Effects of multiple apheresis platelet donations for the iron nutrition condition and platelet parameters of blood donors in China: A meta-analysis study

IF 1.4 4区医学 Q4 HEMATOLOGY

Transfusion and Apheresis Science Pub Date : 2025-02-01 DOI:10.1016/j.transci.2024.104043

Quan Sun , Liying Wu , Yao Shen , Le Wang , Xiujuan Shen

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引用次数: 0

Abstract

Background

Apheresis platelets is a common platelets collection method with high purity and relatively few adverse reactions. This study aimed to explore the effects of multiple apheresis platelet donations on the condition of iron nutrition and platelet parameters of donors in China.

Methods

Eligible studies were selected from PubMed, EMBASE, Wanfang, CQVIP, and the Chinese National Knowledge Infrastructure (CNKI) databases. Pooled serum ferritin (SF), serum iron (SI), transferrin (TRF), soluble transferrin receptor (sTfR), platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), and platelet crit (PCT) were analyzed by weighted mean difference (WMD). Heterogeneity was detected by the Cochran Q test and I² statistical test.

Results

Pooled SF (WMD =-20.837, 95 % CI = −26.403 - −15.271) and SI (WMD = −3.828, 95 % CI = −6.516 - −1.139) were significantly decreased; while TRF (WMD = 0.821, 95 % CI = 0.271–1.371) and sTfR (WMD = 0.846, 95 % CI = 0.442–1.250) were increased by multiple apheresis platelet donations. PLT (WMD = 14.894, 95 % CI = 2.574–27.215) and PCT (WMD = 0.035, 95 % CI = 0.005–0.064) were increased, but MPV (WMD = −0.359, 95 % CI = −0.571 - −0.147) was reduced by multiple donations. Subgroup analysis indicated study design is a source of heterogeneity.

Conclusion

Multiple apheresis platelets could lead to iron deficiency and suppress platelet function in comparison with first-time apheresis platelets.

查看原文本刊更多论文

多次无偿捐献血小板对中国献血者铁营养状况和血小板参数的影响：一项荟萃分析研究。

背景：单采血小板是一种常见的血小板采集方法，其纯度高，不良反应相对较少。本研究旨在探讨多次单采血小板捐献对献血者铁营养状况及血小板参数的影响。方法：从PubMed、EMBASE、万方、CQVIP和中国知网数据库中选择符合条件的研究。采用加权平均差（WMD）分析合并血清铁蛋白（SF）、血清铁（SI）、转铁蛋白（TRF）、可溶性转铁蛋白受体（sTfR）、血小板计数（PLT）、平均血小板体积（MPV）、血小板分布宽度（PDW）和血小板临界值（PCT）。采用Cochran Q检验和I2统计检验检验异质性。结果：合并SF （WMD =-20.837, 95 % CI =- 26.403 ~ -15.271）和SI （WMD =- 3.828, 95 % CI =- 6.516 ~ -1.139）显著降低；多次单采血小板捐献使TRF （WMD = 0.821, 95 % CI = 0.271 ~ 1.371）和sTfR （WMD = 0.846, 95 % CI = 0.442 ~ 1.250）升高。PLT （WMD = 14.894, 95 % CI = 2.574 ~ 27.215）和PCT （WMD = 0.035, 95 % CI = 0.005 ~ 0.064）升高，MPV （WMD = -0.359, 95 % CI = -0.571 ~ -0.147）降低。亚组分析表明，研究设计是异质性的来源。结论：与首次采血小板相比，多次采血小板可导致铁缺乏和血小板功能抑制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Transfusion and Apheresis Science 医学-血液学

CiteScore

3.60

自引率

5.30%

发文量

181

审稿时长

42 days

期刊介绍： Transfusion and Apheresis Science brings comprehensive and up-to-date information to physicians and health care professionals involved in the rapidly changing fields of transfusion medicine, hemostasis and apheresis. The journal presents original articles relating to scientific and clinical studies in the areas of immunohematology, transfusion practice, bleeding and thrombotic disorders and both therapeutic and donor apheresis including hematopoietic stem cells. Topics covered include the collection and processing of blood, compatibility testing and guidelines for the use of blood products, as well as screening for and transmission of blood-borne diseases. All areas of apheresis - therapeutic and collection - are also addressed. We would like to specifically encourage allied health professionals in this area to submit manuscripts that relate to improved patient and donor care, technical aspects and educational issues. Transfusion and Apheresis Science features a "Theme" section which includes, in each issue, a group of papers designed to review a specific topic of current importance in transfusion and hemostasis for the discussion of topical issues specific to apheresis and focuses on the operators'' viewpoint. Another section is "What''s Happening" which provides informal reporting of activities in the field. In addition, brief case reports and Letters to the Editor, as well as reviews of meetings and events of general interest, and a listing of recent patents make the journal a complete source of information for practitioners of transfusion, hemostasis and apheresis science. Immediate dissemination of important information is ensured by the commitment of Transfusion and Apheresis Science to rapid publication of both symposia and submitted papers.