{"title":"A predictive score model based on complete blood count for a single-unit red blood cell transfusion","authors":"Prakarn Sawatdee , Oytip Nathalang , Dollapak Apipongrat , Kamphon Intharanut","doi":"10.1016/j.transci.2025.104242","DOIUrl":"10.1016/j.transci.2025.104242","url":null,"abstract":"<div><h3>Background</h3><div>Red blood cell (RBC) transfusions are life-saving options for those who are unable to carry oxygen. Although administering a single RBC unit usually elicits a sufficient response, identifying the optimal transfusion trigger can be challenging because this variable remains unknown.</div></div><div><h3>Objectives</h3><div>This study aimed to develop a one-unit RBC Transfusion Requirement Scoring Model (1RTRSM), a predictive scoring system through studying the value of each CBC parameter and basic demographics of the patients. Methods: A five-year, retrospective study of patients requesting a single unit of RBC transfusion was carried out to determine the variables influencing transfusion, develop a scoring tool, and pilot test it one year prospectively. Age, sex, ABO grouping and Rh(D) typing department and CBC parameters were included. Based on transfusion status, the results were divided in cases and controls. The score was determined, and the cut-off was assigned using the receiver operating characteristic curve.</div></div><div><h3>Results</h3><div>Totally, 10,995 individuals - 4635 controls and 6320 cases - were included. They were selected to construct the score considering they possessed positively predicted one-unit RBC transfusion: male, age ≥ 43 years, Hb < 8.9, g/dL, RDW ≥ 15.0 %, PLT < 229.9 × 10 ³ /μL, and MPV < 9.9 fL. The total score value of 5 was chosen as the cut-off with strengths of 87 % accuracy, 89 % sensitivity and 85 % specificity. Within a pilot study, the score's accuracy over all departments was 85 %.</div></div><div><h3>Conclusions</h3><div>We established a novel 1RTRSM model that predicts patients' transfusion needs across a variety of departments using a simple, valid and reliable tool demonstrating high accuracy.</div></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"64 5","pages":"Article 104242"},"PeriodicalIF":1.2,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144880264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
İbrahim Kaya , İsmet Mert Erdoğan , Mustafa Çeltik , Yaman Karakoç , Muhammed Furkan Tosun , Özlem Orhan , Coşkun Ulucaköy
{"title":"Preoperative embolization reduces blood loss and recurrence in aneurysmal bone cyst surgery: A retrospective cohort study","authors":"İbrahim Kaya , İsmet Mert Erdoğan , Mustafa Çeltik , Yaman Karakoç , Muhammed Furkan Tosun , Özlem Orhan , Coşkun Ulucaköy","doi":"10.1016/j.transci.2025.104240","DOIUrl":"10.1016/j.transci.2025.104240","url":null,"abstract":"<div><h3>Aim</h3><div>This study aims to evaluate the effectiveness of preoperative embolization in reducing intraoperative blood loss and transfusion requirements, as well as its impact on recurrence in patients with histopathologically confirmed aneurysmal bone cysts (ABCs).</div></div><div><h3>Methods</h3><div>A retrospective review was conducted on 107 patients who underwent surgical treatment for ABC at a tertiary oncology center between 2004 and 2023. Patients were grouped based on whether they received preoperative embolization (n = 50) or not (n = 57). Data collected included demographic features, lesion location, estimated blood loss (EBL), erythrocyte suspension (ES) transfusion volume, operative time, VAS scores, and recurrence rates.</div></div><div><h3>Results</h3><div>Patients in the embolization group had significantly lower EBL (772 ± 445.4 ml vs. 1220.17 ± 523.37 ml; p < 0.001), VAS scores (2.14 ± 1.92 vs. 3.61 ± 2.52; p = 0.002), and ES transfusion volumes (312 ± 337.2 ml vs. 580.7 ± 394.8 ml; p < 0.001). Recurrence rates were also lower in the embolization group (8 % vs. 24.6 %; p = 0.023). Operative time did not differ significantly (p = 0.089).</div></div><div><h3>Conclusion</h3><div>In conclusion, the use of preoperative embolization in patients with aneurysmal bone cysts may help reduce intraoperative blood loss, transfusion requirements, and the likelihood of postoperative recurrence. In light of its potential to minimize both intraoperative complications and long-term recurrence, embolization should be considered as a component of preoperative planning in appropriately selected cases of ABC.</div></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"64 6","pages":"Article 104240"},"PeriodicalIF":1.2,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144903891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Optimizing anti-seizure medication management in therapeutic plasma exchange: A practical case report","authors":"Valentin Coirier , Marie Gallais , Adrien Benard , Dragos-Mihai Maliia , Joanna Bourgine , Bénédicte Franck","doi":"10.1016/j.transci.2025.104239","DOIUrl":"10.1016/j.transci.2025.104239","url":null,"abstract":"<div><div>Therapeutic plasma exchange (TPE) is a widely employed procedure for treating several diseases. However, its impact on drug removal is understudied. In critical care settings, the therapeutic window is often narrow but crucial to optimize drug efficacy. This case report details a new onset of refractory status epilepticus, which required the administration of four concomitant anti-seizure medications and the implementation of TPE. We conducted drug monitoring before and after TPE sessions, describing for the first time the removal rate of midazolam and propofol during TPE (low removal rate), and confirming existing data concerning levetiracetam and phenytoin. In critically ill patients, the concomitant use of narrow therapeutic index drugs and plasma exchange requires close drug monitoring.</div></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"64 5","pages":"Article 104239"},"PeriodicalIF":1.2,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144830500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rui Murahashi , Shin-ichiro Fujiwara , Daisuke Minakata , Masahiro Ashizawa , Chihiro Yamamoto , Kaoru Hatano , Kazuya Sato , Ikuko Otsuki , Ken Ohmine , Yoshinobu Kanda
