Transfusion and Apheresis Science最新文献_第2页

Bacterial contamination of platelets concentrates in a lower middle-income country: Data from a single tertiary care hospital 中低收入国家浓缩血小板的细菌污染：来自一家三级医院的数据

IF 1.4 4区医学

Transfusion and Apheresis Science Pub Date : 2024-10-17 DOI: 10.1016/j.transci.2024.104018

Bhawna Kumari , Muhammad Hasan , Seema Irfan , Abdullah Khalid , Bushra Moiz

{"title":"Bacterial contamination of platelets concentrates in a lower middle-income country: Data from a single tertiary care hospital","authors":"Bhawna Kumari , Muhammad Hasan , Seema Irfan , Abdullah Khalid , Bushra Moiz","doi":"10.1016/j.transci.2024.104018","DOIUrl":"10.1016/j.transci.2024.104018","url":null,"abstract":"<div><h3>Background</h3><div>Transfusion of bacterially contaminated platelets may cause life threatening sepsis in the recipients. Cost of platelet screening is a major challenge for low middle income countries (LMICs). In this study, we evaluated the frequency of bacterial contamination in the platelet units (PUs) and the outcome of transfusing such platelets to the patients in a single institute at Pakistan.</div></div><div><h3>Material and methods</h3><div>During 2018–2022, whole blood-derived (WB-PU) and apheresis platelets (AP) were screened by BacT-ALERT® automated system. Single sample from each AP and samples from ≤ 5 WB-PUs were pooled and cultured within 24 h-post collection. An initial positive signal was followed by re-culture, Gram’s staining, pool resolution and bacterial identification. Results were interpreted as ‘confirmed positive’ or ‘indeterminate’ and ‘confirmed negative’ based on differences in initial-reactive and final results.</div></div><div><h3>Results</h3><div>A total of 84246 PUs (476 AP and 83770 WB-PU) was screened, and 239 (0.28 %) culture bottles were positive on day one. Individual cultures were performed on 1378 PUs (239 bottles) for pool resolution. Seven of 1378 (0.5 %) PUs were ‘confirmed positive’ while 1371 (99.4 %) were ‘indeterminate’. No bacterial growth was observed in 82868 (82392 WB-PU and 476 AP) of 84246 (98.3 %). Overall bacterial contamination rate was low at 1 in 12000 PUs approximately. Seven patients were transfused with contaminated PUs but no transfusion reaction was observed.</div></div><div><h3>Conclusion</h3><div>An insignificant risk of bacterial contamination was observed in this study but remains a concern for patient safety. LMICs need cost effective but efficient techniques to screen platelets for the presence of bacteria.</div></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"63 6","pages":"Article 104018"},"PeriodicalIF":1.4,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142446089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Biographies of the TAS Senior and his Guest Editor for the Theme papers on donors factors TAS Senior 及其捐助方因素主题文件特邀编辑的简历。

IF 1.4 4区医学

Transfusion and Apheresis Science Pub Date : 2024-10-17 DOI: 10.1016/j.transci.2024.104015

Jerard Seghatchian, Jason Acker

引用次数: 0

Guest Editorial: Advancements in blood donor factors: Understanding their variability and implications on the clinical outcomes of recipients. Where are we now! 特邀社论：献血因子的进展：了解其变异性及其对受血者临床结果的影响。我们现在在哪里？

IF 1.4 4区医学

Transfusion and Apheresis Science Pub Date : 2024-10-16 DOI: 10.1016/j.transci.2024.104014

Jerard Seghatchian, Jason Acker

引用次数: 0

It’s in your blood: The impact of age, sex, genetic factors and exposures on stored red blood cell metabolism 它就在你的血液里年龄、性别、遗传因素和暴露对储存的红细胞代谢的影响

IF 1.4 4区医学

Transfusion and Apheresis Science Pub Date : 2024-10-15 DOI: 10.1016/j.transci.2024.104011

