Transfusion and Apheresis Science最新文献

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Editorial commentary: The latest viewpoint on a statistical analysis of total analytical errors in diagnostic tools used for quantitative testing of medical devices in transfusion medicine & insights on the development of autoantibody isotypes to the Annexin A1 protein of the neutrophil in association with COVID-19-induced hyperinflammatory processes 编辑评论:关于输血医学中用于医疗器械定量检测的诊断工具总分析误差统计分析的最新观点,以及关于中性粒细胞Annexin A1蛋白自身抗体异型的发展与COVID-19诱导的高炎症过程相关性的见解。
IF 1.4 4区 医学
Transfusion and Apheresis Science Pub Date : 2024-10-28 DOI: 10.1016/j.transci.2024.104025
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引用次数: 0
A non-parametric framework for evaluating total analytical error in in vitro diagnostic medical devices in transfusion medicine 评估输血医学体外诊断医疗器械总分析误差的非参数框架。
IF 1.4 4区 医学
Transfusion and Apheresis Science Pub Date : 2024-10-26 DOI: 10.1016/j.transci.2024.104026
{"title":"A non-parametric framework for evaluating total analytical error in in vitro diagnostic medical devices in transfusion medicine","authors":"","doi":"10.1016/j.transci.2024.104026","DOIUrl":"10.1016/j.transci.2024.104026","url":null,"abstract":"<div><div>The performance assessment of quantitative measurements is predominantly based on evaluating Total Analytical Error (TAE). This evaluation encompasses several key objectives critical to ensuring accurate, reliable, and clinically relevant test results. Traditional parametric methods often fall short due to data normality assumptions in the performance assessment of <em>in vitro</em> diagnostic medical devices (IVD-MDs). This study presents a non-parametric approach to estimating and evaluating the TAE in transfusion medicine, aiming to enhance the reliability and patient safety of IVD-MDs. A protocol to estimate TAE over diverse data distributions is suggested, employing a robust statistical definition and comparative measurement procedures. Results from 200 samples indicate that non-parametric methods provided a more accurate reflection of TAE. The findings assert that non-parametric TAE estimation is vital for ensuring the 'fitness for purpose' of clinical tests in transfusion medicine, directly impacting post-transfusion outcomes and patient care. The study concludes that adopting non-parametric methods in transfusion services can significantly improve test accuracy, aligning with the highest laboratory practice standards.</div></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
People, places and things: The new WAA board 人、地、物:新一届世界气象组织理事会
IF 1.4 4区 医学
Transfusion and Apheresis Science Pub Date : 2024-10-23 DOI: 10.1016/j.transci.2024.104023
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引用次数: 0
Successful use of therapeutic plasma exchange for the management of acute lung transplant rejection secondary to immune checkpoint inhibitor therapy 成功使用治疗性血浆置换治疗继发于免疫检查点抑制剂疗法的急性肺移植排斥反应
IF 1.4 4区 医学
Transfusion and Apheresis Science Pub Date : 2024-10-23 DOI: 10.1016/j.transci.2024.104024
{"title":"Successful use of therapeutic plasma exchange for the management of acute lung transplant rejection secondary to immune checkpoint inhibitor therapy","authors":"","doi":"10.1016/j.transci.2024.104024","DOIUrl":"10.1016/j.transci.2024.104024","url":null,"abstract":"<div><div>The use of immune checkpoint inhibitors (ICIs) in individuals with a history of solid organ transplantation is fraught with the emergence of solid organ transplantation rejection (SOTR). The current recommendations for the management of SOTRs secondary to ICI include the use of high-dose steroids along with the escalation of immunosuppressive therapy. Therapeutic Plasma Exchange (TPE) has been described to be effective in managing various immune-related toxicities, however, the data for using TPE in the setting of acute SOTRs induced by ICIs are limited. Herein, we describe the successful use of TPE in a patient with a history of bilateral lung transplantation who developed an episode of mixed acute cellular and antibody-mediated lung transplant rejection after a single dose of PD-1 inhibitor Pembrolizumab for the treatment of underlying melanoma.</div></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142560575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
International forum: WAA meets in Yogaykarta 国际论坛:世界气象组织在约盖卡尔塔举行会议
