Transfusion and Apheresis Science最新文献

{"title":"Enhancing clinical insight: Implementing validated questionnaires for comprehensive assessment of clinician expertise in transfusion medicine practices","authors":"Anubhav Gupta ,&nbsp;Hari Krishan Dhawan ,&nbsp;Romesh Jain ,&nbsp;Ratti Ram Sharma ,&nbsp;Vipin Kaushal ,&nbsp;Amarjeet Singh ,&nbsp;Neelam Marwaha","doi":"10.1016/j.transci.2024.104005","DOIUrl":"10.1016/j.transci.2024.104005","url":null,"abstract":"<div><h3>Background</h3><div>Blood transfusion is a cornerstone of modern healthcare, pivotal in saving countless lives annually. However, inadequate knowledge among healthcare providers can lead to serious complications. Despite the availability of assessment tools like the Biomedical Excellence for Safer Transfusion (BEST) test, there is a need for indigenous-validated questionnaires to address knowledge gaps effectively. This study aimed to evaluate bedside transfusion medicine knowledge among clinical residents using a validated questionnaire, focusing on knowledge gaps.</div></div><div><h3>Study design and methods</h3><div>A cross-sectional study was conducted at a tertiary care referral center in Northern India. The questionnaire, developed based on national and international transfusion guidelines, was validated by an expert panel, and administered to 245 clinical residents. The questionnaire covered six domains related to transfusion medicine: blood component storage, blood bank procedures, transfusion-transmitted infections, administration of blood components, transfusion reactions, and transfusion practices.</div></div><div><h3>Results</h3><div>The study revealed varying levels of knowledge across specialties and residency years. Overall, residents scored 61 % in transfusion medicine knowledge, with Pediatrics residents demonstrating the highest scores. The incremental increase in knowledge from first to third-year residents underscores the value of continuous, experience-based learning throughout the residency period.</div></div><div><h3>Discussion</h3><div>Study highlights significant knowledge gaps in bedside transfusion practices among clinical residents, emphasizing the need for structured educational interventions. Tailored programs, integrated into undergraduate and postgraduate curricula, are essential to improve transfusion safety and patient outcomes. Addressing these gaps can lead to better bedside transfusion practices, reducing risks and improving the quality of patient care.</div></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"63 6","pages":"Article 104005"},"PeriodicalIF":1.4,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142299479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does immunohistochemical staining predict mobilization success in multiple myeloma patients?","authors":"Fatma Keklik Karadag ,&nbsp;Murat Aysin ,&nbsp;Nur Soyer ,&nbsp;Ajda Güneş ,&nbsp;Denis Bozer ,&nbsp;Derya Demir ,&nbsp;Aysenur Arslan ,&nbsp;Fahri Sahin ,&nbsp;Mahmut Töbü ,&nbsp;Guray Saydam ,&nbsp;Filiz Vural","doi":"10.1016/j.transci.2024.104004","DOIUrl":"10.1016/j.transci.2024.104004","url":null,"abstract":"<div><h3>Background</h3><p>So many risk factors for mobilization failure have been described so far. We aimed to identify the risk factors and search the possible effects of bone marrow fibrosis (BMF), CD56, c-myc, and cyclinD1 expression on mobilization.</p></div><div><h3>Methods</h3><p>We evaluated 189 patients with MM who were admitted for stem cell mobilization before autologous stem cell transplantation (ASCT) between 2015 and June 2021. Clinical, laboratory, treatment features, and survival outcomes were compared in patients who were successfully mobilized and who were not.</p></div><div><h3>Results</h3><p>Mobilization failure rate was 11.1 % (21) in our study group. Male gender, mobilization with only G-CSF, history of previous ASCT, lenalidomide exposure, and 2 lines of chemotherapy before stem cell mobilization were observed more commonly in mobilization failure group. There is no relationship between mobilization failure and BMF, CD56, c-myc, and cyclin D1 expression status in patients who received either only G-CSF or G-CSF+ chemotherapy for mobilization. Overall survival (OS) was not different in groups of patients who were successfully mobilized and who were not. Neutrophil engraftment was faster in patients who were transfused &gt; 5 × 10⁶/kg stem cells (p = 0.015). ECOG performance status (p = 0.004), c-myc expression (p = 0.005), lenalidomide therapy before mobilization (p = 0.032), and mobilization with G-CSF+chemotherapy was found to be predictive factors for OS.</p></div><div><h3>Conclusion</h3><p>Even though we could not find any predictive value of CD56, c-myc, and cyclin D1 expression on mobilization, c-myc was found to be associated with low OS. Further studies with large and homogenous study population would be more informative.