Journal of Infection in Developing Countries最新文献

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Oral traditional Chinese medicine for mild to moderate cases of COVID-19: a network meta-analysis based on RCTs. 口服中药治疗轻、中度新冠肺炎:基于随机对照试验的网络meta分析
IF 1.4 4区 医学
Journal of Infection in Developing Countries Pub Date : 2024-11-30 DOI: 10.3855/jidc.19398
Wen Cao, Nannan He, Yannian Luo, Zhiming Zhang
{"title":"Oral traditional Chinese medicine for mild to moderate cases of COVID-19: a network meta-analysis based on RCTs.","authors":"Wen Cao, Nannan He, Yannian Luo, Zhiming Zhang","doi":"10.3855/jidc.19398","DOIUrl":"10.3855/jidc.19398","url":null,"abstract":"<p><strong>Introduction: </strong>This systemic review examines the effectiveness and safety of combining traditional Chinese medicine with standard therapy in the treatment of mild to moderate cases of coronavirus disease 2019 (COVID-19).</p><p><strong>Methodology: </strong>We retrieved articles from PubMed, Web of Science, Cochrane, Embase, China National Knowledge Infrastructure (CNKI), Wanfang, Weipi (VIP), and China Biology Medicine disc (CBM). The deadline for retrieval was 20 August 2022, and it was updated on 1 July 2023. Two researchers worked independently on literature screening, data extraction, and evaluation of the quality of the literature.</p><p><strong>Results: </strong>A total of 21 randomized controlled trials were included in this review; consisting of 9 articles in English and 12 articles in Chinese. According to the fixed-effects model, the results of the traditional meta-analysis indicated a significantly superior efficacy of oral traditional Chinese medicine combined with standard therapy in treating mild to moderate cases of COVID-19, compared to standard treatment (OR = 1.81, 95% CI: 1.59-2.06), with no increased adverse effects (OR = 1.28, 95% CI: 0.95-1.73). The network meta-analysis results revealed Lianhua Qingke, Toujie Quwen, and Jinhua Qinggan granules as the three best Chinese medicines with the most effective treatment outcomes; while Lianhua Qingwen capsule/granules, Reyanning, and Shufeng Jiedu capsules were the top three Chinese medicines with the fewest side effects.</p><p><strong>Conclusions: </strong>The efficacy of oral traditional Chinese medicine combined with standard therapy in treating mild to moderate COVID-19 was significantly superior to standard therapy alone. However, the limited quality of evidence reduces the reliability of the meta-analysis.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"18 11","pages":"1671-1681"},"PeriodicalIF":1.4,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142856377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Can antiviral drugs address the treatment challenges of severe fever with thrombocytopenia syndrome? - a systematic meta-analysis. 抗病毒药物能否解决发热伴血小板减少综合征的治疗挑战?-系统的荟萃分析。
IF 1.4 4区 医学
Journal of Infection in Developing Countries Pub Date : 2024-11-30 DOI: 10.3855/jidc.19032
Lumeng Shen, Mingfang Han, Jingjing Lou, Wenya Shen, Shibo Li
{"title":"Can antiviral drugs address the treatment challenges of severe fever with thrombocytopenia syndrome? - a systematic meta-analysis.","authors":"Lumeng Shen, Mingfang Han, Jingjing Lou, Wenya Shen, Shibo Li","doi":"10.3855/jidc.19032","DOIUrl":"10.3855/jidc.19032","url":null,"abstract":"<p><strong>Background: </strong>Severe Fever with Thrombocytopenia Syndrome (SFTS) is an emerging infectious disease with high mortality and severity rates. However, there is no clear treatment plan, specific effective antiviral drugs, or effective vaccine for SFTS. Recent studies have shown that the therapeutic effect of Ribavirin and other commonly used antiviral drugs such as Favipiravir (T-705), on SFTS is still controversial. This meta-analysis was conducted to evaluate the therapeutic efficacy of antiviral drugs on SFTS.