Transfusion and Apheresis Science最新文献

{"title":"A real-time dashboard for optimizing blood product utilization through a FHIR-based data integration pipeline","authors":"Cynthia Sabrina Schmidt ,&nbsp;Johannes Wutzkowsky ,&nbsp;Henning Schäfer ,&nbsp;Lea Reinartz ,&nbsp;Haidar Chahin ,&nbsp;Philipp Winnekens ,&nbsp;Jamal Aldin Alsulaiman ,&nbsp;Christian Temme ,&nbsp;Veronika Lenz ,&nbsp;René Hosch ,&nbsp;Felix Nensa ,&nbsp;Christoph M. Friedrich ,&nbsp;Britta Böckmann ,&nbsp;Peter A. Horn","doi":"10.1016/j.transci.2025.104301","DOIUrl":"10.1016/j.transci.2025.104301","url":null,"abstract":"<div><h3>Background</h3><div>Efficient blood product utilization remains a critical operational challenge in transfusion medicine. One key aspect is the timely identification of products eligible for release and the monitoring of discharged patients with reserved blood products that may no longer be needed, as manual review processes for unused or misallocated units often delay their reintroduction into circulation.</div></div><div><h3>Objective</h3><div>To develop a real-time dashboard that integrates heterogeneous hospital data to identify blood products allocated to patients after discharge, transfer, or death.</div></div><div><h3>Methods</h3><div>Clinical and laboratory data from the Hospital Information System (HIS) and Laboratory Information System (LIS) were harmonized via an Extract-Transform-Load (ETL) pipeline into Fast Healthcare Interoperability Resources (FHIR) and stored in a structured database using a relational FHIR engine. A Grafana dashboard visualizes the information retrieved through SQL queries, consolidating patient data, blood product information and crossmatch status into a unified interface.</div></div><div><h3>Results</h3><div>The dashboard provides an overview of all blood products that could potentially be released back into stock and lists associated patients and departments. It is reviewed daily by blood depot staff as part of the clinical workflow, enabling faster verification and release of unused units. The integration of FHIR-based analytics ensures interoperability and real-time updates.</div></div><div><h3>Conclusion</h3><div>The dashboard demonstrates that structured FHIR data can be leveraged for operational decision support in transfusion medicine, enabling proactive stock management and improved resource utilization through seamless integration with existing clinical systems.</div></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"65 1","pages":"Article 104301"},"PeriodicalIF":1.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145884459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RISK ASSESSMENT IN THE APHERESIS BLOOD COMPONENT DONATION PROCESS","authors":"M.C. Guerrese,&nbsp;E. Campana,&nbsp;L. Lombardi,&nbsp;D. Pastorelli,&nbsp;G. Peluso Cassese,&nbsp;S. Sgromo,&nbsp;V. Falcioni,&nbsp;I. Del Mastro,&nbsp;A. Rainaldi","doi":"10.1016/j.transci.2025.104346","DOIUrl":"10.1016/j.transci.2025.104346","url":null,"abstract":"","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"65 1","pages":"Article 104346"},"PeriodicalIF":1.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146073404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"APHERESIS AND INNOVATIVE THERAPIES IN ANTIBODY-MEDIATED NEUROLOGICAL DISEASES: DOES PLASMAPHERESIS STILL PLAY A ROLE?","authors":"C. Antozzi","doi":"10.1016/j.transci.2025.104356","DOIUrl":"10.1016/j.transci.2025.104356","url":null,"abstract":"","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"65 1","pages":"Article 104356"},"PeriodicalIF":1.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146076808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SUCCINYLATED GELATINE FOR AUTOMATED DMSO REMOVAL FROM THAWED PERIPHERAL BLOOD STEM CELLS: RESULTS FROM A VALIDATION STUDY.","authors":"E. Barone ,&nbsp;S. De Vitis ,&nbsp;D. Troletti ,&nbsp;R. Cacciatore ,&nbsp;C. Perotti ,&nbsp;C. Del Fante","doi":"10.1016/j.transci.2025.104345","DOIUrl":"10.1016/j.transci.2025.104345","url":null,"abstract":"","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"65 1","pages":"Article 104345"},"PeriodicalIF":1.