Transfusion and Apheresis Science最新文献

{"title":"Rare anti-AnWj autoantibody in a 75-year-old male: Case report and review of the literature.","authors":"Ethar Al-Husseinawi, Morgan Heitt, Ty Moore, Sumalatha Muthineni, Gina Folk, Amitava Dasgupta, Zhan Ye","doi":"10.1016/j.transci.2026.104444","DOIUrl":"https://doi.org/10.1016/j.transci.2026.104444","url":null,"abstract":"<p><p>Although AnWj is a high-frequency red blood cell antigen in the ISBT (International Society of Blood Transfusion) 901 series, with a prevalence exceeding 99% in the general population, anti-AnWj is encountered very rarely. We described a 75-year-old man with idiopathic thrombocytopenic purpura (ITP), coronary artery disease (CAD) status post coronary artery bypass graft (CABG) and recent percutaneous coronary interventions (PCIs), aortic stenosis status post aortic valve replacement (AVR), admitted twice due to bleeding and severe anemia. Immunohematology and serological studies suggested the patient's A-negative blood type with anti-AnWj. Given life-threatening anemia, ischemic risk from recent PCI, absence of compatible units and the autoantibody characteristic of anti-AnWj, the team proceeded with transfusions without matching AnWj antigen after multidisciplinary discussions. Subsequent genotyping demonstrated a wild‑type MAL gene, confirming the presence of auto‑anti‑AnWj. Fortunately, there was no transfusion reaction, including hemolysis, probably due to the autoantibody nature or low titer of anti-AnWj. This case presents clinical challenges when a rare antibody, such as anti-AnWj, is encountered in a critically ill patient requiring transfusion.</p>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"65 3","pages":"104444"},"PeriodicalIF":1.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147845191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to \"Immune hemolytic anemia attributed to Tacrolimus: Diagnostic labeling and transfusion risk in post-transplant settings\"","authors":"Bowei Cao,&nbsp;Yanhong Bu,&nbsp;Yongjun Wang,&nbsp;Ningjie Zhang","doi":"10.1016/j.transci.2026.104378","DOIUrl":"10.1016/j.transci.2026.104378","url":null,"abstract":"","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"65 2","pages":"Article 104378"},"PeriodicalIF":1.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146039211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting intraoperative transfusion volumes of blood products in cardiovascular surgery: a retrospective study","authors":"Hiroki Shibata ,&nbsp;Yuma Hirano ,&nbsp;Mikihiro Shimizu ,&nbsp;Kaede Ino ,&nbsp;Akiho Ikeda ,&nbsp;Yui Nagae ,&nbsp;Naoki Nemoto ,&nbsp;Mizuki Oishi ,&nbsp;Takahito Shinba ,&nbsp;Chiaki Yamada ,&nbsp;Keiko Ishizuka ,&nbsp;Takaaki Ono","doi":"10.1016/j.transci.2026.104374","DOIUrl":"10.1016/j.transci.2026.104374","url":null,"abstract":"<div><h3>Background and Objectives</h3><div>Red blood cells are often overprepared for surgery, leading to waste and increased costs, despite the need for cross-matching tests. This study aimed to develop a model for predicting the number of red blood cell units required during cardiovascular surgery using patient characteristics.</div></div><div><h3>Materials and Methods</h3><div>This retrospective study included patients who underwent cardiovascular surgery at our hospital from April 2022 to October 2022. Multiple regression analysis was performed using preoperative patient attributes and blood data, with red blood cell units used during surgery as the objective variable. Models were developed using patient demographics and blood data, with additional models incorporating specific surgical procedures to assess predictive accuracy.</div></div><div><h3>Results</h3><div>Model 1 included age, sex, weight, hematocrit, prothrombin time-international normalized ratio, serum creatinine, volume of preoperatively donated diluted autologous blood, and history of cardiovascular surgery. Model 2 included the same variables as Model 1, plus aortic aneurysm resection as a surgical procedure. The predictive equations of the study showed superior accuracy for both Model 1 and Model 2 compared to the conventional red blood cell units requested by physicians or those predicted using the surgical blood order equation based on correlation coefficients. Model 2 outperformed both Model 1 and conventional methods in predictive utility.</div></div><div><h3>Conclusion</h3><div>This study developed a clinically useful formula for predicting the number of red blood cell units required during surgery based on preoperative patient-specific data, without restricting the analysis to specific procedures. This formula may improve blood product inventory management and reduce medical costs.