Transfusion and Apheresis Science最新文献

{"title":"A Comprehensive SWOT and TOWS analysis of transfusion medicine: Indian Perspective","authors":"Akshay Chopra,&nbsp;Shamee Shastry,&nbsp;Ganesh Mohan,&nbsp;Deepika Chenna,&nbsp;Vinu Rajendran","doi":"10.1016/j.transci.2024.104061","DOIUrl":"10.1016/j.transci.2024.104061","url":null,"abstract":"<div><h3>Background and objective</h3><div>SWOT and TOWS analysis is a strategic planning tool for identifying internal and external factors influencing a field. It helps to identify areas for improvement and growth by maximizing strengths and opportunities while minimizing weaknesses and threats. Transfusion medicine specialists can better understand the field's current status and plan potential growth using SWOT and TWOS strategic tools.</div></div><div><h3>Methods</h3><div>A cross-sectional questionnaire-based study using Google Forms, was conducted among Transfusion Medicine specialists in India. The authors formulated five open-ended questions for each of the S, W, O, and T categories to address and analyze the main aspects of Strengths, Weaknesses, Opportunities, and Threats. Descriptive statistics analyzed demographic details and keywords, extracting factors for SWOT and TOWS analysis to develop strategies.</div></div><div><h3>Results</h3><div>71 specialists, across India: Central (8), East (7), North (18), South (31), and West (7) responded, achieving a 48 % response rate. Strengths focused on Immunohematology and blood safety. Conversely, weaknesses highlighted were limited clinical exposure and insufficient recognition within the medical fraternity. Fostering interdisciplinary collaboration and integrating emerging advancements were key opportunities identified. The prevailing concerns encompassed two primary threats: the potential overlap with related branches like pathology, and the emergence of artificial blood products. The SO, ST, WO, and WT strategies focused on apheresis, recruitment policy, clinical exposure, and newer developments, respectively.</div></div><div><h3>Conclusion</h3><div>This study highlights the application of SWOT and TWOS analysis as a valuable strategic tool for Transfusion Medicine specialists to address these factors proactively and to enhance the field's trajectory.</div></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"64 1","pages":"Article 104061"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142886317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Platelet proteomics: Clinical implications – Decoding the black box!","authors":"Hadi Goubran ,&nbsp;Shahid Ahmed ,&nbsp;Gaafar Ragab ,&nbsp;Jerard Seghatchian ,&nbsp;Thierry Burnouf","doi":"10.1016/j.transci.2024.104060","DOIUrl":"10.1016/j.transci.2024.104060","url":null,"abstract":"<div><div>Platelets are anucleate blood cells traditionally associated with hemostasis but now increasingly recognized for their multifaceted roles in immunity, inflammation, and tissue repair. Advances in platelet proteomics, employing high-throughput techniques such as mass spectrometry, have significantly enhanced our understanding of platelet biology and its clinical implications in transfusion medicine. Platelet proteomics offers a retrospective view of physiological and pathological changes over the platelet's 7–10-day lifespan, making it a unique tool for studying cumulative biological events. Recent applications include the identification of biomarkers for cardiovascular, infectious, autoimmune diseases and cancer. In neurodegeneration and aging, platelets have been explored for their shared molecular pathways with neurons, with findings implicating Tau, amyloid-beta, and alpha-synuclein as potential biomarkers. Proteomics is also emerging as an important factor in the development of evidence-based, tailor-made platelet-derived therapies. While promising, platelet proteomics requires further standardization and computational advances to support transitioning from research to routine clinical practice.