Sao Paulo Medical Journal最新文献_第2页

The relationship between insulin resistance and fibroblast growth factor 23 in patients with non-diabetic pre-dialysis chronic kidney disease: a cross-sectional study. 非糖尿病透析前慢性肾病患者胰岛素抵抗与成纤维细胞生长因子23的关系：一项横断面研究

IF 1.3 4区医学

Sao Paulo Medical Journal Pub Date : 2025-01-27 eCollection Date: 2025-01-01 DOI: 10.1590/1516-3180.2024.0103.03072024

Beyza Algul Durak, Melahat Coban

{"title":"The relationship between insulin resistance and fibroblast growth factor 23 in patients with non-diabetic pre-dialysis chronic kidney disease: a cross-sectional study.","authors":"Beyza Algul Durak, Melahat Coban","doi":"10.1590/1516-3180.2024.0103.03072024","DOIUrl":"10.1590/1516-3180.2024.0103.03072024","url":null,"abstract":"Background: Insulin resistance often occurs in patients with chronic kidney disease (CKD) owing to mineral and bone metabolism disorders. Fibroblast growth factor (FGF)-23 and soluble klotho (s-KL) play crucial roles in linking CKD with mineral and bone metabolism.Objective: This study aimed to examine the relationship between insulin resistance and FGF-23 and s-KL in patients with non-diabetic pre-dialysis patients with CKD.Design and setting: This research was conducted in the Ankara Bilkent City Hospital Nephrology Clinic. Ankara,Turkey.Methods: This study included 133 male and 150 female patients with pre-dialysis CKD. The patients were compared with 80 healthy individuals. FGF-23 and s-KL levels were determined using enzyme-linked immunosorbent assay kits. The homeostasis model assessment of insulin resistance (HOMA-IR) was used to determine insulin resistance.Results: Creatinine, urine protein/creatinine ratio (UPCR), log10 FGF-23, log 10 s-KL, and HOMA-IR were notably higher, while glomerular filtration rate was notably lower, in patients than in healthy individuals. Stage 5 CKD, log10 FGF-23, creatinine, and UPCR were significantly higher in patients with HOMA-IR > 3.06 compared to those with HOMA-IR ≤ 3.06. No difference was observed in s-KL levels between the two groups. Univariate and multivariate logistic regression analyses revealed an increase in HOMA-IR and log10 FGF-23 values.Conclusions: Insulin resistance, serum FGF-23, and s-KL levels increased in patients compared with healthy individuals. Higher creatinine, proteinuria, and FGF-23 levels were associated with greater insulin resistance. The study highlighted a significant relationship between insulin resistance and FGF-23.","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":"143 1","pages":"e2024103"},"PeriodicalIF":1.3,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11774536/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143069176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analyzing the effectivity of evidence-based practice in health science higher education: a narrative review. 循证实践在健康科学高等教育中的有效性分析：叙述性回顾。

IF 1.3 4区医学

Sao Paulo Medical Journal Pub Date : 2025-01-27 eCollection Date: 2025-01-01 DOI: 10.1590/1516-3180.2023.0407.R1.05062024

Victória Guzzo da Silva, Dafne Port Nascimento, Sarah Beatriz Obadovski Alves Nascimento, Amanda Costa Araujo

{"title":"Analyzing the effectivity of evidence-based practice in health science higher education: a narrative review.","authors":"Victória Guzzo da Silva, Dafne Port Nascimento, Sarah Beatriz Obadovski Alves Nascimento, Amanda Costa Araujo","doi":"10.1590/1516-3180.2023.0407.R1.05062024","DOIUrl":"10.1590/1516-3180.2023.0407.R1.05062024","url":null,"abstract":"Background: Although multiple strategies have been suggested for evidence-based practice educational interventions, few studies have focused on the development of abilities for evidence-based practice implementation.Objective: To explore the effectiveness of evidence-based practice in higher education and understand its teaching methods.Design and setting: Narrative review was conducted at the Universidade Municipal de São Caetano do Sul, Brazil.Methods: Narrative review included research studies that measured any type of evidence-based practice teaching method and its effectiveness. Searches included publications from inception to June 2022, conducted on MEDLINE, EMBASE, CINAHL, CENTRAL, ERIC, and the Cochrane Library. Two independent authors descriptively extracted and analyzed the data. The methodological quality of the studies was also analyzed.Results: The results determined that 79.2% of the studies proved their effectiveness. Teaching methods varied according to the time period, format, and types of questionnaire.Conclusions: Most studies demonstrated the effectiveness of the chosen teaching methods. This study shows the importance of health professionals using evidence-based practice to ensure effective patient treatment.","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":"143 1","pages":"e2023407"},"PeriodicalIF":1.3,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11774537/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143069175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retrospective study of factors associated with the clinical severity of covid-19 in older adults in Minas Gerais: structural equation modeling. 米纳斯吉拉斯州老年人covid-19临床严重程度相关因素的回顾性研究：结构方程模型

