Journal of Infection in Developing Countries最新文献

{"title":"Serum IL-6 and IL-10 levels are associated with fatal outcomes in patients with SFTS in China.","authors":"Xiaoyi Liu, Fan Zhang, Jinping Qiao, Wentao He","doi":"10.3855/jidc.19939","DOIUrl":"https://doi.org/10.3855/jidc.19939","url":null,"abstract":"<p><strong>Introduction: </strong>Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease with a high mortality rate and is a public health concern. This study aimed to investigate the associations of serum interleukin 6 (IL-6) and interleukin 10 (IL-10) levels with the prognosis of SFTS patients.</p><p><strong>Methodology: </strong>A total of 95 patients with confirmed SFTS were included. Clinical and laboratory data were compared between the survival and non-survival groups. Multivariate logistic regression analysis was used to assess independent risk factors for mortality. The predictive efficacies of laboratory markers were evaluated using receiver operating characteristic (ROC) curves. Survival analysis was performed using Kaplan‒Meier curves based on the log-rank test.</p><p><strong>Results: </strong>The levels of IL-6 and IL-10 at admission were significantly greater in the non-survival group than in the survival group (p < 0.05). Multivariate logistic regression analysis indicated that the IL-6 and IL-10 levels, estimated glomerular filtration rate, and activated partial thromboplastin time (APTT) were independent risk factors for a poor prognosis in patients with SFTS. ROC curve analysis revealed that the IL-6 and IL-10 levels and the APTT had a greater predictive value than other measured laboratory markers. Kaplan-Meier survival analysis demonstrated that SFTS patients with IL-6 > 39.5 pg/mL or IL-10 > 45.2 pg/mL had significantly lower survival within a 30-day follow-up period.</p><p><strong>Conclusions: </strong>The levels of IL-6 and IL-10 at admission are the best markers for predicting in-hospital mortality of SFTS patients and have potential prognostic value in patients with SFTS.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 2","pages":"273-279"},"PeriodicalIF":1.4,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence of hypermucoviscous Klebsiella pneumoniae and phenotypic detection of their virulence factors along with classical strains among patients visiting tertiary care hospital.","authors":"Tika Bahadur Thapa, Sujina Maharjan, Nisha Giri, Manisha Sapkota, Ojaswee Shrestha, Puspa Raj Khanal, Govardhan Joshi","doi":"10.3855/jidc.19456","DOIUrl":"https://doi.org/10.3855/jidc.19456","url":null,"abstract":"<p><strong>Introduction: </strong>A new strain of Klebsiella pneumoniae named hypermucoviscous K. pneumoniae emerges with a distinctive feature to classical strains. Infections due to hypermucoviscous strains have increased with significant mortality and morbidity. This study aimed to determine the prevalence of hypermucoviscous K. pneumoniae and compare their virulence with the classical strains phenotypically.</p><p><strong>Methodology: </strong>One hundred-five clinical isolates of K. pneumoniae isolates proceeded for the study. A modified string test evaluated the hypermucoviscosity. The determination of antibiotic susceptibility was done using the Kirby-Bauer disk diffusion method. A phenotypic combination disk test was used to detect β-lactamases (ESBL, MBL, and KPC). Serum resistance was determined by the viable count method, and biofilm production by the microtiter plate method.</p><p><strong>Results: </strong>The modified string test detected 27.6% (29/105) of isolates as hypermucoviscous and 72.4% (76/105) as classical K. pneumoniae. Most K. pneumoniae were resistant to ceftazidime (80%) and cefotaxime (78%), and 46.7% were resistant to both imipenem and meropenem. A combination disk test identified 53.3% of ESBL, 28.6% of MBL, and 17.2% of KPC producers. Furthermore, 24.8% of K. pneumoniae were biofilm producers, and 39% were found to be serum resistant.</p><p><strong>Conclusions: </strong>In comparison, classical strains were more likely to develop ESBL, MBL, KPC, and biofilms while hypermucoviscous strains have higher serum resistance. The present study revealed that hypermucoviscous K. pneumoniae strains are prevalent and can be associated with metastatic invasive infections. Therefore, appropriate treatment strategies and timely diagnosis of these strains to limit their infection are crucial.