ACKR1/Duffy抗原在疟疾之外的新作用

IF 1.2 4区医学 Q4 HEMATOLOGY

Transfusion and Apheresis Science Pub Date : 2025-09-09 DOI:10.1016/j.transci.2025.104255

Roshan Shaikh , Kanjaksha Ghosh , Ajit Gorakshakar

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引用次数: 0

摘要

非典型趋化因子受体1 (ACKR1)，以前被称为达菲抗原/趋化因子受体（DARC），主要被认为在间日疟原虫侵袭红细胞中的作用。最近的研究揭示了它在疟疾之外的多种功能，如炎症、癌症生物学、造血和几种疾病的易感性。这一观点强调了这些新兴角色及其潜在的治疗应用。

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The emerging roles of ACKR1/Duffy antigen beyond malaria

Atypical chemokine receptor 1 (ACKR1), formerly known as the Duffy antigen/receptor for chemokines (DARC), has been primarily recognized for its role in Plasmodium vivax invasion of erythrocytes. Recent research has unveiled its diverse functions beyond malaria like susceptibility in inflammation, cancer biology, hematopoiesis, and several diseases. This perspective highlights these emerging roles and their potential therapeutic applications.

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来源期刊

Transfusion and Apheresis Science 医学-血液学

CiteScore

3.60

自引率

5.30%

发文量

181

审稿时长

42 days

期刊介绍： Transfusion and Apheresis Science brings comprehensive and up-to-date information to physicians and health care professionals involved in the rapidly changing fields of transfusion medicine, hemostasis and apheresis. The journal presents original articles relating to scientific and clinical studies in the areas of immunohematology, transfusion practice, bleeding and thrombotic disorders and both therapeutic and donor apheresis including hematopoietic stem cells. Topics covered include the collection and processing of blood, compatibility testing and guidelines for the use of blood products, as well as screening for and transmission of blood-borne diseases. All areas of apheresis - therapeutic and collection - are also addressed. We would like to specifically encourage allied health professionals in this area to submit manuscripts that relate to improved patient and donor care, technical aspects and educational issues. Transfusion and Apheresis Science features a "Theme" section which includes, in each issue, a group of papers designed to review a specific topic of current importance in transfusion and hemostasis for the discussion of topical issues specific to apheresis and focuses on the operators'' viewpoint. Another section is "What''s Happening" which provides informal reporting of activities in the field. In addition, brief case reports and Letters to the Editor, as well as reviews of meetings and events of general interest, and a listing of recent patents make the journal a complete source of information for practitioners of transfusion, hemostasis and apheresis science. Immediate dissemination of important information is ensured by the commitment of Transfusion and Apheresis Science to rapid publication of both symposia and submitted papers.