Iranian Journal of Public Health最新文献_第3页

Long-Term Survival of Patient with End-Stage Renal Disease Using Bayesian Mixture Cure Rate Frailty Models. 使用贝叶斯混合治愈率虚弱模型评估终末期肾病患者的长期生存率

IF 1.3 4区医学

Iranian Journal of Public Health Pub Date : 2024-09-01 DOI: 10.18502/ijph.v53i9.16464

Abbas Bahrampour, Mohammad Reza Baneshi, Ali Karamoozian, Navisa Sadat Seyedghasemi, Abbas Etminan, Mostafa Eghbalian

{"title":"Long-Term Survival of Patient with End-Stage Renal Disease Using Bayesian Mixture Cure Rate Frailty Models.","authors":"Abbas Bahrampour, Mohammad Reza Baneshi, Ali Karamoozian, Navisa Sadat Seyedghasemi, Abbas Etminan, Mostafa Eghbalian","doi":"10.18502/ijph.v53i9.16464","DOIUrl":"10.18502/ijph.v53i9.16464","url":null,"abstract":"Background: Along with the increasing prevalence of ESRD in developing countries, the use of more up-to-date statistical models is highly recommended. It is crucial to control potential cure pattern and heterogenicity among patients.Methods: In this longitudinal study, the data of 170 hemodialysis patients who visited the dialysis department of Shafa Hospital in Kerman from 2006 to 2016 were collected. To provides robust estimates the time to event data (death) were analyzed with a gamma frailty mixed cure Weibull model (MC-WG) using Bayesian inference.Results: About 49% of patients experienced the death and median survival time was 37.5 months. Older patients (0.264), female patients (0.269), and patients with higher mean serum urea levels (0.186) had a higher risk of death. Moreover, we observe a decrease in death with increase in Creatine (Cr).Conclusion: In the MC-WG Bayesian model, the diabetes, AST, calcium, phosphorus and uric acid variables had a significant effect on the survival of hemodialysis patients, while they were not significant in the Cox PH model. The results of MC-WG Bayesian model are more consistent with other studies.","PeriodicalId":49173,"journal":{"name":"Iranian Journal of Public Health","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11490321/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142478776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural Equation Modeling of Clinical Adaptation in Newly Registered Nurses. 新注册护士临床适应性的结构方程模型。

IF 1.3 4区医学

Iranian Journal of Public Health Pub Date : 2024-09-01 DOI: 10.18502/ijph.v53i9.16469

Keun-Sook Park, Kweon Young Ran, Aeri Jang

引用次数: 0

The Societal Impact of the Papers Published in Blended Learning in Medicine on Social Network Sites: An Altmetrics Study. 在社交网站上发表的《医学混合学习》论文的社会影响：Altmetrics 研究。

IF 1.3 4区医学

Iranian Journal of Public Health Pub Date : 2024-09-01 DOI: 10.18502/ijph.v53i9.16465

Shohreh SeyyedHosseini, Mohammadreza Yazdankhahfard, Maryam Azargoon, Reza BasirianJahromi

{"title":"The Societal Impact of the Papers Published in Blended Learning in Medicine on Social Network Sites: An Altmetrics Study.","authors":"Shohreh SeyyedHosseini, Mohammadreza Yazdankhahfard, Maryam Azargoon, Reza BasirianJahromi","doi":"10.18502/ijph.v53i9.16465","DOIUrl":"10.18502/ijph.v53i9.16465","url":null,"abstract":"Background: Nowadays, blended learning in medicine (BLM) has gained the attention of most experts as an invaluable approach to improving the quality of medical education. The level of attention to articles in this field on social networks is substantial. This study aimed to study the effectiveness of published articles in blended learning, indexed in Scopus and Web of Science databases between 2013 and 2022, from an altmetrics perspective.Methods: The research is descriptive-analytical, with a scientometrics approach (using the Altmetrics index). The population includes all the articles on blended learning in medicine, indexed in Scopus and Web of Science databases, two well-known citation databases worldwide. Data were extracted using the Altmetrics bookmarklet tool and analyzed with descriptive statistics methods in Excel software.Results: Out of 1327 articles, 136 articles (10.25%) did not have a digital object identifier (DOI) or PMID number. Mendeley, X (previously Twitter), and Dimensions were the most widely used social networks in blended learning. The United States, the United Kingdom, and Australia had the highest number of tweets in blended learning in medicine.Conclusion: The number of articles with altmetrics indicators, categorized by publication year, demonstrates an improvement in the familiarity and use of social media by blended learning researchers in medicine. Blended learning researchers are advised to carefully select reputable journals - preferably with DOI - to increase the visibility and attention to their articles on social media.","PeriodicalId":49173,"journal":{"name":"Iranian Journal of Public Health","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11490342/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142478796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tuberculosis in Human Bones from 4000 Years Ago, Iran. 伊朗 4000 年前人类骨骼中的结核病。