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 2","pages":"258-266"},"PeriodicalIF":1.4,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative effectiveness of noninvasive ventilation strategies in moderate-to-severe COVID-19: A network meta-analysis of randomized controlled trials.","authors":"Lu Li, Ya Gao, Chao Wu, Shizhe He, Min Shi, Jianmei Liu, Hongjuan Lang","doi":"10.3855/jidc.19065","DOIUrl":"https://doi.org/10.3855/jidc.19065","url":null,"abstract":"<p><strong>Introduction: </strong>Noninvasive respiratory support (NIRS) using helmet devices is an emerging treatment for acute respiratory failure in patients with coronavirus disease 2019 (COVID-19). However, the comparative efficacy of helmet NIRS versus other strategies in this context remains elusive.</p><p><strong>Methodology: </strong>A network meta-analysis was conducted to compare the efficacy of various NIRS strategies in randomized controlled trials (RCTs) involving COVID-19 patients with acute respiratory failure. Strategies assessed included high-flow nasal oxygen (HFNO), continuous positive airway pressure (CPAP), helmet bilevel positive airway pressure (BiPAP), and standard oxygen therapy (SOT). Relevant RCTs were identified via PubMed, Embase, and Cochrane Central Register of Controlled Trials. Outcomes of interest included intubation rate, mortality rate, length of intensive care unit (ICU) stay, and length of hospital stay.</p><p><strong>Results: </strong>Five RCTs published between 2021 and 2022 were included. Helmet BiPAP was associated with a significantly lower intubation risk compared with HFNO (relative risk (RR): 0.37, 95% confidence interval (CI): 0.16-0.86) and SOT (RR: 0.24, 95% CI: 0.10-0.62). Additionally, helmet BiPAP was linked to shorter ICU stay compared with SOT (RR: 0.10, 95% CI: 0.02-0.67). However, no significant differences were identified in mortality or hospital stay length between SOT, HFNO, CPAP, and helmet BiPAP groups.</p><p><strong>Conclusions: </strong>Helmet BiPAP is recommended over HFNO and SOT for moderate-to-severe COVID-19 patients with acute respiratory failure, due to its lower intubation risk and shorter ICU stay. No significant differences were noted in mortality or length of hospital stay among the NIRS strategies.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 2","pages":"202-207"},"PeriodicalIF":1.4,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemic patterns and the immunity levels in hospitalized patients with respiratory syncytial virus infection in 2019-2023.","authors":"Linyan Tang, Lanlan Ma, Yan Liang, Xing Chen","doi":"10.3855/jidc.19729","DOIUrl":"https://doi.org/10.3855/jidc.19729","url":null,"abstract":"<p><strong>Introduction: </strong>The epidemic pattern of the Respiratory syncytial virus (RSV) has changed during the COVID-19 pandemic. To analyze the epidemic pattern of RSV infection and explore the fluctuations of immunity.</p><p><strong>Methodology: </strong>Pediatric inpatients diagnosed with RSV infection or RSV pneumonia from January 2019 to August 2023 in a tertiary hospital were retrospectively included. The children were divided into three groups: before the implementation of non-pharmaceutical interventions (NPIs) group, during the implementation of NPIs group, and after the lifted NPIs group.</p><p><strong>Results: </strong>A total of 462 children were included in this study. During the implementation of NPIs, there were almost no RSV hospitalizations from February to October 2020. In May 2023, the number of children infected with RSV increased dramatically. The RSV infected children in after the lifted NPIs group was mainly ≥ 3 years old. RSV mixed infections (56.93%) were slightly more common than RSV single infection (43.07%). The levels of IgG, IgA, IgM, and CD3+%, CD8+% during the implementation of NPIs and after the lifted NPIs groups were lower than those in the other group of infants 0-6 months old, and the levels of CD3+ % and CD3 + CD4+ % in children 7-12 months old were found to be similar.</p><p><strong>Conclusions: </strong>After the lifted NPIs, the RSV epidemic season was delayed to spring and summer. Humoral immunity and part of the cellular immunity in infants varies before and after NPIs. We pay close attention to the surveillance data of RSV to prevent RSV infection.