Journal of Infection in Developing Countries最新文献

Impact of the COVID-19 pandemic on the measles elimination status in Armenia. 2019冠状病毒病大流行对亚美尼亚消除麻疹状况的影响。

IF 1.4 4区医学

Journal of Infection in Developing Countries Pub Date : 2025-04-29 DOI: 10.3855/jidc.20558

Naira Melkonyan, Mary Ter-Stepanyan, Arman Badalyan, Hasmik Hovhannisyan

{"title":"Impact of the COVID-19 pandemic on the measles elimination status in Armenia.","authors":"Naira Melkonyan, Mary Ter-Stepanyan, Arman Badalyan, Hasmik Hovhannisyan","doi":"10.3855/jidc.20558","DOIUrl":"https://doi.org/10.3855/jidc.20558","url":null,"abstract":"Introduction: The coronavirus disease 2019 (COVID-19) pandemic led to a decrease in immunization rates and measles surveillance, resulting in re-establishment of endemic measles transmission in many countries where measles was previously eliminated.Methodology: We conducted a retrospective study to evaluate the impact of the pandemic on the measles elimination status in Armenia. We studied the prevalence of measles from 2000 to May 2024 and predicted the trend for the coming months. We assessed trends in coverage levels of the mumps-measles-rubella (MMR)1 and MMR2 vaccines in Armenia between 2003 and 2023. The performance indicators of measles surveillance at the national and subnational levels before, after, and during the pandemic (2013-May 2024) were studied.Results: Endemic transmission of measles in Armenia was interrupted in 2008, and was sustained for many years; however, it was re-established in 2023. A total of 988 measles cases were recorded between February 2023 and May 2024. During the pandemic (2020-2022), MMR1 and MMR2 vaccine coverage decreased from the target level to 94%. Case-based measles surveillance was significantly weakened. Discarded case rate was 0.7 in 2020 and 2021, and 0.9 in 2022. After the pandemic, this indicator improved, reaching 33.3 in 2023 and 17.3 in 2024. The mean values of the numbers of discarded cases were 118 (95% CI, 73-163) in 2013-2019, and 23 (95% CI, 20-26) in 2020-2022 (p < 0.05).Conclusions: The measles elimination status of Armenia was lost due to immunity gaps and weakening of measles surveillance during the pandemic.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 4","pages":"482-489"},"PeriodicalIF":1.4,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144027935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk factors affecting the development of adverse outcomes in patients with diabetic foot infection. 影响糖尿病足感染患者不良结局发展的危险因素

IF 1.4 4区医学

Journal of Infection in Developing Countries Pub Date : 2025-04-29 DOI: 10.3855/jidc.19974

Rukiye İnan Sarikaya, Ömer Karaşahin

{"title":"Risk factors affecting the development of adverse outcomes in patients with diabetic foot infection.","authors":"Rukiye İnan Sarikaya, Ömer Karaşahin","doi":"10.3855/jidc.19974","DOIUrl":"https://doi.org/10.3855/jidc.19974","url":null,"abstract":"Introduction: Diabetic foot infection (DFI) can result in lower extremity amputation and death in patients with diabetes and is an important cause of morbidity and mortality. The purpose of this study was to identify predictive factors for adverse outcomes consisting of major lower extremity amputation and mortality in patients with DFI.Methodology: One hundred and two patients diagnosed with DFI and followed up in a tertiary hospital between November 2022 and April 2023 were included in this prospective study. Demographic and diabetic foot characteristics at the time of presentation, degrees of DFI, and clinical and laboratory findings of all patients were recorded. Major amputation and/or mortality were regarded as adverse outcomes. The patients were followed up throughout hospitalization until discharge or mortality. Risk factors for adverse outcomes were identified using univariate and multivariate logistic regression analyses.Results: The median age of the patients was 60.0 years, and the majority (72.5%) were men. Adverse outcomes developed in 11 patients during follow-up. The factors linked to adverse outcomes included fever; wound necrosis; isolation of Enterobacteriaceae species in wound culture; perfusion, extent, depth, infection, and sensation (PEDIS) grade 4; and blood urea nitrogen (BUN) elevation. Following multivariate logistic regression analysis, only BUN > 31 mg/dL and presence of necrosis emerged as significant independent predictive factors for adverse outcomes.Conclusions: The findings show that the above factors may be useful in predicting adverse outcomes in patients with DFI. Early detection of these factors may be useful in preventing morbidity and mortality in these patients.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 4","pages":"520-527"},"PeriodicalIF":1.4,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144027937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Healthcare-associated infections in the first four years of a pediatric surgical intensive care unit. 儿科外科重症监护病房头四年的医疗保健相关感染

