Transfusion and Apheresis Science最新文献

{"title":"The effect of threosulfan-based versus busulfan-based preparation regimens on transplant outcomes","authors":"Burcu Aslan Candir ,&nbsp;Nazik Okumus ,&nbsp;Ipek Yonal Hindilerden ,&nbsp;Mehmet Ali Erkurt ,&nbsp;Sinem Namdaroglu ,&nbsp;Mustafa Merter ,&nbsp;Seda Yilmaz ,&nbsp;Mustafa Koroglu ,&nbsp;Tuğba Zorlu ,&nbsp;Tarik Onur Tiryaki ,&nbsp;Yavuz Katircilar ,&nbsp;Ant Uzay ,&nbsp;Mert Seyhan ,&nbsp;Mustafa Murat Ozbalak ,&nbsp;Mehmet Sinan Dal ,&nbsp;Turgay Ulaş ,&nbsp;Serdal Korkmaz ,&nbsp;Fevzi Altuntas","doi":"10.1016/j.transci.2025.104186","DOIUrl":"10.1016/j.transci.2025.104186","url":null,"abstract":"<div><h3>Background</h3><div>Allogeneic hematopoietic stem cell transplantation is a curative therapy for malignant and non-malignant hematologic disorders. Conditioning regimens, such as those based on busulfan, are utilized to promote engraftment. Busulfan-based regimens are commonly employed but exhibit significant toxicity, leading to interest in alternate drugs such as treosulfan, which may offer a superior safety profile while preserving efficacy.</div></div><div><h3>Methods</h3><div>This retrospective study examined 240 adult patients diagnosed with acute myeloid leukemia or acute lymphoblastic leukemia who received allogeneic hematopoietic stem cell transplantation at nine transplantation centers in Türkiye from 2010 to 2024. Patients underwent either a busulfan-based or treosulfan-based conditioning regimen.</div></div><div><h3>Results</h3><div>Engraftment was effective in both groups, with neutrophil engraftment happening earlier in the busulfan group (13 days vs. 15 days, p = 0.001). The incidence of veno-occlusive disease was significantly higher in the busulfan group (10.1 % vs. 0.9 %, p = 0.002). Cytomegalovirus infections were more prevalent in the busulfan group (51.2 % vs. 26.1 %, p &lt; 0.001). Acute graft versus host disease occurred more frequently in the busulfan group (27.9 % vs. 18.9 %, p = 0.128); nonetheless, this difference did not reach statistical significance. No significant differences in relapse rates were detected through the groups. The overall survival was not reached in the busulfan group, while the treosulfan group demonstrated an overall survival of 40 months.</div></div><div><h3>Conclusion</h3><div>Treosulfan-based conditioning regimens demonstrate similar efficacy to busulfan-based regimens while presenting a more acceptable toxicity profile. Treosulfan-based regimens also show a lower occurrence of veno-occlusive disease and cytomegalovirus infections.</div></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"64 4","pages":"Article 104186"},"PeriodicalIF":1.4,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144364754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does body mass index affect stem cell yield in healthy donors?","authors":"Seda Yilmaz ,&nbsp;Nazik Okumus ,&nbsp;Mert Seyhan ,&nbsp;Rasim Sahin ,&nbsp;Gulten Korkmaz ,&nbsp;Mehmet Ali Erkurt ,&nbsp;Sinem Namdaroglu ,&nbsp;Salih Cirik ,&nbsp;Sinan Demircioglu ,&nbsp;Ant Uzay ,&nbsp;Abdulkadir Sahin ,&nbsp;Mustafa Koroglu ,&nbsp;Ugur Hatipoglu ,&nbsp;Mehmet Sinan Dal ,&nbsp;Turgay Ulaş ,&nbsp;Serdal Korkmaz ,&nbsp;Fevzi Altuntas","doi":"10.1016/j.transci.2025.104181","DOIUrl":"10.1016/j.transci.2025.104181","url":null,"abstract":"<div><h3>Objectives</h3><div>Hematopoietic stem cell transplantation is an important treatment for many benign and malignant diseases. Factors affecting the donor response to mobilization and thus hematopoietic progenitor cell yield have been investigated, but studies on donor body mass index are limited and contradictory. Our aim in our study was to investigate this situation.</div></div><div><h3>Material and methods</h3><div>The data of a total of 665 healthy donors were analyzed and divided into 2 groups as body mass index (BMI) &lt; 25 (group 1, n: 247) and ≥ 25 kg/m² (group 2, n: 418). In addition to demographic data, smoking, blood group, agent used for mobilization, number of days of apheresis, volume of blood processed, amount of product collected, complete blood count before mobilization and biochemical parameters were evaluated.