent causes of renal disease. A positive correlation was found between age and TID (P = 0.007).</p><p><strong>Conclusions: </strong>Primary care in Brazil often fails to effectively detect and manage CKD, leading to a higher incidence of emergency dialysis, particularly among older adults. This delay correlates with increased mortality rates. Older age is associated with delayed TID, prolonged hospital stays, and consequently higher mortality. These findings highlight the need for better primary care to effectively manage CKD and reduce hospitalization and mortality.</p>","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":"143 1","pages":"e2023365"},"PeriodicalIF":1.3,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11655039/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142957813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis and treatment of latent tuberculosis infection among household contacts in inland Bahia, Brazil: a cross-sectional follow-up study.","authors":"Guilherme Lages Matias, Marcio Vinicius Ferreira Sales, Gabriela Santos Andrade, Brenda Dos Santos Teixeira, Maria Eduarda da Macena Tenorio, Maria Augusta Vasconcelos Palácio, Maria Luisa de Carvalho Correia, Iukary Takenami","doi":"10.1590/1516-3180.2023.0339.R2.03072024","DOIUrl":"10.1590/1516-3180.2023.0339.R2.03072024","url":null,"abstract":"<p><strong>Background: </strong>The diagnosis and treatment of latent tuberculosis infection (LTBI) are crucial for tuberculosis (TB) control. Household contacts (HHC) of patients with pulmonary TB are at a high risk of LTBI due to their close proximity to source cases.</p><p><strong>Objective: </strong>To describe the diagnosis and treatment of LTBI among HHC.</p><p><strong>Design and setting: </strong>This cross-sectional follow-up study was conducted in the municipality of Paulo Afonso, northeastern Brazil, between 2013 and 2022.</p><p><strong>Methods: </strong>We retrieved secondary data from the medical records of HHC who were followed up at a specialized referral center for TB. LTBI prevalence estimates were calculated and are presented with 95% confidence intervals (CIs).</p><p><strong>Results: </strong>In total, 622 HHC were screened for LTBI, with 620 evaluated using the tuberculin skin test (TST). Of these, 40 (6.5%) did not return for TST reading. The overall prevalence of LTBI was 53.1% (95% CI: 49-57.1%), with a high prevalence among females and individuals aged 25-34 years. The overall LTBI treatment initiation rate was 26.1% (95%CI: 21.5-31.3%), and 64.2% (95%CI: 53.3-73.8%) of HHC who initiated treatment completed their course.</p><p><strong>Conclusion: </strong>This study revealed a high prevalence of LTBI among HHC, particularly among women and individuals aged 25-34 years, underscoring the ongoing TB transmission within the community. Only 26.1% of the diagnosed HHC initiated treatment, with approximately 64% completing their course. This highlights the challenges in managing LTBI and emphasizes the need for targeted screening and interventions for high-risk groups.</p>","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":"143 1","pages":"e2023339"},"PeriodicalIF":1.3,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11655036/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142957828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of detraining through a six-minute walk test in patients with heart disease.","authors":"Victória Moreira Silva, Vitória Moreira Cintra, Maria de Lourdes da Silva, Joilson Meneguci, Fernando Seiji Silva, Eduardo Elias Vieira de Carvalho, Ana Paula Espindula, Lucina Duarte Novais Silva","doi":"10.1590/1516-3180.2023.0334.R1.03072024","DOIUrl":"10.1590/1516-3180.2023.0334.R1.03072024","url":null,"abstract":"<p><strong>Background: </strong>Detraining can partially or completely reduce training-induced metabolic adaptations. However, the duration for which the rehabilitation effects persist after detraining, especially in patients with heart disease, remains unclear.</p><p><strong>Objectives: </strong>To evaluate the principle of reversibility/detraining in patients with heart disease via the 6-minute walk test (6MWT) after a period of rest.</p><p><strong>Design and setting: </strong>A retrospective cohort study developed at the Rehabilitation Center of the Universidade Federal do Triângulo Mineiro in Uberaba/MG, Brazil.