Transfusion and Apheresis Science最新文献

{"title":"Development and validation of a novel orthopedic blood use prediction model incorporating lab tests and thromboelastography","authors":"Aqin Chen ,&nbsp;Bing Cui ,&nbsp;Chengcheng Xu ,&nbsp;Yuan Xu","doi":"10.1016/j.transci.2025.104287","DOIUrl":"10.1016/j.transci.2025.104287","url":null,"abstract":"<div><h3>Objective</h3><div>To develop and validate a prediction model integrating laboratory parameters and thromboelastography (TEG) for forecasting blood transfusion needs in orthopedic surgery.</div></div><div><h3>Methods</h3><div>This retrospective study enrolled 250 patients undergoing joint replacement, spinal fusion, or fracture fixation. Participants were randomized into training (n = 175) and validation (n = 75) sets. Preoperative demographics, laboratory indices, and TEG parameters were collected. Potential predictors were identified through univariate analysis and Least Absolute Shrinkage and Selection Operator (LASSO) regression. Significant variables were incorporated into multivariate logistic regression to identify independent factors. Multiple machine learning models—random forest (RF), k-nearest neighbors (KNN), and gradient boosting machine (GBM)—were constructed and evaluated using the area under the receiver operating characteristic curve (AUC).</div></div><div><h3>Results</h3><div>No significant differences were observed in baseline characteristics between the training and validation sets (<em>P</em> &gt; 0.05). Univariate analysis revealed statistically significant differences between the non-transfusion and transfusion groups in the training set regarding preoperative Hb, PLT, TEG-R, TEG-K, TEG-MA, TEG-LY30, prothrombin time, and <span>D</span>-dimer levels (all <em>P</em> &lt; 0.05). Multivariate logistic regression analysis demonstrated that preoperative Hb, preoperative PLT, and TEG-MA were independent protective factors against postoperative transfusion (all <em>P</em> &lt; 0.05), whereas TEG-R, TEG-K, TEG-LY30, and preoperative prothrombin time were independent risk factors (all <em>P</em> &lt; 0.05). The random forest model achieved the highest AUC (0.931), significantly outperforming the KNN (0.894) and GBM (0.813) models, thus being selected as the optimal predictive model.</div></div><div><h3>Conclusion</h3><div>The random forest model based on laboratory parameters and TEG parameters effectively predicts postoperative transfusion requirements in orthopedic surgery patients, providing an objective basis for preoperative blood risk assessment and individualized transfusion strategies.</div></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"65 1","pages":"Article 104287"},"PeriodicalIF":1.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145688428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PREVENTION OF EXOGENOUS MICROBIAL CONTAMINATION OF BLOOD COMPONENTS: DISINFECTION OF THE DONOR'S SKIN AND QUALITY CONTROLS.","authors":"C. Zampieri,&nbsp;M. Castelli,&nbsp;AF. Tosetto,&nbsp;F. Stefani,&nbsp;T. Pedon,&nbsp;E. Marcati,&nbsp;D. Ferrando,&nbsp;B. Sartori,&nbsp;M. Rigno,&nbsp;F. Fiorin","doi":"10.1016/j.transci.2025.104355","DOIUrl":"10.1016/j.transci.2025.104355","url":null,"abstract":"","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"65 1","pages":"Article 104355"},"PeriodicalIF":1.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146073401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility of preparing whole blood-derived pooled buffy coat granulocyte concentrates for pediatric patients","authors":"Kriti Batni,&nbsp;Satyam Arora,&nbsp;Seema Dua,&nbsp;Anupa Pokhrel,&nbsp;Akshay Paliwal,&nbsp;Arisha Khan","doi":"10.1016/j.transci.2026.104373","DOIUrl":"10.1016/j.transci.2026.104373","url":null,"abstract":"<div><h3>Background</h3><div>Granulocyte transfusions remain a therapeutic option in managing severe neutropenic sepsis and selected hematological conditions. However, their availability is limited due to challenges in mobilization, collection, and short shelf life. In resource-constrained settings, buffy coat-derived granulocyte pools may serve as a feasible alternative.