</div></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"64 1","pages":"Article 104060"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142886328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is there a relationship between vitamin D levels and graft versus host disease?","authors":"Tugce Nur Yigenoglu ,&nbsp;Bahar Uncu Ulu ,&nbsp;Sinem Namdaroglu ,&nbsp;Mehmet Ali Erkurt ,&nbsp;Rasim Sahin ,&nbsp;Nazik Okumus ,&nbsp;Seda Yilmaz ,&nbsp;Funda Ceran ,&nbsp;Mehmet Koca ,&nbsp;Ugur Hatipoglu ,&nbsp;Mehmet Sinan Dal ,&nbsp;Serdal Korkmaz ,&nbsp;Turgay Ulas ,&nbsp;Fevzi Altuntas","doi":"10.1016/j.transci.2024.104054","DOIUrl":"10.1016/j.transci.2024.104054","url":null,"abstract":"<div><h3>Objective</h3><div>Vitamin D deficiency is common in adult patients undergoing allogenic hematopoietic stem cell transplantation (allo-HSCT). Since vitamin D is an important regulatory factor for the immune system, vitamin D deficiency may have effects on antitumor activity, relapse rates, graft versus host disease (GVHD) occurrence and infection rates in allo-HSCT. We aimed to investigate the effects of vitamin D levels on the outcome of allo-HSCT.</div></div><div><h3>Material and methods</h3><div>This study included 211 patients who underwent allo-HSCT at seven transplant centers in Türkiye. The impact of pretransplant vitamin D level on overall survival (OS), relapse rate, GVHD occurrence and engraftment times was analyzed retrospectively</div></div><div><h3>Results</h3><div>Pretransplant vitamin D levels were not related to the neutrophil engraftment day (p: 0.887), relapse rate (p: 0.433) and GVHD occurrence (p: 0.391). At a median follow-up of 14 months, OS was 84.8 % and median OS was not reached. Univariate Cox Regression analysis showed that higher levels of vitamin D (&gt;12 ng/mL) affected the survival rates (p = 0.029) (HR: 0.392: 95 % CI: 10.170–0.907).</div></div><div><h3>Conclusion</h3><div>In our study, pretransplant vitamin D levels were not related to GVHD occurrence, relapse rate and engraftment times. However, we found that higher levels of pretransplant vitamin D levels (threshold is 12 ng/mL) were associated with increased survival. Further studies with a larger population are necessary to reveal the role of vitamin D in patients undergoing allo-HSCT.</div></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"64 1","pages":"Article 104054"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142878416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of multiple apheresis platelet donations for the iron nutrition condition and platelet parameters of blood donors in China: A meta-analysis study","authors":"Quan Sun ,&nbsp;Liying Wu ,&nbsp;Yao Shen ,&nbsp;Le Wang ,&nbsp;Xiujuan Shen","doi":"10.1016/j.transci.2024.104043","DOIUrl":"10.1016/j.transci.2024.104043","url":null,"abstract":"<div><h3>Background</h3><div>Apheresis platelets is a common platelets collection method with high purity and relatively few adverse reactions. This study aimed to explore the effects of multiple apheresis platelet donations on the condition of iron nutrition and platelet parameters of donors in China.</div></div><div><h3>Methods</h3><div>Eligible studies were selected from PubMed, EMBASE, Wanfang, CQVIP, and the Chinese National Knowledge Infrastructure (CNKI) databases. Pooled serum ferritin (SF), serum iron (SI), transferrin (TRF), soluble transferrin receptor (sTfR), platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), and platelet crit (PCT) were analyzed by weighted mean difference (WMD). Heterogeneity was detected by the Cochran Q test and <em>I</em>² statistical test.</div></div><div><h3>Results</h3><div>Pooled SF (WMD =-20.837, 95 % CI = −26.403 - −15.271) and SI (WMD = −3.828, 95 % CI = −6.516 - −1.139) were significantly decreased; while TRF (WMD = 0.821, 95 % CI = 0.271–1.371) and sTfR (WMD = 0.846, 95 % CI = 0.442–1.250) were increased by multiple apheresis platelet donations. PLT (WMD = 14.894, 95 % CI = 2.574–27.215) and PCT (WMD = 0.035, 95 % CI = 0.005–0.064) were increased, but MPV (WMD = −0.359, 95 % CI = −0.571 - −0.147) was reduced by multiple donations. Subgroup analysis indicated study design is a source of heterogeneity.</div></div><div><h3>Conclusion</h3><div>Multiple apheresis platelets could lead to iron deficiency and suppress platelet function in comparison with first-time apheresis platelets.