Luiz Gustavo Machado, Daiane Silva Resende, Paola Amaral de Campos, Iara Rossi, Melina Lorraine Ferreira, Iolanda Alves Braga, Caio Augusto Martins Aires, Maria Tereza Freitas Tenório, Paulo Pinto Gontijo-Filho, Sabrina Royer, Rosineide Marques Ribas
{"title":"巴西卫生保健相关感染的负担：采用匹配病例对照研究的多医院点流行率","authors":"Luiz Gustavo Machado, Daiane Silva Resende, Paola Amaral de Campos, Iara Rossi, Melina Lorraine Ferreira, Iolanda Alves Braga, Caio Augusto Martins Aires, Maria Tereza Freitas Tenório, Paulo Pinto Gontijo-Filho, Sabrina Royer, Rosineide Marques Ribas","doi":"10.1590/1516-3180.2023.0307.R1.03072024","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Healthcare-associated infections (HAIs) have a significant impact on patient care worldwide and have serious implications for the Brazilian healthcare system.</p><p><strong>Objectives: </strong>This study aimed to describe the trends in HAIs in adult intensive care units (ICUs) using data from a national point-prevalence survey.</p><p><strong>Design and setting: </strong>A point-prevalence study was conducted in 2019 across adult intensive ICUs in large acute care hospitals in Brazil.</p><p><strong>Methods: </strong>A matched case-control study was performed to assess the risk factors associated with the development of infection.</p><p><strong>Results: </strong>A total of 386 patients from 15 hospitals were studied, of whom 102 (26.4%; 102/386) were infected, and 76.5% had at least one ICU-acquired infection. In clinical-surgical ICUs (CSU), the prevalence of infections acquired in the unit was 77.9%, whereas in Coronary ICUs (COU), it was 68.7%. There was a predominance of pneumonia (51.0%), mainly caused by Gram-negative non-fermenters, and bloodstream infections (34.4%), predominantly caused by coagulase-negative Staphylococcus (CoNS). In the risk factor analysis, cancer and general antimicrobial use were independently associated.</p><p><strong>Conclusion: </strong>This study found a high burden of HAIs in adult ICUs in Brazil, mainly associated with the high use of antibiotics for infections and a worse prognosis.</p>","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":"143 2","pages":"e2023307"},"PeriodicalIF":1.3000,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12037148/pdf/","citationCount":"0","resultStr":"{\"title\":\"The burden of healthcare-associated infections in Brazil: multi-hospital point prevalence using a matched case-control study.\",\"authors\":\"Luiz Gustavo Machado, Daiane Silva Resende, Paola Amaral de Campos, Iara Rossi, Melina Lorraine Ferreira, Iolanda Alves Braga, Caio Augusto Martins Aires, Maria Tereza Freitas Tenório, Paulo Pinto Gontijo-Filho, Sabrina Royer, Rosineide Marques Ribas\",\"doi\":\"10.1590/1516-3180.2023.0307.R1.03072024\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Healthcare-associated infections (HAIs) have a significant impact on patient care worldwide and have serious implications for the Brazilian healthcare system.</p><p><strong>Objectives: </strong>This study aimed to describe the trends in HAIs in adult intensive care units (ICUs) using data from a national point-prevalence survey.</p><p><strong>Design and setting: </strong>A point-prevalence study was conducted in 2019 across adult intensive ICUs in large acute care hospitals in Brazil.</p><p><strong>Methods: </strong>A matched case-control study was performed to assess the risk factors associated with the development of infection.</p><p><strong>Results: </strong>A total of 386 patients from 15 hospitals were studied, of whom 102 (26.4%; 102/386) were infected, and 76.5% had at least one ICU-acquired infection. In clinical-surgical ICUs (CSU), the prevalence of infections acquired in the unit was 77.9%, whereas in Coronary ICUs (COU), it was 68.7%. There was a predominance of pneumonia (51.0%), mainly caused by Gram-negative non-fermenters, and bloodstream infections (34.4%), predominantly caused by coagulase-negative Staphylococcus (CoNS). In the risk factor analysis, cancer and general antimicrobial use were independently associated.</p><p><strong>Conclusion: </strong>This study found a high burden of HAIs in adult ICUs in Brazil, mainly associated with the high use of antibiotics for infections and a worse prognosis.</p>\",\"PeriodicalId\":49574,\"journal\":{\"name\":\"Sao Paulo Medical Journal\",\"volume\":\"143 2\",\"pages\":\"e2023307\"},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2025-04-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12037148/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Sao Paulo Medical Journal\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1590/1516-3180.2023.0307.R1.03072024\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Sao Paulo Medical Journal","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1590/1516-3180.2023.0307.R1.03072024","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
The burden of healthcare-associated infections in Brazil: multi-hospital point prevalence using a matched case-control study.
Background: Healthcare-associated infections (HAIs) have a significant impact on patient care worldwide and have serious implications for the Brazilian healthcare system.
Objectives: This study aimed to describe the trends in HAIs in adult intensive care units (ICUs) using data from a national point-prevalence survey.
Design and setting: A point-prevalence study was conducted in 2019 across adult intensive ICUs in large acute care hospitals in Brazil.
Methods: A matched case-control study was performed to assess the risk factors associated with the development of infection.
Results: A total of 386 patients from 15 hospitals were studied, of whom 102 (26.4%; 102/386) were infected, and 76.5% had at least one ICU-acquired infection. In clinical-surgical ICUs (CSU), the prevalence of infections acquired in the unit was 77.9%, whereas in Coronary ICUs (COU), it was 68.7%. There was a predominance of pneumonia (51.0%), mainly caused by Gram-negative non-fermenters, and bloodstream infections (34.4%), predominantly caused by coagulase-negative Staphylococcus (CoNS). In the risk factor analysis, cancer and general antimicrobial use were independently associated.
Conclusion: This study found a high burden of HAIs in adult ICUs in Brazil, mainly associated with the high use of antibiotics for infections and a worse prognosis.
期刊介绍：
Published bimonthly by the Associação Paulista de Medicina, the journal accepts articles in the fields of clinical health science (internal medicine, gynecology and obstetrics, mental health, surgery, pediatrics and public health). Articles will be accepted in the form of original articles (clinical trials, cohort, case-control, prevalence, incidence, accuracy and cost-effectiveness studies and systematic reviews with or without meta-analysis), narrative reviews of the literature, case reports, short communications and letters to the editor. Papers with a commercial objective will not be accepted.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
