Transfusion and Apheresis Science最新文献

{"title":"Bioinformatic applications in blood group molecular typing","authors":"Andre D. Luchessi ,&nbsp;Thomas Sierocinski ,&nbsp;Teenus P. Jayaprakash ,&nbsp;Celina Montemayor Garcia","doi":"10.1016/j.transci.2025.104300","DOIUrl":"10.1016/j.transci.2025.104300","url":null,"abstract":"<div><div>The application of molecular laboratory methods to predict the expression of red blood cell antigens is well established in today’s clinical transfusion practice. The advent of high-throughput molecular blood typing approaches – based on microarray, short-read, and long-read next generation sequencing platforms – has set the stage for widespread, high-resolution donor and patient typing, encompassing the entire breadth of known antigens and propelling swift discovery in this field. Realizing these benefits requires not only carefully designed and validated laboratory assays, but also robust computational and software infrastructures for processing, storing, and interpreting the large volume of generated data, which may represent a new challenge for blood collectors and transfusion centers. To support this practice transition and facilitate adoption of these technologies, we review recent literature on genomic blood typing approaches, outline IT infrastructure considerations, describe available software and analytical algorithms, and discuss the emerging role of artificial intelligence in this rapidly evolving space.</div></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"65 1","pages":"Article 104300"},"PeriodicalIF":1.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145879365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BASIC INFORMATIC SUPPORT FOR IMPLEMENTATION OF A HOSPITAL PBM PROGRAM","authors":"Robecchi B. ,&nbsp;Ambrosio C. ,&nbsp;Arzenton M. ,&nbsp;Poletto C. ,&nbsp;Iodice S. ,&nbsp;Segala M. ,&nbsp;Saccardin S. ,&nbsp;Frigato A.","doi":"10.1016/j.transci.2025.104342","DOIUrl":"10.1016/j.transci.2025.104342","url":null,"abstract":"","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"65 1","pages":"Article 104342"},"PeriodicalIF":1.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146073827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fresh frozen plasma transfusion within 24 h of admission associated with 28-day mortality of pediatric patients with sepsis: A single-center retrospective cohort study","authors":"Duan Ling ,&nbsp;Chen Ping ,&nbsp;Hu Hongbing","doi":"10.1016/j.transci.2025.104283","DOIUrl":"10.1016/j.transci.2025.104283","url":null,"abstract":"<div><h3>Objectives</h3><div>To investigate association between fresh frozen plasma transfusion within 24 h of admission and 28-day mortality, in-hospital mortality and multiple organ dysfunction syndrome (MODS) in pediatric patients with sepsis.</div></div><div><h3>Methods</h3><div>Children with sepsis admitted to the PICU of our hospital, from January 2023 to December 2024 were enrolled in the study. The general socioeconomic data, interventions and laboratory tests with 24 h of admission were recorded. The occurrence of death and MODS during the children's entire hospital stay was recorded. All patients were followed up with for 28 days after admission, with all-cause mortality being recorded.</div></div><div><h3>Results</h3><div>A total of 262 cases were enrolled, included 81 children with FFP transfusion within 24 h after admitted to PICU. The cases of 28-day mortality, in-hospital mortality and MODS in the FFP transfusion group were 41 (50.6 %), 41 (50.6 %) and 60 (74.1 %), respectively. The cases of 28-day mortality, in-hospital mortality and MODS in the Non-FFP transfusion group were 6 (3.3 %), 7 (3.9 %) and 41 (22.7 %), respectively. The 28-day mortality, in-hospital mortality and MODS morbidity were significantly higher in the FFP transfusion group. FFP transfusion within 24 h was significantly associated with increased 28-day mortality (HR 6.150, 95 % CI 1.770–21.367, P = 0.004) by multivariate Cox regression analysis. 