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 2","pages":"289-297"},"PeriodicalIF":1.4,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tocilizumab treatment of COVID-19: relevance of delay in therapy initiation in middle-income countries.","authors":"Branko Beronja, Olja Stevanović, Nataša Nikolić, Nikola Mitrović, Tatjana Gazibara, Nevena Todorović, Ana Filipović, Jelena Dotlic, Mihailo Stjepanović, Jelena Simić, Ivana Milosevic","doi":"10.3855/jidc.19914","DOIUrl":"10.3855/jidc.19914","url":null,"abstract":"<p><strong>Introduction: </strong>During the coronavirus disease 2019 (COVID-19) pandemic, low- and middle- income countries had less access to monoclonal antibodies, such as tocilizumab (TCZ), compared to high-income countries. This retrospective cohort study aimed at evaluating the impact of a delayed TCZ administration on patient outcomes, and at determining the optimum timing of TCZ initiation for COVID-19 pneumonia in Serbia.</p><p><strong>Methodology: </strong>The study included 150 patients who received TCZ at a tertiary referral center. The outcomes analyzed in this study were the need for an intensive care unit (ICU) treatment and mortality.</p><p><strong>Results: </strong>The multiple Cox proportional hazard model suggested that the delay in TCZ administration was an independent predictor of needing ICU treatment and mortality. The receiver operating characteristic (ROC) curve showed that patients who received TCZ after 7.5 days since the onset of symptoms had 74.4% higher chances of needing ICU treatment. Receiving TCZ after 9.5 days since the onset of symptoms, increased the chances of mortality by 78.9%. The multiple Cox proportional hazard model suggested that TCZ administration after 7.5 days since the onset of symptoms increased the hazard for ICU admission by 24.5%; and the hazard of mortality increased by 46.1% after 9.5 days since the onset of symptoms.</p><p><strong>Conclusions: </strong>This study emphasizes the importance of timely administration of TCZ in COVID-19 pneumonia. Better outcomes were observed when TCZ was administered up to 7.5 days since the onset of symptoms.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 2","pages":"192-201"},"PeriodicalIF":1.4,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical presentation of pediatric tuberculous spondylitis in high TB burden setting before and during the COVID-19 pandemic.","authors":"Nazhira P Juslin, Djatnika Setiabudi, Heda M Nataprawira, Ahmad Ramdan","doi":"10.3855/jidc.20075","DOIUrl":"https://doi.org/10.3855/jidc.20075","url":null,"abstract":"<p><strong>Introduction: </strong>Tuberculous spondylitis (TBS) in children can be severe, non-specific, and slowly progressive. Disruptions in tuberculosis (TB) services were observed amid the coronavirus disease (COVID-19) pandemic, prompting a closer examination of its impact on TBS patients. This study compared the presenting symptoms of TBS in children before (A) and during (B) the pandemic.</p><p><strong>Methodology: </strong>An analytic retrospective study was conducted using medical charts and the pediatric respirology registry of all patients (aged ≤ 18 years) diagnosed with TBS before and after the pandemic. Demographic data, clinical features, confirmatory examination, and treatments were analyzed. Statistical significance was determined at p < 0.05.</p><p><strong>Results: </strong>The common presenting symptoms before and after the pandemic were gibbus (A 25; 93% vs. B 19; 79%, p = 0.232), back pain (A 20, 74% vs. B 20, 83%; p = 0.508), and inability to walk (A 15, 56% vs. B 16, 67%; p = 0.567). Involvement of ≥ 3 vertebrae was significantly more prevalent in group B (A 6, 23% vs. B 11, 46%; p = 0.09). The median time from symptom onset to diagnosis was longer in group B (A 13 weeks vs. B 21 weeks; p = 0.07).</p><p><strong>Conclusions: </strong>The pandemic had minimal effect on the clinical characteristics of TBS patients at presentation. However, most patients were in a serious condition at the time of presentation, suggesting that the symptoms had existed, but did not receive appropriate care from primary healthcare facilities. A meticulous assessment enabling early diagnosis and initiation of therapy is crucial.