IF 1.4 4区 医学
Transfusion and Apheresis Science Pub Date : 2024-10-23 DOI: 10.1016/j.transci.2024.104021
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引用次数: 0
GRAIN Study - Granulocytes Against Infections - Use of granulocyte transfusion in haematopoietic stem cell transplant GRAIN 研究--粒细胞抗感染--造血干细胞移植中粒细胞输注的应用
IF 1.4 4区 医学
Transfusion and Apheresis Science Pub Date : 2024-10-19 DOI: 10.1016/j.transci.2024.104020
{"title":"GRAIN Study - Granulocytes Against Infections - Use of granulocyte transfusion in haematopoietic stem cell transplant","authors":"","doi":"10.1016/j.transci.2024.104020","DOIUrl":"10.1016/j.transci.2024.104020","url":null,"abstract":"<div><div>Granulocyte transfusions (GTx) combat infections in neutropenic patients. However, immune-mediated off-target effects in transplant settings are unknown. Between January 2020 and December 2021, all transplants that used GTx during the peri-transplant period were analysed. Engraftment, infections, and days to clearance were retrieved from clinical records. Overall survival is compared with the mean total PMN count and the different products. Pooled buffy coat was used in 110 patients (98 %), of which 38 (34 %) additionally received an apheresed product. The median days of GTx was 4. The median bags pooled to prepare a single buffy coat product was 4. The mean total PMN count was 0.98 × 10<sup>10</sup>/ L granulocytes per pooled buffy coat and 1.93 × 10<sup>10</sup>/L granulocytes per apheresis product. A higher PMN count (&gt;1 × 10<sup>10</sup>/L) was achieved in 48 % with pooled buffy coat versus 85 % with apheresis. Respiratory worsening occurred in 39 % receiving GTx. All patients who received granulocytes had engrafted with a median time of 14 days for neutrophil and 20 days for platelet engraftment. Blood cultures cleared in 81 %, whereas only 28 % cleared other cultures. Fungal pneumonia cleared in 25 %, and invasive fungal sinusitis or otitis cleared in 50 %. Overall survival was 47 %, non-significantly higher (57 % vs 39 %, P = 0.1) with a higher PMN dose. The pooled buffy coat is an affordable alternative to apheresis for an effective PMN dose. Ease of availability and low cost of pooled buffy coat, with comparable overall survival points toward a safe and efficacious product, in the peri-transplant period.</div></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142533499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Red blood cell alloimmunization in transfused patients with hereditary hemorrhagic telangiectasia: A single centre retrospective study 遗传性出血性毛细血管扩张症输血患者的红细胞同种免疫:一项单中心回顾性研究。
IF 1.4 4区 医学
Transfusion and Apheresis Science Pub Date : 2024-10-18 DOI: 10.1016/j.transci.2024.104019
{"title":"Red blood cell alloimmunization in transfused patients with hereditary hemorrhagic telangiectasia: A single centre retrospective study","authors":"","doi":"10.1016/j.transci.2024.104019","DOIUrl":"10.1016/j.transci.2024.104019","url":null,"abstract":"<div><h3>Background</h3><div>Hereditary hemorrhagic telangiectasia (HHT) is a genetic blood vessel disorder which may lead to chronic bleeding and red blood cell (RBC) transfusions. Data on transfusion requirements and complications in HHT patients are sparse.</div></div><div><h3>Study Design and Methods</h3><div>Retrospective chart review was conducted at St. Michael’s Hospital (SMH) in Toronto, Canada. All adults with a definite clinical diagnosis of HHT AND inpatient hospital visits between January 1, 2011 and December 31, 2020 AND had undergone transfusion compatibility testing at SMH, were identified. Data were abstracted from electronic medical records. Simple descriptive statistics were used to analyze data. Institutional Research Ethics Board approval was obtained.</div></div><div><h3>Results</h3><div>63 HHT patients underwent compatibility testing and were subsequently transfused at SMH. Median patient age at data abstraction was 70 years (Interquartile Range [IQR]: 18) and 35 (56 %) were female. RBC alloantibodies were found in 23 transfused patients (36.5 %) and were predominantly directed against Rh and Kell antigens: Anti-E (65 %), Anti-K (39 %) and Anti-c (22 %) were most common. Excluding an outlier who received 611 RBC units during the study period, the mean number of RBC units transfused per HHT patient at SMH was 22.1 units (Standard Deviation: 40.9, IQR: 17). Six (9.5 %) transfused patients experienced at least one transfusion reaction.