IF 1.3 4区医学

Iranian Journal of Public Health Pub Date : 2024-09-01 DOI: 10.18502/ijph.v53i9.16463

Dariush D Farhud, Mahsa Azari, Mehdi Rahbar

{"title":"Tuberculosis in Human Bones from 4000 Years Ago, Iran.","authors":"Dariush D Farhud, Mahsa Azari, Mehdi Rahbar","doi":"10.18502/ijph.v53i9.16463","DOIUrl":"10.18502/ijph.v53i9.16463","url":null,"abstract":"Background: Tuberculosis is caused by a bacterium called Mycobacterium tuberculosis, which is a contagious and infectious disease; in the first stage, it destroys the lungs and in the next stage other body organs, such as the spine and long bones. This disease is transmitted through an infected person and due to the weakness of the immune system, the infection intensifies. Tuberculosis has two stages: low activity and high activity. In this article, we have discussed the signs of tuberculosis destruction with high intensity on the bones of prehistory human remains.Methods: The examples of our research are related to human remains from the ancient cemetery of 4000 years ago from Sagezabad region of Qazvin Province of Iran. That period of history coincides with the Iron Age 2 and 3 in the region. People inside the Sagezabad cemetery were very near to early urban (the late rural) society.Results: By matching the form of bone destruction with international atlases for tuberculosis, we have reached a satisfactory result in this article. Due to the strong penetration of the infection into the bones, destruction in the remains was high, so it has simplified the diagnosis for us.Conclusion: We found tuberculosis among the bones. This common ancient disease existed even among Neanderthals.","PeriodicalId":49173,"journal":{"name":"Iranian Journal of Public Health","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11490334/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142485956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of C-X-C Motif Chemokine Ligand 12 in Colorectal Cancer Associated with Chemoresistance and Radioresistance as Well as Stemness. C-X-C Motif Chemokine Ligand 12 在结直肠癌中的作用与化疗耐药性、放射耐药性和干性有关

IF 1.3 4区医学

Iranian Journal of Public Health Pub Date : 2024-09-01 DOI: 10.18502/ijph.v53i9.16461

Wuzhen Dong, Wen Lin, Chong Li

{"title":"The Effect of C-X-C Motif Chemokine Ligand 12 in Colorectal Cancer Associated with Chemoresistance and Radioresistance as Well as Stemness.","authors":"Wuzhen Dong, Wen Lin, Chong Li","doi":"10.18502/ijph.v53i9.16461","DOIUrl":"10.18502/ijph.v53i9.16461","url":null,"abstract":"Background: We aimed to explore the role of C-X-C motif chemokine ligand 12 (CXCL12) and cytokinecytokine receptor interaction signaling pathway in the radiotherapy and chemotherapy resistance as well as cell stemness in colorectal cancer (CRC).Methods: Bioinformatics analysis was used to identify the differentially expressed mRNAs and signal pathways closely related to differentially expressed mRNAs have also been analyzed in March 2022 at the Jinhua Central Hospital, China. Then, the expression of CXCL12 was detected by qRT-PCR in colorectal cancer cells and testing the effects of transfecting CXCL12 into different CRC-derived cell lines. The effects of CXCL12 on cell proliferation were evaluated by chemosensitivity assay and radiation sensitivity assay.Results: Bioinformatics analysis of DEGs found a total of 2429 differentially expressed genes, THBS3 and CXCL12 genes are two abnormally highly expressed genes in the CRC. KEGG analysis showed the correlative signaling pathway, cytokine-cytokine receptor interaction, which is related to cell stemness. Furthermore, the expression of CXCL12 in CRC cells was detected and an increasing trend was obtained in CRC cells. In addition, the chemosensitivity and radiotherapy tolerance were elevated after transfected with CXCL12.Conclusion: CXCL12 could be a potential promote biomarkers in CRC and also promote the chemosensitivity and radiotherapy tolerance.","PeriodicalId":49173,"journal":{"name":"Iranian Journal of Public Health","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11490330/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142478793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Screening Results for Vancomycin-Resistant Enterococci: Three-Year Surveillance. 耐万古霉素肠球菌筛查结果评估：三年监测。