IF 1.3 4区医学

Sao Paulo Medical Journal Pub Date : 2024-12-20 eCollection Date: 2024-01-01 DOI: 10.1590/1516-3180.2023.0138.R1.03072024

Flavia Aparecida Dias Marmo, Nayara Gomes Nunes Oliveira, Érica Midori Ikegami, Neilzo Nunes Oliveira, Joilson Meneguci, Darlene Mara Dos Santos Tavares

{"title":"Retrospective study of factors associated with the clinical severity of covid-19 in older adults in Minas Gerais: structural equation modeling.","authors":"Flavia Aparecida Dias Marmo, Nayara Gomes Nunes Oliveira, Érica Midori Ikegami, Neilzo Nunes Oliveira, Joilson Meneguci, Darlene Mara Dos Santos Tavares","doi":"10.1590/1516-3180.2023.0138.R1.03072024","DOIUrl":"10.1590/1516-3180.2023.0138.R1.03072024","url":null,"abstract":"Background: Studies have shown an association between the clinical severity of coronavirus disease (COVID-19) and sociodemographic and clinical variables in older adults. However, few studies have described the explanatory factors of the relationship between these variables and the clinical severity of COVID-19 using structural equation modeling.Objective: To analyze the factors directly and indirectly associated with the clinical severity of coronavirus disease (COVID-19) among older adults in Minas Gerais, Brazil.Design and setting: Retrospective epidemiological study.Methods: This study included 51,141 elderly adults with COVID-19 living in Minas Gerais, Brazil. Data were collected through the Individual Registration Form - Hospitalized Cases of Severe Acute Respiratory Syndrome from January 28, 2020, to January 27, 2022.Results: Older age (P < 0.001), male sex (P < 0.001), dyspnea (P < 0.001), change in chest X-ray examination findings (P < 0.001), greater number of risk factors/comorbidities (P < 0.001), and longer hospitalization time (P < 0.001) were directly associated with the clinical severity of COVID-19. Female sex, mediated by the greater number of risk/comorbidity factors (β = -0.02, P < 0.001), and younger age, mediated by longer hospitalization time (β = -0.01; P < 0.001), were indirectly associated with the clinical severity of COVID-19.Conclusion: Demographic and clinical variables were directly associated with increased disease severity. In addition to the direct effect, a greater number of risk/comorbidity factors and longer hospitalization time mediated the association between demographic variables and outcomes.","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":"143 1","pages":"e2023138"},"PeriodicalIF":1.3,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11655041/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142957811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of Temporomandibular Disorder and its association with anxiety in academics: a cross-sectional study. 颞下颌紊乱的患病率及其与学术焦虑的关系：一项横断面研究。

IF 1.3 4区医学

Sao Paulo Medical Journal Pub Date : 2024-12-20 eCollection Date: 2024-01-01 DOI: 10.1590/1516-3180.2023.0338.R2.03072024

