Transfusion and Apheresis Science最新文献

{"title":"Transforming ABO IgG titration: Real-world comparison of automated SPRCA vs. CAT with dithiothreitol (DTT) inactivation of IgM in 1600 ABO-incompatible solid organ transplant patient samples","authors":"Amena Ebadur Rahman ,&nbsp;Rasika Dhawan Setia ,&nbsp;Mitu Dogra ,&nbsp;Abhideep Chaudhary ,&nbsp;Ashwini Goel ,&nbsp;Amit Kumar Singhal ,&nbsp;Vadad ,&nbsp;Sonia Joseph ,&nbsp;Priyasha Prajapat","doi":"10.1016/j.transci.2025.104198","DOIUrl":"10.1016/j.transci.2025.104198","url":null,"abstract":"<div><div>Anti-ABO IgG isohemagglutinin(IHA) titration plays a vital role in guiding ABO-incompatible solid organ transplantation(ABOi-SOT). Column agglutination technology (CAT), though widely used, requires DTT pre-treatment to eliminate IgM interference. This poses significant challenges, including subjectivity, inconsistent IgM inactivation, frequent sample gelling, and prolonged turnaround times(TAT), all of which compromise accuracy and standardization. These limitations have prompted global interest in DTT-free, IgG-specific methods that enhance analytical precision and workflow efficiency.</div></div><div><h3>Study Design and Methods</h3><div>This prospective single-centre study (August 2019–October 2024) evaluated 1622 samples from 300 ABOi-SOT candidates; baseline titres done for all; 139 underwent transplantation. IgG titers were assessed via DTT-treated CAT [CAT(DTT)] and SPRCA during desensitization phase and post-transplant monitoring. IHA IgG titers were compared between CAT(DTT) and fully automated solid-phase red cell adherence assay (SPRCA). Concordance &amp; reproducibility was assessed using Pearson’s correlation and Cohen’s kappa and TATs compared.</div></div><div><h3>Results</h3><div>SPRCA showed strong correlation with CAT (DTT) for IgG titers (r = 0.949; κ = 0.71), with 91.4 % of values within ±1 dilution. Mean IgG TAT was significantly lower for SPRCA (65.26 ± 14.41 min) compared to CAT (DTT) (111.43 ± 19.5 min; p &lt; 0.0001). SPRCA demonstrated minimal inter-technologist variability and elimination of manual pre-DTT treatment steps translating to faster, more consistent results, enabling timely therapeutic decisions.</div></div><div><h3>Conclusion</h3><div>SPRCA is a robust, automated, and IgG-specific platform that overcomes key limitations of CAT. Its implementation in transplant workflows can enhance standardization, reduce delays, and support better outcomes, particularly critical in high-throughput ABOi transplant settings.</div></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"64 4","pages":"Article 104198"},"PeriodicalIF":1.4,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144513526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating recurrent immune-mediated thrombotic thrombocytopenic purpura (iTTP) in pregnancy: A case report and literature review","authors":"Mohadese Golsorkhi ,&nbsp;Niloufar Ebrahimi ,&nbsp;Shahram Kordasti ,&nbsp;Sayna Norouzi ,&nbsp;Amir Abdipour","doi":"10.1016/j.transci.2025.104199","DOIUrl":"10.1016/j.transci.2025.104199","url":null,"abstract":"<div><div>Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is a rare and potentially fatal thrombotic microangiopathy characterized by thrombocytopenia and microangiopathic hemolytic anemia. It primarily affects women of childbearing age, with pregnancy being a significant precipitating factor. TTP overlaps with other pregnancy-related conditions, such as HELLP syndrome, complicating diagnosis and necessitating urgent clinical evaluation and intervention. Plasma-based therapies have significantly improved the prognosis for these patients. Additionally, serial follow-up of ADAMTS-13 activity is recommended at the preconception stage and throughout pregnancy for women with a history of TTP. In this report, we present a case of a 32-year-old patient with a recurrent iTTP on her 11-week gestation of the second pregnancy, which was successfully managed with therapeutic plasma exchange (TPE) and corticosteroids.