IF 1.4 4区医学

Journal of Infection in Developing Countries Pub Date : 2025-04-29 DOI: 10.3855/jidc.21092

Serkan Atıcı, Sinan Kılıç, Kıvılcım Karadeniz Cerit, Gürsu Kıyan, Ahmet Soysal

{"title":"Healthcare-associated infections in the first four years of a pediatric surgical intensive care unit.","authors":"Serkan Atıcı, Sinan Kılıç, Kıvılcım Karadeniz Cerit, Gürsu Kıyan, Ahmet Soysal","doi":"10.3855/jidc.21092","DOIUrl":"https://doi.org/10.3855/jidc.21092","url":null,"abstract":"Introduction: Healthcare-associated infections (HAIs) are a significant cause of morbidity and mortality, particularly among critical pediatric surgical patients. This study aimed to evaluate the incidence, distribution, types, and pathogens involved in HAIs, in a newly established pediatric surgery intensive care unit (PSICU).Methodology: The Infection Control Team of Marmara University Pendik Training and Research Hospital identified and documented HAI cases according to the Centers for Disease Control and Prevention criteria over a four-year period following the unit's opening. Prospective, laboratory-based surveillance of HAIs was conducted within the PSICU from 1 January 2011 to 30 November 2014. Continuous monitoring and early detection of HAIs are crucial for implementing timely and effective infection control measures.Results: A total of 599 patients were admitted to the PSICU, and 90 HAI cases were identified, resulting in an overall HAI rate of 15%. The incidence density was 14.7 per 1,000 patient-days. The most prevalent types were bloodstream infections (40%), pneumonia (23.4%), and urinary tract infections (17.8%). The primary pathogens were Klebsiella spp. (27.8%), Acinetobacter baumannii (13.9%), Staphylococcus spp. (13.9%), and Candida spp. (13.9%).Conclusions: There is limited data on HAI rates in PSICUs, and this study showed that infection rates in the PSICU were not higher than in pediatric intensive care units and neonatal intensive care units. The incidence of HAIs in this study was not higher than reports from other PSICUs in developing countries like Mexico, Brazil, and Egypt; but was higher compared to the rates reported in developed countries such as the US.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 4","pages":"576-581"},"PeriodicalIF":1.4,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidemiology of Shigella, Salmonella, and Campylobacter among diarrheic under-five-year-old children in central Ethiopia. 埃塞俄比亚中部五岁以下腹泻儿童中志贺氏菌、沙门氏菌和弯曲杆菌的流行病学

IF 1.4 4区医学

Journal of Infection in Developing Countries Pub Date : 2025-04-29 DOI: 10.3855/jidc.19921

