Sao Paulo Medical Journal最新文献

{"title":"Does vascular involvement affect erectile dysfunction in patients with Behçet's disease?: a single-center cross-sectional study.","authors":"Bünyamin Polat, Abdulsamet Erden, Selman Ünal, Hakan Apaydin, Berkan Armağan, Serdar Can Güven, Emrah Okulu, Ahmet Omma, Orhan Kucuksahin, Önder Kayigil","doi":"10.1590/1516-3180.2025.3295.12062026","DOIUrl":"10.1590/1516-3180.2025.3295.12062026","url":null,"abstract":"<p><strong>Background: </strong>Behçet's disease (BD) can affect the urogenital system in men, leading to conditions such as epididymitis, urethritis, cystitis, and dorsal penile vein thrombosis. A high incidence of erectile dysfunction (ED) in BD patients has been previously reported; however, the role of vascular involvement in ED is unclear.</p><p><strong>Objectives: </strong>To investigate the effect of vascular involvement on ED in male patients with BD.</p><p><strong>Methods: </strong>Ninety-seven patients diagnosed with BD (mean age, 40.4 ± 10.7 years; disease duration, 12.5 ± 9.6 years) were included in the study and divided into the vascular and non-vascular groups. The presence and severity of ED were assessed using the International Index of Erectile Function-5 (IIEF-5), with a score of ≤21 indicating the presence of ED. Patients with ED underwent corpus cavernosum electromyography and penile color Doppler ultrasonography to diagnose ED.</p><p><strong>Results: </strong>Half of all patients with BD (n = 49, 50.5%) were found to have ED. No significant difference in the presence of ED was observed between the two groups (vascular group: n = 24, 49% vs. non-vascular group: n = 25, 52.1%; p = 0.76). The proportion of patients with peak systolic velocities of less than 30 cm/s was significantly higher in the vascular group than in the non-vascular group (n = 12, 80% vs. n = 2, 22.2%; p = 0.01). No significant between-group difference was found in corpus cavernosum electromyography results (p > 0.05).</p><p><strong>Conclusions: </strong>ED is common in patients with BD, and arterial ED is more prevalent among those with vascular involvement. Sexual dysfunction, which is less frequently screened for in patients with BD, should be thoroughly monitored; early intervention is recommended.</p>","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":"144 5","pages":"e20253295"},"PeriodicalIF":1.2,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13596611/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149041774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal trends in birthweight and its association with overweight/obesity in schoolchildren from a Brazilian city: a cross-sectional panel study (2002-2019).","authors":"Camila Elizandra Rossi, Bernardo Paz Barboza, Patrícia de Fragas Hinnig, Francisco de Assis Guedes de Vasconcelos","doi":"10.1590/1516-3180.2025.3474.24042026","DOIUrl":"10.1590/1516-3180.2025.3474.24042026","url":null,"abstract":"<p><strong>Background: </strong>Long-term metabolic complications in childhood are associated with birthweight.</p><p><strong>Objectives: </strong>This study aimed to examine trends in the prevalence of low and high birthweight over a 16-year period and to investigate the association between birthweight and overweight/obesity among schoolchildren aged 7 to 10 years.</p><p><strong>Design and setting: </strong>The analyses included four school-based cross-sectional surveys conducted in Florianópolis.</p><p><strong>Methods: </strong>The probabilistic panels were conducted in 2002, 2007, 2012-2013, and 2018-2019. Multiple logistic regression models were used to assess the associations between low and high birthweight and childhood overweight/obesity. Adjusted models included biological, socioeconomic, survey-period, and dietary-intake variables.</p><p><strong>Results: </strong>Over the 16-year period, low birthweight showed a progressive and statistically significant increase, rising by 58.3% from 2002 to 2018-2019. In contrast, the prevalence of high birthweight was 9.1% in 2002 and declined significantly over the ten-year period from 2002 to 2012-2013, decreasing by 40.7%. In the adjusted model, high birthweight was significantly associated with overweight/obesity across all study waves (OR = 1.63; 95% CI = 1.32-2).</p><p><strong>Conclusion: </strong>A statistically significant upward trend in the prevalence of low birthweight was observed among schoolchildren in Florianópolis from 2002 to 2018-2019. Despite a reduction in high birthweight over time, high birthweight remained directly associated with overweight/obesity, independently of food intake and other confounding factors.