</div></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"64 4","pages":"Article 104199"},"PeriodicalIF":1.4,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144556777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The comparison of cyclophosphamide at different dose levels for stem cell mobilization in multiple myeloma","authors":"Abdullah Karakus ,&nbsp;Ugur Hatipoglu ,&nbsp;Yavuz Katircilar ,&nbsp;Mehmet Ali Erkurt ,&nbsp;Seda Yilmaz ,&nbsp;Gulsum Akgun Cagliyan ,&nbsp;Fahir Ozturk ,&nbsp;Emine Hidayet ,&nbsp;Sinan Demircioglu ,&nbsp;Mustafa Koroglu ,&nbsp;Ant Uzay ,&nbsp;Abdulkadir Basturk ,&nbsp;Suleyman Sami Karti ,&nbsp;Ahmet Sarici ,&nbsp;Servihan Unal ,&nbsp;Mehmet Sinan Dal ,&nbsp;Turgay Ulaş ,&nbsp;Serdal Korkmaz ,&nbsp;Fevzi Altuntas","doi":"10.1016/j.transci.2025.104183","DOIUrl":"10.1016/j.transci.2025.104183","url":null,"abstract":"<div><h3>Background</h3><div>We conducted a multi-center retrospective non-randomized study to clarify roles of 2 and 3 gr/m² doses of Cyclophosphamide (Cy) for stem cell mobilization in Multiple Myeloma.</div></div><div><h3>Material and methods</h3><div>This study analyzed 169 adult patients who received Cy-based mobilization regimen at doses 2 and 3 gr/m² between 2018 and 2024. All patients included in this study were 18 years old and older. Patients divided into two groups; group 1 represents 2 gr/m² treated patients, and group 2 represents 3 gr/m² dosing. These two groups then compared in terms of CD34⁺ cell number collected by apheresis, apheresis days, peak peripheral blood CD34⁺ value and rates of mobilization failures.</div></div><div><h3>Results</h3><div>Higher doses of Cy yielded more hematopoietic stem cells compared to the lower dose Cy [10.00 (3.00–28.90) vs 9.01 (5.00–14.90), p = 0.002]; while mobilization failures and apheresis days were comparable across groups (p = 0.112 and p = 0.648, respectively). Apheresis days required for adequate stem cell harvest among groups was found statistically similar (p = 0.648).</div></div><div><h3>Conclusion</h3><div>This study indicated the superior efficacy of 3 gr/m² dose of Cy in terms of stem cell yield. However, mobilization failure and prolonged apheresis sessions were not issues with lower doses.</div></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"64 4","pages":"Article 104183"},"PeriodicalIF":1.4,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144570908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of age and gravidity on CD34+ yields in female peripheral blood stem cell donors","authors":"Hong Lin ,&nbsp;Danning Li ,&nbsp;Jamie Thompson ,&nbsp;David Winstone ,&nbsp;Alan Lankester ,&nbsp;Ying Li","doi":"10.1016/j.transci.2025.104196","DOIUrl":"10.1016/j.transci.2025.104196","url":null,"abstract":"<div><div>Donor age has long been recognized as negatively affecting CD34 + yield following Peripheral Blood Stem Cell (PBSC) mobilization. However, its impact on male versus female donors has not been separately examined. In addition, the potential influence of pregnancy history on female donors remains underexplored. The retrospective study extracted donation data from 267 female donors with known pregnancy history, grouped by age and number of gravidities, and CD34 + yields post-PBSC mobilization were compared. The study revealed a decline in CD34 + yields with increasing donor age, but an elevation in yields among female donors aged 41–50, a pattern not seen with male donors. There was no difference in yields between nulligravida donors and those with 2 or 3 gravidities, and the latter cohort showed significantly higher yields than donors with 1 or 4 + gravidities. For donors in their 40 s, CD34 + yields were either higher than or similar to those of younger donors with the same number of gravidities, suggesting an additional effect of this age group on stem cell yields. Nevertheless, recipients’ engraftment outcomes were comparable among donors with varying numbers of gravidities and nulligravida donors. This study demonstrates that female donors aged 41–50 have CD34 + yields similar to male donors, and those with 2–3 previous pregnancies exhibit CD34 + yields comparable to those of nulligravida donors and significantly higher than those of other gravidity groups. These findings suggest that age and pregnancy history influence stem cell mobilisation, emphasizing the need for further research into their underlying biological mechanisms and clinical significance.