</div></div><div><h3>Results</h3><div>Group 1 consisted of 247 and group 2 consisted of 418 participants. Median age was 29 (18–66) years in group 1 and 37 (18–68) years in group 2. Median BMI was 22.49 (16.10–24.98) and 28.06 (25.00–48.27) kg/m², respectively. Male donors constituted 62.7 % in group 1 and 73.9 % in group 2. In group 2, the number of apheresis days was lower and the median CD34⁺ stem cell count on the first day and in total was statistically significantly higher (7.1 ×10⁶/kg and 7.58 ×10⁶/kg, respectively).</div></div><div><h3>Conclusion</h3><div>In healthy donors, CD34⁺ stem cells were correlated with BMI, whereas no statistically significant difference was found between the groups in terms of smoking habit, blood group, granulocyte stimulating agent type, processed blood volume, non-lymphocyte and biochemical parameters other than LDH.</div></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"64 4","pages":"Article 104181"},"PeriodicalIF":1.4,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144535405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A global gathering for the future of apheresis: The 15th ISFA World Congress and 4th TSFA National Congress in Bangkok, Thailand","authors":"Kornchanok Vareesangthip ,&nbsp;Ken Yamaji ,&nbsp;Kriengsak Vareesangthip","doi":"10.1016/j.transci.2025.104178","DOIUrl":"10.1016/j.transci.2025.104178","url":null,"abstract":"","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"64 4","pages":"Article 104178"},"PeriodicalIF":1.4,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144364753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is there a relationship between stem cell yield obtained from healthy donors and healthy donors’ blood type?","authors":"Yavuz Katircilar ,&nbsp;Abdulkadir Sahin ,&nbsp;Muruvvet Seda Aydin ,&nbsp;Kerim Erer ,&nbsp;Mehmet Ali Erkurt ,&nbsp;Sinem Namdaroglu ,&nbsp;Seda Yilmaz ,&nbsp;Sinan Demircioglu ,&nbsp;Ant Uzay ,&nbsp;Ali Durdu ,&nbsp;Mustafa Koroglu ,&nbsp;Gulsum Ozet ,&nbsp;Merve Apaydin ,&nbsp;Mehmet Sinan Dal ,&nbsp;Turgay Ulas ,&nbsp;Serdal Korkmaz ,&nbsp;Fevzi Altuntas","doi":"10.1016/j.transci.2025.104182","DOIUrl":"10.1016/j.transci.2025.104182","url":null,"abstract":"<div><h3>Background and objectives</h3><div>Factors affecting adequate mobilization and apheresis are critical for a good yield of hematopoietic stem cells (HSCs) in the final product. A female donor, advanced age, smoking, high lactate dehydrogenase levels, high absolute lymphocyte count at baseline were found to be inversely correlated to the number of harvested CD34⁺ cells. However, the data on whether there is a correlation between blood types A, B, AB, O and the number of harvested CD34⁺ cells is insufficient. The aim of this study is to investigate the effect of blood types on the stem cell yield in healthy donors.</div></div><div><h3>Material and methods</h3><div>A total of 807 healthy donors from 10 centers in Türkiye were included in this retrospective study. Donors were subdivided into four groups as A, B, AB, O by their blood types. These four groups were compared in terms of age, sex, ECOG performance score, smoking status, and the amount of harvested CD34⁺ stem cells.</div></div><div><h3>Results</h3><div>The median age of the 807 healthy donors included in the study was 35 years (11–70). 256 (31.7 %) donors were female and 551 (68.2 %) donors were male. There were 349 donors in type A blood group, 134 in type B blood group, 53 in type AB blood group and 271 donors in type O blood group. The median amount of CD34⁺ cells in the total apheresis product was 7.67 × 10⁶ per kg in type O blood group, 7.52 × 10⁶ per kg in type A blood group, 7.2 × 10⁶ per kg in type B blood group, and 7.45 × 10⁶ per kg in type AB blood group. There was no statistically significant difference among the groups (p:0.673). Smoking was lower in the type B blood group with 29.1 % compared to the other groups. However, there was no statistically significant difference in total amount of CD34⁺ stem cells in the type B blood group who smoked less (p = 0.949).</div></div><div><h3>Conclusion</h3><div>In our study in which we have retrospectively analyzed the effect of donor blood types on the efficiency of HSCs harvested from peripheral blood in healthy donors, no correlation was found between the blood types and the mobilization and amount of harvested CD34⁺ cells.