Transfusion and Apheresis Science最新文献

{"title":"Immunoadsorption in specific conditions","authors":"Ioannis Griveas","doi":"10.1016/j.transci.2025.104232","DOIUrl":"10.1016/j.transci.2025.104232","url":null,"abstract":"","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"64 5","pages":"Article 104232"},"PeriodicalIF":1.2,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144781724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is fetal RHD genotyping without fetal markers still unacceptable in D-alloimmunized RhD negative pregnant women?","authors":"Çiğdem Akalın Akkök","doi":"10.1016/j.transci.2025.104235","DOIUrl":"10.1016/j.transci.2025.104235","url":null,"abstract":"","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"64 5","pages":"Article 104235"},"PeriodicalIF":1.2,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144750509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Organizing in “green” a plasmapheresis unit","authors":"Ioannis Griveas ,&nbsp;Paraskevi Tseke","doi":"10.1016/j.transci.2025.104228","DOIUrl":"10.1016/j.transci.2025.104228","url":null,"abstract":"<div><div>Eco-friendly policies can actually improve cost-effectiveness and increase productivity. In every country, every region, every city, it is important to emphasize the importance of identifying local sustainability champions to lead efforts to reduce local contributions to climate change and help educate other staff. Many of our decisions, in the future, will have under consideration the eco-footprint of each Blood Purification method.</div></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"64 5","pages":"Article 104228"},"PeriodicalIF":1.2,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144773189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric therapeutic plasma exchange: A comparative assessment of membrane and centrifugal techniques","authors":"Ebru Guney Sahin ,&nbsp;Kubra Boydag Guvenc ,&nbsp;Idris Abdullah Yilmaz ,&nbsp;Fatih Varol ,&nbsp;Cansu Durak","doi":"10.1016/j.transci.2025.104222","DOIUrl":"10.1016/j.transci.2025.104222","url":null,"abstract":"<div><h3>Introduction</h3><div>Therapeutic plasma exchange (TPE) is a critical extracorporeal procedure for removing pathogenic substances from plasma, commonly used in autoimmune, hematologic, and neurological disorders. While both membrane-based (mTPE) and centrifugal TPE (cTPE) are effective, comparative data in pediatric patients remain limited.</div></div><div><h3>Methods</h3><div>This retrospective study analyzed 94 TPE procedures performed at a tertiary hospital between August 2023 and December 2024.</div></div><div><h3>Results</h3><div>Patients underwent either cTPE (36.2 %) or mTPE (63.8 %), with fresh frozen plasma as the primary replacement fluid. cTPE was associated with shorter procedure duration and greater lactate reduction (p &lt; 0.001, p = 0.003, respectively), whereas mTPE required higher blood flow rates. No significant differences were observed in hemoglobin, hematocrit, platelet counts, or coagulation parameters. Complications occurred in 56.4 % of cases, with hypotension exclusively in cTPE and circuit clotting only in mTPE.</div></div><div><h3>Conclusion</h3><div>Although both methods showed similar efficacy in laboratory parameters, cTPE was found to be more advantageous in terms of processing time and lactate level reduction. Procedural differences and divergence in complication profiles highlight the importance of individualized method selection based on patient characteristics. Future multi-center studies with standardized protocols are essential to optimize pediatric TPE strategies and improve clinical outcomes.</div></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"64 5","pages":"Article 104222"},"PeriodicalIF":1.4,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144704268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-disciplinary evaluation of blood donation practices and knowledge among medical graduates","authors":"Pranjal Rai ,&nbsp;Prachi Ghag ,&nbsp;Naynesha Barure ,&nbsp;Faya Sharma ,&nbsp;Vipul Nandu ,&nbsp;Prachi Bedekar ,&nbsp;K.Rajeshwar Reddy ,&nbsp;Geeta Ghag","doi":"10.1016/j.transci.2025.104221","DOIUrl":"10.1016/j.transci.2025.104221","url":null,"abstract":"<div><h3>Background</h3><div>Medical graduates serve as forefront of healthcare workforce, and their knowledge and practices regarding voluntary blood donation (VBD) can significantly influence the future approach to blood donation and transfusion in the general population. This cross-sectional survey aims to evaluate the awareness and attitudes regarding VBD in the medical graduates and residents across multiple healthcare disciplines (allopathy, ayurveda and homeopathy). It also aims to evaluate the sociodemographic factors that may secondarily influence VBD in this subpopulation.</div></div><div><h3>Materials and methods</h3><div>This cross-sectional survey was conducted over a 6-month period across 2 allopathic (government and municipal), 1 homeopathic and 1 ayurvedic hospitals and included medical interns and residents at these institutions. Data was collected electronically using Google Forms™ and results were analyzed using SPSS version 25 (IBM, New York, USA).</div></div><div><h3>Results</h3><div>Data collected from 416 medical graduates (48.8 % allopathy, 31.3 % homeopathy, 20 % ayurveda), revealed that while 98.8 % recognized blood donation as essential, only 39.2 % donated regularly. Key barriers included perceived unfitness (30 %) and fear of needles (4.8 %). Awareness gaps were evident, with only 47.4 % receiving formal training and 57.5 % unaware of rare donor registries. Gender differences showed males donated more frequently (65.6 % vs. 40.5 %, p &lt; 0.0005).