Bianca Paludo, Paula Comin Trevizan, Nana Abena Asantewaa Boamah, Lilian Rigo

{"title":"Prevalence of Temporomandibular Disorder and its association with anxiety in academics: a cross-sectional study.","authors":"Bianca Paludo, Paula Comin Trevizan, Nana Abena Asantewaa Boamah, Lilian Rigo","doi":"10.1590/1516-3180.2023.0338.R2.03072024","DOIUrl":"10.1590/1516-3180.2023.0338.R2.03072024","url":null,"abstract":"Background: Temporomandibular disorders (TMD) are a major cause of non-dental pain in the oral and facial regions.Objective: This study aimed to determine the prevalence and severity of TMD and anxiety among academics and to investigate the relationship between TMD and its associated factors.Design and setting: This cross-sectional study included a sample of 295 academics undertaking health courses at a university in Brazil.Methods: The Simplified Anamnesis Index and Beck Anxiety Inventory were used to evaluate TMD and assess anxiety, respectively. Data were statistically analyzed using relative and absolute frequencies of variables. In the bivariate analysis, Pearson's chi-square test was used, and in the multivariate analysis, raw and adjusted binary logistic regressions were used to obtain the odds ratio (OR) and respective 95% confidence intervals. Statistical significance was set at P < 0.05.Results: The average age of academics was 22.95 (standard deviation ± 6.14) years, predominantly comprising women (82.7%), whites (90.8%), and singles (86.6%). The findings revealed that 81.2% of academics had TMD and 50.5% exhibited symptoms of anxiety. Academics with anxiety were three times more likely to have TMD (OR = 3.6) than those without anxiety.Conclusion: A significant association between anxiety and TMD was observed in academics. The prevalence of TMD was high, with academics with anxiety having a high likely to develop TMD. These findings highlight the importance of addressing mental health concerns in addition to physical health, as they are often related.","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":"143 1","pages":"e2023338"},"PeriodicalIF":1.3,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11655035/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142957834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changes in the prevalence of severe anxiety and depression symptoms and the associated factors in adults living in Manaus: a comparison of two cross-sectional studies conducted in 2015 and 2019. 居住在玛瑙斯的成年人中严重焦虑和抑郁症状患病率的变化及其相关因素：2015年和2019年进行的两项横断面研究的比较。

IF 1.3 4区医学

Sao Paulo Medical Journal Pub Date : 2024-12-20 eCollection Date: 2024-01-01 DOI: 10.1590/1516-3180.2023.0424.R1.03072024

Vanessa Gomes Lima, Marcus Tolentino Silva, Gustavo Magno Baldin Tiguman, Taís Freire Galvão

{"title":"Changes in the prevalence of severe anxiety and depression symptoms and the associated factors in adults living in Manaus: a comparison of two cross-sectional studies conducted in 2015 and 2019.","authors":"Vanessa Gomes Lima, Marcus Tolentino Silva, Gustavo Magno Baldin Tiguman, Taís Freire Galvão","doi":"10.1590/1516-3180.2023.0424.R1.03072024","DOIUrl":"10.1590/1516-3180.2023.0424.R1.03072024","url":null,"abstract":"Background: Emotional distress increases, also affected by the setting.Objective: To estimate changes in prevalence of severe anxiety and depressive symptoms and associated factors.Design and setting: This cross-sectional study included adults living in Manaus selected through a three-stage probability sampling in 2015 and 2019.Methods: This is an analysis of two surveys conducted. The outcomes were assessed by Generalized Anxiety Disorder 7-item (≥ 15 points) and Patient Health Questionnaire 9-item (≥ 20), and changes were tested by chi-square goodness-of-fit. Prevalence ratios (PR) with 95% confidence intervals (95%CI) were calculated by Poisson regression.Results: Severe anxiety symptoms increased from 3.3% (95%CI = 2.7-3.9) in 2015 (n = 3,479) to 8.7% (95%CI = 7.5-9.8) in 2019 (n = 2,321); severe depressive symptoms changed from 2.5% (95%CI = 2.0-3.0) to 8.5% (95%CI = 7.3-9.6). Variations were more pronounced in social vulnerability (P < 0.05). Outcomes were higher in women (anxiety: PR = 1.27; 95%CI = 1.20-1.34, depression: PR = 1.35; 95%CI = 1.27-1.44), low-income individuals (anxiety: PR = 1.90; 95%CI = 1.20-3.00, depression: PR = 1.98; 95%CI = 1.22-3.19), less educated individuals (anxiety: PR = 2.20; 95%CI = 1.16-4.18, depression: PR = 2.37; 95%CI = 1.23-4.60), and individuals with poor health status (anxiety: PR = 9.06; 95%CI = 6.72-12.21, depression: PR = 8.99; 95%CI = 6.67-12.12).Conclusion: Severe anxiety and depression tripled in Manaus, potentially reflecting Brazilian socioeconomic crises.","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":"143 1","pages":"e2023424"},"PeriodicalIF":1.3,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11655034/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142957140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brazilian version of the Kerlan-Jobe orthopedic clinic shoulder and elbow score: translation and cross-cultural adaptation. 巴西版Kerlan-Jobe骨科临床肩肘评分：翻译与跨文化适应。

