Journal of Infection in Developing Countries最新文献

{"title":"Microbial etiology of hospital-acquired pneumonia/ventilator-associated pneumonia in hospitals of Shandong Province.","authors":"Gui Zhang, Yanpeng Cheng, Xiaojie Hu, Weiguang Li, Jian Sun, Zhiyuan Chen, Hua Xu","doi":"10.3855/jidc.21118","DOIUrl":"https://doi.org/10.3855/jidc.21118","url":null,"abstract":"<p><strong>Introduction: </strong>Nosocomial pneumonia includes hospital-acquired pneumonia without association with mechanical ventilation (HAP) and ventilator-associated pneumonia (VAP). The prevalence and microbial etiology of HAP/VAP in Shandong Province were evaluated to provide a reference for hospital infection control.</p><p><strong>Methodology: </strong>Data was obtained from patients with HAP/VAP admitted to hospitals within the network of Shandong Provincial Hospital infection management and monitoring from 2019 to 2023.</p><p><strong>Results: </strong>The prevalence of HAP/VAP showed an overall downward trend across the 5-year period, with range of 0.68-0.43% and 0.067-0.04%, respectively. A total of 83,533 HAP and 7,205 VAP cases were diagnosed (male-to-female ratio of 1.89:1 and 2.13:1; and median age of 67.7 and 64.2 years), among which 47,862 and 9,806 strains were isolated from patients with HAP/VAP, respectively. The primary pathogens in HAP/VAP were similar, and included Acinetobacter baumannii, Pseudomonas aeruginosa, and Klebsiella pneumoniae. The antimicrobial susceptibility was low, with lesser susceptibility in VAP. The major multidrug resistant microorganisms (MDROs) were identical in HAP/VAP; and MDR-A. baumannii had the highest detection rate, followed by MDR-Staphylococcus. aureus and MDR-P. aeruginosa. The Mantel-Haenszel χ2 test suggested that there was a linear relationship between the detection rate of MDR-P. aeruginosa and MDR-S. aureus and time (p < 0.001 for MDR-P. aeruginosa in HAP/VAP and MDR-S. aureus in HAP; p = 0.023 for MDR-S. aureus in VAP).</p><p><strong>Conclusions: </strong>The infection rates of HAP and VAP displayed a declining trend. The major pathogens were similar in HAP and VAP, but with low antimicrobial susceptibility and high detection rate of MDROs.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 9","pages":"1336-1344"},"PeriodicalIF":1.2,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Etiology of diarrhea among children under five years in Thai Binh, Vietnam: a prospective study.","authors":"Xuan Duong Tran, Thi Loi Dao, Van Thuan Hoang, Ndiaw Goumballa, Thi Thom Vu, Trong Kiem Tran, Hong Ha Pham, Duy Cuong Nguyen, Thanh Binh Nguyen, Philippe Parola, Pierre Marty, Philippe Gautret","doi":"10.3855/jidc.20917","DOIUrl":"https://doi.org/10.3855/jidc.20917","url":null,"abstract":"<p><strong>Introduction: </strong>In developing countries like Vietnam, childhood diarrhea remains frequent and is often treated empirically without an etiological diagnosis.</p><p><strong>Methodology: </strong>Patients aged under five years, hospitalized at a gastroenterology department with acute diarrhea, were recruited at one hospital. Enteric pathogens were tested by real-time PCR.</p><p><strong>Results: </strong>451 children with diarrhea were included, 65.2% were male. 56.3% were aged under 12 months. Upon inclusion, 49.7% (224/451) had nausea and vomiting, and 17.5% had bloody diarrhea. 27.1% of children had a fever, and 37.7% and 4.2% had moderate and severe dehydration, respectively. Almost all patients (437/451, 96.9%) received empirical antimicrobial treatment. 76.5% of children were positive for at least one pathogen, with 37.9% positive for two to four pathogens. Adenovirus, norovirus, and enterovirus were the most frequent viruses detected, with a proportion of 35.7%, 25.7%, and 20.6%, respectively, while Campylobacter jejuni was the most frequent bacterium detected (14.2%), followed by Salmonella spp. and Escherichia coli pathotypes. Male gender, patients positive for at least one virus, and rotavirus were associated with an increased risk of severe disease (OR = 1.55, p = 0.04, OR = 2.23, p < 0.001, and OR = 1.86, p = 0.03, respectively).