</p><p><strong>Methods: </strong>This clinical, retrospective longitudinal study involved 20 patients with heart disease who underwent 5 months of supervised cardiac rehabilitation (CR). The mean age of participants was 64.05 ± 9.25 years. The initial rehabilitation was followed by an interruption period and rehabilitation for another 5 months. Functional capacity was assessed using the 6MWT.</p><p><strong>Results: </strong>In the specific analysis of the distance covered, values of P = 0.03 and P = 0.01 were obtained on comparing post-training (669.64 ± 58.80 meters) with post-detraining (640.82 ± 101.23 meters) and post-detraining with post-retraining (650.82 ± 96.28 meters), respectively. No significant difference was observed for the comparison between training and retraining (P = 0.83).</p><p><strong>Conclusion: </strong>Cardiovascular rehabilitation positively stimulates functional capacity, whereas detraining significantly reduces it. The 6MWT is effective in measuring changes in physical capacity.</p>","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":"143 1","pages":"e2023334"},"PeriodicalIF":1.3,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11655032/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142957827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intensity-modulated radiation therapy for early-stage breast cancer: a systematic review and meta-analysis.","authors":"Samir Abdallah Hanna, Bruna Salani Mota, Fabio Ynoe de Moraes, Gustavo Nader Marta, Heloísa de Andrade Carvalho, Rachel Riera","doi":"10.1590/1516-3180.2023.0324.R1.03072024","DOIUrl":"10.1590/1516-3180.2023.0324.R1.03072024","url":null,"abstract":"<p><strong>Background: </strong>Radiation therapy (RT) is a standard treatment for non-metastatic breast cancer and is associated with acute and late toxicities. Intensity-modulated RT (IMRT) may decrease toxicity and is convenient for patients.</p><p><strong>Objectives: </strong>To assess the efficacy and safety of IMRT in women with early stage breast cancer.</p><p><strong>Design and setting: </strong>Systematic review study; Multi-institutional centers.</p><p><strong>Methods: </strong>Seven databases were searched. Randomized controlled trials (RCT) comparing IMRT with any \"non-IMRT\" strategies were included. Primary outcomes were local control and acute toxicity. Cochrane Handbook was use to plan and conduct the review, and PRISMA 2020 was used to report results.</p><p><strong>Results: </strong>Five RCT involving 2,556 women (n = 1,283 IMRT; n = 1,274 control arm) were included. Baseline characteristics were similar between trials and arms. Local relapse-free survival rates were not different (hazard-ratio [HR] 0.62; 95%confidence interval [CI] -0.38 to 1.62; P > 0.05); however, IMRT reduced the overall acute toxicity (RR 0.69, 95%CI 0.58 to 0.82; P < 0.00001) and acute moist desquamation (risk-ratio [RR] 0.71, 95%CI 0.60 to 0.82; P < 0.00001). Lymphedema and pneumonitis rates, and survival outcomes were not affected by IMRT. The 2-year telangiectasia rate was decreased with IMRT (RR 0.66, 95%CI 0.47 to 0.93; P = 0.02); however, edema, pain, pigmentation, or fibrosis remained unaffected. IMRT did not improve cosmesis.</p><p><strong>Conclusions: </strong>IMRT improved acute toxicity and lowered telangiectasia rates, without affecting oncological and aesthetic outcomes.</p><p><strong>Systematic review registration: </strong>This review was registered at Cochrane Database of Systematic Reviews 2013, Issue 3. Art. No.: CD010420. https://doi.org/10.1002/14651858.CD010420.</p>","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":"143 1","pages":"e2023324"},"PeriodicalIF":1.3,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11655040/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142957829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of depressive disorders among pregnant women in Brazil in 2019: A descriptive cross-sectional study.","authors":"Maira Gonçalves de Oliveira Lucas, Maria Isabel do Nascimento","doi":"10.1590/1516-3180.2023.0238.R1.03072024","DOIUrl":"10.1590/1516-3180.2023.0238.R1.03072024","url":null,"abstract":"<p><strong>Background: </strong>Prenatal depression threatens maternal and child well-being and interferes with issues prioritized by the 2030 agenda for the Sustainable Development Goals.