</div></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"65 2","pages":"Article 104374"},"PeriodicalIF":1.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145981854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical study of recombinant human thrombopoietin in platelet engraftment following autologous hematopoietic stem cell transplantation","authors":"Shunsen Wang ,&nbsp;Jie Ji ,&nbsp;Hai Yi ,&nbsp;Lei Ma ,&nbsp;Xiaodong Liu ,&nbsp;Lan Li ,&nbsp;Shan Luo ,&nbsp;Fang Hua ,&nbsp;Kun Chen ,&nbsp;Jian Xiao","doi":"10.1016/j.transci.2026.104375","DOIUrl":"10.1016/j.transci.2026.104375","url":null,"abstract":"<div><h3>Background</h3><div>Autologous transplantation is an effective treatment for hematological malignancies. However, post-transplant thrombocytopenia is a common complication. This study evaluated the efficacy and safety of recombinant human thrombopoietin (rhTPO) in promoting platelet engraftment following autologous hematopoietic stem cell transplantation (ASCT).</div></div><div><h3>Methods</h3><div>A prospective, multicentre, single-arm study screened patients for ASCT at three centers. rhTPO was administered from day +3 to +7 post-ASCT until platelet engraftment. Efficacy was assessed by time to platelet and neutrophil engraftment and platelet transfusion needs. Safety was evaluated via adverse events, hepatic/renal function, and electrolyte balance.</div></div><div><h3>Results</h3><div>In 63 patients, the median platelet engraftment time was 11 days (range: 8–22) and leukocyte engraftment 9 days (range: 7–15). Pre-transplant platelet count (HR=1.01, P = 0.003) and CD34+ cell dose (HR=1.42, P = 0.008) were independent predictors of platelet engraftment. Furthermore, baseline platelet count ≥ 180 × 10⁹/L and CD34+ cell dose &gt;4.46 × 10⁶/kg reduced engraftment time (P &lt; 0.05). Lymphoma patients required more platelet transfusions (P = 0.002). The non-Chi-CGB group demonstrated higher red blood cell and platelet transfusion volumes (P = 0.042, P = 0.002). Adverse events included elevated transaminases (11.1 %), elevated bilirubin (14.3 %), and thrombosis (1.6 %). The primary adverse bleeding events included skin ecchymosis (25.4 %) and gastrointestinal hemorrhage (4.7 %).</div></div><div><h3>Conclusion</h3><div>It has been demonstrated that rhTPO promotes platelet engraftment in ASCT for hematological malignancies, exhibiting a favorable safety profile. Pre-transplant platelet counts ≥180 × 10⁹/L and CD34+ cell doses &gt;4.46 × 10⁶/kg predict faster platelet engraftment.</div></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"65 2","pages":"Article 104375"},"PeriodicalIF":1.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145981853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intra-procedure white blood cell monitoring as a predictor of collection efficiency in mononuclear cell apheresis","authors":"Austin Choi,&nbsp;Shasta Theodore,&nbsp;Yanyun Wu,&nbsp;Yamac Akgun","doi":"10.1016/j.transci.2026.104376","DOIUrl":"10.1016/j.transci.2026.104376","url":null,"abstract":"<div><h3>Background</h3><div>Efficient collection of cellular starting material is critical for the success of chimeric antigen receptor T-cell (CAR-T) therapy. While hematopoietic progenitor cell (HPC) harvests rely on pre-procedure CD34⁺ counts to predict adequacy, equivalent real-time predictors for mononuclear cell (MNC) collections remain lacking. This study evaluated intra-procedure white blood cell (WBC) concentration as a potential indicator of collection performance.</div></div><div><h3>Methods</h3><div>A retrospective review was conducted of CARVYKTI MNC apheresis procedures performed between July 2023 and November 2024 at the University of Miami, Sylvester Comprehensive Cancer Center. Institutional Review Board approval was obtained (protocol #20201331). Pre-procedure peripheral WBC counts (ppWBC), intra-procedure WBC concentrations (ipWBC), total blood volume processed (TBVIP), and collection efficiency (CE) were analyzed. Correlations were assessed using Spearman’s rank coefficients.</div></div><div><h3>Results</h3><div>Forty-seven procedures were analyzed. Median ppWBC was 4.5 × 10³/µL (IQR 3.6–6.4), median ipWBC 75.8 × 10 ³ /µL (IQR 49.4–97.2), and median CE 0.21 (IQR 0.17–0.26). ipWBC showed strong positive correlations with ppWBC (r = 0.68, p = 1.7 ×10⁻⁷) and CE (r = 0.54, p = 9.0 ×10⁻⁵), whereas ppWBC alone did not correlate with CE (r = –0.14, p = 0.35).