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 2","pages":"221-226"},"PeriodicalIF":1.4,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic immune-inflammation index as a prognostic marker for chronic Hepatitis B with non-alcoholic fatty liver disease.","authors":"Bo Xue, Zeyu Wang, Jianguo Li","doi":"10.3855/jidc.19636","DOIUrl":"https://doi.org/10.3855/jidc.19636","url":null,"abstract":"<p><strong>Introduction: </strong>This study investigates the association between high-level systemic immune-inflammatory index (SII) and cirrhosis progression in patients with chronic hepatitis B (CHB) and non-alcoholic fatty liver disease (NAFLD).</p><p><strong>Methodology: </strong>A total of 272 CHB patients with NAFLD treated at Jincheng General Hospital between January 2018 and January 2023 were included. The study endpoint was the development of cirrhosis. The optimal SII cut-off value for predicting cirrhosis progression was determined as 1024 using ROC curve analysis and Youden index. Based on this cut-off, patients were classified into low SII (n = 159) and high SII (n = 113) groups. Univariate and multivariate Cox regression analyses were performed to identify independent predictors of cirrhosis progression and assess the relationship with SII.</p><p><strong>Results: </strong>Univariate Cox analysis revealed that SII was a significant risk factor for cirrhosis progression in CHB with NAFLD (HR = 2.062, 95% CI: 1.717-3.941, p < 0.001). Multivariate Cox regression analysis demonstrated a significant association between elevated SII levels and increased incidence of cirrhosis, with patients in the high SII group having an 88.5% higher risk (HR = 1.885, 95% CI: 1.167-3.045, p = 0.010). Kaplan-Meier survival analysis further confirmed the higher risk of cirrhosis in patients with high SII levels (log-rank p < 0.001) within 60 months.</p><p><strong>Conclusions: </strong>This study suggests that SII is a relevant risk factor for cirrhosis development in CHB individuals with NAFLD, emphasizing the importance of considering SII in current clinical management.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 2","pages":"315-324"},"PeriodicalIF":1.4,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric Gram-negative bloodstream infections: epidemiology, antibiotic resistance, clinical outcomes and factors affecting mortality, a single center retrospective study.","authors":"Seyhan Yilmaz, Gulsen Akkoc, Sevgi Aslan Tuncay, Burcu Parlak, Pinar Canizli Erdemli, Aylin Dizi Isik, Zeynep Ergenc, Arzu Ilki, Nurver Ulger Toprak, Bilgehan Ergan, Sevliya Ocal Demir, Eda Kepenekli","doi":"10.3855/jidc.20258","DOIUrl":"https://doi.org/10.3855/jidc.20258","url":null,"abstract":"<p><strong>Introduction: </strong>The increasing prevalence of Gram-negative bloodstream infections in pediatric patients poses significant treatment challenges, particularly from multi-drug resistant (MDR) strains. Despite advances in medical care, mortality from bloodstream infections remains a concern. Our study aims to understand pediatric patients` demographics, clinical conditions, and microorganisms causing Gram-negative infections, as well as identify factors affecting treatment outcomes and mortality.</p><p><strong>Methodology: </strong>A retrospective, observational study of Gram-negative bacteremia, including all patients < 18 years of age, hospitalized during 2022, with documented bacteremia caused by Enterobacteriaceae or non-fermentative bacteria.</p><p><strong>Results: </strong>In total 123 blood cultures from 102 patients were included study. The median age of patients was 22 months, with 85.3% having an underlying medical condition. Common strains were Klebsiella pneumoniae, Escherichia coli, and Pseudomonas aeruginosa, with 73.2% hospital-acquired infections. Among the isolated species, 28.5% were multidrug-resistant (MDR). The mortality rate was 10.5%. Mortality among patients with antibiotic-resistant isolates was 17.1%. Patients with sepsis had a markedly elevated mortality rate. Additionally, mortality was increased among patients reliant on mechanical ventilation and those with urinary catheters. Furthermore, central venous catheterization was found to be an independent predictor for sepsis (odds ratio: 2.463, 95% confidence interval: 1.095-5.53), while the presence of a urinary catheter was identified as an independent predictor of mortality (odds ratio: 5.681, 95% confidence interval: 1.142-28.249).</p><p><strong>Conclusions: </strong>The study findings highlight a critical need for strategies to reduce MDR Gram-negative infections in children, emphasizing the importance of timely removal of invasive devices and rational antibiotic use to improve patient outcomes.