</p><p><strong>Methods: </strong>Relevant studies were searched from Cochrane Library, Web of Science, Embase. and PubMed from inception to June 30, 2022, and updated to 2023. The study screening, data extraction, and quality assessment were conducted by re-searchers independently. A counterpart assessment tool was used to assess methodological quality, and the Stata15 software was employed to perform meta-analysis.</p><p><strong>Results: </strong>The meta-analysis included 8 studies consisting of 4692 patients. The results showed no significant difference in the mortality rate of SFTS patients between the antiviral drug group and the control group (HR: 0.85, 95% CI: 0.46-1.59, p = 0.618). Antiviral drugs had no noticeable effect on this disease (RR: 0.93, 95% CI: 0.58-1.48, p = 0.747).</p><p><strong>Conclusions: </strong>At present, antiviral drugs (Ribavirin and Favipiravir) used routinely in clinics show no positive effect on the treatment of SFTS yet and fail to reduce the mortality rate. On the other hand, clinical studies specifically evaluating viral load found that antiviral drugs were effective in the treatment of SFTS patients with low viral load, but the efficacy was not statistically significant.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"18 11","pages":"1645-1652"},"PeriodicalIF":1.4,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142856057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Detection and characterization of carbapenemase-producing Enterobacteriaceae in cancer patients: first Sri Lankan report of blaVIM in Enterobacteriaceae. 肿瘤患者产碳青霉烯酶肠杆菌科的检测与鉴定:斯里兰卡首次报道肠杆菌科blaVIM。
IF 1.4 4区 医学
Journal of Infection in Developing Countries Pub Date : 2024-11-30 DOI: 10.3855/jidc.19499
Gayashan Chathuranga, Thushari Dissanayake, Neluka Fernando, Chandanie Amila Wanigatunge
{"title":"Detection and characterization of carbapenemase-producing Enterobacteriaceae in cancer patients: first Sri Lankan report of blaVIM in Enterobacteriaceae.","authors":"Gayashan Chathuranga, Thushari Dissanayake, Neluka Fernando, Chandanie Amila Wanigatunge","doi":"10.3855/jidc.19499","DOIUrl":"https://doi.org/10.3855/jidc.19499","url":null,"abstract":"<p><strong>Background: </strong>Carbapenem-resistant Enterobacteriaceae (CRE) are an important cause of infections in cancer patients. The proportion of carbapenem resistance and the types of carbapenemase-encoding genes in Enterobacteriaceae isolated from cancer patients were determined in this study.</p><p><strong>Methodology: </strong>Bacteria isolated from adult, in-ward cancer patients with lower respiratory tract infections (LRTI), skin and soft tissue infections (SSTI), or urinary tract infections (UTI) were included in the study. Enterobacteriaceae were identified up to the species level by API® 20E test kits. Carbapenem resistance was defined as non-susceptibility to either imipenem or meropenem in the disc diffusion test. Major carbapenemase-encoding genes (blaKPC, blaNDM, blaOXA-48, blaIMP, and blaVIM) were detected by the GeneXpert® Carba-R real-time PCR instrument.</p><p><strong>Results: </strong>Enterobacteriaceae comprised 57% (94/165) of the bacterial isolates. Carbapenem resistance among Enterobacteriaceae was 46.8% (44/94). Klebsiella pneumoniae (65.9%, 29/44) was the predominant CRE isolate followed by Escherichia coli (25%, 11/44). The majority of CRE isolates (72.7%, 32/44) had a meropenem MIC of ≥ 32 µg/mL. Carbapenemase-encoding genes were identified in 43 of the 44 CRE isolates. blaNDM was the most prevalent carbapenemase-encoding gene and was detected in 67.4% (29/43) of Enterobacteriaceae isolates. No isolate was positive for blaIMP. Sixteen (37.2%) isolates co-harbored more than one carbapenemase-encoding gene. Two Enterobacteriaceae isolates were found to harbor blaVIM.</p><p><strong>Conclusions: </strong>Nearly all CRE isolated in this study were carbapenemase producers. This study documented the emergence of blaVIM harboring Enterobacteriaceae for the first time in Sri Lanka.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"18 11","pages":"1715-1720"},"PeriodicalIF":1.4,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142856159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnostic value of serum markers and C-reactive protein of joint fluid in purulent arthritis. 血清标志物及关节液c反应蛋白对化脓性关节炎的诊断价值。