</p>","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":"144 4","pages":"e20253474"},"PeriodicalIF":1.2,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13592218/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149041717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spiritual well-being, surgical fear, and quality of recovery in patients undergoing abdominal surgery: a descriptive and correlational study.","authors":"Kezban Koraş Sözen, Özge Havva Birim","doi":"10.1590/1516-3180.2026.3677.28072026","DOIUrl":"10.1590/1516-3180.2026.3677.28072026","url":null,"abstract":"<p><strong>Background: </strong>Despite the increasing emphasis placed on holistic care in healthcare, the impact of spiritual well-being on postoperative outcomes is unclear, particularly in patients who have undergone abdominal surgery. The postoperative period is characterized by significant physical and psychological stress.</p><p><strong>Objective: </strong>To examine the relationship between spiritual well-being, surgical fear, and the quality of postoperative recovery in patients undergoing abdominal surgery.</p><p><strong>Design and setting: </strong>Descriptive and correlational study.</p><p><strong>Methods: </strong>A total of 116 patients participated in the study. Data were collected using the Descriptive Characteristics Form, Three-Factor Spiritual Well-Being Scale, Surgical Fear Questionnaire, and Quality of Recovery-40 Questionnaire. We evaluated the relationships between patients' levels of spiritual well-being, their fear of surgery, and the quality of postoperative recovery.</p><p><strong>Results: </strong>Patients reported high spiritual well-being and low levels of surgical fear; the mean Quality of Recovery-40 Questionnaire score was 109.36 ± 8.52, below the theoretical midpoint of the scale. Correlation analysis revealed no statistically significant relationship between spiritual well-being and surgical fear (ρ = 0.02, p = 0.83) or postoperative quality of recovery (ρ = 0.12, p = 0.2). No significant relationship was found between surgical fear and quality of recovery (ρ = 0.11, p = 0.23).</p><p><strong>Conclusion: </strong>Spiritual well-being was not significantly associated with surgical fear or postoperative quality of recovery among patients undergoing abdominal surgery. These findings suggest that, although spirituality may contribute to patients' internal coping processes, it may not directly influence immediate postoperative outcomes. Further studies involving diverse patient populations and longitudinal designs are needed to better understand the relationship between spirituality, psychological responses, and recovery outcomes in surgical care.</p>","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":"144 5","pages":"e20263677"},"PeriodicalIF":1.2,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13592789/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149041754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender disparities among Brazil's top 2% of influential scientists for career-long impact.","authors":"Jullyana de Souza Siqueira Quintans, Adriana Gibara Guimarães, Lucindo Quintans-Júnior, Adriano Antunes de Souza Araújo, Victor Santana Santos, Paulo Ricardo Martins-Filho","doi":"10.1590/1516-3180.2025.3131.03022026","DOIUrl":"10.1590/1516-3180.2025.3131.03022026","url":null,"abstract":"","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":"144 4","pages":"e20253131"},"PeriodicalIF":1.2,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13592217/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149041670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Standard versus miniaturized percutaneous nephrolithotomy in pediatric patients: a systematic review and meta-analysis.","authors":"Fernanda Santos da Anunciação, João Lucas de Magalhães Leal Moreira, Caio Cezar Ferreira Fraga, Caio Vinicius Suartz, Ricardo Brianezi Tiraboschi, José Bessa Júnior, Roberto Iglesias Lopes","doi":"10.1590/1516-3180.2025.3486.29062026","DOIUrl":"10.1590/1516-3180.2025.3486.29062026","url":null,"abstract":"<p><strong>Background: </strong>Although miniaturized percutaneous nephrolithotomy (mini-PCNL) is a less invasive alternative to standard percutaneous nephrolithotomy (PCNL), its comparative outcomes in pediatric patients remain unclear.</p><p><strong>Objectives: </strong>To compare the efficacy and safety of mini-PCNL versus standard PCNL in children with nephrolithiasis.</p><p><strong>Design and setting: </strong>Systematic review and meta-analysis conducted according to PRISMA guidelines, including randomized controlled trials (RCTs) and retrospective cohort studies of pediatric patients undergoing mini-PCNL or standard PCNL.</p><p><strong>Methods: </strong>Major databases (Cochrane Library, PubMed/MEDLINE, and Embase) were searched through August 2024. The primary endpoint was the stone-free rate. Secondary endpoints included operative time, postoperative fever, and complications classified by the Clavien-Dindo system.