IF 1.3 4区医学

Sao Paulo Medical Journal Pub Date : 2024-12-20 eCollection Date: 2024-01-01 DOI: 10.1590/1516-3180.2023.0139.03072024

Felipe Marques da Silva, Raquel Lins de Sousa Lima, Gabriel Alves Dos Santos, Germanna Medeiros Barbosa, Valéria Mayaly Alves de Oliveira, Danilo Harudy Kamonseki

{"title":"Brazilian version of the Kerlan-Jobe orthopedic clinic shoulder and elbow score: translation and cross-cultural adaptation.","authors":"Felipe Marques da Silva, Raquel Lins de Sousa Lima, Gabriel Alves Dos Santos, Germanna Medeiros Barbosa, Valéria Mayaly Alves de Oliveira, Danilo Harudy Kamonseki","doi":"10.1590/1516-3180.2023.0139.03072024","DOIUrl":"10.1590/1516-3180.2023.0139.03072024","url":null,"abstract":"Background: The Kerlan-Jobe Orthopedic Clinic (KJOC) Shoulder and Elbow Score is commonly used to assess the functional status of athletes with conditions affecting the shoulder and elbow. However, a Brazilian Portuguese version of the KJOC questionnaire is currently unavailable.Objectives: This study aimed to develop a Brazilian Portuguese version of the KJOC questionnaire.Design and setting: This translation and cultural adaptation study was conducted at the Federal University of Paraíba, Brazil.Methods: The procedures adopted in this study followed guidelines recommending translation by two independent translators, synthesis of the translations, back-translation performed by two native English-speaking translators, analysis by an expert committee, and pre-testing. The Portuguese version was tested with 32 athletes to assess their understanding of the assessment tool. Items were deemed adequate if they were understood by at least 90% of the athletes.Results: The terms and expressions of some original items were modified to achieve better comprehensibility in the Brazilian context. No further modifications were necessary after the pre-test; all terms were comprehensible to over 90% of athletes.Conclusion: The translation and cultural adaptation of the KJOC questionnaire into Portuguese were completed, resulting in a Brazilian version of the scale. Further studies are needed to evaluate the reliability and validity of this scale.","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":"143 1","pages":"e2024139"},"PeriodicalIF":1.3,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11655037/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142957830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence and quality of life associated with erectile dysfunction and lower urinary tract symptoms: a cross-sectional study. 与勃起功能障碍和下尿路症状相关的患病率和生活质量：一项横断面研究

IF 1.3 4区医学

Sao Paulo Medical Journal Pub Date : 2024-12-20 eCollection Date: 2024-01-01 DOI: 10.1590/1516-3180.2024.0045.R1.03072024

Felipe Jun Kijima, Liz Cristina Motta, Jean Sousa Cavalcante, Lucas Jordão, Carlos Eduardo Dias Olioze, Plinio Takashi Karubi Palavicini Santos, João Carlos Leite da Cruz, Luis Expedito Sabage, Gabriel Araújo Medeiros, Alessandra Mazzo, Aguinaldo Cesar Nardi

{"title":"Prevalence and quality of life associated with erectile dysfunction and lower urinary tract symptoms: a cross-sectional study.","authors":"Felipe Jun Kijima, Liz Cristina Motta, Jean Sousa Cavalcante, Lucas Jordão, Carlos Eduardo Dias Olioze, Plinio Takashi Karubi Palavicini Santos, João Carlos Leite da Cruz, Luis Expedito Sabage, Gabriel Araújo Medeiros, Alessandra Mazzo, Aguinaldo Cesar Nardi","doi":"10.1590/1516-3180.2024.0045.R1.03072024","DOIUrl":"10.1590/1516-3180.2024.0045.R1.03072024","url":null,"abstract":"Background: Genitourinary health significantly affects the quality of life of men, particularly those in middle age. Recent studies have shown that more than half of the men aged over 40 years experience some degree of low urinary tract symptoms (LUTS) or erectile dysfunction (ED).Objective: To assess the prevalence of ED and LUTS in middle-aged men and correlate this with quality of life data.Design and setting: A cross-sectional study was conducted in a municipality in the countryside of São Paulo.Methods: A trained team collected data between July 2021 and August 2022 through face-to-face interviews using a characterization instrument, International Prostate Symptom Score (IPSS), International Index of Erectile Function-6 (IIEF-6), and World Health Organization Quality-of-Life Scale.Results: The study included 375 male participants with a median age of 53 years (interquartile range [IQR] 38.5-66). The IIEF-6 showed the presence of some degree of ED in 51.1% (n = 188) of patients, with a median score of 25 (IQR 21-29). The IPSS revealed that 35.2% (n = 132) of the patients had some degree of LUTS, with a median score of 5 (IQR 2-11). The urological questionnaires had a direct proportional correlation with age (P < 0.001) and significant differences between the medians of different marital statuses (P < 0.001). The presence or severity of these disorders was inversely correlated with the individuals' quality of life (P < 0.001).Conclusions: ED and LUTS significantly correlated with the quality of life, marital status, and age in men.","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":"143 1","pages":"e2024045"},"PeriodicalIF":1.3,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11655038/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142957831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Time to initiation of dialysis and length of stay in hospitalized patients with kidney damage: a cross-sectional study. 肾损害患者开始透析的时间和住院时间：一项横断面研究。