IF 1.4 4区 医学
Journal of Infection in Developing Countries Pub Date : 2024-11-30 DOI: 10.3855/jidc.19736
Chaoyan Xu, Changyi Lin, Damei Ye, Peicheng Wu, Minghui Song, Youtian Liu, Qiong Deng, Xueyan Huang, Zhongxiao Fan, Xuelan You
{"title":"Diagnostic value of serum markers and C-reactive protein of joint fluid in purulent arthritis.","authors":"Chaoyan Xu, Changyi Lin, Damei Ye, Peicheng Wu, Minghui Song, Youtian Liu, Qiong Deng, Xueyan Huang, Zhongxiao Fan, Xuelan You","doi":"10.3855/jidc.19736","DOIUrl":"https://doi.org/10.3855/jidc.19736","url":null,"abstract":"<p><strong>Introduction: </strong>Predicting purulent arthritis with a single marker may result in low sensitivity and specificity. We investigated the diagnostic value of serum markers and joint fluid C-reactive protein (CRP) in purulent arthritis.</p><p><strong>Methodology: </strong>A total of 183 patients with acute joint infection, who were treated at our hospital between April 2019 and September 2022, were retrospectively analyzed via convenient sampling. Serum markers and joint fluid CRP levels were compared between the infection group and the control group to assess their early diagnostic value.</p><p><strong>Results: </strong>Based on multivariate analysis, delta neutrophil index, DNI (odds ratio (OR) = 8.428, 95% confidence interval (CI): 4.753-9.134, p < 0.001); erythrocyte sedimentation rate, ESR (OR = 1.981, 95% CI: 1.435-4.123, p < 0.001); procalcitonin, PCT (OR = 2.418, 95% CI: 1.575-5.639, p < 0.001); serum CRP (OR = 2.784, 95% CI: 1.982-4.243, p < 0.001); and joint fluid CRP (OR = 3.279, 95% CI: 2.142-5.510, p < 0.001) were identified as risk factors for purulent arthritis. Predictive value assessment showed that the DNI, ESR, PCT, serum CRP, and joint fluid CRP all held a predictive value for purulent arthritis (p < 0.05), with the highest predictive value in the combination of all five markers, yielding an area under the curve (AUC) of 0.922 (95% CI: 0.854-0.962).</p><p><strong>Conclusions: </strong>The DNI, ESR, PCT, serum CRP, and joint fluid CRP are crucial diagnostic indicators for identifying acute purulent arthritis. Notably, joint fluid CRP demonstrated the highest predictive value among the indicators.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"18 11","pages":"1695-1701"},"PeriodicalIF":1.4,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142856209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of infants administered prophylactic intravenous immunoglobulin following exposure to measles. 婴儿暴露于麻疹后预防性静脉注射免疫球蛋白的评价。
IF 1.4 4区 医学
Journal of Infection in Developing Countries Pub Date : 2024-11-30 DOI: 10.3855/jidc.18701
Canan Caymaz, Ahmet Soysal, Işıl Maral, Rengin Şiraneci, Ümmü Hatipoğlu, Perihan Alkan, Esat Rıdvan Dikleli, Ali Alptekin, Ateş Kara, Mustafa Taşdemir
{"title":"Evaluation of infants administered prophylactic intravenous immunoglobulin following exposure to measles.","authors":"Canan Caymaz, Ahmet Soysal, Işıl Maral, Rengin Şiraneci, Ümmü Hatipoğlu, Perihan Alkan, Esat Rıdvan Dikleli, Ali Alptekin, Ateş Kara, Mustafa Taşdemir","doi":"10.3855/jidc.18701","DOIUrl":"https://doi.org/10.3855/jidc.18701","url":null,"abstract":"<p><strong>Introduction: </strong>Intravenous immunoglobulin (IVIG) is an alternative for post-exposure prophylaxis if a vaccine is contraindicated and intramuscular immunoglobulin is unavailable. We retrospectively examined the effect of IVIG administration time on measles development in measles-contact infants younger than 6 months of age.