</p><p><strong>Results: </strong>Five studies (two RCTs and three retrospective cohort studies) involving 490 patients (46% underwent mini-PCNL) were included. Stone-free rates were comparable between the groups (relative risk [RR], 0.98; 95% confidence interval [CI], 0.929-1.041; p = 0.56; I2 = 0%). Mini-PCNL was associated with longer operative times (mean difference [MD], 7.5 min; 95% CI, 0.2-14.9; p = 0.04; I2 = 78%) but a lower risk of Clavien-Dindo grade I complications (RR 0.464; 95% CI 0.442-0.944; p < 0.05; I2 = 0%). No significant differences were observed in postoperative fever or Clavien-Dindo grade II-IV complications.</p><p><strong>Conclusion: </strong>Mini-PCNL and standard PCNL achieve comparable stone-free rates in pediatric patients. Mini-PCNL is associated with fewer minor complications, whereas standard PCNL is associated with shorter operative times. Both techniques demonstrate similar safety profiles with respect to major complications.</p><p><strong>Clinical trial or systematic review registration: </strong>PROSPERO: CRD42024618399; available at: https://www.crd.york.ac.uk/PROSPERO/view/CRD42024567890.</p>","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":"144 4","pages":"e20253486"},"PeriodicalIF":1.2,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13588546/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149041724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of the thermal stability of EMAIS-SR autonomous packaging for preservation of porcine lungs: cooling curve in an experimental model.","authors":"Flavio Pola Dos Reis, Pedro Henrique Andrade Guimarães, Matheus Werner Fantato, Selma Ferrer da Silva, Liliane Moreira Ruiz, Natalia Aparecida Nepomuceno, Edson Caoru Kitani, Bartira de Aguiar Roza, Paulo Manuel Pêgo Fernandes","doi":"10.1590/1516-3180.2026.3638.27022026","DOIUrl":"10.1590/1516-3180.2026.3638.27022026","url":null,"abstract":"<p><strong>Background: </strong>Intermediate temperatures (10°C) better preserve mitochondrial function and extend ischemic time, which are fundamental for lung preservation during transplantation. The EMAIS-SR device was developed as a reusable, cost-effective alternative to maintain the 10°C set-point, thereby overcoming logistical and economic barriers in organ transport.</p><p><strong>Objective: </strong>This study aimed to validate the thermal stability of the EMAIS-SR system in a swine model by evaluating the organ-cooling curve and the time spent within the target temperature range.</p><p><strong>Design and setting: </strong>Validation study using experimental surgery on porcine organs.</p><p><strong>Methods: </strong>Lung blocks were harvested from two Landrace swine in independent experiments (P1, P2). The organs were placed in triple sterile packaging. Thermal stability was monitored for 48 h by using four negative temperature coefficient (NTC) thermistors (three intrapulmonary and one extrapulmonary) with data acquisition at a 0.1-s interval. Another datalogger (Hantek ® HTM208B) was used for control and validation. Thermal distribution was further characterized by infrared thermography (FLIR C3-X).</p><p><strong>Results: </strong>In Experiment 1 (P1), intrapulmonary temperatures reached the predefined target range (≤ 12°C) approximately 1.4 h after lung extraction, and the mean temperature recorded in the container was 8.01 °C (standard deviation, 2.88°C). In Experiment 2 (P2), a mean temperature reduction of 6.6°C was observed, bringing the intrapulmonary temperature to the target range (≤ 12°C) within approximately 2 h post-extraction.</p><p><strong>Conclusion: </strong>The EMAIS-SR device effectively maintained lung-preservation temperatures within the target 8°C-12°C range over 48 h. These results demonstrate the system's technical feasibility and its capacity to provide consistent thermal stability across intrapulmonary compartments.</p>","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":"144 4","pages":"e20263638"},"PeriodicalIF":1.2,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13588545/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149041785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between information overload, adjustment to cancer, and level of health perception in patients with cancer: a descriptive cross-sectional study.","authors":"Ömer Tanriverdi, Derya Biçak Ayik","doi":"10.1590/1516-3180.2025.3521.20072026","DOIUrl":"10.1590/1516-3180.2025.3521.20072026","url":null,"abstract":"<p><strong>Background: </strong>Patients with cancer are frequently exposed to excessive, fragmented, and inconsistent health information; this may contribute to cognitive overload and hinder their psychological adjustment to the illness. Understanding how information overload influences coping mechanisms and perceived health status is essential for designing effective psychosocial and nursing interventions.</p><p><strong>Objective: </strong>This study aimed to examine the relationship between information overload, psychosocial adjustment to cancer, and health perception among patients undergoing chemotherapy.