IF 1.3 4区医学

Iranian Journal of Public Health Pub Date : 2024-08-01 DOI: 10.18502/ijph.v53i8.16279

Zeynep Ayaydın, Ayşe Batgi Azarkan, Özge Alkan Bilik, Ali Cem Tekin

{"title":"Evaluation of Screening Results for Vancomycin-Resistant Enterococci: Three-Year Surveillance.","authors":"Zeynep Ayaydın, Ayşe Batgi Azarkan, Özge Alkan Bilik, Ali Cem Tekin","doi":"10.18502/ijph.v53i8.16279","DOIUrl":"https://doi.org/10.18502/ijph.v53i8.16279","url":null,"abstract":"Background: Enterococci are facultative anaerobic, binary, or chained Gram-positive cocci. The gastrointestinal colonization of hospitalized patients is the most important reservoir of vancomycin-resistant enterococci. We aimed to evaluate retrospectively the screening results of vancomycin-resistant enterococci, studied by the simultaneous (real-time) polymerase chain reaction method on rectal swabs of adult and pediatric patients hospitalized in our hospital in 2019-2021.Methods: Adult and pediatric patients were included in our study between Jan 2019 and Dec 2021. The results of vancomycin-resistant enterococci, studied with the real-time polymerase chain reaction method from rectal swabs sent from intensive care units and services, were analyzed retrospectively. Isolation of the samples was performed using the Fluorion VRE QLP 1.0 real-time polymerase chain reaction kit (Iontek, Turkey), and detection was performed with the Fluorion Detection System (Iontek, Turkey) real-time polymerase chain reaction device.Results: Overall, 31,725 patients were included in our study. When evaluated in order of years, in 2019, 379 (7%) of 5,389 adults, 322 (7.4%) of 4,003 children, 234 (5.5%) of 4,185 adults in 2020, 157 (2.4%) of 6,499 children, and in 2021, vancomycin-resistant enterococci were detected in 469 (7.5%) of 6,232 adults and 224 (4.1%) of 5,417 children.Conclusion: The prevalence of vancomycin-resistant enterococci is greater in adults, particularly in intensive care units, compared to children. Infection control precautions and training be augmented in high-risk clinics, while the unnecessary utilization of glycopeptides should be limited.","PeriodicalId":49173,"journal":{"name":"Iranian Journal of Public Health","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11475171/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142478712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adaptation Potential and Body Mass Index in Assessing the Vital Activity of the Population in Mountain Regions. 评估山区人口生命活动的适应潜力和体重指数。

IF 1.3 4区医学

Iranian Journal of Public Health Pub Date : 2024-08-01 DOI: 10.18502/ijph.v53i8.16296

Ainura Manasovna Satarkulova, Shadiya Yusupdjanovna Aisaeva, Kanykei Sadyrbekovna Keneshova, Asel Abdumomunovna Usenova, Shirin Syrgakovna Bakirova