</div></div><div><h3>Aims</h3><div>To assess the feasibility of pooling buffy coat (BC) derived granulocytes, validate the pooling process, and compare granulocyte yield between two different pooling strategies (pool of 4 vs. pool of 6 BC)</div></div><div><h3>Materials and Methods</h3><div>A prospective study was conducted using buffy coats from routine 450 mL whole blood donations (N = 150). BCs were pooled (N = 60 for pool of 4 vs N = 90 for pool of 6 BC-GCs). Donor, individual buffy coat, pooled buffy coat samples were analyzed for volume, complete blood counts, platelet and granulocyte yield. European (EDQM) and UK standards were used as quality benchmarks.</div></div><div><h3>Results</h3><div>Granulocyte yield, volume, and red cell content were significantly higher in 6-BC pools compared to 4-BC pools (p &lt; 0.001). All 6-BC pools met the EDQM granulocyte dose threshold (&gt;5 × 10⁹/unit), whereas only 33 % of 4-BC pools did. Sterility was maintained throughout. To reduce red cell content for pediatric suitability, 6 RBC-reduced pools underwent high-speed centrifugation. Compared to the unmanipulated pools, RBC-reduced pools demonstrated significantly lower volume and RBC volume and significantly higher granulocyte concentration (42.8 ± 16.1 vs. 24.0 ± 3.1 ×10 ³/µL, p = 0.035) with preserved total granulocyte yield (p = 0.40). However, a key limitation of our study is the lack of functional assays to assess post-processing granulocyte viability and phagocytic activity.</div></div><div><h3>Conclusion</h3><div>This approach offers a cost-effective, logistically simpler method for generating granulocyte-rich components where apheresis is not feasible. Pooled buffy coat granulocytes can be a viable alternative in settings with limited access to granulocytapheresis, meeting acceptable quality standards for clinical use.</div></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"65 1","pages":"Article 104373"},"PeriodicalIF":1.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145924951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PV UNIT: A MULTISPECIALISTIC WORKING GROUP ON POLYCYTHEMIA VERA AIMED AT CLINICAL MANAGEMENT AND SCIENTIFIC RESEARCH","authors":"Scirè E ,&nbsp;Bongiorno MR ,&nbsp;Campisi G ,&nbsp;Caputo V ,&nbsp;Ciaccio M ,&nbsp;Di Lisi D ,&nbsp;Florena AM ,&nbsp;Giannone AG ,&nbsp;Novo G ,&nbsp;Panzarella V ,&nbsp;Siragusa S ,&nbsp;Santoro M","doi":"10.1016/j.transci.2025.104317","DOIUrl":"10.1016/j.transci.2025.104317","url":null,"abstract":"","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"65 1","pages":"Article 104317"},"PeriodicalIF":1.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146073721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HYPOPHOSPHATEMIA RELATED TO MARTIAL THERAPY WITH IRON-CARBOXY-MALTOSE, USED IN PBM PROGRAMS","authors":"A. Balestrieri ,&nbsp;A. Di Santi ,&nbsp;O. Petti ,&nbsp;G. Marra ,&nbsp;C. Graziano ,&nbsp;F. Soldovieri ,&nbsp;F. Cantalupo ,&nbsp;M.G. Di Sevo ,&nbsp;G. Pipolo ,&nbsp;M. D’Onofrio","doi":"10.1016/j.transci.2025.104340","DOIUrl":"10.1016/j.transci.2025.104340","url":null,"abstract":"","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"65 1","pages":"Article 104340"},"PeriodicalIF":1.