</p><p><strong>Methodology: </strong>Contact tracing of measles cases was performed by the Istanbul Public Health Directorate (IPHD) between August 24, 2012, and June 16, 2013. The mothers of 187 infants younger than 6 months were found to have negative IgG for measles. Under IPHD supervision, IVIG (0.4 g/kg) was administered to these infants within the first 6-10 days following exposure. These infants were monitored for rash and fever by IPHD for up to 28 days after IVIG prophylaxis. The study was conducted retrospectively, infants were divided into two groups, those who received IVIG at 6 days and later. These groups were compared according to the development of measles.</p><p><strong>Results: </strong>Only 2 out of 187 infants developed measles after IVIG prophylaxis. No significant difference in measles frequency was observed between infants who received IVIG within the first 6 days after exposure and those who received IVIG after 6 days. Nine infants received IVIG in the first 3 days, and none of them developed measles. The risk of developing measles was higher in infants who had experienced contact at home (p = 0.002).</p><p><strong>Conclusion: </strong>IVIG administration may provide stronger protection in the first 3 days and may be given until 10 days after exposure.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"18 11","pages":"1739-1745"},"PeriodicalIF":1.4,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142856216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of Mycobacterium marinum in subcutaneous abscesses of an infected patient's foot. 一名感染患者足部皮下脓肿中海洋分枝杆菌的鉴定。
IF 1.4 4区 医学
Journal of Infection in Developing Countries Pub Date : 2024-11-30 DOI: 10.3855/jidc.18730
Yong Wei, Jiachun Zhang, Xuli Xin, Yang Wu, Lin Wang, Kai Guo, Yingchun Xu, Song He
{"title":"Identification of Mycobacterium marinum in subcutaneous abscesses of an infected patient's foot.","authors":"Yong Wei, Jiachun Zhang, Xuli Xin, Yang Wu, Lin Wang, Kai Guo, Yingchun Xu, Song He","doi":"10.3855/jidc.18730","DOIUrl":"https://doi.org/10.3855/jidc.18730","url":null,"abstract":"<p><strong>Introduction: </strong>Mycobacterium marinum is a well-known pathogenic non-tuberculous mycobacterium for skin and soft tissue infections. Infection, often presenting as superficial lesions, is seen after exposure of skin abrasions to contaminated water or infected fish and is known as \"swimming pool\" or \"fish tank\" granuloma. This study reported a case of M. marinum infection in subcutaneous abscesses of a patients' foot.</p><p><strong>Methodology: </strong>A diagnosis of M. marinum infection was established with the help of tissue biopsy, culture, matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) and molecular analysis.</p><p><strong>Results: </strong>The patient was diagnosed with M. marinum infection in his left foot and received appropriate antibiotic treatment with the desired effect.</p><p><strong>Conclusions: </strong>In many parts of the developing world, M. marinum infections may remain undiagnosed due to limited symptoms, as well as the lack of medical services and laboratory facilities. Key diagnostic elements for M. marinum infections include a high index of suspicion raised by chronic lesions, poor response to conventional treatments, a properly obtained exposure history, culture, and microorganism identification. This study provides some references and suggestions for the clinical characteristics, diagnosis, treatment and prevention of M. marinum infection.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"18 11","pages":"1787-1792"},"PeriodicalIF":1.4,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142856249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Application of nirmatrelvir/ritonavir for the treatment of severe COVID-19 in a 3-year-old child. 尼马特利韦/利托那韦治疗3岁重症COVID-19患儿的应用
IF 1.4 4区 医学
Journal of Infection in Developing Countries Pub Date : 2024-11-30 DOI: 10.3855/jidc.18685