</p></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"63 6","pages":"Article 104004"},"PeriodicalIF":1.4,"publicationDate":"2024-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142239150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cell throughput and performance ratio as quality indicators on hematopoietic stem cell apheresis: A single-center experience","authors":"Yandy Marx Castillo-Aleman ,&nbsp;Carlos Agustin Villegas-Valverde ,&nbsp;Antonio Alfonso Bencomo-Hernandez ,&nbsp;Yendry Ventura-Carmenate ,&nbsp;Shinnette Lumame ,&nbsp;Charisma Castelo ,&nbsp;Nameer Abdul Al-Saadawi ,&nbsp;Mohamed Ibrahim Abu-Haleeqa ,&nbsp;Inas El-Najjar ,&nbsp;Fatema Mohammed Al-Kaabi","doi":"10.1016/j.transci.2024.104003","DOIUrl":"10.1016/j.transci.2024.104003","url":null,"abstract":"<div><h3>Background</h3><p>Benchmarking in CD34⁺ cell apheresis is crucial for optimizing resources, ensuring consistent collection performance, and ultimately, decision-making algorithms to improve donor safety. Key performance indicators such as the “performance ratio” (PR) are applied routinely in some apheresis centers, whereas this report identifies the “cell throughput” (CT) as another quality indicator in apheresis.</p></div><div><h3>Material and methods</h3><p>This single-center study includes retrospective data from 117 aphereses. CT and PR were calculated based on the mononuclear cell collection (MNC) or continuous mononuclear cell collection (cMNC) protocols of the Spectra Optia® apheresis system, types of venous access, transplant settings, and</p><p>mobilization regimens.</p></div><div><h3>Results</h3><p>CTs (× 10⁶ CD34⁺ cells/min) were found to be greater in cMNC compared to MNC protocols (1.4 vs. 1.0, p = 0.0037), in allogeneic versus autologous (1.3 vs. 1.1, p = 0.0274), and in the mobilization regimen of G-CSF alone versus the G-CSF combined (1.3 vs. 1.0, p = 0.0249). In contrast, PR (%) was only statistically significant in favor of the cMNC protocol (213.0 vs. 186.8 for MNC).</p></div><div><h3>Conclusions</h3><p>CT and PR are feasible quality indicators on CD34⁺ cell apheresis, are easy to calculate and implement, and have clinical and administrative implications. Analyzing CT and PR may strengthen the institutional criteria for selecting cMNC or MNC protocols; they may also be used to evaluate the performance of new personnel or cell separator devices or, eventually, trigger investigations for those aphereses under-collected by specific thresholds.</p></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"63 6","pages":"Article 104003"},"PeriodicalIF":1.4,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142167974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The practical use of artificial intelligence in Transfusion Medicine and Apheresis","authors":"Celine Anstey ,&nbsp;David Ullman ,&nbsp;Leon Su ,&nbsp;Chuying Su ,&nbsp;Chad Siniard ,&nbsp;Sierra Simmons ,&nbsp;Jesse Edberg ,&nbsp;Lance A. Williams III","doi":"10.1016/j.transci.2024.104001","DOIUrl":"10.1016/j.transci.2024.104001","url":null,"abstract":"<div><h3>Background</h3><p>Blood and plasma volume calculations are a daily part of practice for many Transfusion Medicine and Apheresis practitioners. Though many formulas exist, each facility may have their own modifications to consider. ChatGPT (Generative Pre-trained Transformer) provides a new and exciting pathway for those with no programming experience to create personalized programs to meet the demands of daily practice. Additionally, this pathway creates computer programs that provide accurate and reproducible outputs. Herein, we aimed to create a step-by-step process for clinicians to create customized computer programs for use in everyday practice.</p></div><div><h3>Methods</h3><p>We created a process of inputs to ChatGPT-4₀, which generated computer programming code. This code was copied and pasted into Notepad (and saved as a Python file) and Google Colaboratory to verify functionality. We validated the durability of our process by repeating it over a 5-day timeframe and by recruiting volunteers to reproduce our outputs using the suggested process.</p></div><div><h3>Results</h3><p>Computer code generated by ChatGPT-4₀ in response to our common language inputs was accurate and durable over time. The code was fully functional in both Python and Colaboratory. Volunteers reproduced our process and outputs with minimal assistance.</p></div><div><h3>Conclusion</h3><p>We analyzed the practical application of ChatGPT-4₀ and artificial intelligence (AI) to perform daily calculations encountered in Transfusion Medicine. Our results provide a proof of concept that people with no programming experience can create customizable solutions for their own facilities. Our future work will expand to the creation of comprehensive and customizable websites designed for each individual user.</p></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"63 6","pages":"Article 104001"},"PeriodicalIF":1.4,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142167976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between mutations in severe hemophilia A and risk of inhibitor development: A large single-center study","authors":"Arash Ahmadfard Moghadam ,&nbsp;Amir Reza Manafzadeh ,&nbsp;MR Nikoonia ,&nbsp;Seyedeh Somayeh Moazezi ,&nbsp;Khadijeh Dajliry Nekoei ,&nbsp;Farahnaz Ramezan ,&nbsp;Davood Bashash ,&nbsp;Mohsen Hamidpour ,&nbsp;Shadi Tabibian","doi":"10.1016/j.transci.2024.104002","DOIUrl":"10.1016/j.transci.2024.104002","url":null,"abstract":"<div><h3>Background</h3><p>One of the major problems for patients with severe hemophilia A (HA) is the development of neutralizing antibodies against factor VIII. This study aimed to analyze the molecular and clinical profiles of patients with severe HA and to determine if certain genetic variants predispose to inhibitor development in these patients.