Transfusion and Apheresis Science最新文献

Plant-based diets for CKD patients, green- based Mediterranean diet: A green nephrology view CKD患者的植物性饮食，绿色地中海饮食：绿色肾病学观点

IF 1.2 4区医学

Transfusion and Apheresis Science Pub Date : 2025-07-29 DOI: 10.1016/j.transci.2025.104231

Dora Oikonomaki

引用次数: 0

The ecological footprint of therapeutic plasmapheresis methods 治疗性血浆分离方法的生态足迹

IF 1.2 4区医学

Transfusion and Apheresis Science Pub Date : 2025-07-28 DOI: 10.1016/j.transci.2025.104227

Paraskevi Tseke , Petros Tsekes , Ioannis Griveas

引用次数: 0

Irradiation and beyond: Mitigating TA-GVHD in transfusion 辐照及其他：减轻输血中的TA-GVHD

IF 1.2 4区医学

Transfusion and Apheresis Science Pub Date : 2025-07-28 DOI: 10.1016/j.transci.2025.104237

Pratham D. Patel , Ethan A. Simpson , Jason P. Acker

{"title":"Irradiation and beyond: Mitigating TA-GVHD in transfusion","authors":"Pratham D. Patel , Ethan A. Simpson , Jason P. Acker","doi":"10.1016/j.transci.2025.104237","DOIUrl":"10.1016/j.transci.2025.104237","url":null,"abstract":"<div><div>Transfusion-associated graft-versus-host disease (TA-GVHD) is a rare but often fatal complication of allogeneic transfusion, caused by the activation and expansion of donor T lymphocytes in susceptible recipients. Prevention focuses on reducing these immune cells through leukoreduction and irradiation. While leukoreduction of blood components decreases white blood cell content and improves overall transfusion safety, it does not fully prevent TA-GVHD, as viable T cells may persist. Irradiation using gamma or X-ray methods remain the most effective strategy, inactivating donor T cells by inducing DNA damage and suppressing proliferation. However, it also compromises red blood cell quality by increasing hemolysis, oxidative injury, membrane damage, extracellular potassium, and reducing storage duration. As an alternative, hypothermic storage of leukoreduced red blood cells is gaining attention. Evidence suggests that extending storage beyond 21 days significantly reduces T cell viability and proliferation without compromising red blood cell integrity. Further research is needed to directly compare the efficacy of hypothermic storage to irradiation.</div></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"64 5","pages":"Article 104237"},"PeriodicalIF":1.2,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144750508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial Commentary - Expert insights on advancing innovations in modernised blood components therapy and a shift from conventional storage using hypoxic/hypothermic storage of red blood cells, in select clinical scenarios, to improve patient-centred transfusion care 编辑评论-专家对推进现代化血液成分治疗创新的见解，以及在特定临床情况下使用低氧/低温红细胞的传统储存方式的转变，以改善以患者为中心的输血护理

IF 1.2 4区医学

Transfusion and Apheresis Science Pub Date : 2025-07-28 DOI: 10.1016/j.transci.2025.104233

Jerard Seghatchian

引用次数: 0

Norway: Blood donors and the innovative research and development on some unmet challenges 挪威：献血者和针对一些未遇挑战的创新研究与开发

IF 1.2 4区医学

Transfusion and Apheresis Science Pub Date : 2025-07-28 DOI: 10.1016/j.transci.2025.104236

Tor Audun Hervig

引用次数: 0

Is fetal RHD genotyping without fetal markers still unacceptable in D-alloimmunized RhD negative pregnant women? 没有胎儿标记的胎儿RHD基因分型在d -异体免疫的RHD阴性孕妇中仍然不可接受吗？

IF 1.2 4区医学

Transfusion and Apheresis Science Pub Date : 2025-07-28 DOI: 10.1016/j.transci.2025.104235

Çiğdem Akalın Akkök

引用次数: 0

Pediatric therapeutic plasma exchange: A comparative assessment of membrane and centrifugal techniques 儿科治疗性血浆交换：膜和离心技术的比较评估

IF 1.4 4区医学

Transfusion and Apheresis Science Pub Date : 2025-07-25 DOI: 10.1016/j.transci.2025.104222

Ebru Guney Sahin , Kubra Boydag Guvenc , Idris Abdullah Yilmaz , Fatih Varol , Cansu Durak