</p><p><strong>Conclusions: </strong>These findings underscore the complex interplay of viral and bacterial pathogens in pediatric diarrheal illness and highlight the need for targeted interventions focusing on appropriate diagnostic strategies, antimicrobial stewardship, and gender-specific considerations to mitigate the burden of childhood diarrhea in resource-limited settings like Vietnam.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 9","pages":"1391-1399"},"PeriodicalIF":1.2,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological evaluation of measles cases seen in 2019-2023: an example from Türkiye.","authors":"Leyla Tekdemir, Semiha Zeynep Özsaydı, Arda Borlu","doi":"10.3855/jidc.21398","DOIUrl":"https://doi.org/10.3855/jidc.21398","url":null,"abstract":"<p><strong>Introduction: </strong>Measles is highly contagious and transmitted via droplets, leading to complications such as encephalitis, pneumonia, diarrhea, and death. Although global vaccination efforts have reduced cases, gaps in vaccination coverage and vaccine hesitancy continue to cause outbreaks. This study aims to evaluate measles cases reported in Kayseri, Türkiye, from 2019 to 2023.</p><p><strong>Methodology: </strong>The study analysed measles cases reported to the Kayseri Provincial Health Directorate's İZCİ system from 1 January 2019 to 31 December 2023. Demographic characteristics, vaccination status, symptoms, complications, and case classifications were recorded. Annual incidence rates were calculated using data from the Turkish Statistical Institute.</p><p><strong>Results: </strong>A total of 137 measles cases were reported, of which 126 were included in the analysis. Among confirmed cases, 48.2% were children aged 0-4 years. The most common symptoms were rash (89.7%) and fever (81.0%). Among confirmed cases, 17.9% developed complications, including pneumonia (12.5%) and diarrhea (1.8%). The incidence of measles peaked in 2019 and 2023.</p><p><strong>Conclusions: </strong>The resurgence of measles is driven by factors such as inadequate vaccination coverage, with 35.7% of the population remaining unvaccinated. Strengthening immunization programs and primary healthcare services is essential for the elimination of measles.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 9","pages":"1285-1290"},"PeriodicalIF":1.2,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of BIPQ score with socioeconomic characteristics of patients with COVID-19 pneumonia and CT severity score.","authors":"Jelena Jankovic, Aleksandra Sljivic, Vladimir Djukic, Vladan Vukomanovic, Suncica Kapor, Nikola Blagojevic, Dragana Blagojevic, Isidora Guslarevic, Predrag Savic, Ivan Nesic, Uros Karic, Mirjana Stjepanovic","doi":"10.3855/jidc.21911","DOIUrl":"https://doi.org/10.3855/jidc.21911","url":null,"abstract":"<p><strong>Introduction: </strong>Coronavirus disease 2019 (COVID-19) rapidly became a global pandemic with clinical manifestations ranging from asymptomatic infection to life-threatening illness. While physician assessment of disease severity is largely objective, patient perception of illness is often influenced by psychosocial and demographic factors. This study aimed to explore determinants of illness perception among patients hospitalized with COVID-19.</p><p><strong>Methodology: </strong>A cohort of 262 patients with confirmed SARS-CoV-2 infection was evaluated. Baseline characteristics included age, gender, smoking history, body mass index, and sociodemographic information (relationship status, education, employment, and physical activity). Disease severity was assessed using chest computed tomography (CT) scans. Illness perception was measured with the Brief Illness Perception Questionnaire (BIPQ).</p><p><strong>Results: </strong>The median patient age was 56.3 years, and 65.6% were male. More than half (56.5%) had completed higher education, 90% were married or in a relationship, 57.6% were unemployed, and 85.9% reported no regular physical activity. Male patients demonstrated higher absolute CT scores (p = 0.018) but lower BIPQ scores. Severe pneumonia, as defined by CT findings, correlated with longer hospitalization, although no significant differences in total BIPQ scores were observed across CT severity groups. Illness perception was not influenced by education (p = 0.43), employment (p = 0.096), or physical activity (p = 0.94). However, relationship status significantly affected total BIPQ scores (p = 0.034).