Could serum intestinal fatty acid-binding protein and citrulline levels be predictive markers of mortality in critically ill COVID-19 patients?

IF 1.2 4区医学 Q4 INFECTIOUS DISEASES

Journal of Infection in Developing Countries Pub Date : 2025-07-28 DOI:10.3855/jidc.20862

Sevda Onuk, Nurhayat Tugra Ozer, Serap Sahin Ergul, Esma Eryilmaz Eren, Cigdem Karakukcu, Hilal Sipahioglu, Aynur Karayol Akin, Kursat Gundogan

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引用次数: 0

Abstract

Introduction: The global Coronavirus Disease 2019 (COVID-19) pandemic has been demonstrated to cause severe acute respiratory syndrome and is frequently associated with gastrointestinal (GI) manifestations. Intestinal fatty acid binding protein (IFABP) and citrulline have been identified as potential biomarkers of intestinal (dys)function. The present study was undertaken to ascertain the relationship between serum IFABP and citrulline concentrations and mortality in patients with COVID-19.

Methodology: This observational study was conducted in the medical intensive care unit (ICU) and included adult patients diagnosed with PCR-confirmed cases of severe acute respiratory syndrome (SARS-CoV-2). Serum citrulline and IFABp concentrations were quantitatively analyzed using an enzyme-linked immunosorbent assay (ELISA) within the initial 24 hours following ICU admission.

Results: A total of 85 critically ill patients (mean age: 70.0  12.4 years) were recruited for this study. The mean Acute Physiology and Chronic Health Evaluation (APACHE II) score was 20.0  7.1. In comparison with survivors (n = 48 patients), non-survivors (n = 37 patients) exhibited significantly elevated serum IFABp concentrations (median (interquartile range, IQR): 13.27 [6.41-17.87] vs. 7.23 [3.26-12.25] ng/mL, p = 0.007) and diminished citrulline levels (median (IQR): 7.61 [4.37-8.52] vs. [4.67 (3.34-8.90] nmol/L, p = 0.043). Receiver operating characteristic (ROC) analysis revealed that the cut off value of serum IFABp and citrulline concentrations to predict ICU mortality was 8.15 ng/mL (AUC: 0.722, 95% Cl: 0.611-0.833, p = 0.001) and 5.99 nmol/L (AUC: 0.671, 95% Cl: 0.551-0.791, p = 0.009), respectively.

Conclusions: The findings of this study indicate that serum IFABP and citrulline concentrations possess the potential to function as biomarkers for predicting mortality in critically ill patients with confirmed cases of SARS-CoV-2.

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血清肠道脂肪酸结合蛋白和瓜氨酸水平能否作为COVID-19危重患者死亡率的预测指标？

导语：全球2019冠状病毒病（COVID-19）大流行已被证明可导致严重急性呼吸综合征，并经常与胃肠道（GI）表现相关。肠道脂肪酸结合蛋白（IFABP）和瓜氨酸已被确定为肠道功能的潜在生物标志物。本研究旨在确定COVID-19患者血清IFABP和瓜氨酸浓度与死亡率之间的关系。方法：本观察性研究在重症监护病房（ICU）进行，纳入经pcr确诊的严重急性呼吸综合征（SARS-CoV-2）成年患者。采用酶联免疫吸附试验（ELISA）定量分析患者入院后24小时内血清瓜氨酸和IFABp浓度。结果：共纳入85例危重患者（平均年龄：70.012.4岁）。急性生理和慢性健康评估（APACHE II）平均评分为20.07.1。与幸存者（n = 48例）相比，非幸存者（n = 37例）血清IFABp浓度显著升高（中位数（四分位间距，IQR）： 13.27 [6.41-17.87] vs. 7.23 [3.26-12.25] ng/mL, p = 0.007），瓜氨酸水平降低（中位数（IQR）： 7.61 [4.37-8.52] vs. 4.67 (3.34-8.90) nmol/L, p = 0.043）。受试者工作特征（ROC）分析显示，血清IFABp和瓜氨酸浓度预测ICU死亡率的临界值分别为8.15 ng/mL （AUC: 0.722, 95% Cl: 0.611-0.833, p = 0.001）和5.99 nmol/L （AUC: 0.671, 95% Cl: 0.551-0.791, p = 0.009）。结论：本研究结果表明，血清IFABP和瓜氨酸浓度有可能作为预测SARS-CoV-2确诊危重患者死亡率的生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Infection in Developing Countries INFECTIOUS DISEASES-

CiteScore

3.70

自引率

5.30%

发文量

239

审稿时长

4-8 weeks

期刊介绍： The Journal of Infection in Developing Countries (JIDC) is an international journal, intended for the publication of scientific articles from Developing Countries by scientists from Developing Countries. JIDC is an independent, on-line publication with an international editorial board. JIDC is open access with no cost to view or download articles and reasonable cost for publication of research artcles, making JIDC easily availiable to scientists from resource restricted regions.