Sao Paulo Medical Journal最新文献

{"title":"HFE mutations in patients with iron overload in Santa Catarina: a cross-sectional study.","authors":"Cristiane Manfé Pagliosa, Vivian Karla Brognoli Franco, Thiago Sousa Matias, Bruno Vieira Dias, Andrea Thives de Carvalho Hoepers","doi":"10.1590/1516-3180.2023.0359.R1.07032025","DOIUrl":"https://doi.org/10.1590/1516-3180.2023.0359.R1.07032025","url":null,"abstract":"<p><strong>Background: </strong>Investigating the frequency and characteristics of iron overload cases with HFE gene mutation is crucial, given the population-level risks associated with excessive iron.</p><p><strong>Objective: </strong>To determine the frequency of HFE mutations in patients with iron overload in Santa Catarina, Brazil.</p><p><strong>Design and setting: </strong>A cross-sectional study of patients with iron overload at the Ambulatory Department of the Centro de Hematologia e Hemoterapia de Santa Catarina (Hemorrede-HEMOSC) in Santa Catarina.</p><p><strong>Methods: </strong>HFE genotype frequencies were determined, and a division were made between carriers of HFE -C282Y/C282Y mutations and carriers of other HFE-non-C282Y/C282Y mutations, according to each region of Santa Catarina. Binary logistic regression was used for association between sex and age with genetic mutation trait.</p><p><strong>Results: </strong>Among the 1,022 patients, 10.4% had secondary hemochromatosis, and 89.6% were evaluated for iron overload due to hereditary hemochromatosis (HH). Of these, 367 underwent genetic testing, which revealed HFE mutations in 77.3%. Most patients with HFE mutations had non-C282Y/C282Y-hemochromatosis, especially H63D/WT (> 39%), regardless of the Santa Catarina region. The frequency of C282Y/C282Y was higher in the West (20.9%) and North (28.3%) regions. Adjusted association analysis showed that men have an increased chance of hemochromatosis when involving 'non-C282Y/C282Y' mutations (OR: 2.77; 95% CI: 1.60-6.608).</p><p><strong>Conclusions: </strong>The data show the magnitude and characteristics of iron overload cases with HFE mutations in Santa Catarina. As most patients referred for treatment have H63D mutation, we suggest further studies to assess whether other factors, including dietary habits and mandatory iron fortification policies, contribute to iron overload or HH manifestation.</p>","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":"143 4","pages":"e2023359"},"PeriodicalIF":1.3,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology of severe heart disease among Unified Health System (SUS) users in Rio Grande do Norte: a cross-sectional study.","authors":"Gustavo Gomes Torres, Angelo Giuseppe Roncalli","doi":"10.1590/1516-3180.2023.0261.R1.07032025","DOIUrl":"https://doi.org/10.1590/1516-3180.2023.0261.R1.07032025","url":null,"abstract":"<p><strong>Background: </strong>Severe heart disease has high prevalence, morbidity, and mortality rates.Heart stimulation is important in the final stages of heart disease. The concentration of procedures in a service allows for the epidemiological analysis of our population.</p><p><strong>Objective: </strong>To analyze the epidemiological profile of severe heart disease in Rio Grande do Norte by registering all patients undergoing artificial cardiac stimulation (ACS) in a Unified Health System reference service in Rio Grande do Norte.</p><p><strong>Design and setting: </strong>This cross-sectional study included all patients who underwent ACS procedures at the Hospital Onofre Lopes, Universidade Federal do Rio Grande do Norte (UFRN), from 2006 to 2021. Sociodemographic characteristics, procedures, and health conditions were examined. Additionally, a spatial analysis of casuistry was performed according to the municipality of origin.</p><p><strong>Methods: </strong>This cross-sectional study analyzed data derived from patients treated at Hospital Onofre Lopes, UFRN, from 2006 to 2021, including sociodemographic characteristics, procedures, and health conditions.</p><p><strong>Results: </strong>A total of 894 patients (male, 59.8%; mean age: 65.5 years) were included. Third-degree atrioven tricular block was indicated in 191 patients, an ischemic etiology was found in 269 patients, whereas dyspnea was reported by 398 patients. Furthermore, 69.5%, 24.4%, and 31.7% of patients had hypertension, diabetes, and dyslipidemia, respectively. Spatial analysis showed no significant differences in the formation of clusters.