Xia Wang, Shuyan Quan, Zhifeng Wu, Yuping Zhang, Enyi Wen, Jingbin Huang, Wang Yang
{"title":"Application of nirmatrelvir/ritonavir for the treatment of severe COVID-19 in a 3-year-old child.","authors":"Xia Wang, Shuyan Quan, Zhifeng Wu, Yuping Zhang, Enyi Wen, Jingbin Huang, Wang Yang","doi":"10.3855/jidc.18685","DOIUrl":"https://doi.org/10.3855/jidc.18685","url":null,"abstract":"<p><strong>Introduction: </strong>Nirmatrelvir/ritonavir (Paxlovid) is an effective antiviral drug for treating coronavirus disease 2019 (COVID-19) in adults. However, Paxlovid treatment of children, especially those who are under 12 years and with severe underlying diseases, is rare.</p><p><strong>Case report: </strong>A three-year-old COVID-19 patient (weighing 14.5 kg) was infected by the Omicron variant (BA.5.2) after undergoing allogeneic hematopoietic stem cell transplantation. The patient had severe bilateral pneumonia along with recurrent fever. The patient was administered 150 mg of nirmatrelvir plus 50 mg of ritonavir twice daily for 5 days, starting 27 days after the initial severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positive test. Clinical manifestations and chest computed tomography improved considerably after the treatment. The real time reverse transcriptase polymerase chain reaction (RT-PCR) cycle threshold values increased from 23.92 to 38.40 in the case of ORF 1-ab gene, and from 22.22 to 36.28 in the case of N gene. Only a mild increase in serum urea nitrogen (10.10 mmol/L), alanine transaminase (ALT, 65 IU/L), and aspartate transaminase (AST, 68.5 IU/L) was observed.</p><p><strong>Conclusions: </strong>Paxlovid can effectively inhibit the replication of SARS-CoV-2 and help in improving the clinical manifestations in pediatric COVID-19 patients. Our study provided novel information on Paxlovid treatment in very young children.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"18 11","pages":"1682-1686"},"PeriodicalIF":1.4,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142856036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Burden and predictors of M-pox suspected cases in a rural setting of Cameroon: implications for developing countries. 喀麦隆农村地区m痘疑似病例的负担和预测因素:对发展中国家的影响
IF 1.4 4区 医学
Journal of Infection in Developing Countries Pub Date : 2024-11-30 DOI: 10.3855/jidc.18397
Flaure Rasana P Nganmegni, Julienne Louise L Ngo, René G Essomba, Philippe S Nguwoh, Franck S Metomb, Emilienne Epee, Nadia Mandeng, Georges-Alain E Mballa, Yap Boum Ii, Marie Claire A Okomo, Christian N Taheu, Joseph Fokam
{"title":"Burden and predictors of M-pox suspected cases in a rural setting of Cameroon: implications for developing countries.","authors":"Flaure Rasana P Nganmegni, Julienne Louise L Ngo, René G Essomba, Philippe S Nguwoh, Franck S Metomb, Emilienne Epee, Nadia Mandeng, Georges-Alain E Mballa, Yap Boum Ii, Marie Claire A Okomo, Christian N Taheu, Joseph Fokam","doi":"10.3855/jidc.18397","DOIUrl":"https://doi.org/10.3855/jidc.18397","url":null,"abstract":"<p><strong>Introduction: </strong>M-pox is a re-emerging pathogen that is spreading rapidly in developing countries, presenting a serious health risk. Data are scarce on M-pox and its determinants in endemic countries such as Cameroon. This study aimed to assess the epidemiological burden and factors linked to the resurgence of M-pox in high-risk communities in Cameroon.</p><p><strong>Methodology: </strong>A community-based surveillance was conducted from April to October 2022, among 88 individuals at the Ayos Health District (AHD). Participants were interviewed, and cases of M-pox were defined based on World Health Organization (WHO) clinical criteria. Data were analyzed using CSPro v.6.0 and SPSS v.20.0, with p < 0.05 as the statistical significance level.