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146073859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanisms of immune modulation by therapeutic plasma exchange","authors":"Nicholas Parisi,&nbsp;Menatalla Nadim,&nbsp;Yamac Akgun","doi":"10.1016/j.transci.2026.104371","DOIUrl":"10.1016/j.transci.2026.104371","url":null,"abstract":"<div><div>Therapeutic plasma exchange (TPE) is a cornerstone extracorporeal therapy with broad immunomodulatory effects across diverse immune-mediated and inflammatory diseases. By removing circulating pathogenic substances such as autoantibodies, immune complexes, complement components, and pro-inflammatory cytokines, TPE rapidly interrupts humoral pathways driving tissue injury. This review summarizes the mechanisms through which plasma exchange modulates immune activity, including both depletion of harmful plasma factors and restoration of normal homeostatic proteins when donor plasma is used. Biomarker analyses demonstrate predictable reductions in immunoglobulins, cytokines, and complement activity, reflecting the profound but transient immune reset achieved with TPE. Comparisons with related apheresis modalities, such as immunoadsorption, double filtration plasmapheresis, and extracorporeal photopheresis, highlight the unique advantages of TPE as a broadspectrum immunomodulatory intervention. Clinically, TPE remains a vital therapeutic option in conditions ranging from thrombotic thrombocytopenic purpura and myasthenia gravis to vasculitis and cytokine storm syndromes. As evidence and technology evolve, plasma exchange continues to exemplify how biophysical removal of pathogenic plasma constituents can effectively restore immune balance and improve patient outcomes in both acute and chronic immune-mediated diseases.</div></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"65 1","pages":"Article 104371"},"PeriodicalIF":1.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145913572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MOBILIZATION AND COLLECTION OF ALLOGENEIC HSCS: G-CSF ADMINISTRATION PLANS COMPARED.","authors":"M. Colonna,&nbsp;C. Battista,&nbsp;C. Citarella,&nbsp;A. Tullo,&nbsp;M. Giannoccaro,&nbsp;R. Procacci,&nbsp;C. Lippolis,&nbsp;R. Galasso,&nbsp;R. Frappampina,&nbsp;A. Ostuni","doi":"10.1016/j.transci.2025.104326","DOIUrl":"10.1016/j.transci.2025.104326","url":null,"abstract":"","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"65 1","pages":"Article 104326"},"PeriodicalIF":1.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146074209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CD161+ REGULATORY T CELLS: A NOVEL MECHANISM OF ACTION FOR THE GRAFT VERSUS LEUKEMIA EFFECT","authors":"F. Guardalupi ,&nbsp;G. Corradi ,&nbsp;P. Accorsi ,&nbsp;P. Lanuti ,&nbsp;M. Di Ianni","doi":"10.1016/j.transci.2025.104352","DOIUrl":"10.1016/j.transci.2025.104352","url":null,"abstract":"","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"65 1","pages":"Article 104352"},"PeriodicalIF":1.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146076811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"QUALIFICATION AND VALIDATION OF AN ELECTRONICALLY REGULATED DRY THAWING DEVICE FOR HEMATOPOIETIC STEM CELLS","authors":"M. Di Cerbo ,&nbsp;M. Prisciandaro ,&nbsp;C. Gregorj ,&nbsp;C. Bonchi ,&nbsp;M. Di Cecca ,&nbsp;C. Bancone ,&nbsp;G. Marconi ,&nbsp;M. Valente ,&nbsp;A. Morgia ,&nbsp;O. Annibali ,&nbsp;M. Vacca","doi":"10.1016/j.transci.2025.104348","DOIUrl":"10.1016/j.transci.2025.104348","url":null,"abstract":"","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"65 1","pages":"Article 104348"},"PeriodicalIF":1.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146076793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PREDICTIVE ALGORITHM FOR HAEMATOPOIETIC STEM CELL COLLECTION AS A TOOL FOR INTERCONNECTION BETWEEN TRANSPLANT PROGRAM FACILITIES","authors":"M. Prisciandaro ,&nbsp;C. Bancone ,&nbsp;G. Palazzo ,&nbsp;C. Bonchi ,&nbsp;C. Nobile ,&nbsp;L. D'Amore ,&nbsp;C. Gregorj ,&nbsp;A. Marinucci ,&nbsp;S. Vaccaro ,&nbsp;D. Armiento ,&nbsp;O. Annibali ,&nbsp;M. Vacca","doi":"10.1016/j.transci.2025.104332","DOIUrl":"10.1016/j.transci.2025.104332","url":null,"abstract":"","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"65 1","pages":"Article 104332"},"PeriodicalIF":1.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146077242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}