</p><p><strong>Conclusions: </strong>The characteristics of the service contributed to possible differences in the literature. The spatial distribution of severe heart disease was random in the state, indicating an adequate distribution of reference services even in the absence of a defined flowchart for such services.</p>","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":"143 4","pages":"e2023261"},"PeriodicalIF":1.3,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional Index Questionnaire: structural validity study in Brazilian patients with anterior knee pain.","authors":"André Pontes-Silva, Almir Vieira Dibai-Filho, Flávio de Oliveira Pires, Carlos Eduardo Girasol, Gabriel Gardhel Costa Araujo, Plínio da Cunha Leal, José Djalma Arrais Junior, Cid André Fidelis-de-Paula-Gomes, Christian Emmanuel Torres Cabido","doi":"10.1590/1516-3180.2024.0153.R1.07032025","DOIUrl":"10.1590/1516-3180.2024.0153.R1.07032025","url":null,"abstract":"<p><strong>Objective: </strong>To assess the Functional Index Questionnaire (FIQ) structure using confirmatory factor analysis (CFA) in Brazilian patients with anterior knee pain.</p><p><strong>Methods: </strong>Brazilian patients of both sexes (n = 100), aged ≥ 18 years, with anterior knee pain for at least 3 months were included. Eligible participants completed an online form that collected personal and clinical data as well as responses to the assessment tools. We used CFA and the following fit indices: chi-square/degrees of freedom (DF), comparative fit index (CFI), Tucker-Lewis index (TLI), root mean square error of approximation (RMSEA), and standardized root mean square residuals (SRMR).</p><p><strong>Results: </strong>The majority of the respondents were women, young adults, overweight, with incomplete higher education, were physically active, and had pain in sitting or squatting positions. The mean duration of pain was 38.24 months, and the mean pain intensity was 4.54 points. The model fit indices were as follows: χ2/DF = 2.08, TLI = 0.978, CFI = 0.969, RMSEA = 0.104, and SRMR = 0.077. Therefore, the one-dimensional structure with eight items yielded an RMSEA value above the 0.08 cutoff point, suggesting a poorer fit and more residual error than is acceptable for a well-fitting model. Using the modification indices within the CFA, we observed a correlation between Items 2 (climbing up two flights of stairs [16 steps]) and 6 (climbing up four flights of stairs [32 steps]) and Items 3 (squatting) and 4 (kneeling), indicating the similarity in the response pattern for these items. After adding these correlations to the model, we obtained improved fit indices (χ2/DF = 1.51, TLI = 0.990, CFI = 0.985, RMSEA = 0.072, and SRMR = 0.061).</p><p><strong>Conclusion: </strong>This version of the FIQ should be used with caution, as the unidimensional model demonstrates substantial residuals, mainly because of item redundancy.</p>","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":"143 5","pages":"e2024153"},"PeriodicalIF":1.3,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12204634/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144561761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in organ- and tissue-specific donation refusals in São Paulo, Brazil, a quantitative cross-sectional study.","authors":"Barbara Rossana Gimenez Hidalgo, Rafael Rodrigo da Silva Pimentel, Marcelo José Dos Santos, Edvaldo Leal de Moraes","doi":"10.1590/1516-3180.2024.0175.R1.29112024","DOIUrl":"10.1590/1516-3180.2024.0175.R1.29112024","url":null,"abstract":"<p><strong>Background: </strong>The mismatch between the supply and demand for organs and tissues for transplantation is one of the reasons for the high rates of donation refusal. A more recent contributing factor has been the COVID-19 pandemic.</p><p><strong>Objectives: </strong>To analyze, through the Terms of Donation of Organs and Tissues, the rates and trends of specific refusals for each organ and tissue from brain-dead donors between 2001 and 2020 in an Organ Procurement Organization.</p><p><strong>Design and setting: </strong>This was a cross-sectional, exploratory, and retrospective quantitative study on specific donation refusals conducted in one of the ten Organ Procurement Organizations in São Paulo, Brazil.</p><p><strong>Methods: </strong>The variables collected included year, age, gender, cause of death, type of hospital, and organs and tissues donated and refused. The data were transferred to Stata software for descriptive and inferential analysis, using generalized linear regression to examine time trends. A significance level of P lt; 0.05 was adopted.