从健康献血者获得的干细胞产量与健康献血者的血型之间是否存在关系？

IF 1.2 4区医学 Q4 HEMATOLOGY

Transfusion and Apheresis Science Pub Date : 2025-06-20 DOI:10.1016/j.transci.2025.104182

Yavuz Katircilar , Abdulkadir Sahin , Muruvvet Seda Aydin , Kerim Erer , Mehmet Ali Erkurt , Sinem Namdaroglu , Seda Yilmaz , Sinan Demircioglu , Ant Uzay , Ali Durdu , Mustafa Koroglu , Gulsum Ozet , Merve Apaydin , Mehmet Sinan Dal , Turgay Ulas , Serdal Korkmaz , Fevzi Altuntas

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引用次数: 0

摘要

背景和目的影响充分动员和分离的因素对于最终产物中造血干细胞（hsc）的良好产量至关重要。研究发现，女性供体、高龄、吸烟、乳酸脱氢酶水平高、基线淋巴细胞绝对计数高与收获的CD34+细胞数量呈负相关。然而，关于a、B、AB、O血型与采集的CD34+细胞数量之间是否存在相关性的数据并不充分。本研究的目的是探讨血型对健康献血者干细胞产量的影响。材料与方法本回顾性研究共纳入来自日本10个中心的807名健康献血者。献血者按血型分为A、B、AB、O四组。这四组在年龄、性别、ECOG表现评分、吸烟状况和收获的CD34+干细胞数量方面进行比较。结果807例健康献血者年龄中位数为35岁（11 ~ 70岁）。256例（31.7% %）为女性，551例（68.2% %）为男性。其中，A型血349人，B型血134人，AB型血53人，O型血271人。总采血产物中CD34+细胞的中位数为：O型血7.67 × 106 / kg， A型血7.52 × 106 / kg， B型血7.2 × 106 / kg， AB型血7.45 × 106 / kg。各组间差异无统计学意义（p:0.673）。与其他组相比，B型血的吸烟率为29.1 %，较低。而吸烟较少的B血型患者CD34+干细胞总量差异无统计学意义（p = 0.949）。在我们的研究中，我们回顾性分析了供者血型对健康供者外周血造血干细胞提取效率的影响，发现血型与CD34+细胞的动员和数量之间没有相关性。

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Is there a relationship between stem cell yield obtained from healthy donors and healthy donors’ blood type?

Background and objectives

Factors affecting adequate mobilization and apheresis are critical for a good yield of hematopoietic stem cells (HSCs) in the final product. A female donor, advanced age, smoking, high lactate dehydrogenase levels, high absolute lymphocyte count at baseline were found to be inversely correlated to the number of harvested CD34⁺ cells. However, the data on whether there is a correlation between blood types A, B, AB, O and the number of harvested CD34⁺ cells is insufficient. The aim of this study is to investigate the effect of blood types on the stem cell yield in healthy donors.

Material and methods

A total of 807 healthy donors from 10 centers in Türkiye were included in this retrospective study. Donors were subdivided into four groups as A, B, AB, O by their blood types. These four groups were compared in terms of age, sex, ECOG performance score, smoking status, and the amount of harvested CD34⁺ stem cells.

Results

The median age of the 807 healthy donors included in the study was 35 years (11–70). 256 (31.7 %) donors were female and 551 (68.2 %) donors were male. There were 349 donors in type A blood group, 134 in type B blood group, 53 in type AB blood group and 271 donors in type O blood group. The median amount of CD34⁺ cells in the total apheresis product was 7.67 × 10⁶ per kg in type O blood group, 7.52 × 10⁶ per kg in type A blood group, 7.2 × 10⁶ per kg in type B blood group, and 7.45 × 10⁶ per kg in type AB blood group. There was no statistically significant difference among the groups (p:0.673). Smoking was lower in the type B blood group with 29.1 % compared to the other groups. However, there was no statistically significant difference in total amount of CD34⁺ stem cells in the type B blood group who smoked less (p = 0.949).

Conclusion

In our study in which we have retrospectively analyzed the effect of donor blood types on the efficiency of HSCs harvested from peripheral blood in healthy donors, no correlation was found between the blood types and the mobilization and amount of harvested CD34⁺ cells.

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来源期刊

Transfusion and Apheresis Science 医学-血液学

CiteScore

3.60

自引率

5.30%

发文量

181

审稿时长

42 days

期刊介绍： Transfusion and Apheresis Science brings comprehensive and up-to-date information to physicians and health care professionals involved in the rapidly changing fields of transfusion medicine, hemostasis and apheresis. The journal presents original articles relating to scientific and clinical studies in the areas of immunohematology, transfusion practice, bleeding and thrombotic disorders and both therapeutic and donor apheresis including hematopoietic stem cells. Topics covered include the collection and processing of blood, compatibility testing and guidelines for the use of blood products, as well as screening for and transmission of blood-borne diseases. All areas of apheresis - therapeutic and collection - are also addressed. We would like to specifically encourage allied health professionals in this area to submit manuscripts that relate to improved patient and donor care, technical aspects and educational issues. Transfusion and Apheresis Science features a "Theme" section which includes, in each issue, a group of papers designed to review a specific topic of current importance in transfusion and hemostasis for the discussion of topical issues specific to apheresis and focuses on the operators'' viewpoint. Another section is "What''s Happening" which provides informal reporting of activities in the field. In addition, brief case reports and Letters to the Editor, as well as reviews of meetings and events of general interest, and a listing of recent patents make the journal a complete source of information for practitioners of transfusion, hemostasis and apheresis science. Immediate dissemination of important information is ensured by the commitment of Transfusion and Apheresis Science to rapid publication of both symposia and submitted papers.