</div></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"64 4","pages":"Article 104196"},"PeriodicalIF":1.4,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144517576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of storage temperature and time on growth factor concentration in single-harvest platelet-rich plasma","authors":"Yulin Wang ,&nbsp;Xiaona Fu ,&nbsp;Dongdong Cao","doi":"10.1016/j.transci.2025.104197","DOIUrl":"10.1016/j.transci.2025.104197","url":null,"abstract":"<div><h3>Introduction</h3><div>Based on its therapeutic potential, the Platelet-rich plasma (PRP) therapy doubled in interest. Storage of this blood product in appropriate conditions allows for many interventions and increased clinical use. This research was intended to determine how the change in the storage temperature and time affects the concentrations of the essential growth factors of the PRP, which determines its biological activity.</div></div><div><h3>Methods</h3><div>PRP was prepared from 10 healthy donors and stored at room temperature (RT; 22°C), 4°C, and −65°C. Aliquots were analyzed at baseline (0 days), 1, 3, and 6 days post-preparation. Growth factors platelet-derived growth factor-AA (PDGF-AA), transforming growth factor-β (TGF-β), vascular endothelial growth factor (VEGF), and fibroblast growth factor-basic (b-FGF) were quantified after activation using Triton-X (PDGF-AA, VEGF, b-FGF) or sonication (TGF-β1), with sandwich immunoassays.</div></div><div><h3>Results</h3><div>PDGF-AA concentrations consistently declined over time across all storage conditions. In contrast, TGF-β1 levels progressively increased, reaching peak concentrations by day 6. VEGF exhibited a reduction in samples stored at RT and −65 °C, while b-FGF concentrations dropped sharply after 24 h in these same groups. Refrigeration (4 °C) showed intermediate effects on growth factor stability compared to other temperatures.</div></div><div><h3>Conclusion</h3><div>Growth factor concentrations in PRP varied significantly depending on the activation technique, with no difference in activators for the same growth factor. These findings underscore the importance of optimizing storage protocols to preserve PRP’s bioactive properties. For clinical efficacy, PRP should be activated and stored under conditions that maintain growth factor integrity, ensuring maximal therapeutic benefit.</div></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"64 4","pages":"Article 104197"},"PeriodicalIF":1.4,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144490233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of peripheral stem cell mobilization research progress (2000–2023) based on bibliometric data","authors":"Semih Basci,&nbsp;Sinem Namdaroglu,&nbsp;Hikmetullah Batgi","doi":"10.1016/j.transci.2025.104189","DOIUrl":"10.1016/j.transci.2025.104189","url":null,"abstract":"<div><h3>Background</h3><div>Peripheral stem cell mobilization is a key process in hematopoietic stem cell transplantation (HSCT), enabling efficient stem cell collection from peripheral blood. This bibliometric study provides a comprehensive analysis of research trends, major publications, and emerging themes in this field.</div></div><div><h3>Material and methods</h3><div>In this study, bibliographic research on peripheral stem cell mobilization was carried out on peripheral stem cell mobilization using the Web of Science Core Collection (WoSCC) database. Data was gathered from the Science Citation Index Expanded and Emerging Sources Citation Index databases. Bibliometrics was used to evaluate trends in the scientific literature. The study used the Bibliometrix R package for quantitative sociometric research, enabling seamless data extraction and analysis of scholarly literature interconnectedness and trends.</div></div><div><h3>Results</h3><div>The analysis of 293 publications from 2000 to 2023 shows a declining growth trend. There were 19.63 citations per article. Collaborative efforts involve 2176 authors, with an average of 8.74 co-authors per document and a 10.58 % international co-authorship rate. The United States leads in annual article output, while Europe and Asia contribute prominently. Notable journals include \"Bone Marrow Transplantation\" and \"Transfusion and Apheresis Science.\" Keyword analysis highlights key themes in hematopoietic stem cell transplantation research. Top cited articles and detailed citation impact analysis provide insights into global scientific production, trends, and collaborative dynamics.