28-day survival rate was significantly higher in the non-FFP transfusion group (HR 19.931, 95 % CI: 10.350–38.404, P = 0.000) by Kaplan–Meier analysis. FFP transfusion within 24 h was significantly associated with increased in-hospital mortality (HR 9.708, 95 % CI 2.003–47.041, P = 0.005) and MODS morbidity (HR 4.351, 95 % CI 1.587–11.926, P = 0.004), respectively by multivariate logistic regression analysis.</div></div><div><h3>Conclusions</h3><div>FFP transfusion within 24 h of admission independently and significantly associated with increased 28-day mortality, in-hospital mortality and MODS morbidity in pediatric patients with sepsis.</div></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"65 1","pages":"Article 104283"},"PeriodicalIF":1.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145594742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A CASE OF VON BALO'S CONCENTRIC SCLEROSIS TREATED WITH PLASMA EXCHANGE","authors":"N. Marletta ,&nbsp;L. Tripoli ,&nbsp;M. Vecchio","doi":"10.1016/j.transci.2025.104320","DOIUrl":"10.1016/j.transci.2025.104320","url":null,"abstract":"","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"65 1","pages":"Article 104320"},"PeriodicalIF":1.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146076795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"INDURATIO PENIS PLASTICA GESTITA CON PLASMA RICCO DI PIASTRINE: DATI PRELIMINARI IN SINGOLO CENTRO","authors":"Citarella C ,&nbsp;D’Achille G ,&nbsp;Ditonno P ,&nbsp;Iaculli ML ,&nbsp;Vitarelli A ,&nbsp;Lorusso A ,&nbsp;Carbonara U ,&nbsp;Lopinto M ,&nbsp;Capurso AM ,&nbsp;Reho M ,&nbsp;Rella L ,&nbsp;Ambruoso F ,&nbsp;Lavelli E ,&nbsp;Procacci R ,&nbsp;Ostuni A","doi":"10.1016/j.transci.2025.104335","DOIUrl":"10.1016/j.transci.2025.104335","url":null,"abstract":"","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"65 1","pages":"Article 104335"},"PeriodicalIF":1.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146077241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MONONUCLEATE CELL COLLECTION EFFICIENCY AND RESPONSE TO ECP IN PATIENTS WITH GVHD: SINGLE CENTER EXPERIENCE.","authors":"Frappampina R.,&nbsp;Battista C.,&nbsp;Citarella C.,&nbsp;Colonna M.,&nbsp;Galasso R.,&nbsp;Giannoccaro M.,&nbsp;Lippolis C.,&nbsp;Procacci R.,&nbsp;Tullo A.,&nbsp;Ostuni A.","doi":"10.1016/j.transci.2025.104324","DOIUrl":"10.1016/j.transci.2025.104324","url":null,"abstract":"","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"65 1","pages":"Article 104324"},"PeriodicalIF":1.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146077324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“Go with O Pos” – Blood transfusion during mass casualty in The Pitt","authors":"Sheharyar Raza ,&nbsp;Garrett S. Booth ,&nbsp;Jeremy W. Jacobs","doi":"10.1016/j.transci.2025.104299","DOIUrl":"10.1016/j.transci.2025.104299","url":null,"abstract":"","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"65 1","pages":"Article 104299"},"PeriodicalIF":1.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145829008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recommendation for a new transfusion threshold in pediatric platelet transfusion: Platelet mass measurement","authors":"Ceren Kılcı ,&nbsp;Fatma Burcu Belen Apak ,&nbsp;Meriç Ergene ,&nbsp;Khaled Warashne ,&nbsp;Buket Daldaban Sarıca ,&nbsp;Lale Olcay ,&nbsp;Figen Özçay ,&nbsp;Esra Baskın ,&nbsp;İlkay Erdoğan ,&nbsp;Ayşenur Ecevit ,&nbsp;Pamir Işık","doi":"10.1016/j.transci.2026.104370","DOIUrl":"10.1016/j.transci.2026.104370","url":null,"abstract":"<div><div>The decision for platelet transfusion in children and newborns is associated with etiology of thrombocytopenia and concomitant comorbid conditions. In recent years, it has been shown that transfusion may be appropriate in newborn cases using platelet mass thresholds obtained by multiplying mean platelet volume (MPV) and platelet count. A number of 183 platelet transfusion administered to 82 patient aged 0–18 years between January 2017 and January 2019 at Başkent University Ankara Hospital were evaluated in our study in terms of transfusion threshold values, transfusion type and efficacy. It was observed that among