Angelo D’Alessandro

{"title":"It’s in your blood: The impact of age, sex, genetic factors and exposures on stored red blood cell metabolism","authors":"Angelo D’Alessandro","doi":"10.1016/j.transci.2024.104011","DOIUrl":"10.1016/j.transci.2024.104011","url":null,"abstract":"<div><div>Transfusion of packed red blood cell (RBCs) saves millions of lives yearly worldwide, making packed RBCs the most commonly administered drug in hospitals after vaccines. However, not all blood units are created equal. By examining blood products as they age in blood banks, transfusion scientists are gaining insights into the intricacies of human chemical individuality as regulated by biological factors (such as sex, age, and body mass index), genetic and non-genetic factors like environmental, dietary, and other exposures. Here, we review recent literature on this topic, with an emphasis on studies linking genetic traits to the metabolic heterogeneity of blood products, the hemolytic propensity of stored RBCs, and transfusion outcomes in both healthy autologous and non-autologous patients requiring transfusion. Given the role of RBCs as a simplified model of eukaryotic cells, and RBC storage as a medically relevant application modeling erythrocyte responses to oxidant stress, these insights have the potential not only to guide the development of precision transfusion strategies, but also to identify novel mechanisms of RBC metabolic regulation relevant to responses to hypoxia and oxidant stress in human (patho)physiology.</div></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"63 6","pages":"Article 104011"},"PeriodicalIF":1.4,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142446215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Haemolysis in red blood cell components is associated with donor ferritin and body mass index status, but not donation frequency 红细胞成分中的溶血与捐献者的铁蛋白和体重指数状况有关，但与捐献频率无关。

IF 1.4 4区医学

Transfusion and Apheresis Science Pub Date : 2024-10-15 DOI: 10.1016/j.transci.2024.104009

Joanne C.G. Tan , Yeojoon Cha , Htet Htet Aung , Joanna Speedy , Denese C. Marks

{"title":"Haemolysis in red blood cell components is associated with donor ferritin and body mass index status, but not donation frequency","authors":"Joanne C.G. Tan , Yeojoon Cha , Htet Htet Aung , Joanna Speedy , Denese C. Marks","doi":"10.1016/j.transci.2024.104009","DOIUrl":"10.1016/j.transci.2024.104009","url":null,"abstract":"<div><div>Whole blood donors who donate more frequency are more likely to develop iron deficiency, which could potentially affect the quality of the red blood cell (RBC) components during storage. Additional donor factors such as sex, age at donation, donor body mass index (BMI), as well as the manufacturing method could also affect RBC component quality, particularly haemolysis. The aim of this study was to examine the relationship between donation frequency, donor ferritin levels and BMI status on an extensive set of RBC characteristics <em>in vitro</em>, during storage at 2–6 °C for 42 days. A whole blood donation was collected from 787 Australian blood donors, held overnight, before top-and-bottom separation to produce RBC components. RBC components were tested using a panel of <em>in vitro</em> assays. Serum ferritin was tested from a sample taken at the time of donation, and donor demographic data was collected. Haemolysis in RBC components was not found to be associated with donation frequency. Increased red cell haemolysis, lactate concentration, extracellular potassium and RBC-derived microparticle numbers were significantly associated with a high BMI in male donors. There was also a trend towards increased red cell haemolysis in donors with ferritin concentrations in the upper range. Our findings indicate that although older male donors with potentially higher BMI are able to donate whole blood quite frequently, the resultant RBC components may have poorer <em>in vitro</em> quality.</div></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"63 6","pages":"Article 104009"},"PeriodicalIF":1.4,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142478975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Genetic determinants of plasma testosterone in male blood donors are associated with altered red blood cell characteristics and survival in cold storage and after transfusion 男性献血者血浆睾酮的遗传决定因素与红细胞特性的改变以及冷藏和输血后的存活率有关。

IF 1.4 4区医学

Transfusion and Apheresis Science Pub Date : 2024-10-15 DOI: 10.1016/j.transci.2024.104017

Fang Fang , Nareg H. Roubinian , Scott-Wesley Bean , Cassie Kemmler , Grier G. Page , Tamir Kanias