</p><p><strong>Objectives: </strong>This study aimed to estimate the prevalence of depressive disorders during pregnancy using the Patient Health Questionnaire-9 (PHQ-9).</p><p><strong>Design and setting: </strong>A cross-sectional study using a sample of pregnant Brazilian women, representative of Brazil as a whole.</p><p><strong>Methods: </strong>Data were obtained from the National Health Survey 2019 (PNS-2019), as coordinated by the Instituto Brasileiro de Geografia e Estatística (IBGE). Women aged 18-49 years who were pregnant during PNS-2019 data collection were included. The prevalence of depressive disorders and 95% confidence intervals (95%CI) were calculated.</p><p><strong>Results: </strong>The prevalence of depression before the current pregnancy was 6.03% (95%CI: 3.80%; 8.25%). Using the PHQ-9, the prevalence of Major Depressive Disorder (MDD) in the current pregnancy was estimated to be 17.39% (95%CI: 12.70%-22.06%) among pregnant women who were targeted by the PNS-2019. Moreover, MDD was 15.26% (95%CI: 10.54%; 19.97%) among those who were free from depression history and in half of the pregnant woman population with depression history. Suicidal ideation has been reported in almost 23% of pregnant women with a history of depression. The two items from Patient Health Questionnaire-2 (PHQ-2) (anhedonia and depressed mood) with a cutoff of ≥ 3 presented similar results.</p><p><strong>Conclusions: </strong>Depression during pregnancy affects a non-negligible proportion of pregnant women, thus constituting an important public health problem. Therefore, it is crucial to discuss the implementation of regular screening for depression during prenatal care programs in Brazil.</p>","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":"143 1","pages":"e2023238"},"PeriodicalIF":1.3,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11655033/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142957833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy and precision of non-invasive thermometers compared with the pulmonary artery temperature: a cross-sectional study.","authors":"Rafael Lima Rodrigues de Carvalho, Mariana Avendanha Victoriano, Camila Claúdia Campos, Paula Frizera Vassallo, Vandack Nobre, Flávia Falci Ercole","doi":"10.1590/1516-3180.2023.0409.R1.05062024","DOIUrl":"10.1590/1516-3180.2023.0409.R1.05062024","url":null,"abstract":"<p><strong>Background: </strong>Temperature fluctuations are critical indicators of a patient's condition in intensive care units (ICUs). While invasive methods offer a more reliable measurement of core temperature, they carry greater risks of complications, limiting their use in most situations. This underscores the need for research evaluating the reliability of non-invasive temperature monitoring methods.</p><p><strong>Objectives: </strong>This study aimed to assess the accuracy and precision of four non-invasive temperature measurement techniques compared to pulmonary artery temperature, considered the gold standard.</p><p><strong>Design and setting: </strong>We conducted a cross-sectional clinical study with repeated measures in the ICUs at Hospital das Clínicas da Universidade Federal de Minas Gerais and Hospital Felício Rocho, Belo Horizonte, Brazil.</p><p><strong>Methods: </strong>All patients admitted with a pulmonary artery catheter were included. We simultaneously recorded temperatures from the pulmonary artery, axillary area, oral cavity, temporal artery, and tympanic membrane. Bland-Altman plots were employed to assess the agreement between the different temperature measurements.</p><p><strong>Results: </strong>A total of 48 patients participated, with a mean age of 54 years. Females comprised 66.67% of the sample. Compared to pulmonary artery temperature, the accuracy and precision (mean and standard deviation) of the non-invasive methods were: axillary (-0.42°C, 0.59°C), oral (-0.30°C, 0.37°C), tympanic membrane (-0.21°C, 0.44°C), and temporal artery (-0.25°C, 0.61°C). Notably, in patients with abnormal body temperature (non-normothermic), only oral and tympanic membrane methods maintained their accuracy and precision.