</p><p><strong>Conclusions: </strong>The study found BIPQ useful for rapid illness perception assessment, recommended for routine practice. Socio-economic factors influenced responses, while CT severity did not. Linking CT scores with BIPQ may identify patients at risk of psychological distress.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 9","pages":"1291-1298"},"PeriodicalIF":1.2,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression analysis of DDC, dACE2, and EPO genes in Moroccan COVID-19 patients: links to viral load and demographics.","authors":"Oumaima Laazaazia, Ahd Ouladlahsen, Safaa Aqillouch, Haya Altawalah, Rachid Noureddine, M'hammed Sarih, Pascal Pineau, Abderrahmane Maaroufi, Mustapha Lkhider, Sayeh Ezzikouri","doi":"10.3855/jidc.21079","DOIUrl":"https://doi.org/10.3855/jidc.21079","url":null,"abstract":"<p><strong>Introduction: </strong>Interactions between host and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are incompletely understood. Studies have highlighted the roles of L-dopa decarboxylase (DDC), interferon-inducible truncated isoform of angiotensin-converting enzyme 2 (dACE2), and immunomodulatory hypoxia-regulated gene erythropoietin (EPO) in viral infections. This study investigated the expression levels of DDC, dACE2, and EPO in 136 coronavirus disease 2019 (COVID-19) patients and 88 controls.</p><p><strong>Methodology: </strong>Real-time quantitative reverse transcription polymerase chain reaction (RT-qPCR) was used to quantify mRNA levels of DDC, dACE2, and EPO; and the SARS-CoV-2 viral load in nasopharyngeal swabs.</p><p><strong>Results: </strong>Significantly elevated levels of dACE2 (p = 0.003), DDC (p = 0.004), and EPO (p = 0.006) were observed in patients compared to controls. No correlation with the viral load (DDC: r = 0.12, p = 0.136; EPO: r = 0.02, p = 0.802; dACE2: r = 0.05, p = 0.491), and no associations with age or gender (all p > 0.05) were noted. There were positive correlations between DDC and dACE2 mRNA levels in infected (r = 0.31, p = 0.0002) and uninfected individuals (r = 0.25, p = 0.015); and between DDC and EPO in infected (r = 0.22, p = 0.008) and uninfected individuals (r = 0.27, p = 0.010). There was a positive correlation between dACE2 and EPO mRNA levels in both groups (infected: r = 0.22, p = 0.007; uninfected: r = 0.38, p = 0.0002).</p><p><strong>Conclusions: </strong>DDC, dACE2, and EPO may contribute to COVID-19 pathogenesis through mechanisms independent of viral load, age, or gender.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 9","pages":"1299-1307"},"PeriodicalIF":1.2,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of the COVID-19 pandemic on the temporal trend of indicators for access to tuberculosis diagnosis: A systematic review.","authors":"Mariana Gaspar Botelho Funari de Faria, Rubia Laine De Paula Andrade Gonçalves, Livia Maria Lopes, Elisangela Fransiscon Naves, Rafaele Oliveira Bonfim, Diogo Henrique Mendes da Silva, Ana Beatriz Marques Valença, Valdes Roberto Bollela, Maria Josefa Perón Rujula, Ricardo Alexandre Arcêncio, Ione Carvalho Pinto, Pedro Fredemir Palha, Jaqueline Garcia de Almeida Balestero, Dulce Gomes, Zhiting Guo, Jason Farley, Nancy Reynolds, Aline Aparecida Monroe","doi":"10.3855/jidc.21045","DOIUrl":"https://doi.org/10.3855/jidc.21045","url":null,"abstract":"<p><strong>Introduction: </strong>The COVID-19 pandemic influenced the behaviour of numerous diseases, overloading health systems and weakening public health infrastructure and access.</p><p><strong>Methodology: </strong>This study aimed to analyse the repercussions of the COVID-19 pandemic on tuberculosis diagnosis indicators. A systematic review was conducted, examining studies published between 2020 and 2024 in Portuguese, English, or Spanish across five databases and Google Scholar. The search, performed in March 2024, led to the identification of 6,378 studies, of which 23 were included after an independent review of titles, abstracts, and full texts. Data were extracted and narratively synthesized following a methodological quality assessment.