IF 1.3 4区医学

Sao Paulo Medical Journal Pub Date : 2024-12-20 eCollection Date: 2024-01-01 DOI: 10.1590/1516-3180.2023.0365.R1.03072024

Douglas Vieira Gemente, Marcelo Rodrigues Bacci

{"title":"Time to initiation of dialysis and length of stay in hospitalized patients with kidney damage: a cross-sectional study.","authors":"Douglas Vieira Gemente, Marcelo Rodrigues Bacci","doi":"10.1590/1516-3180.2023.0365.R1.03072024","DOIUrl":"10.1590/1516-3180.2023.0365.R1.03072024","url":null,"abstract":"Background: Universal healthcare is a cornerstone of Brazil's public health system. However, delayed diagnosis and treatment of chronic kidney disease (CKD) remain substantial issues. The scarcity of outpatient dialysis facilities contributes to extended hospital stays. This study aimed to examine how the time to dialysis initiation (TID) impacts mortality in patients with renal disease.Objectives: This study aimed to evaluate the correlation between variables affecting TID and mortality in hospitalized patients with renal disease.Design and setting: A cross-sectional study was conducted at Santa Marcelina Hospital in São Paulo.Methods: This cross-sectional study was conducted in a tertiary hospital, involving adults with kidney disease who were referred to the emergency department between 2014 and 2017. Primary outcomes included TID and mortality rates.Results: Among the 402 patients studied, the average age was 58.6 years, and 59.4% were men. The median hospital stay was 44.5 d. Notably, 28.1% of the patients began dialysis under emergency conditions. Diabetes and hypertension were the most prevalent causes of renal disease. A positive correlation was found between age and TID (P = 0.007).Conclusions: Primary care in Brazil often fails to effectively detect and manage CKD, leading to a higher incidence of emergency dialysis, particularly among older adults. This delay correlates with increased mortality rates. Older age is associated with delayed TID, prolonged hospital stays, and consequently higher mortality. These findings highlight the need for better primary care to effectively manage CKD and reduce hospitalization and mortality.","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":"143 1","pages":"e2023365"},"PeriodicalIF":1.3,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11655039/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142957813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnosis and treatment of latent tuberculosis infection among household contacts in inland Bahia, Brazil: a cross-sectional follow-up study. 巴西巴伊亚州内陆家庭接触者中潜伏结核感染的诊断和治疗：一项横断面随访研究。

IF 1.3 4区医学

Sao Paulo Medical Journal Pub Date : 2024-12-20 eCollection Date: 2024-01-01 DOI: 10.1590/1516-3180.2023.0339.R2.03072024

Guilherme Lages Matias, Marcio Vinicius Ferreira Sales, Gabriela Santos Andrade, Brenda Dos Santos Teixeira, Maria Eduarda da Macena Tenorio, Maria Augusta Vasconcelos Palácio, Maria Luisa de Carvalho Correia, Iukary Takenami