{"title":"Pediatric therapeutic plasma exchange: A comparative assessment of membrane and centrifugal techniques","authors":"Ebru Guney Sahin , Kubra Boydag Guvenc , Idris Abdullah Yilmaz , Fatih Varol , Cansu Durak","doi":"10.1016/j.transci.2025.104222","DOIUrl":"10.1016/j.transci.2025.104222","url":null,"abstract":"<div><h3>Introduction</h3><div>Therapeutic plasma exchange (TPE) is a critical extracorporeal procedure for removing pathogenic substances from plasma, commonly used in autoimmune, hematologic, and neurological disorders. While both membrane-based (mTPE) and centrifugal TPE (cTPE) are effective, comparative data in pediatric patients remain limited.</div></div><div><h3>Methods</h3><div>This retrospective study analyzed 94 TPE procedures performed at a tertiary hospital between August 2023 and December 2024.</div></div><div><h3>Results</h3><div>Patients underwent either cTPE (36.2 %) or mTPE (63.8 %), with fresh frozen plasma as the primary replacement fluid. cTPE was associated with shorter procedure duration and greater lactate reduction (p < 0.001, p = 0.003, respectively), whereas mTPE required higher blood flow rates. No significant differences were observed in hemoglobin, hematocrit, platelet counts, or coagulation parameters. Complications occurred in 56.4 % of cases, with hypotension exclusively in cTPE and circuit clotting only in mTPE.</div></div><div><h3>Conclusion</h3><div>Although both methods showed similar efficacy in laboratory parameters, cTPE was found to be more advantageous in terms of processing time and lactate level reduction. Procedural differences and divergence in complication profiles highlight the importance of individualized method selection based on patient characteristics. Future multi-center studies with standardized protocols are essential to optimize pediatric TPE strategies and improve clinical outcomes.</div></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"64 5","pages":"Article 104222"},"PeriodicalIF":1.4,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144704268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multi-disciplinary evaluation of blood donation practices and knowledge among medical graduates 医学毕业生献血实践和献血知识的多学科评价

IF 1.2 4区医学

Transfusion and Apheresis Science Pub Date : 2025-07-25 DOI: 10.1016/j.transci.2025.104221

Pranjal Rai , Prachi Ghag , Naynesha Barure , Faya Sharma , Vipul Nandu , Prachi Bedekar , K.Rajeshwar Reddy , Geeta Ghag

{"title":"Multi-disciplinary evaluation of blood donation practices and knowledge among medical graduates","authors":"Pranjal Rai , Prachi Ghag , Naynesha Barure , Faya Sharma , Vipul Nandu , Prachi Bedekar , K.Rajeshwar Reddy , Geeta Ghag","doi":"10.1016/j.transci.2025.104221","DOIUrl":"10.1016/j.transci.2025.104221","url":null,"abstract":"<div><h3>Background</h3><div>Medical graduates serve as forefront of healthcare workforce, and their knowledge and practices regarding voluntary blood donation (VBD) can significantly influence the future approach to blood donation and transfusion in the general population. This cross-sectional survey aims to evaluate the awareness and attitudes regarding VBD in the medical graduates and residents across multiple healthcare disciplines (allopathy, ayurveda and homeopathy). It also aims to evaluate the sociodemographic factors that may secondarily influence VBD in this subpopulation.</div></div><div><h3>Materials and methods</h3><div>This cross-sectional survey was conducted over a 6-month period across 2 allopathic (government and municipal), 1 homeopathic and 1 ayurvedic hospitals and included medical interns and residents at these institutions. Data was collected electronically using Google Forms™ and results were analyzed using SPSS version 25 (IBM, New York, USA).</div></div><div><h3>Results</h3><div>Data collected from 416 medical graduates (48.8 % allopathy, 31.3 % homeopathy, 20 % ayurveda), revealed that while 98.8 % recognized blood donation as essential, only 39.2 % donated regularly. Key barriers included perceived unfitness (30 %) and fear of needles (4.8 %). Awareness gaps were evident, with only 47.4 % receiving formal training and 57.5 % unaware of rare donor registries. Gender differences showed males donated more frequently (65.6 % vs. 40.5 %, p < 0.0005).</div></div><div><h3>Conclusion</h3><div>Medical graduates across all healthcare disciplines face gaps in knowledge, attitudes, and practices regarding VBD, driven by misconceptions and limited training. Targeted education and institutional support are vital to enable them as advocates and active participants in sustaining blood donation efforts within the general population.</div></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"64 5","pages":"Article 104221"},"PeriodicalIF":1.2,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144722140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lipoprotein apheresis: Current overview and future outlook in clinical practice 脂蛋白分离：临床应用的现状与展望