</div></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"64 4","pages":"Article 104182"},"PeriodicalIF":1.4,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144570907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of second allogeneic hematopoietic stem cell transplantation as salvage therapy for hematologic diseases after a first allogeneic transplantation","authors":"Hikmetullah Batgi ,&nbsp;Tuğba Zorlu ,&nbsp;Mehmet Ali Erkurt ,&nbsp;Ant Uzay ,&nbsp;Ipek Yonal Hindilerden ,&nbsp;Mehmet Sezgin Pepeler ,&nbsp;Merve Apaydin ,&nbsp;Yavuz Katircilar ,&nbsp;Mustafa Koroglu ,&nbsp;Emin Kaya ,&nbsp;Ali Durdu ,&nbsp;Mustafa Merter ,&nbsp;Irfan Kuku ,&nbsp;Mehmet Sinan Dal ,&nbsp;Turgay Ulaş ,&nbsp;Serdal Korkmaz ,&nbsp;Fevzi Altuntas","doi":"10.1016/j.transci.2025.104187","DOIUrl":"10.1016/j.transci.2025.104187","url":null,"abstract":"<div><h3>Background and objectives</h3><div>Acute leukemia patients who relapse after the first allogeneic stem-cell transplantation (HSCT1) have a poor prognosis. Second allogeneic hematopoietic stem-cell transplantation (HSCT2) is a therapeutic option for patients with acute myeloid leukemia (AML)/acute lymphoblastic leukemia (ALL) relapsing after HSCT1. Our aim is to evaluate the efficacy of HSCT2 in acute leukemia patients who relapsed after HSCT1.</div></div><div><h3>Material and methods</h3><div>In the current study, we retrospectively analyzed the data of 72 patients who underwent HSCT2. Forty-six patients with AML and 26 patients with ALL were included in the study.</div></div><div><h3>Results</h3><div>Before undergoing HSCT2, 47 % of patients were in complete remission. Median follow-up was 8 (1–109) months. Mortality at last follow-up was 61.1 %, and the median overall survival was 11 months (95 % CI: 1–22.9). Univariate analysis identified that age, Eastern Cooperative Oncology Group (ECOG), Body Mass Index, chimerism, conditioning regimen, CD34⁺ infused cell count, post-transplant cyclophosphamide usage, disease type, pre transplant hemoglobin-lymphocyte-lactate dehydrogenase-ferritin might be significant factors. After multivariate analysis ECOG (HR: 2.142; 95 % CI: 1.061–4.326; p = 0.034) was the only independent predictor for survival.</div></div><div><h3>Conclusion</h3><div>HSCT2 remains a feasible but high-risk treatment option for patients with relapsed acute leukemia after HSCT1. Our findings confirm that ECOG performance status is a key determinant of survival despite advances in transplantation techniques.</div></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"64 4","pages":"Article 104187"},"PeriodicalIF":1.4,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144331216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fresh and cryopreserved stem cell transplantation in myeloma patients: Does it make a difference on transplant outcomes?","authors":"Mehmet Ali Erkurt ,&nbsp;Seda Yilmaz ,&nbsp;Sinem Namdaroglu ,&nbsp;Sinan Demircioglu ,&nbsp;Ahmet Sarici ,&nbsp;Salih Cirik ,&nbsp;Mustafa Koroglu ,&nbsp;Mustafa Merter ,&nbsp;Semih Basci ,&nbsp;Ilhami Berber ,&nbsp;Abdulkadir Basturk ,&nbsp;Mehmet Sinan Dal ,&nbsp;Turgay Ulaş ,&nbsp;Serdal Korkmaz ,&nbsp;Fevzi Altuntas","doi":"10.1016/j.transci.2025.104184","DOIUrl":"10.1016/j.transci.2025.104184","url":null,"abstract":"<div><h3>Objective</h3><div>The standard approach for multiple myeloma patients eligible for transplantation includes 4–6 cycles of induction therapy, followed by autologous stem cell transplantation (aHSCT). The aHSCT process starts with stem cell mobilization and collection, followed by high-dose chemotherapy and reinfusion of the harvested stem cells. These cells can be infused fresh within 24–48 h post-collection or cryopreserved for future use. Herein we analyzed the outcomes of aHSCT patients receiving infusions of fresh versus cryopreserved hematopoietic stem cells.</div></div><div><h3>Materials and methods</h3><div>This multicenter retrospective study analyzed 88 adult patients diagnosed with multiple myeloma who underwent aHSCT (n = 43 for cryopreserved; n = 45 for fresh infused group).</div></div><div><h3>Results</h3><div>A total of 88 patients were included in the study. 