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 2","pages":"238-247"},"PeriodicalIF":1.4,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health workers' knowledge, attitudes, and perceptions concerning MRSA at two hospitals in Ghana.","authors":"Rose Maj Kugbeadzor, Fleischer Cn Kotey, Eric S Donkor","doi":"10.3855/jidc.18747","DOIUrl":"https://doi.org/10.3855/jidc.18747","url":null,"abstract":"<p><strong>Introduction: </strong>This study assessed the knowledge, attitudes, and perceptions (KAPs) regarding methicillin-resistant Staphylococcus aureus (MRSA) among healthcare workers at the Ho Teaching Hospital and Ho Municipal Hospital in Ghana.</p><p><strong>Methodology: </strong>This cross-sectional study involved 157 healthcare workers whose KAPs were assessed using a standard questionnaire.</p><p><strong>Results: </strong>The overall knowledge of the respondents about MRSA was sufficient (mean score = 0.58 ± 0.15). Medical doctors demonstrated the highest knowledge (mean score = 0.80), but their knowledge on the challenges in implementing effective preventive measures against MRSA acquisition, risk factors for transmission, and predominant mode of transmission were poor (mean scores = 0.18-0.37). The respondents' MRSA-related attitudes (mean score = 2.74 ± 0.31) and perceptions (mean score = 2.88 ± 0.29) were generally positive, with the highest scores recorded among laboratory staff (n = 10) (mean attitude score = 2.92 ± 0.25; mean perception score = 3.06 ± 0.24). The factors that influenced MRSA KAPs included age group (knowledge [p < 0.001]), educational level (knowledge [p < 0.001], and perception [p = 0.044]), and healthcare worker designation (knowledge [p = 0.044]). Nurses were six times more likely to have good knowledge about MRSA compared to pharmacy staff (OR = 6.05, p = 0.045).</p><p><strong>Conclusions: </strong>The respondents had adequate knowledge, and positive MRSA-related attitudes and perceptions, although some knowledge deficits were identified. These knowledge deficiencies can be addressed during the design of educational programs on MRSA, and by increasing research on KAPs regarding MRSA, among key stakeholders in healthcare, particularly, in Ghana.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 2","pages":"227-237"},"PeriodicalIF":1.4,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for urinary tract infection and asymptomatic bacteriuria after stroke.","authors":"Vladimir S Jankovic, Svetlana D Miletic Drakulic, Slobodan M Jankovic, Snezana R Lazarevic, Sandra M Radevic, Ivana P Jovovic","doi":"10.3855/jidc.20260","DOIUrl":"https://doi.org/10.3855/jidc.20260","url":null,"abstract":"<p><strong>Introduction: </strong>Urinary tract infections occur in approximately 19% of stroke patients. Urinary tract infections are proven to adversely affect the short-term and long-term outcomes of stroke, prolong hospitalization, and increase treatment costs. This study aimed to determine the risk factors for the occurrence of urinary tract infection and asymptomatic bacteriuria.</p><p><strong>Methodology: </strong>This retrospective case-control study was conducted in the neurological intensive care unit, in a tertiary healthcare facility, from July 2018 to July 2022.</p><p><strong>Results: </strong>Our study demonstrated that older patients with worse neurological status upon admission, were at a higher risk for the occurrence of urinary tract infection. This factor also predisposed the occurrence of asymptomatic bacteriuria. The patients who received ceftriaxone and fluoroquinolone were at a lower risk of developing a urinary tract infection, while carbapenem and vancomycin administration could potentiate the occurrence of a urinary tract infection.</p><p><strong>Conclusions: </strong>Based on these results, we can identify the patients who are at a higher risk of developing a urinary tract infection and take measures to prevent infection, such as decreasing the duration of catheterization or replacing the urinary catheter more frequently. The results also enable us to identify the patients who are at a higher risk of developing asymptomatic bacteriuria.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 2","pages":"267-272"},"PeriodicalIF":1.4,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}