</p><p><strong>Conclusions: </strong>The non-invasive thermometers evaluated in this study demonstrated acceptable accuracy and precision (within the clinically relevant threshold of 0.5°C) compared to pulmonary artery temperature. Among the non-invasive methods, the tympanic membrane measurement proved to be the most reliable, followed by the oral method.</p>","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":"142 6","pages":"e2023409"},"PeriodicalIF":1.3,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11639236/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alcohol consumption habits and their impact on academic performance: analysis of ethanol patterns among health students. A cross-sectional study.","authors":"Ana Paula Amaral de Brito, Aísa de Santana Lima, Átina Carneiro Rocha, Beatriz Muniz Gonçalves, Dalila Maria Costa Baraúna de Freitas, Gleice de Jesus Oliveira, Jamily Kaliny Azevedo Lima, Katia de Miranda Avena","doi":"10.1590/1516-3180.2023.0410.R1.05062024","DOIUrl":"10.1590/1516-3180.2023.0410.R1.05062024","url":null,"abstract":"<p><strong>Background: </strong>Studies have indicated a substantial increase in alcohol consumption among university students. Specifically, abusive consumption among health students can adversely affect their academic training and future professional practice.</p><p><strong>Objective: </strong>This study aimed to analyze alcohol consumption habits among healthcare students and investigate the associations between alcohol consumption patterns and sociodemographic and academic variables.</p><p><strong>Design and setting: </strong>We performed this cross-sectional study at a private university located in the city of Salvador, Bahia.</p><p><strong>Methods: </strong>We conducted this study with 770 students using a printed, self-administered, anonymous questionnaire containing sociodemographic and academic performance data, as well as the Alcohol Use Disorders Identification Test (AUDIT) and Rutgers Alcohol Problems Inventory (RAPI).</p><p><strong>Results: </strong>We observed that the prevalence of alcohol consumption (65.1%) and binge drinking (57.5%) among Brazilian healthcare students was high, with more frequent consumption among men (73.1%), in medicine (83.0%) and veterinary medicine (79.1%) programs and in semesters beyond the fourth (71.7%). We found associations between drinking habits and sex (P = 0.016), religion (P < 0.000), course (P < 0.000) and semester (P = 0.047). Binge drinking was associated with attending academic activities without getting any sleep (P < 0.000), missing classes due to hangovers (P < 0.000), encountering issues with the institution's administration (P = 0.028), and failing to complete activities due to alcohol consumption (P < 0.000).</p><p><strong>Conclusion: </strong>The prevalence of alcohol consumption and binge drinking among Brazilian healthcare students was high and associated with sex, religion, course, academic semester, risky behaviors, and negative academic impacts.</p>","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":"142 6","pages":"e2023410"},"PeriodicalIF":1.3,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11493372/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142511674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perceptions of childhood immunization in São Paulo: quantitative-qualitative cross-sectional study.","authors":"Lucas de Brito Costa, Carolina Nunes França, Luiz Henrique da Silva Nali, Patrícia Colombo-Souza, Neil Ferreira Novo, Yára Juliano","doi":"10.1590/1516-3180.2023.0447.R1.05062024","DOIUrl":"10.1590/1516-3180.2023.0447.R1.05062024","url":null,"abstract":"<p><strong>Background: </strong>Vaccination hesitation spans from historical diseases such as smallpox to the current challenges with the coronavirus disease (COVID-19). In Brazil, vaccination faces obstacles related to trust and convenience. Despite the National Immunization Program, fear of adverse effects as well as misinformation challenge confidence in vaccines, and anti-vaccine movements have gained momentum.</p><p><strong>Objectives: </strong>This study investigated childhood vaccine refusal, including COVID-19 vaccines, by comparing the reasons for and sociodemographic differences between vaccinated individuals and those who hesitated or refused immunization.</p><p><strong>Design and setting: </strong>A cross-sectional study was conducted in São Paulo, Brazil, using questionnaires administered during pediatric consultations between January and April 2023.