{"title":"Adaptation Potential and Body Mass Index in Assessing the Vital Activity of the Population in Mountain Regions.","authors":"Ainura Manasovna Satarkulova, Shadiya Yusupdjanovna Aisaeva, Kanykei Sadyrbekovna Keneshova, Asel Abdumomunovna Usenova, Shirin Syrgakovna Bakirova","doi":"10.18502/ijph.v53i8.16296","DOIUrl":"https://doi.org/10.18502/ijph.v53i8.16296","url":null,"abstract":"Background: We aimed to evaluate the functional state of the population of the midlands and highlands of Alai region (Kyrgyzstan) on the basis of body mass index (BMI) and adaptation potential (AP). The characteristic of people with overweight and underweight are presented. A clean dependence of AP on BMI was revealed.Methods: In Alai region (Kyrgyzstan), 285 citizens of Gulcha village (1.540 m above sea level) and 312 citizens of Sary-Tash village (3.200 m above sea level) were examined in July-August 2023. Blood pressure (BP) was generally measured at rest in the seated position. The BMI and AP were calculated.Results: In the midlands and highlands BP correspond to the physiological norm. The AP scores in the midlands region for men was 2.32 points, for women - 2.38 points, but in highlands areas these values were slightly higher: for men - 2.52 points, for women - 2.42 points. The total BMI values for men in the midlands and highlands were 23.39 and 23.24 kg/m2 respectively, for women in the midlands this indicator became higher than normal (26.53 kg/m2), but in the highlands it corresponded to the norm (24.78 kg/m2).Conclusion: It is necessary to determine the value of AP, BMI and type of self-regulation of blood circulation when assessing the functional state of residents living in mountain areas. In the highlands overweight, which is one of the significant risk factors for health disorders, with tension of regulatory mechanisms can become a trigger for the development of cardiovascular diseases.","PeriodicalId":49173,"journal":{"name":"Iranian Journal of Public Health","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11475178/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142478802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating the Governance Ability of Urban Public Health Using EM-AHP-TOPSIS Method: A Case Study in China. 利用 EM-AHP-TOPSIS 方法评估城市公共卫生治理能力：中国案例研究。

IF 1.3 4区医学

Iranian Journal of Public Health Pub Date : 2024-08-01 DOI: 10.18502/ijph.v53i8.16287

Ysijun Shou, Jixia Shou

{"title":"Evaluating the Governance Ability of Urban Public Health Using EM-AHP-TOPSIS Method: A Case Study in China.","authors":"Ysijun Shou, Jixia Shou","doi":"10.18502/ijph.v53i8.16287","DOIUrl":"https://doi.org/10.18502/ijph.v53i8.16287","url":null,"abstract":"Background: Evaluating the governance capacity of urban public health is the key to improving the level of urban public health. We aimed to evaluate the governance ability of urban public health.Methods: An index system of governance ability of urban public health was established. The governance ability of urban public health was evaluated, and major constraints against the ability improvement were analyzed through the EM (Entropy Method)-AHP (Analytic Hierarchy Process)-TOPSIS (Technique for Order Preference by Similarity to an Ideal Solution) model and data of urban agglomeration in Yangtze River Delta, China in 2023.Results: Shanghai, Nanjing, Hangzhou, Suzhou, and Ningbo rank top 5 in terms of governance ability of public health, and they are in the first echelon. Hefei, Yancheng, Wuxi, Taizhou and Shaoxing rank 6-10, and they are in the second echelon. The remaining 17 cities are in the third echelon. Major sources of governance ability of urban public health and major factors that decrease governance ability are Medical Facility (A12), Health Improvement (A33), Medical Staff (A13), Government Ability (A11), and Health Loss (A34). For urban agglomeration in Yangtze River Delta, China, public health foundations, environmental exposure risks, public health performance, and public health emergencies all can influence the governance ability of public health.Conclusion: Accurate evaluation of the governance ability of urban public health can provide guidance and policy propositions to improve the governance system of public health and improve the emergency coordination ability of the government.","PeriodicalId":49173,"journal":{"name":"Iranian Journal of Public Health","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11475180/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142478711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy and Safety of Autologous Cytokine-Induced Killer (CIK) Cellular Immunotherapy Combined with Chemotherapy in Non-Small-Cell Carcinoma (NSCLC): A Meta-Analysis. 自体细胞因子诱导的杀伤细胞（CIK）细胞免疫疗法联合化疗治疗非小细胞癌（NSCLC）的有效性和安全性：一项 Meta 分析。

IF 1.3 4区医学

Iranian Journal of Public Health Pub Date : 2024-08-01 DOI: 10.18502/ijph.v53i8.16277