39.7 % of patients were female and 60.3 % of patients were male. No correlation was observed between pre-mobilization disease status, mobilization regimen, and disease risk status as defined by the R-ISS system (p = 0.1, p = 0.8). The median neutrophil engraftment time was 10 days in the fresh group and 12 days in the cryopreserved group (p &lt; 0.01). In contrast, the median platelet engraftment time was 12 days in the fresh group and 11 days in the cryopreserved group (p &lt; 0.01). Engraftment was achieved in all patients included in the study.</div></div><div><h3>Conclusion</h3><div>The shorter neutrophil engraftment time in the fresh group and the shorter platelet engraftment time in the cryopreserved group, along with successful engraftment in all patients, suggest that both options are reasonable within the MM aHSCT protocol.</div></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"64 4","pages":"Article 104184"},"PeriodicalIF":1.4,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144470936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative performance analysis of artificial intelligence models in therapeutic apheresis training: A pilot study","authors":"Mehmet Koca","doi":"10.1016/j.transci.2025.104188","DOIUrl":"10.1016/j.transci.2025.104188","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aims to evaluate the theoretical knowledge level, consistency, and performance of three different artificial intelligence (AI) models—ChatGPT-4o, o1-preview, and Claude 3.5 Sonnet (New)—based on 75 five-option multiple-choice questions from the question pool of the therapeutic apheresis certification exam organized by the Republic of Türkiye Ministry of Health.</div></div><div><h3>Methods</h3><div>In the study, 75 questions from the apheresis course exam were presented to the AI models in separate conversation sessions, requiring step-by-step reasoning. Each question was asked twice to prevent inconsistencies in the models' responses; if a discrepancy was detected between the first two answers, a third query was conducted. This method resulted in a total of 485 question-answer records. The data were analyzed using correct answer rates, Cohen's kappa coefficient for agreement between runs, correlation analysis, and the chi-square test.</div></div><div><h3>Results</h3><div>The overall accuracy rates were determined as 61 % for ChatGPT-4o, 67 % for o1-preview, and 59 % for Claude 3.5 Sonnet. The consistency between the two runs of the models was found to be good (kappa = 0.700–0.765). In correlation analyses between the AI models' responses and the answer key, the o1-preview model demonstrated the highest agreement (<em>r</em> = 0.494, <em>p</em> &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>The findings suggest that the examined AI models perform at a level close to the certification threshold in the field of therapeutic apheresis. Future studies are recommended to include larger question pools and explore different medical disciplines.</div></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"64 4","pages":"Article 104188"},"PeriodicalIF":1.4,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144366048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Education in transfusion medicine – What is preferred?","authors":"Cees Th. Smit Sibinga","doi":"10.1016/j.transci.2025.104191","DOIUrl":"10.1016/j.transci.2025.104191","url":null,"abstract":"<div><div>Transfusion Medicine is one of the youngest medical branches. The specialty started around 1900 with the discovery of red cell characteristics (blood groups) by Landsteiner and his research group. Although it opened the door to more safe clinical transfusion, the field largely explored the technical laboratory aspects related to the manufacturing and preservation of blood and blood products and the provider of the human source material, the blood donor. As a consequence, education largely covered these technical elements focusing on laboratory skills, test tube oriented. That raises the question: is it knowledge or the regular skills which are regarded as the most important? There is a great variety of educational or learning curricula designed around the technical laboratory aspects of blood transfusion (Transfusion Medicine), with little attention to the important aspects of knowledge, the deeper theoretical background