Tizazu Zenebe, Ermiyas Endewunet, Aminu Seman, Tadesse Eguale, Tamrat Abebe

{"title":"Epidemiology of Shigella, Salmonella, and Campylobacter among diarrheic under-five-year-old children in central Ethiopia.","authors":"Tizazu Zenebe, Ermiyas Endewunet, Aminu Seman, Tadesse Eguale, Tamrat Abebe","doi":"10.3855/jidc.19921","DOIUrl":"https://doi.org/10.3855/jidc.19921","url":null,"abstract":"Introduction: Diarrheagenic bacteria are among the major contributors to the global diarrheal burden. The absence of up-to-date data on the etiologies of diarrhea due to limited active surveillance and clinical laboratory capacity makes the burden more severe. Shigella, Salmonella, and Campylobacter are among the most common bacterial etiologies of childhood diarrhea. The present study aimed to provide epidemiological data on these bacterial etiologies in under-five-year-old children in Ethiopia.Methodology: A cross-sectional health facility-based study was conducted from December 2020 to August 2021 in Addis Ababa and Debre Berhan, Ethiopia. Standard microbiological techniques including culture, antimicrobial susceptibility, and polymerase chain reaction (PCR) were used to characterize bacterial isolates.Results: A total of 391 under-five-year-old children were tested. Shigella was the most common isolate in 10% (39/391), followed by Campylobacter in 7.2% (28/391). Age range of 0-12 months, poor childcare practice, and taking supplements early were associated with acquisition of the pathogens. The highest antibacterial resistance was observed for ampicillin among Salmonella and Shigella (100% and 87%, respectively). Extended spectrum ß-lactamase (ESBL) and carbapenemases production was observed in 8% and 3% of Shigella strains respectively. The majority of the bacterial isolates were susceptible to carbapenems.Conclusions: The burden of bacterial pathogens continues to be a serious problem in Ethiopia. Detection of ESBL-and carbapenemase-producing Shigella strains could reveal the presence of resistant pathogenic strains in the area. Strengthening diagnostic laboratory capacity in healthcare facilities could reduce the burden.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 4","pages":"597-607"},"PeriodicalIF":1.4,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144034514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Traditional Chinese Medicine on antituberculosis drug therapy for pulmonary tuberculosis and liver function. 中药对抗结核药物治疗肺结核及肝功能的影响。

IF 1.4 4区医学

Journal of Infection in Developing Countries Pub Date : 2025-04-29 DOI: 10.3855/jidc.18452

Qing Huang, Kunxia Li, Qian Li

{"title":"Effect of Traditional Chinese Medicine on antituberculosis drug therapy for pulmonary tuberculosis and liver function.","authors":"Qing Huang, Kunxia Li, Qian Li","doi":"10.3855/jidc.18452","DOIUrl":"https://doi.org/10.3855/jidc.18452","url":null,"abstract":"Introduction: We performed a case-control study to examine the effect of antituberculosis drugs associated with the acupoint application of traditional Chinese medicine (TCM) on pulmonary tuberculosis and the effects on liver function and immune function.Methodology: A retrospective analysis was conducted, dividing hospitalized pulmonary tuberculosis patients into a control group and a study group. The controls were treated with 2HRZE/4HR standard chemotherapy regimen, and the latter was treated with an acupoint application of TCM based on the control group. The clinical efficacy, focus absorption rate, T lymphocyte group level, immunoglobulin level, serum analysis, and liver function index were compared.Results: The study group was absorbed in 32 patients, absorbed in 24 patients, and unchanged in four patients; no one worsened, and the lesion absorption rate was 93.33%. In the control group, 18 patients were remarkably absorbed, 30 were absorbed, 12 were unchanged, and no one deteriorated. The studied group was treated in 12 patients, noticeably resulting in 34 patients, effective in 12 patients, ineffective in 2 patients, and the resultful rate was 96.67%. The effectiveness rate in the control group was 78.33%. According to the blood gas analysis, PA was higher, while IL-6 and PCT were lower in the study group. A lower ALT, AST, and DBIL were observed in the study group (p < 0.05).Conclusions: In conclusion, Traditional Chinese Medicine (TCM) acupoint application with antituberculosis medication improves liver and immunological functioning, accelerating recovery and reducing drug-related liver and kidney damage.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 4","pages":"504-511"},"PeriodicalIF":1.4,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and performance evaluation of a multiplex fluorescent PCR method for the detection of fastidious pathogens causing respiratory infections in children. 儿童呼吸道感染病原菌多重荧光PCR检测方法的建立及性能评价

IF 1.4 4区医学

Journal of Infection in Developing Countries Pub Date : 2025-04-29 DOI: 10.3855/jidc.20282

