Journal of Infection in Developing Countries最新文献_第2页

Clinical features and drug resistance analysis of non-typhoidal Salmonella infection in children. 儿童非伤寒沙门氏菌感染的临床特点及耐药性分析。

IF 1.3 4区医学

Journal of Infection in Developing Countries Pub Date : 2026-09-30 DOI: 10.3855/jidc.22215

Guolin Rao, Changqiang Yang, Xuemei Zhao, Hongcai He, Chen Xiong, Ziyang Kuang, Liqun Lu, Yue Song

{"title":"Clinical features and drug resistance analysis of non-typhoidal Salmonella infection in children.","authors":"Guolin Rao, Changqiang Yang, Xuemei Zhao, Hongcai He, Chen Xiong, Ziyang Kuang, Liqun Lu, Yue Song","doi":"10.3855/jidc.22215","DOIUrl":"https://doi.org/10.3855/jidc.22215","url":null,"abstract":"Introduction: There is limited information on non-typhoidal Salmonella (NTS) infections among children in China. The aim of this study was to explore the clinical features, strain serotypes, and drug resistance patterns of NTS infection in children.Methodology: A retrospective study of children with NTS admitted to three tertiary hospitals between January 2015 and December 2024 was conducted. The clinical features and drug resistance were compared among the patients.Results: Out of a total of 131 patients, 94 cases (71.76%) visited the hospital between June and September, and 82 cases (62.60%) were aged 6 months to 2 years. The main clinical manifestations were fever and diarrhea, with 94 cases (71.76%) presenting high fever (> 39 ℃) and 129 cases (98.50%) experiencing diarrhea. Stool consistency was predominantly loose paste or watery. Regarding serotypes, Salmonella Typhimurium was the most common (96 cases, 73.28%), while Salmonella Dublin ranked second (12 cases, 9.16%). The study revealed an increasing resistance rate to ceftriaxone. High resistance rates (> 80%) were observed for ampicillin, cefazolin, and gentamicin; whereas high sensitivity (> 90%) was noted for ceftazidime, piperacillin-tazobactam, and carbapenems. The rate of sensitivity to ceftazidime was linearly correlated with age (p = 0.03).Conclusions: NTS predominantly occurred in summer and autumn among children aged 6 months to 2 years. The clinical features were primarily fever and diarrhea. Given the rising resistance to ceftriaxone, ceftazidime may be prioritized for empirical treatment.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"20 9","pages":"1308-1314"},"PeriodicalIF":1.3,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149171277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular and morphological characterization of hard ticks (Acari: Ixodidae) infesting rodents in Southern Iran: evidence of a cryptic Haemaphysalis species. 伊朗南部啮齿动物感染的硬蜱（蜱螨：伊蚊科）的分子和形态特征：一种隐血蜱物种的证据。

IF 1.3 4区医学

Journal of Infection in Developing Countries Pub Date : 2026-09-30 DOI: 10.3855/jidc.22589

Kourosh Azizi, Saeed Shahabi, Bahador Sarkari, Mohammad Djaefar Moemenbellah-Fard, Azim Paksa, Zahra Vahabi-Baabsangi, Zahra Nasiri, Sajjad Moshavernia

{"title":"Molecular and morphological characterization of hard ticks (Acari: Ixodidae) infesting rodents in Southern Iran: evidence of a cryptic Haemaphysalis species.","authors":"Kourosh Azizi, Saeed Shahabi, Bahador Sarkari, Mohammad Djaefar Moemenbellah-Fard, Azim Paksa, Zahra Vahabi-Baabsangi, Zahra Nasiri, Sajjad Moshavernia","doi":"10.3855/jidc.22589","DOIUrl":"https://doi.org/10.3855/jidc.22589","url":null,"abstract":"Background: Hard ticks are important vectors of various zoonotic diseases. Identifying closely related tick species using morphological methods alone can be challenging. This study aimed to assess the taxonomic status of hard ticks infesting rodents in southern Iran using morphological and molecular approaches.Methods: Ticks were collected from the ear bases and rears of rodents and identified morphologically. Genomic DNA was extracted, and the cytochrome oxidase subunit 1 (COX1) and internal transcribed spacer 2 (ITS2) genes were amplified via polymerase chain reaction (PCR). Sequencing and phylogenetic analyses were performed using assembled DNA sequences and reference sequences from GenBank.Results: A total of 62 rodents from seven species were examined. Collected ticks were identified as Rhipicephalus turanicus and Haemaphysalis spp. Phylogenetic analysis revealed that the Haemaphysalis samples were genetically distinct from 29 congeneric species recorded in the Barcode of Life Data System (BOLD) and GenBank. No sequence matches were found with known Haemaphysalis species in Iran, except for H. caucasica and H. aponommoides, which lack sequence data in these databases.Conclusions: This study represents the first molecular characterization of Haemaphysalis and Rhipicephalus ticks infesting rodents in Iran. Our findings confirm the presence of Rhipicephalus turanicus on Rattus species. More significantly, we identified a distinct Haemaphysalis lineage parasitizing Calomyscus cf. bailwardi, a rodent endemic to the Zagros Mountains. The considerable genetic divergence observed in both the COX1 and ITS2 genes suggests that this Haemaphysalis lineage may represent a cryptic species or a unique ecotype adapted to this specific host and geographic location.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"20 9","pages":"1393-1402"},"PeriodicalIF":1.3,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149171258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does the status of micronutrients affect immune response to COVID-19 mRNA vaccination in rheumatoid arthritis patients? 微量营养素状况是否影响类风湿关节炎患者对COVID-19 mRNA疫苗接种的免疫反应？