and governance structure of the technical manufacturing aspects. Much education or learning is not systematically and nationally organized and often locally provided by non-professional teachers. The data assembled by the World Health Organization (WHO) and United Nations Development Program (UNDP), but also through surveys conducted by professional associations provide a sad picture that needs focused action by governments particularly in the Low-and Middle-Income Countries (LMICs). This review illustrates the importance and economy of sharing of knowledge as the driving force in education: Awareness and understanding, an education environment and a learning climate under the guidance of the Ministry of Education – policy and strategies, the legal system and regulation of the education system are required to respect recognition of education outcomes and implementation of required knowledge.</div></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"64 4","pages":"Article 104191"},"PeriodicalIF":1.4,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144470834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of heparin in autologous stem cell mobilization in patients with multiple myeloma","authors":"Ahmet Sarici ,&nbsp;Mehmet Ali Erkurt ,&nbsp;Seda Yilmaz ,&nbsp;Sinan Demircioglu ,&nbsp;Ilhami Berber ,&nbsp;Abdulkadir Basturk ,&nbsp;Mustafa Merter ,&nbsp;Irfan Kuku ,&nbsp;Mustafa Koroglu ,&nbsp;Emin Kaya ,&nbsp;Mehmet Sinan Dal ,&nbsp;Serdal Korkmaz ,&nbsp;Turgay Ulaş ,&nbsp;Fevzi Altuntas","doi":"10.1016/j.transci.2025.104185","DOIUrl":"10.1016/j.transci.2025.104185","url":null,"abstract":"<div><h3>Background</h3><div>Autologous hematopoietic stem cell transplantation (aHSCT) has become the standard treatment modality for eligible multiple myeloma (MM) patients. One of the most important parameters affecting the success of transplantation is the number of CD34⁺ stem cells collected. The most commonly used agents to facilitate the release of CD34⁺ stem cells into peripheral blood are granulocyte colony-stimulating factor and plerixafor. Heparin has also been shown to enhance the release of CD34⁺ stem cells into peripheral blood. We aimed to report the effect of heparin on the number of CD34⁺ stem cells in peripheral blood in MM patients who underwent aHSCT.</div></div><div><h3>Materials and methods</h3><div>This multicenter retrospective study analyzed 138 adult patients diagnosed with MM who underwent aHSCT. Patients were divided into two groups: those who received heparin (n = 108) and those who did not receive heparin before aHSCT (n = 30).</div></div><div><h3>Results</h3><div>The complete response, partial response, and very good partial response rates in the heparin group were 17 % (n = 18), 24 % (n = 26), and 59 % (n = 64), respectively. In the non-heparin group, 20 % of patients (n = 6) achieved complete response, while partial response and very good partial response rates were 33 % (n = 10) and 47 % (n = 14), respectively. There was no statistically significant difference between the groups regarding obesity, ECOG performance scores, and smoking status (p = 0.399, 0.578, and 0.602, respectively). The number of collected CD34⁺ stem cells and the peak CD34⁺ stem cell count in peripheral blood were significantly higher in the heparin group compared to the control group (both p &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>Heparin has been shown to enhance the migration of CD34⁺ stem cells into peripheral blood and facilitate the peripheral stem cell collection process.</div></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"64 4","pages":"Article 104185"},"PeriodicalIF":1.4,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144470935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biographies of the guest editors for this issue's theme papers on stem cell mobilization and transplantation from a Turkish perspective","authors":"Fevzi Altuntas,&nbsp;Turgay ULAS","doi":"10.1016/j.transci.2025.104180","DOIUrl":"10.1016/j.transci.2025.104180","url":null,"abstract":"","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"64 4","pages":"Article 104180"},"PeriodicalIF":1.4,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144490226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}