IF 1.4 4区医学

Transfusion and Apheresis Science Pub Date : 2025-07-17 DOI: 10.1016/j.transci.2025.104209

V.J.J. Schettler

{"title":"Lipoprotein apheresis: Current overview and future outlook in clinical practice","authors":"V.J.J. Schettler","doi":"10.1016/j.transci.2025.104209","DOIUrl":"10.1016/j.transci.2025.104209","url":null,"abstract":"<div><div>Lipoprotein apheresis (LA) remains a critical therapeutic approach for patients with severe lipid disorders, particularly those who fail to achieve target LDL-C or lipoprotein(a) [Lp(a)] levels despite advances in pharmacological therapies. While new therapies, such as PCSK9 inhibitors, antisense oligonucleotides, and siRNA-based treatments, have expanded the options for lipid management, LA continues to serve as an essential last resort for high-risk individuals. Patients with homozygous familial hypercholesterolemia (HoFH) or severe hypercholesterolemia (sHCH) often require LA to mitigate extreme cardiovascular risks, including premature myocardial infarction and aortic valve stenosis. Furthermore, LA is the only available therapy capable of effectively reducing elevated Lp(a) levels, a known independent risk factor for cardiovascular events. The recent introduction of anti-inflammatory treatments for atherosclerosis, such as low-dose colchicine, highlights the multifaceted nature of cardiovascular disease and underscores the importance of multimodal treatment strategies. LA, with its dual ability to remove LDL-C and Lp(a) particles as well as inflammation-inducing agents, may offer unique advantages in addressing these complex pathologies. In light of these developments, LA retains its relevance as a safe and effective intervention for individuals who do not respond adequately to other lipid-lowering therapies. By integrating LA into broader treatment frameworks, including acute-phase cardiovascular event management, its potential to improve long-term outcomes warrants further clinical investigation. To date, the pivotal role of LA in modern cardiovascular care must be reaffirmed, emphasizing its continued significance as a fundamental component of comprehensive lipid-lowering strategies for high-risk patient populations.</div></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"64 5","pages":"Article 104209"},"PeriodicalIF":1.4,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144679208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genotypic distribution of hepatitis E virus among asymptomatic blood donors and its impact on transfusion safety 戊型肝炎病毒在无症状献血者中的基因型分布及其对输血安全的影响

IF 1.4 4区医学

Transfusion and Apheresis Science Pub Date : 2025-07-16 DOI: 10.1016/j.transci.2025.104206

Singson Sangthang , N. Sudheesh , P. Pragathi , Kiran Chawla , Riya Nair , Shamee Shastry

{"title":"Genotypic distribution of hepatitis E virus among asymptomatic blood donors and its impact on transfusion safety","authors":"Singson Sangthang , N. Sudheesh , P. Pragathi , Kiran Chawla , Riya Nair , Shamee Shastry","doi":"10.1016/j.transci.2025.104206","DOIUrl":"10.1016/j.transci.2025.104206","url":null,"abstract":"<div><div>Hepatitis E virus is an emerging transfusion transmissible infectious disease of public health concern. Understanding the predominant genotype is crucial for implementing screening techniques and comprehending viral dynamics. Therefore, this study was conducted to investigate the presence of detectable HEV-RNA among the asymptomatic blood donors to identify the prevalent HEV genotype. Serologically HEV IgM reactive samples from asymptomatic voluntary blood donors were screened for HEV RNA using real-time RT-PCR. Additionally, modified Sanger sequencing and phylogenetic analysis were conducted to determine the prevalent genotype. Of the 27 seroreactive samples, two (7 %) had detectable viremia with a high Ct value. Sequence analysis confirmed both HEV RNA-positive samples as genotype 1, the only human-infecting genotype in India. Existing literature reports HEV seroprevalence among Indian blood donors as high as 60 %, with HEV RNA detected in approximately 1 in 1864 donations. Transfusion-transmitted HEV (TT-HEV) can be effectively prevented through blood unit screening. Estimating the Hepatitis E disease burden across different regions and identifying prevalent genotypes among blood donors and at-risk populations are crucial for guiding the effective implementation of an HEV screening policy.</div></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"64 5","pages":"Article 104206"},"PeriodicalIF":1.4,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144665468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0