Yijun Zhu, Jingchao Shi, Shihang Zhang, Weixian Yang, Xiaoyun Shan

{"title":"Development and performance evaluation of a multiplex fluorescent PCR method for the detection of fastidious pathogens causing respiratory infections in children.","authors":"Yijun Zhu, Jingchao Shi, Shihang Zhang, Weixian Yang, Xiaoyun Shan","doi":"10.3855/jidc.20282","DOIUrl":"https://doi.org/10.3855/jidc.20282","url":null,"abstract":"Introduction: This study was performed to develop a multiplex fluorescent PCR method for the concurrent detection of six fastidious bacteria associated with respiratory tract infections. These bacteria include Streptococcus pneumoniae（SPN）, Bordetella pertussis (BP), Neisseria meningitidis (NM), Legionella pneumophila (LP), Moraxella catarrhalis (MC), and Haemophilus influenzae (HI).Methodology: A multiplex fluorescent PCR test using SYBR Green as a DNA dye was developed and optimised. Clinical samples from 296 children with respiratory tract infections were then tested using the proposed method to assess its applicability for detecting the six pathogens.Results: The SYBR Green-based multiplex fluorescent PCR method was successfully employed for the simultaneous identification of five pathogens through the analysis of melting curves and determination of the melting temperatures (Tm) values. However, the method exhibited limitations in distinguishing HI, necessitating separate detection using singleplex fluorescent PCR for this pathogen. In the methodological evaluation involving 296 clinical specimens, the multiplex fluorescent PCR successfully detected SPN, MC, NM, BP, and LP with sensitivities of 97.3%, 96.3%, 85.7%, 95.7%, and 80%, and areas under the ROC curve (AUC) of 0.977, 0.978, 0.927, 0.976 and 0.900, respectively.Conclusions: Compared to conventional bacterial culture methods, the multiplex fluorescent PCR method with SYBR Green as the DNA dye is a sensitive and cost-effective approach for the simultaneous and rapid identification of five fastidious bacteria, making it a valuable alternative for clinical diagnostic laboratories.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 4","pages":"582-589"},"PeriodicalIF":1.4,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143994713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A retrospective study on factors related to in-hospital mortality among patients with COVID-19, March 2020 to November 2021. 2020年3月至2021年11月COVID-19患者住院死亡率相关因素的回顾性研究

IF 1.4 4区医学

Journal of Infection in Developing Countries Pub Date : 2025-04-29 DOI: 10.3855/jidc.20868

Elisabetta Zinellu, Sara S Fois, Biagio Di Lorenzo, Stefano Zoroddu, Maria C Pau, Lorenzo Tassi, Barbara Piras, Alessandro G Fois, Ciriaco Carru, Arduino A Mangoni, Angelo Zinellu, Pietro Pirina

{"title":"A retrospective study on factors related to in-hospital mortality among patients with COVID-19, March 2020 to November 2021.","authors":"Elisabetta Zinellu, Sara S Fois, Biagio Di Lorenzo, Stefano Zoroddu, Maria C Pau, Lorenzo Tassi, Barbara Piras, Alessandro G Fois, Ciriaco Carru, Arduino A Mangoni, Angelo Zinellu, Pietro Pirina","doi":"10.3855/jidc.20868","DOIUrl":"https://doi.org/10.3855/jidc.20868","url":null,"abstract":"Introduction: Four years since the pandemic was declared, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains an important cause of illness around the world. Although many countries were able to overcome the health crisis at its peak, there are still individuals at high risk of a severe course of coronavirus disease 2019 (COVID-19). Therefore, it is important to continue research on the factors that could predict disease severity and adverse outcomes.Methodology: We conducted a retrospective study on 171 consecutive hospitalized cases of COVID-19 from March 2020 to November 2021. Past medical history, drug history, clinical and laboratory parameters on admission, and the choice of treatment during hospital stay were obtained and associated with in-hospital mortality.Results: Older age was significantly associated with mortality. Non-survivors also showed a significantly lower PaO2/FiO2 (P/F) ratio at the time of hospital admission; a lower lymphocyte count; and increased levels of white blood cell count, C-reactive protein (CRP), lactate dehydrogenase (LDH), D-dimer, and creatinine. Significant differences were also observed with regards to both long-term medications and treatments administered during hospital stay.Conclusions: Our findings highlight the importance of age, clinical features, biochemical biomarkers, and therapeutic interventions in predicting COVID-19 disease severity and outcomes.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 4","pages":"467-475"},"PeriodicalIF":1.4,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143992313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isolation and cultivation of Borrelia lusitaniae from the blood of a patient with multiple erythema migrans. 从一例多发性迁移性红斑患者血液中分离培养卢西塔疏螺旋体。