</div></div><div><h3>Conclusions</h3><div>Intra-procedure WBC concentration correlates with collection efficiency and provides a more meaningful real-time indicator of MNC harvest performance than pre-procedure counts alone. Incorporating intra-procedure monitoring into apheresis workflows may enhance yield predictability and streamline CAR-T manufacturing logistics</div></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"65 2","pages":"Article 104376"},"PeriodicalIF":1.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145981935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification strategy for patients with ABO blood typing difficulties caused by IgM autoantibodies","authors":"Chen Wang ,&nbsp;Xian Huang ,&nbsp;Lina Wu ,&nbsp;Shichun Wang ,&nbsp;Pengyu Zhang","doi":"10.1016/j.transci.2026.104372","DOIUrl":"10.1016/j.transci.2026.104372","url":null,"abstract":"<div><h3>Objective</h3><div>The objective of this study was to investigate the characteristics of autoantibodies and cause of autoantibodies production and clinical blood transfusion strategies in the ABO blood group system by identifying and analysing 2 rare ABO blood group antigen-specific autoantibodies.</div></div><div><h3>Methods</h3><div>Blood group antigens and antibodies were detected via the conventional tube method, a gel microcolumn assay and the absorption<img>elution technique. The antibodies were characterized by direct antiglobulin tests and sulfhydryl reagent treatment of the plasma. ABO genotyping was performed using Sanger double-stranded sequencing of the ABO exons. Review the patient's medical records such as medical history and treatment history, and continuously monitor the ABO blood group.</div></div><div><h3>Results</h3><div>The blood type of the first case was confirmed to be type A₁ by serological and molecular biological tests, with autoanti-A antibodies, the production of this autoantibody was associated with the disease itself; The blood type of the second case was type A₁B, with autoanti-B antibody, the production of this autoantibody was associated with the use of immune checkpoint inhibitors.</div></div><div><h3>Conclusions</h3><div>ABO blood group autoantibodies should be considered when antibodies against the A or B antigen are suspected in ABO reverse group typing after ruling out the possibility of alloantibodies, subtype antibodies and foreign antibodies. For patients with autoantibodies, appropriate blood products for transfusion should be selected based on the results of cross-matching tests, antibody thermal amplitude, and in-vitro hemolysis tests, and the transfusion process should be closely monitored.</div></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"65 2","pages":"Article 104372"},"PeriodicalIF":1.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145957749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PLASMA SELF-SUFFICIENCY THROUGH PRODUCTIVE APHERESIS: CONTRIBUTION OF THE SIT OF POLLA ASL SALERNO","authors":"A. Di Santi,&nbsp;A Balestrieri,&nbsp;O. Petti,&nbsp;G. Marra,&nbsp;C. Graziano,&nbsp;F. Soldovieri,&nbsp;G. Pipolo,&nbsp;M. D'Onofrio","doi":"10.1016/j.transci.2025.104354","DOIUrl":"10.1016/j.transci.2025.104354","url":null,"abstract":"","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"65 1","pages":"Article 104354"},"PeriodicalIF":1.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146076810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"INACTIVATION OF PLTS: WHERE DO WE STAND?","authors":"A. Ostuni","doi":"10.1016/j.transci.2025.104363","DOIUrl":"10.1016/j.transci.2025.104363","url":null,"abstract":"","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"65 1","pages":"Article 104363"},"PeriodicalIF":1.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146076809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SIDEM-GITMO ECP BEST PRACTICE: ONLINE VERSUS OFFLINE TECHNOLOGY","authors":"Colpo A","doi":"10.1016/j.transci.2025.104357","DOIUrl":"10.1016/j.transci.2025.104357","url":null,"abstract":"","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"65 1","pages":"Article 104357"},"PeriodicalIF":1.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146076806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MANAGEMENT OF PERIOPERATIVE ANEMIA WITH IRON CARBOXYMALTOSE IN JEHOVAH'S WITNESSES UNDERGOING CYTOREDUCTIVE SURGERY FOR CANCER","authors":"Ferrazza G ,&nbsp;Panzini E ,&nbsp;Terracina S ,&nbsp;Del Federico D ,&nbsp;Frilicca A ,&nbsp;Cobo V ,&nbsp;Conforti MF ,&nbsp;Pavan A","doi":"10.1016/j.transci.2025.104341","DOIUrl":"10.1016/j.transci.2025.104341","url":null,"abstract":"","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"65 1","pages":"Article 104341"},"PeriodicalIF":1.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146077099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}