</div></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"64 1","pages":"Article 104043"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142848196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of ruxolitinib in the management of acute GVHD","authors":"Sinem Namdaroglu ,&nbsp;Emine Hidayet ,&nbsp;Muruvvet Seda Aydin ,&nbsp;Mehmet Ali Erkurt ,&nbsp;Ilhami Berber ,&nbsp;Olgu Erkin Cinar ,&nbsp;Gulsum Ozet ,&nbsp;Seda Yilmaz ,&nbsp;Merve Apaydin ,&nbsp;Mehmet Sinan Dal ,&nbsp;Serdal Korkmaz ,&nbsp;Abdulkadir Basturk ,&nbsp;Turgay Ulaş ,&nbsp;Fevzi Altuntas","doi":"10.1016/j.transci.2024.104055","DOIUrl":"10.1016/j.transci.2024.104055","url":null,"abstract":"<div><h3>Background and objectives</h3><div>Following an allogeneic hematopoietic stem cell transplant (allo-HSCT), a primary cause of morbidity and mortality is still steroid-refractory acute graft-versus-host disease (SR-aGVHD). Recently, ruxolitinib, an oral inhibitor of JAK1 and JAK2, was approved for use in individuals suffering from SR-aGVHD. This study aimed to analyze the efficacy and toxicity of ruxolitinib in the real world.</div></div><div><h3>Material and methods</h3><div>In the present study, we investigated the effectiveness and toxicity of ruxolitinib in patients with SR-aGVHD using a multicenter retrospective analysis. We enrolled 23 patients between 2018 and 2024 who received ruxolitinib treatment for SR-aGVHD.</div></div><div><h3>Results</h3><div>The first response was acheived in a median of 28 days (range, 12–150). The overall response rate (ORR) for ruxolitinib therapy was 43.5 % (10/23) after one month and 61 % (14/23) after two months, respectively. The median overall survival was 69 months. Reactivation of cytomegalovirus (26.1 %) and grade 3–4 anemia (30.4 %) were the two main side effects of ruxolitinib therapy. Seven patients (30.4 %) passed away following a follow-up of a median of six months (range 1–70). The reasons for death included sepsis (n = 2, 28.6 %), progression of aGVHD (n = 3, 42.8 %), and other reasons.</div></div><div><h3>Conclusion</h3><div>Ruxolitinib has an ORR of 61 % for SR-aGVHD, making it a safe and effective therapy choice in real-world settings.</div></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"64 1","pages":"Article 104055"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142886333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term complications, survival and mortality in splenectomised adult transfusion-dependent thalassemia patients","authors":"Urmimala Bhattacharjee ,&nbsp;Alka Khadwal ,&nbsp;Charanpreet Singh ,&nbsp;Deepak Bansal ,&nbsp;Amita Trehan ,&nbsp;Thakur Deen Yadav ,&nbsp;Arihant Jain ,&nbsp;Gaurav Prakash ,&nbsp;Prashant Sharma ,&nbsp;Reena Das ,&nbsp;Pankaj Malhotra","doi":"10.1016/j.transci.2024.104064","DOIUrl":"10.1016/j.transci.2024.104064","url":null,"abstract":"<div><h3>Background</h3><div>Splenectomy is frequently performed in transfusion-dependent thalassemia (TDT) patients to lower blood transfusion needs but is associated with significant long-term complications, including sepsis, thrombosis, and pulmonary hypertension. This study examines the long-term complications, survival rates, and causes of mortality among adult patients with TDT who have undergone splenectomy in a low and middle-income country (LMIC).</div></div><div><h3>Methods</h3><div>A retrospective analysis was conducted on 103 adult TDT patients (≥18 years) who underwent splenectomy between July 2013 and March 2024. Data collected included demographic and clinical characteristics, haematological parameters, transfusion requirements before splenectomy and at the last follow-up, survival rates, complications, and mortality causes.</div></div><div><h3>Results</h3><div>The median age at splenectomy was 12 years (range 5–34). The majority (98 %) underwent open splenectomy. The yearly transfusion volume decreased from 276.7 ml/kg/year pre-splenectomy (range 207–433) to 146.2 (range 0–252.9) post-splenectomy at the last follow-up, p &lt; 0.0001. Three patients were completely transfusion-free at the last follow-up. Complications included pulmonary hypertension in 10 (9.7 %), thrombosis in 5 (4.8 %), and overwhelming post-splenectomy infection (OPSI) in 4 (3.9 %). The iron-overload-related complications included cardiomyopathy in 17 (16.5 %), endocrinopathy in 56 (54.3 %), chronic liver disease in 15 (14.5 %) and hepatocellular carcinoma in 2 (0.9 %). The 15-year post-splenectomy overall survival (OS) was 84.7 % (95 % CI- 77.3 % - 92.8 %), with 17 deaths (16.5 %) recorded. Iron-overload-related cardiomyopathy was the leading cause of death in 8 (53.3 %).</div></div><div><h3>Conclusion</h3><div>Splenectomy significantly reduces transfusion requirements in TDT patients but is associated with risks such as thrombosis, pulmonary hypertension, and OPSI. Long-term mortality is primarily driven by iron-overload-related cardiomyopathy.