</p><p><strong>Methods: </strong>A descriptive, cross-sectional design was used. The study involved 152 patients undergoing chemotherapy at the Oncology Unit of Mardin Training and Research Hospital between June and September 2025. Data were collected using a Personal Information Form, and the Cancer Information Overload Scale, Mental Adjustment to Cancer Scale, and Health Perception Scale. Descriptive statistics, Pearson correlation analyses, and multiple linear regression were conducted, with statistical significance set at p < 0.05.</p><p><strong>Results: </strong>The mean health perception score was 51.02 ± 7.44, indicating a moderate to high level of perceived health. Pearson correlation analysis revealed a positive and statistically significant relationship between information overload and health perception (r = .183; p = .024).</p><p><strong>Conclusion: </strong>Information overload and coping style played influential roles in shaping health perception among patients with cancer. Although excessive information can overwhelm individuals, access to accurate, comprehensible, and well-structured information appears to enhance awareness and support adaptive coping. Healthcare professionals-particularly nurses-are crucial in guiding patients through effective information management and provision of psychosocial support, ultimately improving patients' perceived health and overall well-being.</p>","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":"144 5","pages":"e20253521"},"PeriodicalIF":1.2,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13576985/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148992051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of BIS-guided sevoflurane anesthesia on postoperative nausea and vomiting in pediatric adenoidectomy: a prospective randomized controlled trial.","authors":"Engin Cetin, Ayse Sencan, Ahmet Yuksek, Bedirhan Gunel, Fatihhan Zeytun, Mehmet Yilmaz","doi":"10.1590/1516-3180.2026.3631.13052026","DOIUrl":"10.1590/1516-3180.2026.3631.13052026","url":null,"abstract":"<p><strong>Background: </strong>Postoperative nausea and vomiting (PONV) is a frequent complication in pediatric patients undergoing adenoidectomy. Bispectral index (BIS) monitoring, an electroencephalography-based method for assessing anesthetic depth, enables individualized sevoflurane titration and may reduce unnecessary exposure to volatile anesthetics.</p><p><strong>Objectives: </strong>To determine whether BIS-guided sevoflurane anesthesia reduces PONV in children undergoing adenoidectomy.</p><p><strong>Design and setting: </strong>Single-center, prospective, randomized, assessor-blinded trial conducted at University of Health Sciences, Kocaeli City Hospital, Kocaeli, Türkiye.</p><p><strong>Methods: </strong>Fifty-eight children aged 3-8 years (American Society of Anesthesiologists score I-II) undergoing elective adenoidectomy were randomized to BIS-guided anesthesia (n = 29) or standard care (n = 29). Both groups received sevoflurane anesthesia. The primary outcome was PONV within the first 24 postoperative hours. Secondary outcomes were emergence time, total sevoflurane consumption, remifentanil dose, and rescue antiemetic use.</p><p><strong>Results: </strong>PONV within 24 hours occurred less frequently in the BIS-guided group than in controls (p = 0.015), with the greatest between-group differences observed at 0-1 hour and 1-6 hours. Sevoflurane consumption and emergence time were lower in the BIS-guided group (p < 0.05). BIS-guided anesthesia was independently associated with lower odds of PONV (OR = 0.212; 95% CI: 0.067-0.675; p = 0.009).</p><p><strong>Conclusions: </strong>BIS monitoring may be a useful strategy for optimizing anesthetic depth and reducing early PONV in pediatric patients.</p><p><strong>Clinical trial registration: </strong>ClinicalTrials.gov (NCT07189845). Available at: https://clinicaltrials.gov/study/NCT07189845.</p>","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":"144 3","pages":"e20263631"},"PeriodicalIF":1.2,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13528402/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148888624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of mandibular functional impairment and orofacial pain with subtypes of male sexual dysfunction: a cross-sectional study.","authors":"Ümit Erkut, Abdurrahim Yildiz, Rüstem Mustafaoglu","doi":"10.1590/1516-3180.2026.3624.20072026","DOIUrl":"10.1590/1516-3180.2026.3624.20072026","url":null,"abstract":"<p><strong>Background: </strong>Temporomandibular disorder (TMD) are among the most common causes of orofacial pain and have been associated with several systemic conditions. However, their relationship with male sexual dysfunctions (MSDs) remains largely unexplored.</p><p><strong>Objectives: </strong>To investigate the association between TMD symptoms and different subtypes of MSDs.