Hong Lin , Danning Li , Jamie Thompson , David Winstone , Alan Lankester , Ying Li
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引用次数: 0
Abstract
Donor age has long been recognized as negatively affecting CD34 + yield following Peripheral Blood Stem Cell (PBSC) mobilization. However, its impact on male versus female donors has not been separately examined. In addition, the potential influence of pregnancy history on female donors remains underexplored. The retrospective study extracted donation data from 267 female donors with known pregnancy history, grouped by age and number of gravidities, and CD34 + yields post-PBSC mobilization were compared. The study revealed a decline in CD34 + yields with increasing donor age, but an elevation in yields among female donors aged 41–50, a pattern not seen with male donors. There was no difference in yields between nulligravida donors and those with 2 or 3 gravidities, and the latter cohort showed significantly higher yields than donors with 1 or 4 + gravidities. For donors in their 40 s, CD34 + yields were either higher than or similar to those of younger donors with the same number of gravidities, suggesting an additional effect of this age group on stem cell yields. Nevertheless, recipients’ engraftment outcomes were comparable among donors with varying numbers of gravidities and nulligravida donors. This study demonstrates that female donors aged 41–50 have CD34 + yields similar to male donors, and those with 2–3 previous pregnancies exhibit CD34 + yields comparable to those of nulligravida donors and significantly higher than those of other gravidity groups. These findings suggest that age and pregnancy history influence stem cell mobilisation, emphasizing the need for further research into their underlying biological mechanisms and clinical significance.
期刊介绍:
Transfusion and Apheresis Science brings comprehensive and up-to-date information to physicians and health care professionals involved in the rapidly changing fields of transfusion medicine, hemostasis and apheresis. The journal presents original articles relating to scientific and clinical studies in the areas of immunohematology, transfusion practice, bleeding and thrombotic disorders and both therapeutic and donor apheresis including hematopoietic stem cells. Topics covered include the collection and processing of blood, compatibility testing and guidelines for the use of blood products, as well as screening for and transmission of blood-borne diseases. All areas of apheresis - therapeutic and collection - are also addressed. We would like to specifically encourage allied health professionals in this area to submit manuscripts that relate to improved patient and donor care, technical aspects and educational issues.
Transfusion and Apheresis Science features a "Theme" section which includes, in each issue, a group of papers designed to review a specific topic of current importance in transfusion and hemostasis for the discussion of topical issues specific to apheresis and focuses on the operators'' viewpoint. Another section is "What''s Happening" which provides informal reporting of activities in the field. In addition, brief case reports and Letters to the Editor, as well as reviews of meetings and events of general interest, and a listing of recent patents make the journal a complete source of information for practitioners of transfusion, hemostasis and apheresis science. Immediate dissemination of important information is ensured by the commitment of Transfusion and Apheresis Science to rapid publication of both symposia and submitted papers.