</p><p><strong>Results: </strong>Bones and skin had the highest rates of tissue donation refusal, at 56.40% and 55.37%, respectively. Among solid organs, the pancreas (4.05%) and lungs (5.23%) had the highest refusal rates. In the first decade analyzed, there were increasing time trends in refusals of valves, heart, pancreas, and lungs. In contrast, during the second decade, refusals of valves, kidneys, and pancreas showed decreasing trends. In 2020, the number of refusals for all tissues declined.</p><p><strong>Conclusion: </strong>To reduce tissue-specific refusals, it is important to address and mitigate family beliefs, myths, and negative attitudes toward organ and tissue donation.</p>","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":"143 3","pages":"e2024175"},"PeriodicalIF":1.3,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12148309/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electronic cigarette: a grand deception?","authors":"Jaqueline Ribeiro Scholz, Sara Del Vecchio Ziotti, Paulo Manuel Pêgo Fernandes","doi":"10.1590/1516-3180.2025.1433.15042025","DOIUrl":"10.1590/1516-3180.2025.1433.15042025","url":null,"abstract":"","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":"143 3","pages":"e20251433"},"PeriodicalIF":1.3,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12148310/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sociodemographic factors associated with physical activity and sedentary behavior in Brazilian adults living with type 1 diabetes: a cross-sectional study.","authors":"Bruno Pereira de Moura, Bruna Priscila Colombo, Valter Paulo Neves Miranda, Isabella Toledo Caetano, Jeffer Eidi Sasaki, Paulo Roberto Dos Santos Amorim","doi":"10.1590/1516-3180.2024.0215.R1.27112024","DOIUrl":"10.1590/1516-3180.2024.0215.R1.27112024","url":null,"abstract":"<p><strong>Background: </strong>Physical activity (PA) and sedentary behavior (SB) are key determinants of health outcomes in individuals living with type 1 diabetes (T1D). However, the influence of sociodemographic and clinical factors on engagement in these behaviors is not yet well understood.</p><p><strong>Objective: </strong>This study aimed to analyze the associations of sociodemographic factors, body mass index, and both the duration and age at diagnosis of diabetes with SB, light-intensity physical activity (LPA), and moderate-to-vigorous physical activity (MVPA) in Brazilian adults.</p><p><strong>Design and setting: </strong>A cross-sectional study was conducted at the Diabetes and Metabolism Service of a public secondary care unit in Rio de Janeiro.</p><p><strong>Methods: </strong>One hundred adults diagnosed with T1D had their daily awake time spent in SB, LPA, and MVPA measured using triaxial accelerometers. Sociodemographic and clinical factors were assessed using questionnaires. Generalized Linear Models were used to analyze the relationships of these factors with SB, LPA, and MVPA.</p><p><strong>Results: </strong>Significant associations were found between age, education level, and employment status with SB and LPA, but not with MVPA. On average, each additional year of age was associated with decreased time in SB and increased time in LPA. Higher education levels and unemployment were linked to more SB and less time in LPA.</p><p><strong>Conclusions: </strong>Age, education level, and employment status emerged as key sociodemographic predictors of SB and LPA in Brazilian adults living with T1D. These findings contribute to a better understanding of the sociodemographic determinants associated with SB and PA in individuals diagnosed with T1D.</p>","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":"143 3","pages":"e2024215"},"PeriodicalIF":1.3,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12148311/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of heat therapy compared with strength training on metabolic profile, heat shock response, inflammation, cardiovascular responses and microbiota in individuals with type 2 diabetes: study protocol of a randomized trial.","authors":"Patrícia Martins Bock, Lucas Stahlhöfer Kowalewski, Layane Ramos Ayres, Mariana Kras Borges Russo, Gabriela Tomedi Leites, Andreza Francisco Martins, Álvaro Reischak de Oliveira, Mauricio Krause","doi":"10.1590/1516-3180-2024.0040.R1.13082024","DOIUrl":"10.1590/1516-3180-2024.0040.R1.13082024","url":null,"abstract":"<p><strong>Background: </strong>Interventions capable of modulating the heat shock response (HSR), such as physical exercise and heat therapy (HT), are potential therapeutic strategies for the prevention and treatment of diabetes.