{"title":"Actual versus ideal donor body weight in planning bone marrow harvest","authors":"Rui Murahashi , Shin-ichiro Fujiwara , Daisuke Minakata , Masahiro Ashizawa , Chihiro Yamamoto , Kaoru Hatano , Kazuya Sato , Ikuko Otsuki , Ken Ohmine , Yoshinobu Kanda","doi":"10.1016/j.transci.2025.104238","DOIUrl":"10.1016/j.transci.2025.104238","url":null,"abstract":"<div><h3>Background</h3><div>Donor selection and harvest volume calculation typically use actual body weight (ABW). However, in obese donors, increased ABW mainly reflects adipose tissue rather than hematopoietic stem cell (HSC)-rich bone marrow. This study aimed to investigate whether ideal body weight (IBW) is a better indicator than ABW for estimating the required HSC yield.</div></div><div><h3>Study design and methods</h3><div>This study included 157 donors (106 men and 51 women) with a body mass index of ≥ 22. An analysis of the correlation between harvested HSCs and harvested volume per ABW and IBW was performed. Another analysis of the correlation between the decrease in hemoglobin levels and the harvested volume per ABW or IBW was performed.</div></div><div><h3>Results</h3><div>No significant differences were observed in the correlations between total nucleated cell counts and the harvested volume per ABW or IBW, between CD34+ HSCs and the harvested volume per ABW or IBW, and between the decrease in hemoglobin levels and the harvested volume per ABW or IBW in all donors and obese donors.</div></div><div><h3>Conclusions</h3><div>These results showed no significant differences between IBW and ABW as indicators for estimating the required HSC yield. Additionally, the results showed that harvesting per ABW was not excessive.</div></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"64 5","pages":"Article 104238"},"PeriodicalIF":1.2,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144781726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Editorial Note on the contribution from the Spanish Apheresis Group (GEA)","authors":"Gail Rock","doi":"10.1016/j.transci.2025.104223","DOIUrl":"10.1016/j.transci.2025.104223","url":null,"abstract":"","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"64 5","pages":"Article 104223"},"PeriodicalIF":1.2,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144831430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Plant-based diets for CKD patients, green- based Mediterranean diet: A green nephrology view","authors":"Dora Oikonomaki","doi":"10.1016/j.transci.2025.104231","DOIUrl":"10.1016/j.transci.2025.104231","url":null,"abstract":"","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"64 5","pages":"Article 104231"},"PeriodicalIF":1.2,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144763967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Biography of the guest editor for this issue's theme papers on \"Green\" methodology in blood purification techniques","authors":"Ioannis Griveas","doi":"10.1016/j.transci.2025.104225","DOIUrl":"10.1016/j.transci.2025.104225","url":null,"abstract":"","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"64 5","pages":"Article 104225"},"PeriodicalIF":1.2,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144779645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A place for plasmapheresis","authors":"Lise Sofie H. Nissen-Meyer","doi":"10.1016/j.transci.2025.104234","DOIUrl":"10.1016/j.transci.2025.104234","url":null,"abstract":"<div><div>The increased need for source plasma in the production of plasma-derived medical products has received attention and elicited diverse actions in Europe lately. The discrepancy between production and utilization poses ethical as well as medical questions to be discussed in the international community. The contribution of non-remunerated voluntary donors should be encouraged, and several nations have addressed the problem in national plasma strategy documents. Independent of this, blood centers have increased their plasmapheresis activity in efforts to increase plasma donation and retain valuable donors, in parallel with decreased use of cellular blood products. In Oslo Blood Center we have encouraged our whole blood donors to also donate plasma, by which we keep them active and prepared for whole blood donation if an urgent situation rises. In this commentary I describe the change of mind set necessary to increase the number of plasmaphereses within the current frameworks.</div></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"64 5","pages":"Article 104234"},"PeriodicalIF":1.2,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144781725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Citrate, a green alternative to heparin","authors":"Ioannis Griveas","doi":"10.1016/j.transci.2025.104229","DOIUrl":"10.1016/j.transci.2025.104229","url":null,"abstract":"<div><div>An alternative to systemic heparin anticoagulation for HD is citrate dialysate (CD) which contains a small amount of citric acid. The nephrology community demands an environmentally sustainable kidney care and among others, heparin is a threat to planetary health. Citrate is the green alternative to heparin in HD and it is most likely better for the internal enviromment since it simultaneously provokes increased hemoglobin with a fixed dose of erythropoietin and reduced iron administration.</div></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"64 5","pages":"Article 104229"},"PeriodicalIF":1.2,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144773185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"\"Green\" methodology: An overview and basic principles","authors":"Ioannis Griveas","doi":"10.1016/j.transci.2025.104226","DOIUrl":"10.1016/j.transci.2025.104226","url":null,"abstract":"<div><div>Annual carbon emissions for dialysis treatments in different regions range from 3818–10,200 kgrs for haemodialysis (HD) and 1450–4503 CO2 eq/pt/year which correlates to the carbon foot print of production of 2727–7285 lits or driving a car for 27,291–72,909 km. In order to communicate as a scientific team and to understand each other we have to use terms that actually describe our “problem”. There is also need of a full environmental assessment concerning blood purification technology.</div></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"64 5","pages":"Article 104226"},"PeriodicalIF":1.2,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144779646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}