</p><p><strong>Methods: </strong>This study investigated vaccine hesitancy and the attitudes of parents and caregivers of children (0-12 years) towards vaccines. The questionnaire was administered during routine pediatric consultations at three different locations, each with 50 participants for a total of 150 participants, to avoid selection bias.</p><p><strong>Results: </strong>Marked differences were evident among caregivers in terms of sex, race, income, education, and religion, which influenced their attitudes toward vaccination. There was an increase in the refusal of seasonal vaccinations and a significant distrust of the efficacy of the COVID-19 vaccine (52%), with concerns about its side effects. Although most patients did not stop vaccination, significant delays occurred, especially in the clinical setting (58%).</p><p><strong>Conclusions: </strong>This study emphasizes the importance of childhood health decisions, indicating the need to build trust in vaccines, tailor health policies, and investigate the causes of distrust to promote childhood immunizations.</p>","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":"142 6","pages":"e2023447"},"PeriodicalIF":1.3,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11493370/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142511675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between angiogenic growth factors and atherosclerosis in renal transplantation recipients: a cross-sectional study.","authors":"Melahat Çoban, Beyza Algul Durak, Mine Sebnem Karakan","doi":"10.1590/1516-3180.2024.0120.05062024","DOIUrl":"10.1590/1516-3180.2024.0120.05062024","url":null,"abstract":"<p><strong>Background: </strong>Accelerated development of atherosclerosis has been observed in renal transplant recipients (RTRs). Angiopoietin-2 (Ang-2) and vascular endothelial growth factor (VEGF) are vascular enzymes that play important roles in vascular development and angiogenesis.</p><p><strong>Objective: </strong>This study aimed to investigate the relationship between Ang-2 and VEGF and atherosclerosis in RTRs.</p><p><strong>Design and setting: </strong>This study was conducted at Ankara City Hospital, Turkey.</p><p><strong>Methods: </strong>This cross-sectional study included 36 (37.5%) female and 60 (62.5%) male RTRs. All findings were compared with those of 70 healthy controls. Ultrasonographic measurements of the carotid artery intima-media thickness (CA-IMT) and renal resistive index (RRI) were used as indicators of atherosclerosis.</p><p><strong>Results: </strong>Log10 Ang-2, log10 VEGF, CA-IMT, and RRI levels were significantly higher in patients than in healthy controls. No significant differences were detected in CA-IMT and RRI between those with log10 Ang-2 ≥ 3.53 pg/mL and those with < 3.53 pg/mL. No significant differences were detected in CA-IMT and RRI between those with log10 VEGF ≥ 1.98 pg/mL and those with < 1.98 pg/mL. No correlation was detected between log10 Ang-2 and log10 VEGF, CA-IMT, or RRI.</p><p><strong>Conclusions: </strong>Increased serum angiogenic growth factor levels and increased atherosclerosis development were detected in RTRs compared to healthy individuals. No relationship was observed between angiogenic growth factors and atherosclerosis. This may be due to the decreased synthesis and effect of angiogenic growth factor receptors synthesized from atherosclerotic plaques due to atherosclerosis, which improves after renal transplantation.</p>","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":"142 6","pages":"e2024120"},"PeriodicalIF":1.3,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11493371/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142511676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenges and perspectives in preventing and treating obesity.","authors":"Denis Pajecki, Paulo Manuel Pêgo Fernandes","doi":"10.1590/1516-3180.2024.1426.13062024","DOIUrl":"10.1590/1516-3180.2024.1426.13062024","url":null,"abstract":"","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":"142 6","pages":"e20241426"},"PeriodicalIF":1.3,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11492533/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142479074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}