</div></div><div><h3>Conclusion</h3><div>Medical graduates across all healthcare disciplines face gaps in knowledge, attitudes, and practices regarding VBD, driven by misconceptions and limited training. Targeted education and institutional support are vital to enable them as advocates and active participants in sustaining blood donation efforts within the general population.</div></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"64 5","pages":"Article 104221"},"PeriodicalIF":1.2,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144722140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipoprotein apheresis: Current overview and future outlook in clinical practice","authors":"V.J.J. Schettler","doi":"10.1016/j.transci.2025.104209","DOIUrl":"10.1016/j.transci.2025.104209","url":null,"abstract":"<div><div>Lipoprotein apheresis (LA) remains a critical therapeutic approach for patients with severe lipid disorders, particularly those who fail to achieve target LDL-C or lipoprotein(a) [Lp(a)] levels despite advances in pharmacological therapies. While new therapies, such as PCSK9 inhibitors, antisense oligonucleotides, and siRNA-based treatments, have expanded the options for lipid management, LA continues to serve as an essential last resort for high-risk individuals. Patients with homozygous familial hypercholesterolemia (HoFH) or severe hypercholesterolemia (sHCH) often require LA to mitigate extreme cardiovascular risks, including premature myocardial infarction and aortic valve stenosis. Furthermore, LA is the only available therapy capable of effectively reducing elevated Lp(a) levels, a known independent risk factor for cardiovascular events. The recent introduction of anti-inflammatory treatments for atherosclerosis, such as low-dose colchicine, highlights the multifaceted nature of cardiovascular disease and underscores the importance of multimodal treatment strategies. LA, with its dual ability to remove LDL-C and Lp(a) particles as well as inflammation-inducing agents, may offer unique advantages in addressing these complex pathologies. In light of these developments, LA retains its relevance as a safe and effective intervention for individuals who do not respond adequately to other lipid-lowering therapies. By integrating LA into broader treatment frameworks, including acute-phase cardiovascular event management, its potential to improve long-term outcomes warrants further clinical investigation. To date, the pivotal role of LA in modern cardiovascular care must be reaffirmed, emphasizing its continued significance as a fundamental component of comprehensive lipid-lowering strategies for high-risk patient populations.</div></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"64 5","pages":"Article 104209"},"PeriodicalIF":1.4,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144679208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genotypic distribution of hepatitis E virus among asymptomatic blood donors and its impact on transfusion safety","authors":"Singson Sangthang ,&nbsp;N. Sudheesh ,&nbsp;P. Pragathi ,&nbsp;Kiran Chawla ,&nbsp;Riya Nair ,&nbsp;Shamee Shastry","doi":"10.1016/j.transci.2025.104206","DOIUrl":"10.1016/j.transci.2025.104206","url":null,"abstract":"<div><div>Hepatitis E virus is an emerging transfusion transmissible infectious disease of public health concern. Understanding the predominant genotype is crucial for implementing screening techniques and comprehending viral dynamics. Therefore, this study was conducted to investigate the presence of detectable HEV-RNA among the asymptomatic blood donors to identify the prevalent HEV genotype. Serologically HEV IgM reactive samples from asymptomatic voluntary blood donors were screened for HEV RNA using real-time RT-PCR. Additionally, modified Sanger sequencing and phylogenetic analysis were conducted to determine the prevalent genotype. Of the 27 seroreactive samples, two (7 %) had detectable viremia with a high Ct value. Sequence analysis confirmed both HEV RNA-positive samples as genotype 1, the only human-infecting genotype in India. Existing literature reports HEV seroprevalence among Indian blood donors as high as 60 %, with HEV RNA detected in approximately 1 in 1864 donations. Transfusion-transmitted HEV (TT-HEV) can be effectively prevented through blood unit screening. Estimating the Hepatitis E disease burden across different regions and identifying prevalent genotypes among blood donors and at-risk populations are crucial for guiding the effective implementation of an HEV screening policy.</div></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"64 5","pages":"Article 104206"},"PeriodicalIF":1.4,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144665468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The molecular diagnosis and management of rare D--/D-- variants within a family of Iranian descent","authors":"Mobin Setayeshnezhad ,&nbsp;Arezoo Oodi ,&nbsp;Mohammad Ali JalaliFar","doi":"10.1016/j.transci.2025.104210","DOIUrl":"10.1016/j.transci.2025.104210","url":null,"abstract":"<div><div>Anti-Hr0 (Anti-Rh17) is an uncommon antibody to high-frequency antigens within the Rh blood group system. It is found in individuals who do not possess the typical antigens of the Rh system, such as those with D--/D-- and Dc–/Dc- phenotypes, particularly after they have been exposed to red blood cells of the prevalent Rh phenotype through pregnancy or blood transfusion. This antibody has impacted numerous expectant mothers, resulting in perinatal fatalities. As a result, prompt and efficient handling of these situations is crucial. We present a case involving a mother with a D-- phenotype who tested positive for anti-Rh17 and subsequently gave birth to an infant exhibiting anemia and elevated bilirubin levels. In the course of this study, the family members were assessed, revealing that four individuals were identified with the D-- phenotype.