The burden of healthcare-associated infections in Brazil: multi-hospital point prevalence using a matched case-control study.

IF 1.3 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Sao Paulo Medical Journal Pub Date : 2025-04-28 eCollection Date: 2025-01-01 DOI:10.1590/1516-3180.2023.0307.R1.03072024

Luiz Gustavo Machado, Daiane Silva Resende, Paola Amaral de Campos, Iara Rossi, Melina Lorraine Ferreira, Iolanda Alves Braga, Caio Augusto Martins Aires, Maria Tereza Freitas Tenório, Paulo Pinto Gontijo-Filho, Sabrina Royer, Rosineide Marques Ribas

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引用次数: 0

Abstract

Background: Healthcare-associated infections (HAIs) have a significant impact on patient care worldwide and have serious implications for the Brazilian healthcare system.

Objectives: This study aimed to describe the trends in HAIs in adult intensive care units (ICUs) using data from a national point-prevalence survey.

Design and setting: A point-prevalence study was conducted in 2019 across adult intensive ICUs in large acute care hospitals in Brazil.

Methods: A matched case-control study was performed to assess the risk factors associated with the development of infection.

Results: A total of 386 patients from 15 hospitals were studied, of whom 102 (26.4%; 102/386) were infected, and 76.5% had at least one ICU-acquired infection. In clinical-surgical ICUs (CSU), the prevalence of infections acquired in the unit was 77.9%, whereas in Coronary ICUs (COU), it was 68.7%. There was a predominance of pneumonia (51.0%), mainly caused by Gram-negative non-fermenters, and bloodstream infections (34.4%), predominantly caused by coagulase-negative Staphylococcus (CoNS). In the risk factor analysis, cancer and general antimicrobial use were independently associated.

Conclusion: This study found a high burden of HAIs in adult ICUs in Brazil, mainly associated with the high use of antibiotics for infections and a worse prognosis.

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巴西卫生保健相关感染的负担：采用匹配病例对照研究的多医院点流行率

背景：医疗保健相关感染（HAIs）对全球患者护理产生重大影响，并对巴西医疗保健系统产生严重影响。目的：本研究旨在描述成人重症监护病房（icu）的HAIs趋势，使用来自全国点状流行调查的数据。设计和环境：2019年在巴西大型急性护理医院的成人重症监护病房进行了一项点患病率研究。方法：采用配对病例对照研究，评估与感染发展相关的危险因素。结果：共纳入15家医院386例患者，其中102例（26.4%）；102/386)感染，76.5%至少有一次icu获得性感染。在临床外科重症监护室（CSU），获得性感染的患病率为77.9%，而在冠状动脉重症监护室（COU），这一比例为68.7%。肺炎以革兰氏阴性非发酵菌为主（51.0%），血流感染以凝固酶阴性葡萄球菌（con）为主（34.4%）。在危险因素分析中，癌症和一般抗菌药物的使用是独立相关的。结论：本研究发现巴西成人icu患者HAIs负担高，主要与感染抗生素使用高和预后较差有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Sao Paulo Medical Journal 医学-医学：内科

CiteScore

2.20

自引率

7.10%

发文量

210

审稿时长

6-12 weeks

期刊介绍： Published bimonthly by the Associação Paulista de Medicina, the journal accepts articles in the fields of clinical health science (internal medicine, gynecology and obstetrics, mental health, surgery, pediatrics and public health). Articles will be accepted in the form of original articles (clinical trials, cohort, case-control, prevalence, incidence, accuracy and cost-effectiveness studies and systematic reviews with or without meta-analysis), narrative reviews of the literature, case reports, short communications and letters to the editor. Papers with a commercial objective will not be accepted.