IF 1.4 4区医学

Journal of Infection in Developing Countries Pub Date : 2025-04-29 DOI: 10.3855/jidc.20497

Gorana Veinović, Jovan Malinić, Ratko Sukara, Darko Mihaljica, Nataša Katanić, Jasmina Poluga, Snežana Tomanović

{"title":"Isolation and cultivation of Borrelia lusitaniae from the blood of a patient with multiple erythema migrans.","authors":"Gorana Veinović, Jovan Malinić, Ratko Sukara, Darko Mihaljica, Nataša Katanić, Jasmina Poluga, Snežana Tomanović","doi":"10.3855/jidc.20497","DOIUrl":"https://doi.org/10.3855/jidc.20497","url":null,"abstract":"Introduction: The region of Serbia is characterised by a high prevalence and diversity of Borrelia species, with Borrelia lusitaniae dominating, followed by Borrelia afzelii. Before this report, there were no data on Borrelia species causing Lyme borreliosis (LB) in Serbia.Case presentation: We report the case of a 10-year-old boy with a clinical presentation of disseminated erythema migrans (EM). His results showed IgM antibodies at 6.27 (negative ˂ 0.20; positive ˃ 0.32) against Borrelia burgdorferi sensu lato, which was confirmed via ELFA. Except for skin lesions, the patient did not show any other clinical signs of systemic infection. His blood was taken to isolate and cultivate spirochetes and for molecular analysis. Antimicrobial therapy was prescribed according to the recommended treatment for patients with LB. A follow-up examination was conducted after nine days. The EMs on the skin had disappeared, and antibiotic therapy was continued for 14 days. A second follow-up was conducted one month after the end of therapy. The boy's health condition was normal. After 16 days of incubation in BSK-H medium, viable, motile, and spiral-shaped spirochetes were observed in the culture tube, and cultivation was prolonged for 29 days. PCR and sequencing were successful in both the blood sample and the culture and confirmed the presence of B. lusitaniae.Conclusions: The results presented here is the first Borrelia isolate from the blood of a patient with the clinical manifestation of LB-disseminated EM. The presented results confirm the potential of B. lusitaniae for dissemination via the hematogenous route.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 4","pages":"630-635"},"PeriodicalIF":1.4,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144051768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidemiology and clinical outcomes of monomicrobial carbapenem-resistant Enterobacteriaceae (CRE) from a metropolitan area of Kerala, India. 印度喀拉拉邦市区单菌耐碳青霉烯肠杆菌科（CRE）的流行病学和临床结果

IF 1.4 4区医学

Journal of Infection in Developing Countries Pub Date : 2025-04-29 DOI: 10.3855/jidc.18777

Sanjeev K Singh, Sangita Sudhir, Vidya Menon, Anup R Warrier, Arya R V, Fabia Edathadathil, Dipu T Sathyapalan, Sivaprasad Ps, Sabu Thomas