</p></div><div><h3>Methods</h3><p>A single-center study was conducted among patients with severe HA between March 20, 2000, and June 31, 2023. Demographic data and laboratory results of patients were collected. The inverse-shifting PCR (IS-PCR) technique was initially used to screen patients for intron 22 and 1 inversions (Inv-22 and Inv-1).</p></div><div><h3>Results</h3><p>A total of 480 patients with severe HA (408 without inhibitors and 72 with inhibitors) were enrolled in this study. The median age of the patients at the time of diagnosis was 6 months (IQR: 3 months to 18 months). Inv-22 was observed in 199 (41.5 %) of the cases. Among those patients who developed inhibitors, 53 (73.6 %) were classified as high-titer and 19 (26.4 %) as low-titer. Inv-22, positive family history of inhibitor formation, and history of intense injections revealed a statistically significant association with the risk of inhibitor development.</p></div><div><h3>Conclusion</h3><p>The results of this study confirm the important role of different genetic variants, family history of inhibitor formation, and history of intense injections for the formation of inhibitors in patients with severe HA. This would allow us to stratify the patients which can have important clinical implications, especially in terms of their management and outcome.</p></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"63 6","pages":"Article 104002"},"PeriodicalIF":1.4,"publicationDate":"2024-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142171654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Considerations regarding the potential resurgence of transfusion-transmitted syphilis in the United States due to increasing disease incidence and use of fresh blood products","authors":"Brian D. Adkins,&nbsp;Jordan Keith,&nbsp;Jeremy W. Jacobs,&nbsp;Garrett S. Booth","doi":"10.1016/j.transci.2024.103993","DOIUrl":"10.1016/j.transci.2024.103993","url":null,"abstract":"","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"63 6","pages":"Article 103993"},"PeriodicalIF":1.4,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142141591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “ACKR1 gene polymorphisms in Bombay blood group (Oh) individuals of Indian origin” [Transfus Apher Sci 63 (2024) 103975]","authors":"R. Shaikh,&nbsp;G. Kanjaksha,&nbsp;V. Kashivishwanath,&nbsp;S. Kulkarni,&nbsp;S. Jadhav,&nbsp;H. Maru,&nbsp;A. Gorakshakar","doi":"10.1016/j.transci.2024.103992","DOIUrl":"10.1016/j.transci.2024.103992","url":null,"abstract":"","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"63 5","pages":"Article 103992"},"PeriodicalIF":1.4,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1473050224001630/pdfft?md5=235bbdd6ae0a5d42189f83001ca74b70&pid=1-s2.0-S1473050224001630-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142047927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allogeneic serum-based eye drops may give better results than autologous drops in Sjögren's syndrome dry eye","authors":"Joanna Janus,&nbsp;Katarzyna Chmielewska,&nbsp;Jolanta Antoniewicz-Papis","doi":"10.1016/j.transci.2024.103991","DOIUrl":"10.1016/j.transci.2024.103991","url":null,"abstract":"<div><h3>Purpose</h3><p>Sjögren’s syndrome (SS) may cause severe dry eye symptoms. One of the therapeutic option known for almost 40 years are autologous serum eye drops (ASEDs). Due to the presence of many pro-inflammatory factors in the autologous serum of SS patients, the use of allogeneic serum is often considered a better option. In our facility almost one-fifth of the patients using allogeneic serum-based eye drops (alloSEDs) suffered from autoimmune diseases, including SS. The study aim was to compare the effectiveness of both ASEDs and alloSEDs in SS patients.</p></div><div><h3>Methods</h3><p>From the group of SS patients using alloSEDs, five female SS patients aged 39–73 years were selected. They had the longest history of the use of the product. The analysis was based on OSDI forms and internal questionnaires which compared the effects of ASEDs and alloSEDs application. The patients used alloSEDs for a period of 5–28 months. All had previously used ASEDs for at least 2 years.</p></div><div><h3>Results</h3><p>For all five patients the mean OSDI after application of ASEDs and before introducing alloSEDs was 68.71, while the mean OSDI after the use of alloSEDs was 30.49.</p></div><div><h3>Conclusion</h3><p>In SS the treatment results are better with alloSEDs than with ASEDs. Almost all SS patients who applied both autologous and allogeneic drops reported better effects with the latter as also confirmed by the study cases.