</p><p><strong>Results: </strong>The overall suspected M-pox cases rate was 25% (22/88). Following logistic regression, history of chickenpox (OR 0.14, p = 0.05); history of smallpox (OR 9.14, p < 0.001), vaccination against poxviruses (p < 0.001), skin infection (OR 210, p < 0.001), upper respiratory infection (p < 0.001), atypical dermatitis (OR 144, p < 0.001), skin allergy (OR 68.57, p < 0.001), contact with an individual suffering from M-pox in the last 14 days before symptoms onset (OR 9.14, p < 0.001), contact with animals in the last 14 days before symptom onset (OR 12.68, p  0.001), regular meal consumption (OR 0.35, p = 0.04), meal-sharing, and handling of bushmeat (p = 0.01) were significantly associated with M-pox infection.</p><p><strong>Conclusions: </strong>The clinical features of M-pox were common in rural Cameroonian setting, suggesting the need for active surveillance in these high-risk communities.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"18 11","pages":"1756-1763"},"PeriodicalIF":1.4,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142856052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Human papillomavirus DNA detection in cervical samples from women of reproductive age in Mogadishu, Somalia. 索马里摩加迪沙育龄妇女宫颈样本中的人乳头瘤病毒DNA检测。
IF 1.4 4区 医学
Journal of Infection in Developing Countries Pub Date : 2024-11-30 DOI: 10.3855/jidc.19982
Bashiru Garba, Maryan A Sh Nur, Maryam Adawe, Mohamed H Adam, Jamal H Mohamoud, Hassan A Dahie, Mohamed M Ahmed, Abdirahman K Mohamud, Sadio A Mohamed, Fartun Ah Orey, Jihaan Hassan, Hodo A Asowe, Najib I Dirie
{"title":"Human papillomavirus DNA detection in cervical samples from women of reproductive age in Mogadishu, Somalia.","authors":"Bashiru Garba, Maryan A Sh Nur, Maryam Adawe, Mohamed H Adam, Jamal H Mohamoud, Hassan A Dahie, Mohamed M Ahmed, Abdirahman K Mohamud, Sadio A Mohamed, Fartun Ah Orey, Jihaan Hassan, Hodo A Asowe, Najib I Dirie","doi":"10.3855/jidc.19982","DOIUrl":"https://doi.org/10.3855/jidc.19982","url":null,"abstract":"<p><strong>Introduction: </strong>Somalia is among the countries with a high burden of human papillomavirus (HPV) infection in Sub-Saharan Africa. In 2022, 660,000 infections are reported among women globally, out of which 350,000 died from the disease. Most of the studies on HPV reported from Somalia are based on cytologic analysis which is a subjective and suboptimal assessment. The recent World Health Organization (WHO) guidelines for HPV recommend DNA-based testing as a better alternative to the traditional pap smear test.</p><p><strong>Methodology: </strong>This study was undertaken to determine the prevalence of HPV based on the preferred HPV DNA assay on cervical samples of women of reproductive age in Mogadishu, Somalia. The HPV DNA detection was carried out using real-time quantitative polymerase chain reaction (RT-PCR) assays to identify high-risk oncogenic HPV16, HPV18, and other high-risk HPV types.</p><p><strong>Results: </strong>Overall, 31.7% (60/189) of cervical samples were positive for HPV DNA. Out of this, 19.6% were high risk-HPV (hrHPV), 13.8% were HPV16, and 5.3% were HPV18. Moreover, age, income and education level were found to be significant risk factors for HPV infection.</p><p><strong>Conclusions: </strong>These results provide further proof that HPV continues to be a serious public health challenge in Somalia with the risk of progressing to fatal cervical cancer.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"18 11","pages":"1746-1755"},"PeriodicalIF":1.4,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142856243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genetic diversity and characterization of potentially pathogenic Escherichia coli isolated from artisanal cheese in Venezuela. 从委内瑞拉手工奶酪中分离的潜在致病性大肠杆菌的遗传多样性和特性
IF 1.4 4区 医学
Journal of Infection in Developing Countries Pub Date : 2024-11-30 DOI: 10.3855/jidc.19441
Leidys Guillén, María Araque
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