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146077101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A MULTIDISCIPLINARY APPROACH FOR AUTOLOGOUS PBSC LEUKAPHERESIS IN PRESCHOOL AGE PATIENTS WITH SOLID TUMORS","authors":"S. Alcamo ,&nbsp;R .Albasini ,&nbsp;M .Dentella ,&nbsp;R. Luksch ,&nbsp;M. Armiraglio ,&nbsp;L. Miradoli ,&nbsp;G. Papagni ,&nbsp;F. Arienti ,&nbsp;P Coluccia","doi":"10.1016/j.transci.2025.104325","DOIUrl":"10.1016/j.transci.2025.104325","url":null,"abstract":"","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"65 1","pages":"Article 104325"},"PeriodicalIF":1.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146077240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE ROLE OF LIPOPROTEIN APHERESIS IN THE ERA OF NEW LIPID-LOWERING THERAPIES.","authors":"Francesco Sbrana MD,&nbsp;Beatrice Dal Pino MD","doi":"10.1016/j.transci.2025.104365","DOIUrl":"10.1016/j.transci.2025.104365","url":null,"abstract":"","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"65 1","pages":"Article 104365"},"PeriodicalIF":1.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146077340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Balancing accuracy and efficiency in peripheral blood stem cell collection: A protocol comparison study","authors":"Nidhi Sharma,&nbsp;Khushboo Likhar,&nbsp;Sachin Sharma,&nbsp;Ashok Yadav","doi":"10.1016/j.transci.2025.104297","DOIUrl":"10.1016/j.transci.2025.104297","url":null,"abstract":"<div><h3>Background</h3><div>Peripheral blood stem cell (PBSC) collection is influenced by multiple factors. Present study is done to identify factors influencing successful stem cell collection in our setting and compare pre-peripheral blood CD34 + count (PBCC) based predictive protocols with current intra-procedure CD34 + count (IPC)-based protocol for dose prediction accuracy.</div></div><div><h3>Methods</h3><div>Retrospective analysis of data of PBSC collections performed over two years was done. Predictive algorithms were generated based on PBCC, CE2, IPC, blood volume processed (nTBV) and recipient body weight. For the prediction formulae, target dose (TD) of 5x10⁶CD34 + cells/Kg for autologous and 10x10⁶CD34 + cells/Kg for allogeneic collections was used.</div></div><div><h3>Results</h3><div>41 PBSC collections (31 allogeneic and 10 autologous) were included in the study. Correlation analysis showed FD was strongly associated with PBCC (r = 0.9,p &lt; 0.001), IPD (r = 0.891,p = 0.001) in autologous collections, and only with IPD (r = 0.848,p &lt; 0.001) in allogeneic collections. Prediction analysis revealed pFD as the most accurate protocol in autologous collections, with very strong correlation and low error. In allogeneic collections, pFD and prTBV correlated moderately, though pFD carried higher error. Re-evaluation using fractional procedure values to achieve target dose improved accuracy, with pceTBV and prTBV performing reliably, while pPV remained inconsistent despite strong correlation.</div></div><div><h3>Conclusions</h3><div>IPC-based algorithms showed the strongest correlations but were limited by poor error metrics, reducing reliability. Conversely, PBCC-based predictions provide more reliable balance of accuracy, error control and operational consistency, making it the preferred approach for minimizing donor burden and ensuring optimal processing.</div></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"65 1","pages":"Article 104297"},"PeriodicalIF":1.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145790251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ionized calcium changes in adult patients undergoing therapeutic plasma exchanges","authors":"Yi Yuan Zhou ,&nbsp;Robert W. Maitta","doi":"10.1016/j.transci.2025.104295","DOIUrl":"10.1016/j.transci.2025.104295","url":null,"abstract":"<div><h3>Background</h3><div>Ionized calcium [Ca^2 + ] is the free active form found in circulation used to monitor a patient’s calcium during therapeutic plasma exchange (TPE). Hypocalcemia during TPE is caused by citrate anticoagulation. Citrate toxicity can be mitigated by calcium supplementation; however, there is no standard protocol for its use. We describe our institutional experience using calcium supplementation during TPE.</div></div><div><h3>Methods</h3><div>A retrospective review was conducted for patients who underwent TPE procedures between 10/01/2023 and 4/30/2025. Patients’ age, gender, TPE indication, procedure duration, pre- and post-procedure [Ca²⁺], plasma volume, and calcium supplementation dose were analyzed.