</div></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"64 5","pages":"Article 104210"},"PeriodicalIF":1.4,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144663026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic characterization of an ABO*O.01.02-A2.05 hybrid allele associated with the Ael phenotype in a Chinese individual","authors":"Shuang Liang,&nbsp;Yan-Lian Liang,&nbsp;Fan Wu,&nbsp;Tong Liu,&nbsp;Li-Yan Sun,&nbsp;Qiong Yu","doi":"10.1016/j.transci.2025.104211","DOIUrl":"10.1016/j.transci.2025.104211","url":null,"abstract":"<div><h3>Background</h3><div>Discrepancies in ABO typing can arise from genetic variations, posing risks in transfusions. Traditional sequencing handles point mutations well but struggles with recombination events, which long-read sequencing can accurately identify. Here, we report a case of A_el phenotype associated with a novel recombination allele in the <em>ABO</em> gene in a Chinese individual.</div></div><div><h3>Study design and methods</h3><div>We used serological methods to identify the phenotype, and applied sequencing-based typing (SBT) and third-generation long-read sequencing (TGS) to determine the <em>ABO</em> genotype.</div></div><div><h3>Results</h3><div>Serological testing revealed an A_el subtype. SBT sequencing identified seven heterozygous mutation sites, with one allele hypothesized as <em>ABO*O.01.01</em> (c.261delG). The remaining six variants did not match any known allele combination. Two <em>ABO</em> haplotype sequences were obtained through TGS. Analysis confirmed a second haplotype as a hybrid of <em>O.01.02-A02.05</em>, with the breakpoint located between c.220C&gt;T (g.chr9: 133258116C&gt;T; p.Pro74Ser) and c.239+103delCCC (g.chr9: 133257993delCCC) . The novel allele sequence has been submitted to GenBank (Accession number: OR2834978).</div></div><div><h3>Conclusion</h3><div>Our study demonstrates a case of a Chinese individual with an A_el phenotype caused by a novel allele resulting from the recombination of <em>O.01.02</em> and <em>A2.05</em>. This finding underscores the significant advantage of long-read TGS technology in resolving structural variations.</div></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"64 5","pages":"Article 104211"},"PeriodicalIF":1.4,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144653938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The number of apheresis procedures to treat immune-mediated neurological diseases is on the rise","authors":"Kaatje Le Poole ,&nbsp;Hans Vrielink ,&nbsp;Astrid Aandahl ,&nbsp;Tanya Nadia Glatt ,&nbsp;Yona Skosana ,&nbsp;Radomira Hridlickova ,&nbsp;Sarka Blahutova ,&nbsp;Miriam Lanska ,&nbsp;Dries Deeren ,&nbsp;Antanas Griscevicius ,&nbsp;Judita Audzijoniene ,&nbsp;Elizabeth Newman ,&nbsp;Zdenka Gasova ,&nbsp;Zdenka Bhuiyanova Ludvikova ,&nbsp;Volker Witt ,&nbsp;Gösta Berlin ,&nbsp;Jan Kielstein ,&nbsp;Guldane Cengiz Seval ,&nbsp;Michael Ott ,&nbsp;Anders Svenningsson ,&nbsp;Bernd Stegmayr","doi":"10.1016/j.transci.2025.104208","DOIUrl":"10.1016/j.transci.2025.104208","url":null,"abstract":"<div><div>Apheresis is used for the treatment of many different diseases, especially when conventional therapy lacks efficacy. There are however some diseases in which apheresis is accepted as first line therapy. The aim of this analysis was to investigate the use of apheresis for the treatment of neurological diseases and the changes over two decades in the World Apheresis Association registry. During the period 2003–2023, a total of 23,699 apheresis procedures in 2963 patients with a neurological disease were performed. Data were collected during different periods by 44 centers, out of which 22 centers had been registering continuously over the latest 10 years. An increase in the proportion of neurological diseases developed over the period (p &lt; 0.001) while the overall apheresis procedures remained stable (p = 0.46). Most procedures were due to myasthenia gravis (MG; n = 11,049 (31 % of patients), Guillain-Barré Syndrome (GBS; n = 3247 (30 %), multiple sclerosis (MS; n = 2665 (18 %)), chronic inflammatory demyelinating polyradiculoneuropathy (CIDP; n = 2367 (3 %)), and neuromyelitis optica (NMO; n = 650 (2 %)). A change in the proportion of these diseases was noted over time. Adverse events (AEs) differed significantly between the diseases. Patients with GBS had most moderate and severe AEs. Hypotension was the most common severe AE. The panorama of different neurological diseases may cause different AEs based on the variation in neurological response to the apheresis procedure and replacement fluid. It is important to expand this knowledge among those who are prescribing and those performing the apheresis procedures.</div></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"64 5","pages":"Article 104208"},"PeriodicalIF":1.4,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144653937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}