</p><p><strong>Objective: </strong>This study aims to evaluate the effects of resistance training (RT) and HT on HbA1c levels, metabolic and inflammatory profiles, gut microbiota, and HSR in patients with type 2 diabetes mellitus (T2DM).</p><p><strong>Design and setting: </strong>A randomized, double-blind, parallel clinical trial will be conducted for 12 weeks in southern Brazil.</p><p><strong>Methods: </strong>Participants with T2DM will be randomized into control (any intervention), RT, or HT groups. In the RT group, participants will perform supervised exercise, and the HT group will undergo whole-body heat treatment in an environmental chamber initially set at 55.0°C, both on three non-consecutive days of the week (60 min). Blood samples will be collected before and after 12 weeks of treatment. Heat shock response, body composition and physical fitness, glycemic control, lipid profile, gut microbiota composition and diversity, inflammatory markers, and flow-mediated dilation will be evaluated.</p><p><strong>Conclusion: </strong>Since the HSR response is decreased in individuals with diabetes, we believe that improving the HSR may be important in preventing chronic complications associated with T2DM. This randomized clinical trial will determine the efficacy of HT compared to RT in improving HSR when combined with conventional therapy in individuals with T2DM. Multiple HT and RT effects may contribute to a lower mortality risk in these individuals.</p><p><strong>Clinical trial registration: </strong>Unique Identifier NCT05847075. https://clinicaltrials.gov/study/NCT05847075.</p>","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":"143 3","pages":"e2024040"},"PeriodicalIF":1.3,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12131943/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144227377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subclinical hypothyroidism, focusing on carpal tunnel syndrome and peroneal neuropathy at the fibular head: a prospective case-control study.","authors":"Yunus Coşkun, Halit Fidanci","doi":"10.1590/1516-3180.2024.0280.R1.07032025","DOIUrl":"10.1590/1516-3180.2024.0280.R1.07032025","url":null,"abstract":"<p><strong>Background: </strong>Peripheral nerves may be affected in subclinical hypothyroidism (SH).</p><p><strong>Objectives: </strong>This study aimed to investigate the presence of common entrapment mononeuropathies in patients with SH.</p><p><strong>Design and setting: </strong>A prospective case-control study conducted between September 2022 and November 2023 at Adana City Training and Research Hospital, Adana, Türkiye.</p><p><strong>Methods: </strong>SH patients without neurological complaints and healthy individuals over the age of 18 were included. Serum levels of free T3, free T4, thyroid-stimulating hormone (TSH), thyroid peroxidase (TPO) antibody, and creatine kinase (CK) were measured. All participants underwent nerve conduction studies of the upper and lower extremities.</p><p><strong>Results: </strong>Thirty patients with SH and 40 healthy individuals were included in the study. The percentage reduction in compound muscle action potential (CMAP) amplitude across the knee segment was 2.8 ± 3.5% in healthy individuals and 6.7 ± 6.6% in SH patients (P = 0.017). Apart from this significant difference, other nerve conduction study findings did not differ between the two groups. A positive correlation was observed between CK levels and the percentage reduction in peroneal nerve CMAP amplitude across the knee segment (P = 0.021, r = 0.421). Additionally, there was a positive correlation between TPO antibody levels and F-wave latency in both the median and ulnar nerves (P = 0.028 r = 0.400/P = 0.005 r = 0.501). Electrodiagnostic evaluations revealed carpal tunnel syndrome (CTS) in four patients, peroneal neuropathy at the fibular head (PNFH) in four patients, and ulnar neuropathy at the elbow (UNE) in one patient.</p><p><strong>Conclusion: </strong>This study suggests that patients with SH may develop subclinical CTS and PNFH, but not UNE. Accordingly, it highlights the importance of avoiding risk factors that may contribute to the development of CTS and PNFH. Serum CK and TPO antibody levels may be useful in monitoring subclinical neuropathy in SH.