</p><p><strong>Methods: </strong>A cross-sectional study was conducted with 91 men aged 18 to 50, classified as having premature ejaculation (n = 33), delayed ejaculation (n = 10), or erectile dysfunction (n = 22), or being control participants (n = 26). TMD symptoms were assessed using the Mandibular Function Impairment Questionnaire (MFIQ), and sexual function was evaluated using the International Index of Erectile Function (IIEF), Premature Ejaculation Diagnostic Tool (PEDT), and intravaginal ejaculatory latency time (IELT).</p><p><strong>Results: </strong>Significant group differences were found in the IELT and all IIEF subdomain (p < 0.001) values. Participants with delayed ejaculation had the longest IELTs, whereas those with erectile dysfunction had the shortest. PEDT scores were significantly higher in the premature-ejaculation and erectile-dysfunction groups than in the control group, with no significant difference observed between the delayed-ejaculation and control groups. Orofacial pain (cheek-temple-jaw) was more frequent in all MSD groups (p = 0.001), whereas temporomandibular joint pain (ear area) was particularly more prevalent in the delayed-ejaculation group. MFIQ scores indicated greater mandibular impairment primarily in the erectile-dysfunction group. Multinomial regression analysis results showed that orofacial pain independently predicted all MSD subtypes, but temporomandibular joint pain was specifically associated with delayed ejaculation.</p><p><strong>Conclusion: </strong>The results indicate a potential association between TMD-related symptoms and MSDs, suggesting that orofacial pain and functional jaw impairment may be related to male sexual health. These findings highlight the potential importance of using a multidisciplinary approach involving collaboration between dentists, urologists, and physical therapists to improve both jaw and sexual health outcomes.</p>","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":"144 5","pages":"e20263624"},"PeriodicalIF":1.2,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13528403/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148888665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depression and sleep disturbances in children and adolescents with familial Mediterranean fever: a prospective case-control study.","authors":"Şeyda Doğantan, Evin İlter Bahadur, Burcu Bozkaya Yücel, Esma Bekece","doi":"10.1590/1516-3180.2025.3355.13052026","DOIUrl":"10.1590/1516-3180.2025.3355.13052026","url":null,"abstract":"<p><strong>Background: </strong>Familial Mediterranean fever (FMF) is a hereditary autoinflammatory disorder characterized by recurrent febrile episodes and serositis.</p><p><strong>Objectives: </strong>The aim of this study was to assess the impact of FMF on sleep quality in children and adolescents and to explore the relationship between depressive symptoms and sleep disturbances in this patient population.</p><p><strong>Design and setting: </strong>A prospective case-control study was conducted at a secondary hospital in Istanbul between July 2024 and January 2025.</p><p><strong>Methods: </strong>Children and adolescents diagnosed with FMF who were followed at a pediatric rheumatology clinic were included. Sleep disturbances were assessed using the Sleep Disturbance Scale for Children (SDSC), and depressive symptoms were evaluated using the Beck Depression Inventory (BDI). Correlations between these scores were analyzed.</p><p><strong>Results: </strong>The mean age of the patient group (n = 97) was significantly higher than that of the control group (n = 90) (10.6 ± 2.9 years vs. 9.3 ± 2.4 years; p < 0.001). The median SDSC and BDI scores were significantly higher in the patient group than in the control group (p < 0.05). Analysis of the SDSC subscales indicated that patients with FMF experienced difficulties in sleep initiation and maintenance, sleep-related breathing problems, hyperhidrosis, arousal disturbances, sleep-wake transitions, and excessive daytime somnolence (p < 0.05). No significant differences were found between patient subgroups categorized by MEFV gene mutations in total BDI scores, total SDSC scores, all SDSC subscale scores, or depression severity classes (p > 0.05). Furthermore, no significant correlations were observed between total BDI scores and total SDSC scores or any of the SDSC subscale scores (p > 0.05)..</p><p><strong>Conclusion: </strong>Children and adolescents with FMF had significantly higher levels of depressive symptoms and sleep disturbances than controls.</p>","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":"144 4","pages":"e20253355"},"PeriodicalIF":1.2,"publicationDate":"2026-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13506170/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148841980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}