Cheng Zhong, Haowei Tang, Qun Wang

{"title":"Efficacy and Safety of Autologous Cytokine-Induced Killer (CIK) Cellular Immunotherapy Combined with Chemotherapy in Non-Small-Cell Carcinoma (NSCLC): A Meta-Analysis.","authors":"Cheng Zhong, Haowei Tang, Qun Wang","doi":"10.18502/ijph.v53i8.16277","DOIUrl":"https://doi.org/10.18502/ijph.v53i8.16277","url":null,"abstract":"Background: To investigate the efficacy and safety of autologous Cytokine-induced killer (CIK) cellular immunotherapy combined with chemotherapy for non-small-cell carcinoma (NSCLC).Methods: The literature related to the efficacy and safety of autologous CIK cellular immunotherapy combined with chemotherapy in NSCLC were collected. The Chinese literature databases were collected from CNKI, Wanfang and Weipu, and the English literature were retrieved from Cochrane Library and PubMed. All literature were retrieved until the year of 2022, and evaluated by its method quality and analyzed by RevMan5.3 software.Results: A Meta-analysis on the 11 included literature showed that the treatment efficacy and disease control rate (DCR) of patients in the observation group were significantly higher than those in the control group (P < 0.05), and significantly increased the levels of CD3+, CD4+, CD4+/CD8+ indexes than the control group (P < 0.05), and the incidence of bone marrow suppression, liver injury and gastrointestinal symptoms were significantly lower than those of the control group (P < 0.05).Conclusion: Compared with single chemotherapy, CIK combined with chemotherapy in the treatment of patients with NSCLC can improve the efficacy of treatment and DCR, significantly improve their immune function, reduce the incidence of adverse reactions, and is beneficial to the recovery of prognosis.","PeriodicalId":49173,"journal":{"name":"Iranian Journal of Public Health","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11475181/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142478709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bone Mineral Density, Osteoporosis Prevalence and Influential Factors in Osteogenesis in Patients with Beta Thalassemia Major: A Cross-Sectional Study. 重型β地中海贫血患者的骨密度、骨质疏松症患病率和骨生成的影响因素：一项横断面研究。

IF 1.3 4区医学

Iranian Journal of Public Health Pub Date : 2024-08-01 DOI: 10.18502/ijph.v53i8.16294

Saba Behzadifard, Ali Arianezhad, Donya Nazarinia, Roya Behmanesh, Hosein Sinaei, Davood Alinezhad Dezfuli, Mahin Behzadifard

{"title":"Bone Mineral Density, Osteoporosis Prevalence and Influential Factors in Osteogenesis in Patients with Beta Thalassemia Major: A Cross-Sectional Study.","authors":"Saba Behzadifard, Ali Arianezhad, Donya Nazarinia, Roya Behmanesh, Hosein Sinaei, Davood Alinezhad Dezfuli, Mahin Behzadifard","doi":"10.18502/ijph.v53i8.16294","DOIUrl":"https://doi.org/10.18502/ijph.v53i8.16294","url":null,"abstract":"Background: Osteoporosis and osteopenia considered as severe problems in Beta thalassemia major (BTM) that can lead to bone fractures. We aimed to investigate bone mineral density status and the laboratory parameters related to bone metabolism in BTM patients and compare the statically differences between the mentioned parameters in the patients with or without bone fractures.Methods: The results of laboratory parameters including; Hemoglobin (Hb), Calcium (Ca), Vitamin D (Vit D), Phosphorus (P), Magnesium (Mg), Alkaline Phosphatase (ALP), Ferritin (FER), Serum Iron (SFe), Thyroid Stimulating Hormone (TSH), T3, T4 and Parathyroid Hormone (PTH), and BMD (by using Dual-Energy X-ray Absorptiometry (DEXA) method) were investigated in 143 BTM patients from thalassemia center of Dezful University of Medical Sciences in 2023.Results: Seventy-two women and 71 men with confirmed BTM diagnosis with age range (32.4 ± 9.7) were entered in the study. Laboratory parameters including TSH, T3, T4, ALP, FER 247) and SFe showed a significant difference between fracture and non-fracture groups respectively (P≤0.05). In this study, Z-Score between -1.1 and -2.4 was considered osteopenia, and below -2.5 was osteoporosis. Among the studied patients 36.6%, 39.1% and 24.2% had normal bone density, osteopenia and had osteoporosis respectively.Conclusion: Osteopenia and osteoporosis had a high frequency among the studied patients that can prone them to bone fractures. Continuous examinations of laboratory tests, especially T3, T4, TSH, FER, SFE, can be helpful for faster diagnosis and therapeutic interventions to prevent the occurrence of osteopenia and pathological fractures.","PeriodicalId":49173,"journal":{"name":"Iranian Journal of Public Health","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11475165/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142478804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0