</p></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"63 5","pages":"Article 103991"},"PeriodicalIF":1.4,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142076960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of acute and chronic graft-versus-host disease with extracorporeal photopheresis: Update of best practice recommendations from Italian Society of Hemapheresis and Cell Manipulation (SIdEM) and the Italian Transplant Group for Bone Marrow Transplantation, Hematopoietic Stem Cells and Cell Therapy (GITMO)","authors":"Anna Colpo ,&nbsp;Monia Marchetti ,&nbsp;Irene Bianco ,&nbsp;Fabio Cruciani ,&nbsp;Francesco Ipsevich ,&nbsp;Mauro Montanari ,&nbsp;Maria Teresa Lupo Stanghellini ,&nbsp;on behalf of the Italian Society of Hemapheresis and Cell Manipulation (SIdEM) and the Italian Transplant Group for Bone Marrow Transplantation, Hematopoietic Stem Cells and Cell Therapy (GITMO)","doi":"10.1016/j.transci.2024.103990","DOIUrl":"10.1016/j.transci.2024.103990","url":null,"abstract":"<div><p>These guidelines represent a GRADE-method revision of the recommendations produced by the Italian Society of Hemapheresis and Cell Manipulation (SIDEM) and the Italian Transplant Group for Bone Marrow Transplantation, Hematopoietic Stem Cells and Cell Therapy (GITMO) in 2013. Since 2013 several studies have been published that have strengthened the role of ECP in the management of GVHD. Thus, it was deemed appropriate to proceed with an update, with the aim to define uniform criteria for the application of ECP in adult and pediatric patients affected by GVHD throughout the national territory, in line with international guidelines, in maintaining of high standards of safety for patients and quality of the procedures provide. Post-HSCT GvHD therapies other than ECP and ECP therapy of other diseases, such as CTCL, are not covered by these guidelines.The development panel for this guideline includes professionals from various specialties who routinely interact in the management of the patient with GVHD, namely the transfusionist, the adult and pediatric hematologist, and the hospital pharmacist. A hematologist experienced in systematic reviews and GRADE guideline development ccordinated the development process, and an experienced transfusionist coordinated the assignment of tasks and reporting. External reviewers of the guideline included a patient representative.</p></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"63 5","pages":"Article 103990"},"PeriodicalIF":1.4,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142087874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of continuous negative pressure suction combined with autologous platelet-rich gel on the levels of CRP, IL-6, wound healing and length of stay in clients with diabetic foot","authors":"Lan Zhang ,&nbsp;Yuan Zhao ,&nbsp;Xiaoyun Fan,&nbsp;Dongliang Liu,&nbsp;Yan Geng","doi":"10.1016/j.transci.2024.103989","DOIUrl":"10.1016/j.transci.2024.103989","url":null,"abstract":"<div><h3>Objective</h3><p>Continuous passive pressure suction and APG gel therapy effect diabetic foot IL-6, CRP, wound healing, and hospitalization.</p></div><div><h3>Methods</h3><p>Clinicopathological data from 102 diabetic foot ulcer patients treated at our institution between March 2018 and May 2022 was examined. Tables generated 51 joint and controlling teams randomly. The observation team received passive pressure suction and APG gel whereas the controlled team received conventional treatment. Teams monitored therapy outcomes, adverse responses, wound healing, hospital stay, and costs. Both teams compared blood uric acid, cystatin C, homocysteine, and serum IL-6, IL-10, and CRP before and after medication.</p></div><div><h3>Results</h3><p>The joint team had higher hospitalization costs, shorter stays, and faster wound healing than the controlled team. Diaparity was significant (P &lt; 0.05). The united team worked 100 %, unlike the controlling team. This difference was significant (P &lt; 0.05). Both teams showed significant decreases in CRP, IL-6, and IL-10 levels after therapy (P &lt; 0.05). After therapy, both the combined and controlled teams had substantial differences in blood CRP, IL-6, and IL-10 levels (P &lt; 0.05). Both teams had significantly decreased uric acid, cystatin C, and homocysteine after treatment. The combined team showed significantly decreased uric acid, cystatin C, homocysteine levels following therapy compared to the control team (P &lt; 0.05).</p></div><div><h3>Conclusion</h3><p>The joint team experienced considerably fewer adverse events (3.92 % vs. 17.65 %) than the controls team (P &lt; 0.05). Permanent passive pressure suction and APG gel therapy lower inflammatory response, blood uric acid, cystatin C, and homocysteine, speeding wound healing, reducing side effects.</p></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"63 5","pages":"Article 103989"},"PeriodicalIF":1.4,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1473050224001605/pdfft?md5=d51a6d22580fffd15948e33e78b4063b&pid=1-s2.0-S1473050224001605-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141990352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}