</div></div><div><h3>Results</h3><div>[Ca²⁺] change across TPE procedures ranged between −0.65–0.74 mmol/L with a mean of 0.03 <u>+</u> 0.11 mmol/L. [Ca²⁺] changes followed a normal distribution with 95 % of [Ca²⁺] occurring between −0.19 and 0.24 mmol/L. Procedure duration and plasma fluid replacement percentage did not influence [Ca²⁺] changes. By contrast, significant [Ca²⁺] changes were seen based on calcium gluconate replacement dosage. A higher dose of calcium gluconate (1.65 g/L of plasma exchanged) showed a significant average [Ca²⁺] increase of 0.06 mmol/L (p &lt; 0.001) compared to the normal calcium gluconate dose (1.5 g/L of plasma exchanged). Gender had statistically significant effects on [Ca²⁺] but the effect of TPE indication remains to be elucidated.</div></div><div><h3>Conclusion</h3><div>Use of prophylactic calcium during TPE is the major variable governing [Ca²⁺] changes during the procedure with minor contribution from patients’ gender and TPE indication. A dose of at least 1.5 g/L prevented excessive decrease in [Ca²⁺] and reduced occurrence of citrate toxicity.</div></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"65 1","pages":"Article 104295"},"PeriodicalIF":1.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145624878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does the availability of non-cross matched blood in the trauma bay effect the outcome of trauma patients? A retrospective study from a level-II trauma center","authors":"Daniella Moshe ,&nbsp;Noa Dina Rose ,&nbsp;Asher Winder ,&nbsp;Zipi Kazar ,&nbsp;Asad Asem ,&nbsp;Ronit Bar-Haim ,&nbsp;Moshe Kamar ,&nbsp;Shachar Laks ,&nbsp;Katia Dayan ,&nbsp;Mordechai Shimonov ,&nbsp;Adam Lee Goldstein","doi":"10.1016/j.transci.2025.104286","DOIUrl":"10.1016/j.transci.2025.104286","url":null,"abstract":"<div><h3>Background</h3><div>Timely administration of blood products is critical in trauma resuscitation. Many trauma centers worldwide do not store blood products within the emergency room (ER), potentially delaying transfusion. This study evaluated the impact of immediate availability of uncrossmatched O-type packed red blood cells (UORBC) in the trauma bay on patient management and outcomes.</div></div><div><h3>Methods</h3><div>We conducted a retrospective cohort study at a single level-II trauma center, comparing all trauma patients triaged to the trauma bay in the year before (April 2020–March 2021) and after (April 2021–March 2022) UORBC was stored in a dedicated trauma bay refrigerator. Demographics, injury characteristics, blood product use, surgical interventions, intensive care unit (ICU) admission, length of stay (LOS), and mortality were analyzed.</div></div><div><h3>Results</h3><div>Of 216 patients, 74 presented pre-implementation (Yr1) and 142 post-implementation (Yr2). Baseline demographics and injury patterns were similar between groups. ER administration of packed red blood cells was significantly higher in Yr2 (5 % vs. 15 %, p = 0.04). Fewer emergent surgeries were observed post-implementation without statistical significance (38 % vs. 27 %, p = 0.09). No significant differences were found in overall hospitalization blood product use (p = 0.55), hospital LOS (7.0 vs. 5.8 days, p = 0.24), ICU LOS, mortality (2.7 % vs. 4.9 %, p = 0.72), or discharge disposition.</div></div><div><h3>Conclusions</h3><div>Immediate trauma bay access to UORBC increased early ER transfusion rates and showed a lower percent of patients having emergent surgeries, but did not significantly affect LOS or mortality. Larger multicenter studies are warranted to clarify clinical impact and optimize trauma system logistics.</div></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"65 1","pages":"Article 104286"},"PeriodicalIF":1.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145594741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"USE OF GELOFUSINE FOR WASHING HEMATOPOIETIC STEM CELLS FOR TRANSPLANT","authors":"Nappo S ,&nbsp;Esposito M ,&nbsp;Maisto G ,&nbsp;Casalino R ,&nbsp;Gallo L ,&nbsp;Coppola S ,&nbsp;Castellano G ,&nbsp;Topo F ,&nbsp;Penta de Vera d’Aragona R ,&nbsp;Toriello M","doi":"10.1016/j.transci.2025.104350","DOIUrl":"10.1016/j.transci.2025.104350","url":null,"abstract":"","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"65 1","pages":"Article 104350"},"PeriodicalIF":1.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146076794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}