</div></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"64 1","pages":"Article 104064"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142957804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alloanti-D induction in a rare RhD variant (DBT-2) case: Insights from serological and molecular biological testing","authors":"Zhiyuan Xu,&nbsp;Ye Zhang,&nbsp;Tianhong Miao,&nbsp;Tingting Liu,&nbsp;Xiaofei Li","doi":"10.1016/j.transci.2025.104083","DOIUrl":"10.1016/j.transci.2025.104083","url":null,"abstract":"<div><h3>Background</h3><div>The RhD antigen is the most immunogenic within the Rh blood group system， playing a pivotal role in clinic. The D variant phenotype is a rare occurrence, characterized by low expression of the D antigen or partial deletion of the RhD antigen on the surface of red blood cells (RBCs). For individuals with the D variant, transfusion with RhD-negative blood is crucial for ensuring transfusion safety.</div></div><div><h3>Case presentation</h3><div>We present a case of a 63-year-old Han Chinese female, identified as a D variant phenotype without a history of blood transfusion but with a history of pregnancy. Pre-transfusion testing revealed the presence of alloanti-D antibodies. Genetic analysis confirmed the patient's genotype as <em>RHD-CE (5−9)-D,</em> and her phenotype was classified as DBT-2.</div></div><div><h3>Conclusion</h3><div>This report marks the first case in China of anti-D alloimmunization in patients with the D variant. Both serological and molecular detection of the D variant are essential to ensure the safety of blood transfusions.</div></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"64 2","pages":"Article 104083"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143148999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case report of anti-f(ce) antibody identified with unknown autoantibody from ABO discrepancy in a patient with liver cell carcinoma","authors":"Hyorin Kim,&nbsp;Suk Won Seo,&nbsp;Han Joo Kim,&nbsp;Sang-Hyun Hwang,&nbsp;Heung-Bum Oh,&nbsp;Dae-Hyun Ko","doi":"10.1016/j.transci.2024.104046","DOIUrl":"10.1016/j.transci.2024.104046","url":null,"abstract":"<div><div>The Rh blood type has 57 antigens, including D, C, E, c, and e. This blood type is clinically significant, alongside the ABO blood type. The anti-f(ce) antibody is an unexpected antibody that targets an antigen composed of the c and e antigens. We would like to report a case of the anti-f(ce) antibody discovered during an investigation of an ABO discrepancy. A 63-year-old man diagnosed with liver cell carcinoma was hospitalized for endoscopic variceal ligation due to esophageal varix. To prepare for the possibility of transfusion during the procedure, an ABO blood type test was conducted, resulting in B and O in cells and serum/plasma typing, respectively. The unexpected antibody identification test revealed the presence of the anti-f(ce) antibody. The Rh phenotype of the B cells used in the ABO serum/plasma typing test was determined to be ce. The anti-f(ce) antibody present in the patient’s serum reacted with the B cells in the ABO serum/plasma typing test. To our knowledge, this is the first report of anti-f(ce) causing ABO discrepancy in Korea, and only the second reported case worldwide. We hope that our case report on the identification of the rare anti-f(ce) antibody from an ABO discrepancy will be beneficial for transfusion medicine laboratories.</div></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"64 1","pages":"Article 104046"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Message from the new WAA President","authors":"Joseph Schwartz","doi":"10.1016/j.transci.2024.104047","DOIUrl":"10.1016/j.transci.2024.104047","url":null,"abstract":"","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"64 1","pages":"Article 104047"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging trends and controversies in GVHD management: Bridging research and clinical practice","authors":"Fevzi Altuntas","doi":"10.1016/j.transci.2024.104049","DOIUrl":"10.1016/j.transci.2024.104049","url":null,"abstract":"","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"64 1","pages":"Article 104049"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}