</div></div><div><h3>Discussion</h3><div>This bibliometric article provides a comprehensive overview of peripheral stem cell mobilization research, offering valuable insights for researchers and clinicians in advancing hematopoietic stem cell transplantation and related therapies.</div></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"64 4","pages":"Article 104189"},"PeriodicalIF":1.4,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144490225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors affecting the development of hypokalemia during apheresis in healthy donors","authors":"Wataru Kitamura ,&nbsp;Keiko Fujii ,&nbsp;Hiroki Kobayashi ,&nbsp;Masaya Abe ,&nbsp;Takuya Fukumi ,&nbsp;Kazuhiro Ikeuchi ,&nbsp;Fumio Otsuka ,&nbsp;Yoshinobu Maeda ,&nbsp;Nobuharu Fujii","doi":"10.1016/j.transci.2025.104195","DOIUrl":"10.1016/j.transci.2025.104195","url":null,"abstract":"<div><div>Despite being generally safe, apheresis for peripheral blood stem cell collection potentially disrupts electrolyte balance owing to the use of citric acid as an anticoagulant. As prior research has primarily studied hypocalcemia, information on the kinetics of potassium levels during apheresis in healthy donors is scarce. We investigated the fluctuation in potassium levels during apheresis and the risk factors for hypokalemia. This subanalysis used data from an open-label, randomized controlled trial of “oral calcium supplementation versus placebo in mitigating citrate toxicity” conducted between January 2021 and July 2022, at Okayama University Hospital. Potassium levels were significantly reduced after 5-day granulocyte colony-stimulating factor (G-CSF) administration (<em>p</em> &lt; 0.0001), with seven patients (16.7 %) given oral potassium administration before apheresis because the treating physician deemed potassium levels potentially unsafe and three (7.1 %) presenting with hypokalemia at apheresis. Potassium levels after apheresis were significantly lower than those before apheresis (baseline; <em>p</em> &lt; 0.0001), and 28 of 42 donors (66.7 %) experienced biochemical, clinically unapparent hypokalemia immediately after the completion of apheresis. A &gt; 15 % reduction in potassium levels from baseline was associated with age and the acid citrate dextrose solution A (ACD-A) volume in univariate analysis. In the multivariable analysis, both factors were associated (hazard ratio [HR], 11.60; 95 % confidence interval [CI], 1.60–83.70; <em>p</em> = 0.02 and HR, 17.50; 95 % CI, 1.07–136.00; <em>p</em> = 0.04). In conclusion, G-CSF administration and apheresis ultimately induced hypokalemia in two-thirds of the donors. Older age and higher ACD-A volume may affect potassium levels during apheresis in healthy donors.</div><div><strong>Clinical Trial registration:</strong> jRCTs061200035.</div></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"64 4","pages":"Article 104195"},"PeriodicalIF":1.4,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144366050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mastering quality in transfusion medicine: Establishing best practices through global expert collaboration – September 2025","authors":"Jerard Seghatchian","doi":"10.1016/j.transci.2025.104193","DOIUrl":"10.1016/j.transci.2025.104193","url":null,"abstract":"","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"64 4","pages":"Article 104193"},"PeriodicalIF":1.4,"publicationDate":"2025-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144366049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rotational thromboelastometry (ROTEM) in pediatric intensive care: A single center experience","authors":"Ayşen Durak Aslan ,&nbsp;Fevzi Kahveci ,&nbsp;Nur Ayça Çelik ,&nbsp;Hacer Uçmak ,&nbsp;Bayram Bayramov ,&nbsp;Eda Eyduran ,&nbsp;Merve Havan ,&nbsp;Onat Bermede ,&nbsp;Tanıl Kendirli","doi":"10.1016/j.transci.2025.104194","DOIUrl":"10.1016/j.transci.2025.104194","url":null,"abstract":"<div><div>The study aimed to analyze ROTEM's impact on transfusion practices and investigate the correlation between standard coagulation tests and ROTEM parameters. We designed it as a retrospective descriptive study, using single-center data from January 2021 to February 2023. All