</p><p><strong>Results: </strong>The review revealed significant declines in TB incidence, detection, notification, and diagnosis during the pandemic, alongside reduced etiological confirmation of cases.</p><p><strong>Conclusions: </strong>The findings highlight a need to reorganize and enhance health service responses to address the disruptions caused by the pandemic. Strengthening these services is crucial to recover missed TB cases and improve indicators, supporting the goal of eliminating TB by 2030.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 9","pages":"1314-1321"},"PeriodicalIF":1.2,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive insights into pediatric infectious mononucleosis: a retrospective study.","authors":"Chen Wang, Saeed Saboor, Yiyang Zhang, Gang Li, Chunming Jiang","doi":"10.3855/jidc.21351","DOIUrl":"https://doi.org/10.3855/jidc.21351","url":null,"abstract":"<p><strong>Introduction: </strong>The objectives of this study were to identify clinical and laboratory markers of infectious mononucleosis (IM) in children, investigate the risk factors for liver damage and prolonged hospitalization, and enhance Epstein-Barr virus (EBV) diagnostic precision.</p><p><strong>Methodology: </strong>This retrospective study analyzed 288 pediatric IM cases hospitalized from January 2023 to December 2024. Clinical features, laboratory parameters, and EBV-DNA loads were evaluated using statistical analyses to identify predictors of disease severity and outcomes.</p><p><strong>Results: </strong>Among the 288 children (median age: 5 years; 48.3% male), fever, cervical lymphadenopathy, creatine kinase (CK), IgM, and CD4/CD8 ratios were significantly associated with high EBV-DNA load. Liver damage (35.1% of cases) correlated with age, splenomegaly, alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyltransferase (GGT), lactate dehydrogenase (LDH), ferritin, and immune markers (p < 0.05). Prolonged hospitalization was associated with hepatomegaly, ALT, AST, GGT, LDH, and ferritin levels (p < 0.05). Multivariate analysis identified fever as a predictor of high EBV-DNA load; while age, LDH, and ferritin were independent risk factors for liver damage. Hepatomegaly was a key predictor of extended hospitalization (p < 0.05).</p><p><strong>Conclusions: </strong>IM predominantly affected children aged 3-7 years in Hangzhou. Fever predicted high EBV-DNA load, while elevated LDH, ferritin, and hepatomegaly signaled increased risks of liver damage and prolonged hospitalization, informing more precise management strategies.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 9","pages":"1359-1369"},"PeriodicalIF":1.2,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of drainage strategies on recovery in Stage III tuberculous empyema: a retrospective study.","authors":"Jian Xu, Yuhua Chen, Cheng Gong, Hong Liu","doi":"10.3855/jidc.21028","DOIUrl":"https://doi.org/10.3855/jidc.21028","url":null,"abstract":"<p><strong>Introduction: </strong>Tuberculous empyema, a severe complication of pulmonary tuberculosis, often requires surgical intervention in stage III to remove fibrotic tissue and restore lung function.</p><p><strong>Methodology: </strong>This retrospective study enrolled 224 stage III tuberculous empyema patients undergoing single-port thoracoscopic decortication and closed chest drainage. Patients were divided into three groups: Single-Tube group (n = 42), Double-Tube group (n = 51), and Double-Tube with Negative Pressure (Double-NP) group (n = 131, with -8 to -10 cm H₂O negative pressure applied from postoperative day 2). Primary outcomes included postoperative drainage volume, chest tube duration, hospital stay, complications, and Visual Analog Scale (VAS) pain scores. Data were analyzed using Analysis of Variance (ANOVA), chi-square tests, and multivariate regression.</p><p><strong>Results: </strong>Baseline characteristics were comparable across groups. Postoperative drainage volumes were similar, but chest tube duration and hospital stay were significantly shorter in the Double-Tube and Double-NP groups compared to the Single-Tube group (p < 0.05). The Double-NP group exhibited lower rates of persistent air leak, pleural effusion, atelectasis, and reintubation (p < 0.05). VAS scores were significantly lower in the Single-Tube group than in the Double-Tube and Double-NP groups (p < 0.01).