</div></div><div><h3>Conclusion</h3><div>RBC alloimmunization rate was 36.5 % in our cohort of transfused HHT patients; this is much higher than described in the general population and another transfused HHT cohort. The most commonly observed alloantibodies were Rh and Kell, supporting our policy of prophylactic phenotypic matching for these antigens for all transfused patients with HHT.</div></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142511620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bacterial contamination of platelets concentrates in a lower middle-income country: Data from a single tertiary care hospital 中低收入国家浓缩血小板的细菌污染:来自一家三级医院的数据
IF 1.4 4区 医学
Transfusion and Apheresis Science Pub Date : 2024-10-17 DOI: 10.1016/j.transci.2024.104018
{"title":"Bacterial contamination of platelets concentrates in a lower middle-income country: Data from a single tertiary care hospital","authors":"","doi":"10.1016/j.transci.2024.104018","DOIUrl":"10.1016/j.transci.2024.104018","url":null,"abstract":"<div><h3>Background</h3><div>Transfusion of bacterially contaminated platelets may cause life threatening sepsis in the recipients. Cost of platelet screening is a major challenge for low middle income countries (LMICs). In this study, we evaluated the frequency of bacterial contamination in the platelet units (PUs) and the outcome of transfusing such platelets to the patients in a single institute at Pakistan.</div></div><div><h3>Material and methods</h3><div>During 2018–2022, whole blood-derived (WB-PU) and apheresis platelets (AP) were screened by BacT-ALERT® automated system. Single sample from each AP and samples from ≤ 5 WB-PUs were pooled and cultured within 24 h-post collection. An initial positive signal was followed by re-culture, Gram’s staining, pool resolution and bacterial identification. Results were interpreted as ‘confirmed positive’ or ‘indeterminate’ and ‘confirmed negative’ based on differences in initial-reactive and final results.</div></div><div><h3>Results</h3><div>A total of 84246 PUs (476 AP and 83770 WB-PU) was screened, and 239 (0.28 %) culture bottles were positive on day one. Individual cultures were performed on 1378 PUs (239 bottles) for pool resolution. Seven of 1378 (0.5 %) PUs were ‘confirmed positive’ while 1371 (99.4 %) were ‘indeterminate’. No bacterial growth was observed in 82868 (82392 WB-PU and 476 AP) of 84246 (98.3 %). Overall bacterial contamination rate was low at 1 in 12000 PUs approximately. Seven patients were transfused with contaminated PUs but no transfusion reaction was observed.</div></div><div><h3>Conclusion</h3><div>An insignificant risk of bacterial contamination was observed in this study but remains a concern for patient safety. LMICs need cost effective but efficient techniques to screen platelets for the presence of bacteria.</div></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142446089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biographies of the TAS Senior and his Guest Editor for the Theme papers on donors factors TAS Senior 及其捐助方因素主题文件特邀编辑的简历。
IF 1.4 4区 医学
Transfusion and Apheresis Science Pub Date : 2024-10-17 DOI: 10.1016/j.transci.2024.104015
{"title":"Biographies of the TAS Senior and his Guest Editor for the Theme papers on donors factors","authors":"","doi":"10.1016/j.transci.2024.104015","DOIUrl":"10.1016/j.transci.2024.104015","url":null,"abstract":"","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142478972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Guest Editorial: Advancements in blood donor factors: Understanding their variability and implications on the clinical outcomes of recipients. Where are we now! 特邀社论:献血因子的进展:了解其变异性及其对受血者临床结果的影响。我们现在在哪里?
IF 1.4 4区 医学
Transfusion and Apheresis Science Pub Date : 2024-10-16 DOI: 10.1016/j.transci.2024.104014
{"title":"Guest Editorial: Advancements in blood donor factors: Understanding their variability and implications on the clinical outcomes of recipients. Where are we now!","authors":"","doi":"10.1016/j.transci.2024.104014","DOIUrl":"10.1016/j.transci.2024.104014","url":null,"abstract":"","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142478974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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