</p>","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":"143 4","pages":"e2024280"},"PeriodicalIF":1.3,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12131942/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144227380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of planned visual education on university students' attitudes and beliefs regarding skin cancer: a cluster-randomized controlled trial.","authors":"Esin Sevgi Dogan, Ozden Dedeli Caydam","doi":"10.1590/1516-3180.2024.0252.R1.14022025","DOIUrl":"10.1590/1516-3180.2024.0252.R1.14022025","url":null,"abstract":"<p><strong>Background: </strong>The incidence of skin cancer is increasing globally. However, it is largely preventable through early detection. Therefore, raising public awareness through education is essential.</p><p><strong>Objective: </strong>This study aimed to evaluate the effect of a planned visual education program-based on the Health Belief Model-on university students' attitudes and beliefs regarding skin cancer.</p><p><strong>Design and setting: </strong>This cluster-randomized controlled trial was conducted in two departments at a university in Manisa, Türkiye.</p><p><strong>Methods: </strong>The study was conducted with 116 university students, divided equally into an intervention group (n = 58) and a control group (n = 58). Data were collected using the Student Information Form and the Health Belief Model Scale in Skin Cancer.</p><p><strong>Results: </strong>Following the visual education program based on the Health Belief Model, significant differences were observed between the intervention and control groups in perceived severity, perceived susceptibility, perceived barriers, perceived benefits, and self-efficacy scores. While the intervention group showed significant improvements across these domains, no significant difference was found in perceived severity scores.</p><p><strong>Conclusion: </strong>The findings indicate that planned visual education based on the Health Belief Model positively influenced students' attitudes and beliefs regarding skin cancer.</p><p><strong>Clinical trial registration: </strong>The research was recorded at https://clinicaltrials.gov/study/NCT05788939.</p>","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":"143 4","pages":"e2024252"},"PeriodicalIF":1.3,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12133199/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144227378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selenium intake, food sources, and associated factors in Brazilian Longitudinal Study of Adult Health (ELSA-Brasil): a cross-sectional study.","authors":"Elen Cintia Vale Pedro, Jéssica Levy, Dirce Maria Lobo Marchioni, Isabela Judith Martins Bensenor","doi":"10.1590/1516-3180.2024.0104.R1.07032025","DOIUrl":"10.1590/1516-3180.2024.0104.R1.07032025","url":null,"abstract":"<p><strong>Background: </strong>Selenium is essential to human health. There are few reports on the analysis of selenium intake in the Brazilian population; however, data have shown that Brazilian are in the deficient range of consumption.</p><p><strong>Objectives: </strong>This study aimed to identify the major foods that contribute to dietary selenium and determine the socioeconomic and lifestyle factors associated with selenium intake.</p><p><strong>Design and setting: </strong>This cross-sectional study used baseline data from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).</p><p><strong>Methods: </strong>Selenium consumption was evaluated using a food frequency questionnaire (FFQ) developed and validated for the ELSA-Brasil. To determine the contribution of selenium consumption, each food item was divided by the total selenium intake of the population. Associations between selenium intake (mg/day, dependent variable) and sociodemographic and lifestyle factors (predictors) were tested using multiple linear regression analyses.</p><p><strong>Results: </strong>The sample comprised 14,780 participants, most of whom were adults (78.5%). Individuals with income ≥ 3 minimum wages were mostly concentrated in the 5th quintile of selenium consumption; positive and significant correlations were found between selenium intake and female sex, age ≥ 60 years, income ≥ 3 minimum wages, higher or postgraduate education, alcohol consumption, and moderate physical activity level. Nuts and fish contributed the most to dietary selenium.</p><p><strong>Conclusion: </strong>Nuts, meat, and fish contributed the most to the dietary intake of selenium, and selenium intake was associated with sociodemographic and lifestyle factors among the evaluated individuals.</p>","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":"143 4","pages":"e2024104"},"PeriodicalIF":1.3,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12133198/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144227379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}