{"title":"Genetic determinants of plasma testosterone in male blood donors are associated with altered red blood cell characteristics and survival in cold storage and after transfusion","authors":"Fang Fang , Nareg H. Roubinian , Scott-Wesley Bean , Cassie Kemmler , Grier G. Page , Tamir Kanias","doi":"10.1016/j.transci.2024.104017","DOIUrl":"10.1016/j.transci.2024.104017","url":null,"abstract":"<div><div>Genetic mutations in genes regulating plasma testosterone in men may interfere with effective erythropoiesis, and may result in red blood cell (RBC) dysfunction and hemolysis. The aim of this study was to identify genetic polymorphisms in male donors that regulate plasma testosterone and impact RBC survival in cold storage and after transfusion. We evaluated nine single nucleotide polymorphisms (SNPs) previously reported to be associated with circulating testosterone in male plasma. These SNPs were linked with donor-component-recipient databases (NIH REDS program) to determine SNP associations with donor RBC hematological indices, osmotic and oxidative hemolysis, and RBC transfusion effectiveness defined as adjusted hemoglobin increments (delta hemoglobin, ΔHb) following a single RBC unit transfusion. Four of the nine testosterone SNPs were located on the X chromosome, of which two (rs7057002, rs73629199) were significantly associated with reduced hemoglobin increments (0.2 and 0.3 g/dL, respectively) compared with reference alleles in transfused recipients. Seven of the nine testosterone SNPs were associated with significant changes in RBC susceptibility to osmotic hemolysis including a missense mutation in the major plasma carrier of testosterone (SHBG<em>,</em> rs6259), and four SNPs with changes in oxidative hemolysis. Four SNPs were associated with decreased RBC count, hemoglobin, and hematocrit. Ancestry/ethnicity-specific (African and Hispanic) associations were observed between two SNPs (rs7057002, rs7879462) and oxidative hemolysis. Genetic determinants of plasma testosterone in male donors significantly impact the quality and transfusion effectiveness of cold stored RBCs. Testosterone SNPs associated with decreased RBC transfusion effectiveness may have clinical implications and warrant further revaluation.</div></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"63 6","pages":"Article 104017"},"PeriodicalIF":1.4,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142478973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Donor clinical characteristics and impacts on transfusion recipient outcomes 捐献者的临床特征及其对输血受体结果的影响。

IF 1.4 4区医学

Transfusion and Apheresis Science Pub Date : 2024-10-15 DOI: 10.1016/j.transci.2024.104012

Shuoyan Ning , Michelle Zeller , Nancy M. Heddle

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Sex discrepancies in blood donation: Implications for red blood cell characteristics and transfusion efficacy 献血中的性别差异：对红细胞特性和输血效果的影响

IF 1.4 4区医学

Transfusion and Apheresis Science Pub Date : 2024-10-15 DOI: 10.1016/j.transci.2024.104016

Abdulrahman Alshalani , Hamood AlSudais , Sarah Binhassan , Nicole P. Juffermans

{"title":"Sex discrepancies in blood donation: Implications for red blood cell characteristics and transfusion efficacy","authors":"Abdulrahman Alshalani , Hamood AlSudais , Sarah Binhassan , Nicole P. Juffermans","doi":"10.1016/j.transci.2024.104016","DOIUrl":"10.1016/j.transci.2024.104016","url":null,"abstract":"<div><div>Red blood cell (RBC) transfusions carry risks, and the mechanisms mediating adverse transfusion outcomes are not fully understood. This review explores the impact of donor sex and donor-recipient sex mismatch on RBC characteristics and transfusion outcomes. Females, at least those in their reproductive age, have a higher proportion of young RBCs in the circulation when compared to males, associated with higher post transfusion recovery. Also, female RBCs exhibit a greater resilience to the storage lesion, with lower hemolysis rates and better rheologic properties. Despite these qualities, transfusion of female RBCs may be associated with adverse transfusion outcomes, such as pulmonary injury, increased mortality, and immunomodulatory effects, which may differ depending on the sex of the recipient, although not all observations are consistent. As a potential mechanism, the presence of immature RBCs, especially reticulocytes, in transfused blood is associated with immunomodulatory effects. Reticulocytes contain residual cellular components which can interact with surrounding blood cells and endothelial cells, in particular in neonates and cancer patients. Understanding the influence of donor sex and RBC age-subpopulation on RBC quality, and investigating the risks and benefits of immature RBCs in transfusions, offers opportunities for optimizing transfusion practices.</div></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"63 6","pages":"Article 104016"},"PeriodicalIF":1.4,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142446088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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RBC subpopulations in RCCs affected by donor factors 受供体因素影响的 RCC 中的红细胞亚群。

IF 1.4 4区医学

Transfusion and Apheresis Science Pub Date : 2024-10-15 DOI: 10.1016/j.transci.2024.104010

Mahsa Yazdanbakhsh , Celina Phan , Nishaka William , Jason P. Acker

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Circulating microRNAs and migrasomes: Present and future bullseyes in extracorporeal photopheresis? 循环微RNA和迁移体：体外光子疗法的现状与未来？

IF 1.4 4区医学

Transfusion and Apheresis Science Pub Date : 2024-09-26 DOI: 10.1016/j.transci.2024.104008

Yandy Marx Castillo-Aleman

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