platelet transfusions, 94 % were prophylactic and 6 % were therapeutic.There was no difference between the appropriateness of transfusion according to platelet mass and the prevention of bleeding and cost (p &gt; 0.05).The number of transfusions that did not meet the platelet mass threshold value was 32 (17.7 %).Considering that conventional platelet transfusion threshold in pediatric cases is lower than in newborn cases (defined as 0-≤30 day old babies), we think that platelet mass threshold values similar to newborns can be used effectively in pediatric cases as well. The transfusion threshold values in our hypothesis may reduce morbidity and cost without reducing its effectiveness.</div></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"65 1","pages":"Article 104370"},"PeriodicalIF":1.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145924949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A real-time dashboard for optimizing blood product utilization through a FHIR-based data integration pipeline","authors":"Cynthia Sabrina Schmidt ,&nbsp;Johannes Wutzkowsky ,&nbsp;Henning Schäfer ,&nbsp;Lea Reinartz ,&nbsp;Haidar Chahin ,&nbsp;Philipp Winnekens ,&nbsp;Jamal Aldin Alsulaiman ,&nbsp;Christian Temme ,&nbsp;Veronika Lenz ,&nbsp;René Hosch ,&nbsp;Felix Nensa ,&nbsp;Christoph M. Friedrich ,&nbsp;Britta Böckmann ,&nbsp;Peter A. Horn","doi":"10.1016/j.transci.2025.104301","DOIUrl":"10.1016/j.transci.2025.104301","url":null,"abstract":"<div><h3>Background</h3><div>Efficient blood product utilization remains a critical operational challenge in transfusion medicine. One key aspect is the timely identification of products eligible for release and the monitoring of discharged patients with reserved blood products that may no longer be needed, as manual review processes for unused or misallocated units often delay their reintroduction into circulation.</div></div><div><h3>Objective</h3><div>To develop a real-time dashboard that integrates heterogeneous hospital data to identify blood products allocated to patients after discharge, transfer, or death.</div></div><div><h3>Methods</h3><div>Clinical and laboratory data from the Hospital Information System (HIS) and Laboratory Information System (LIS) were harmonized via an Extract-Transform-Load (ETL) pipeline into Fast Healthcare Interoperability Resources (FHIR) and stored in a structured database using a relational FHIR engine. A Grafana dashboard visualizes the information retrieved through SQL queries, consolidating patient data, blood product information and crossmatch status into a unified interface.</div></div><div><h3>Results</h3><div>The dashboard provides an overview of all blood products that could potentially be released back into stock and lists associated patients and departments. It is reviewed daily by blood depot staff as part of the clinical workflow, enabling faster verification and release of unused units. The integration of FHIR-based analytics ensures interoperability and real-time updates.</div></div><div><h3>Conclusion</h3><div>The dashboard demonstrates that structured FHIR data can be leveraged for operational decision support in transfusion medicine, enabling proactive stock management and improved resource utilization through seamless integration with existing clinical systems.</div></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"65 1","pages":"Article 104301"},"PeriodicalIF":1.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145884459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RISK ASSESSMENT IN THE APHERESIS BLOOD COMPONENT DONATION PROCESS","authors":"M.C. Guerrese,&nbsp;E. Campana,&nbsp;L. Lombardi,&nbsp;D. Pastorelli,&nbsp;G. Peluso Cassese,&nbsp;S. Sgromo,&nbsp;V. Falcioni,&nbsp;I. Del Mastro,&nbsp;A. Rainaldi","doi":"10.1016/j.transci.2025.104346","DOIUrl":"10.1016/j.transci.2025.104346","url":null,"abstract":"","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"65 1","pages":"Article 104346"},"PeriodicalIF":1.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146073404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}