{"title":"Epidemiology and clinical outcomes of monomicrobial carbapenem-resistant Enterobacteriaceae (CRE) from a metropolitan area of Kerala, India.","authors":"Sanjeev K Singh, Sangita Sudhir, Vidya Menon, Anup R Warrier, Arya R V, Fabia Edathadathil, Dipu T Sathyapalan, Sivaprasad Ps, Sabu Thomas","doi":"10.3855/jidc.18777","DOIUrl":"10.3855/jidc.18777","url":null,"abstract":"Introduction: The emergence of Carbapenem-resistant Enterobacteriaceae (CRE) is a major public health threat in India posing challenges in infection management. Our study aims to address the regional incidence of monomicrobial CRE in a metropolitan area of Kerala and characterize prescriptions in relation to clinical management.Methodology: The multicentre, prospective observational study was conducted in secondary and tertiary care centres jointly following public-private partnership model in Ernakulam district of Kerala, India from October 2018 to October 2019.Results: The overall incidence of monomicrobial CRE-positive cases from the study hospital network was found to be 0.855 per 1000 patient-days. Among the available data in the cohort, 77 % (312/405) were observed to attain clinical cure and in-hospital all-cause mortality was at 20% (83/410). The proportion of patients with clinical cure to treatment was found to be significantly higher than clinical failure among patients with urinary tract infections (p < 0.001, OR 2.88, 95% CI 1.73 - 4.79) and pneumonia (p < 0.001, OR 0.36, 95% CI 0.21 - 0.6) at 87% and 61% respectively in comparison to other infections. The prevalence of colistin resistance among the total number of patients recruited with isolated monomicrobial CRE was found to be at 3%.Conclusions: Our prospective study on the regional epidemiology of monomicrobial CRE has revealed notable incidence and all-cause mortality. The antimicrobial regimens for clinical management detailed in the study and the assessment of focus of infection-based clinical cure status rates indicate the need of optimized antimicrobial therapy to improve treatment practices in CRE infections.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 4","pages":"569-575"},"PeriodicalIF":1.4,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144062706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Catheter-associated Urinary Tract Infections in a trauma care facility in India: trend over ten years. 导尿管相关尿路感染在印度创伤护理机构：趋势超过十年。

IF 1.4 4区医学

Journal of Infection in Developing Countries Pub Date : 2025-04-29 DOI: 10.3855/jidc.20371

Aparna Ningombam, Arpan Kumar Thakur, Ashish Kumar Srivastava, Sharin Varma, Madhavi Kirti, M Nizam Ahmed, Vanlal Tluanpuii, Kapil Dev Soni, Richa Aggarwal, Gyanendra Pal Singh, Ashish Bindra, Navdeep Sokhal, Keshav Goyal, Kamran Farooque, Purva Mathur

{"title":"Catheter-associated Urinary Tract Infections in a trauma care facility in India: trend over ten years.","authors":"Aparna Ningombam, Arpan Kumar Thakur, Ashish Kumar Srivastava, Sharin Varma, Madhavi Kirti, M Nizam Ahmed, Vanlal Tluanpuii, Kapil Dev Soni, Richa Aggarwal, Gyanendra Pal Singh, Ashish Bindra, Navdeep Sokhal, Keshav Goyal, Kamran Farooque, Purva Mathur","doi":"10.3855/jidc.20371","DOIUrl":"https://doi.org/10.3855/jidc.20371","url":null,"abstract":"Introduction: Catheter-associated urinary tract infections (CAUTIs) are one of the most common device-associated infections acquired in a hospital. Trauma patients are highly susceptible to CAUTI, as catheterization is a lifesaving measure often required for their management. This study focuses on the profile of CAUTI, the organism profile with antibiotic susceptibility patterns, and the clinical outcomes in the ICUs of a trauma care center.Methodology: A retrospective analysis of prospective surveillance data of patients in ICUs was done over a period of ten years (2010-2019) in a level 1 trauma center. A modified NHSN definition of CAUTI was used. Microbiological processing and antibiotic susceptibility profile was done based on standard guidelines. Clinical outcomes were considered for analysis.Results: A total of 10,732 patients were included in the study, accounting for 98,131 patient days and 78,126 urinary catheter days (UCD). Among 546 patients, 577 episodes of CAUTI were recorded, giving a CAUTI rate of 7.4/1,000 catheter days. The average length of stay (LOS) of patients was 19.9 days. There was a significant relationship between UCD and the development of CAUTI. Orthopedic and spinal injuries (91%) accounted for the maximum device utilization ratio, followed by polytrauma (90%), miscellaneous injuries (88%), and head injuries (69%). CAUTI episodes were the highest in head injury patients. Gram-negative organisms (53.4%) dominated the pathogen profile. The crude mortality was 25.1%.Conclusions: Surveillance of CAUTI with analysis of the organisms and the antibiotic susceptibility trend will help improve infection prevention practices and antibiotic stewardship programs in local hospital settings.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 4","pages":"590-596"},"PeriodicalIF":1.4,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144041645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0