</p><p><strong>Conclusions: </strong>While the double-tube with delayed low-negative-pressure drainage strategy did not reduce postoperative pain, it significantly shortened chest tube duration and hospital stay while reducing complications, thereby improving overall prognosis in stage III tuberculous empyema patients.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 9","pages":"1400-1406"},"PeriodicalIF":1.2,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Routine hemoglobin-A1c screening is required before the next pandemic to reduce morbidity and in-hospital costs.","authors":"Yasemin Saygideger, Aslihan Candevir, Bengu Curuk, Ersoy Altunok, Merve Sancioglu Demir, Efraim Güzel, Ezgi Ozyilmaz, Oya Baydar Toprak, Ferit Kuscu, Sedat Kuleci","doi":"10.3855/jidc.20233","DOIUrl":"https://doi.org/10.3855/jidc.20233","url":null,"abstract":"<p><strong>Introduction: </strong>Glycosylated hemoglobin (HbA1c) levels are routinely used in secondary and tertiary care centers for monitoring diabetes patients. However, since it is an expensive test, it is not routinely tested in primary care or used as a screening test. This study aimed to examine the relationship between HbA1c levels and in-hospital costs in hospitalized patients during the pandemic period to draw attention to the issue and to be prepared for future pandemics.</p><p><strong>Methodology: </strong>The design of the study was retrospective and cross-sectional. The study was conducted in a tertiary hospital between March and December 2020. Independent variables, including HbA1c levels, comorbidities, age, and gender; and dependent variables including in-hospital costs, prolonged hospital stay (≥ 14 days), and 30-day mortality; were statistically analyzed.</p><p><strong>Results: </strong>Overall, 517 patients were included in the study, and 96 of them had high HbA1c levels (HbA1c ≥ 7). The in-hospital costs were significantly correlated with HbA1c ≥ 7 as continuous variables, and HbA1c ≥ 7 was a better indicator of in-hospital costs compared to the diagnosis of diabetes. Patients with HbA1c ≥ 7 also had prolonged hospital stays and higher mortality rates, in addition to high in-hospital costs.</p><p><strong>Conclusions: </strong>Routine testing of HbA1c levels might be cost-effective and should be performed at primary healthcare facilities.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 9","pages":"1330-1335"},"PeriodicalIF":1.2,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decreased albumin to INR ratio is a prognostic marker of 30-day mortality in neonatal sepsis: a retrospective study.","authors":"Xiangwen Tu, Junkun Chen, Wen Liu","doi":"10.3855/jidc.20968","DOIUrl":"https://doi.org/10.3855/jidc.20968","url":null,"abstract":"<p><strong>Introduction: </strong>Neonatal sepsis is a leading cause of neonatal mortality. This study aims to assess the clinical significance of the serum albumin (ALB) to international normalized ratio (INR) ratio (AIR) as a predictor for 30-day mortality in neonates with sepsis.</p><p><strong>Methodology: </strong>Neonates diagnosed with sepsis between January 2019 and December 2022 were included. Admission data were collected, enabling the categorization of neonates into survival and non-survival groups. Logistic regression analyses and receiver operating characteristic (ROC) curves, were employed.</p><p><strong>Results: </strong>A total of 195 neonates with sepsis were analyzed. The non-survival group exhibited significantly lower AIR compared to the survival group. Multivariate analysis identified low AIR as an independent risk factor (hazard ratio [HR]: 9.091, p < 0.001), achieving an area under the curve (AUC) of 0.746 for AIR. The sensitivity and specificity of AIR were 79.31% and 66.87%, respectively.</p><p><strong>Conclusions: </strong>AIR serves as a cost-effective and easily obtainable marker in neonatal sepsis research. It emerges as an independent predictor of adverse outcomes in neonatal sepsis, demonstrating good predictive capabilities.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 9","pages":"1370-1376"},"PeriodicalIF":1.2,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}