{"title":"Diagnosis and treatment of latent tuberculosis infection among household contacts in inland Bahia, Brazil: a cross-sectional follow-up study.","authors":"Guilherme Lages Matias, Marcio Vinicius Ferreira Sales, Gabriela Santos Andrade, Brenda Dos Santos Teixeira, Maria Eduarda da Macena Tenorio, Maria Augusta Vasconcelos Palácio, Maria Luisa de Carvalho Correia, Iukary Takenami","doi":"10.1590/1516-3180.2023.0339.R2.03072024","DOIUrl":"10.1590/1516-3180.2023.0339.R2.03072024","url":null,"abstract":"Background: The diagnosis and treatment of latent tuberculosis infection (LTBI) are crucial for tuberculosis (TB) control. Household contacts (HHC) of patients with pulmonary TB are at a high risk of LTBI due to their close proximity to source cases.Objective: To describe the diagnosis and treatment of LTBI among HHC.Design and setting: This cross-sectional follow-up study was conducted in the municipality of Paulo Afonso, northeastern Brazil, between 2013 and 2022.Methods: We retrieved secondary data from the medical records of HHC who were followed up at a specialized referral center for TB. LTBI prevalence estimates were calculated and are presented with 95% confidence intervals (CIs).Results: In total, 622 HHC were screened for LTBI, with 620 evaluated using the tuberculin skin test (TST). Of these, 40 (6.5%) did not return for TST reading. The overall prevalence of LTBI was 53.1% (95% CI: 49-57.1%), with a high prevalence among females and individuals aged 25-34 years. The overall LTBI treatment initiation rate was 26.1% (95%CI: 21.5-31.3%), and 64.2% (95%CI: 53.3-73.8%) of HHC who initiated treatment completed their course.Conclusion: This study revealed a high prevalence of LTBI among HHC, particularly among women and individuals aged 25-34 years, underscoring the ongoing TB transmission within the community. Only 26.1% of the diagnosed HHC initiated treatment, with approximately 64% completing their course. This highlights the challenges in managing LTBI and emphasizes the need for targeted screening and interventions for high-risk groups.","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":"143 1","pages":"e2023339"},"PeriodicalIF":1.3,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11655036/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142957828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of detraining through a six-minute walk test in patients with heart disease. 通过心脏病患者的6分钟步行测试评估去训练。

IF 1.3 4区医学

Sao Paulo Medical Journal Pub Date : 2024-12-20 eCollection Date: 2024-01-01 DOI: 10.1590/1516-3180.2023.0334.R1.03072024

Victória Moreira Silva, Vitória Moreira Cintra, Maria de Lourdes da Silva, Joilson Meneguci, Fernando Seiji Silva, Eduardo Elias Vieira de Carvalho, Ana Paula Espindula, Lucina Duarte Novais Silva

{"title":"Assessment of detraining through a six-minute walk test in patients with heart disease.","authors":"Victória Moreira Silva, Vitória Moreira Cintra, Maria de Lourdes da Silva, Joilson Meneguci, Fernando Seiji Silva, Eduardo Elias Vieira de Carvalho, Ana Paula Espindula, Lucina Duarte Novais Silva","doi":"10.1590/1516-3180.2023.0334.R1.03072024","DOIUrl":"10.1590/1516-3180.2023.0334.R1.03072024","url":null,"abstract":"Background: Detraining can partially or completely reduce training-induced metabolic adaptations. However, the duration for which the rehabilitation effects persist after detraining, especially in patients with heart disease, remains unclear.Objectives: To evaluate the principle of reversibility/detraining in patients with heart disease via the 6-minute walk test (6MWT) after a period of rest.Design and setting: A retrospective cohort study developed at the Rehabilitation Center of the Universidade Federal do Triângulo Mineiro in Uberaba/MG, Brazil.Methods: This clinical, retrospective longitudinal study involved 20 patients with heart disease who underwent 5 months of supervised cardiac rehabilitation (CR). The mean age of participants was 64.05 ± 9.25 years. The initial rehabilitation was followed by an interruption period and rehabilitation for another 5 months. Functional capacity was assessed using the 6MWT.Results: In the specific analysis of the distance covered, values of P = 0.03 and P = 0.01 were obtained on comparing post-training (669.64 ± 58.80 meters) with post-detraining (640.82 ± 101.23 meters) and post-detraining with post-retraining (650.82 ± 96.28 meters), respectively. No significant difference was observed for the comparison between training and retraining (P = 0.83).Conclusion: Cardiovascular rehabilitation positively stimulates functional capacity, whereas detraining significantly reduces it. The 6MWT is effective in measuring changes in physical capacity.","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":"143 1","pages":"e2023334"},"PeriodicalIF":1.3,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11655032/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142957827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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