critically ill children admitted to PICU who underwent ROTEM analysis as part of their diagnostic and therapeutic management were included in the study. During the analysis period, ROTEM testing was performed on a total of 26 pediatric patients in our PICU, more than half of whom were ECMO patients. To evaluate the impact of ROTEM-guided transfusion on ECMO patients, a control group of ECMO patients who did not receive ROTEM-guided transfusions during the same period was utilized. Propensity score matching, based on baseline characteristics, was employed to create comparable groups of 14 ECMO patients each. The analysis revealed no significant difference in transfusion requirements between those who received ROTEM-guided therapy and those who did not. While no correlation was found between traditional coagulation tests and ROTEM's EXTEM and INTEM parameters, a moderate positive correlation was observed between FIBTEMMCF and fibrinogen levels. A regression model demonstrated that for every unit increase in FIBTEM-MCF, fibrinogen levels increased by 0.046 g/L, accounting for approximately 30.4 % of the variability. The study may encourage clinicians to use ROTEM in the intensive care. Additionally, our linear regression model shows a significant relationship between FIBTEM-MCF and fibrinogen levels. The predictiveformula we have demonstrated may improve clinical decision-making by providing a rapid predictive method to assess coagulation status.</div></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"64 4","pages":"Article 104194"},"PeriodicalIF":1.4,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144480596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of the practice of pretransfusion medication in the oncohematology unit and knowledge of physicians and nurses","authors":"Tatiane Manoela Ribeiro Castilho Ferreira ,&nbsp;Anna Cecília Dias Maciel Carneiro ,&nbsp;Sarah Cristina Sato Vaz Tanaka ,&nbsp;Leonardo Rodrigues de Oliveira,&nbsp;Fernanda Bernadelli De Vito ,&nbsp;Helio Moraes-Souza","doi":"10.1016/j.transci.2025.104177","DOIUrl":"10.1016/j.transci.2025.104177","url":null,"abstract":"<div><div>Blood transfusion was a revolution in Medicine, however, the reactions transfusions permeates it. This study aimed to evaluate and characterize the practice of pretransfusion medication and perception of physicians and nurses regarding this approach. Data concerning premedication were collected from physical and electronic medical records of onco-hematologic patients throughout the year 2021. Semistructured interviews were conducted to assess the knowledge of prescribing physicians and nursing staff. During this period, there were 688 transfusion events in the Oncologyhematology Unit, with premedication being used in 522 cases (75.87 %), most frequently for platelet concentrates. The most commonly used classes of medications were antihistamines (52.3 %) followed by analgesics (28.7 %). The majority of physicians reported prescribing premedication in cases of previous transfusion reactions. The most frequently hemocomponent prescribed (80 %) was random platelet concentrates. Concerning specific medications, 60 % mentioned diphenhydramine and 40 % mentioned dipyrone. Regarding nursing staff, 50 % stated that premedication was employed in 70–80 % of transfusions; 70 % reported that antiallergics were the most commonly prescribed, consistent with physician responses. Only 40 % mentioned seeking alternative measures to premedication, such as bedside observation, and 90 % expressed reluctance to administer blood components without premedication. Our findings reveal a widespread practice of premedication, reflecting a conservative approach that is increasingly being questioned and challenged. The high rates of premedication underscore need for reformulation and adoption of protocols that encompass best medical practices and continuous pursuit of preventive strategies, including alternatives to premedication and even transfusion itself, emphasizing restrictive transfusion practices through proper patient management.</div></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"64 4","pages":"Article 104177"},"PeriodicalIF":1.4,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144490232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}