IF 1.3 4区医学

Journal of Infection in Developing Countries Pub Date : 2026-09-30 DOI: 10.3855/jidc.22383

Sanaa Gadbaan Hama

{"title":"Does the status of micronutrients affect immune response to COVID-19 mRNA vaccination in rheumatoid arthritis patients?","authors":"Sanaa Gadbaan Hama","doi":"10.3855/jidc.22383","DOIUrl":"10.3855/jidc.22383","url":null,"abstract":"Introduction: Rheumatoid arthritis (RA) is a chronic autoimmune disease that primarily affects the joints. It is recommended to start disease-modifying anti-rheumatic drugs (DMARDs) as soon as RA diagnosis is confirmed. The role of zinc, copper, magnesium, and ceruloplasmin on vaccine-induced immunoglobulin G (IgG) responses remains uncertain, particularly in the context of RA patients receiving ongoing immunosuppressive treatments. This study aimed to explore the association between baseline levels of these trace elements and IgG responses in RA patients following the second dose of the coronavirus disease 2019 (COVID-19) mRNA vaccine, within a 12-16-week interval. It also examined how DMARD treatments and trace element status relate to vaccine-induced immune responses, by comparing to a healthy control group.Methodology: An observational cross-sectional study was conducted including 79 RA patients and 47 healthy controls. Serum levels of zinc, copper, magnesium, ceruloplasmin, and IgG were measured.Results: Significant differences in zinc, copper, and magnesium levels were observed between vaccinated and unvaccinated individuals within both patient and control groups (p < 0.05). However, there were no significant associations between IgG positivity and trace element levels within any group (p > 0.05). Similarly, IgG positivity was not significantly associated with biological or non-biological treatment intake (p = 0.439).Conclusions: COVID-19 mRNA vaccines produced a broadly consistent humoral immune response across participants, regardless of zinc, copper, magnesium, and ceruloplasmin levels. There were no significant associations between trace element status, RA treatment, and long-term antibody durability; suggesting that humoral immunity may be maintained across different nutritional and therapeutic profiles.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"20 9","pages":"1281-1289"},"PeriodicalIF":1.3,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149168573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of probiotic Saccharomyces cerevisiae on Candida parapsilosis biofilm and antifungal efficacy in vitro and in a murine model in Türkiye. 益生菌酿酒酵母对假丝酵母菌副酵母菌生物膜的影响及体外和小鼠模型的抗真菌效果。

IF 1.3 4区医学

Journal of Infection in Developing Countries Pub Date : 2026-09-30 DOI: 10.3855/jidc.23048

Gamze Alçi, Sema Aşkın Keçeli, Devrim Dündar

{"title":"Effects of probiotic Saccharomyces cerevisiae on Candida parapsilosis biofilm and antifungal efficacy in vitro and in a murine model in Türkiye.","authors":"Gamze Alçi, Sema Aşkın Keçeli, Devrim Dündar","doi":"10.3855/jidc.23048","DOIUrl":"https://doi.org/10.3855/jidc.23048","url":null,"abstract":"Introduction: This study investigated the effects of the probiotic Saccharomyces cerevisiae on Candida parapsilosis biofilm formation and antifungal susceptibility in vitro and evaluated its potential to enhance antifungal efficacy in a murine candidiasis model.Methodology: C. parapsilosis ATCC 22019 and S. cerevisiae ATAFM-2021 were tested with fluconazole (FLU), caspofungin (CAS), and amphotericin B (AMB). Biofilm formation was quantified using the crystal violet assay under mono- and co-culture conditions with different inoculation timings. Antifungal susceptibility was assessed by microbroth dilution and checkerboard methods, and interactions were interpreted using the fractional inhibitory concentration index (FICi). In vivo candidiasis was induced in BALB/C mice. Antifungals were administered intraperitoneally for five days starting 24 hours after infection, while the probiotic was supplied in drinking water either 14 days before infection or 5 days after infection. Renal fungal burden was quantified as CFU/g.Results: In vitro, S. cerevisiae reduced biofilm formation by 11-28%, with the strongest inhibition observed when applied before fungal inoculation. Minimum inhibitory concentration values of biofilm-embedded cells decreased, particularly for CAS and AMB. Synergistic interactions were consistently observed with CAS and AMB and were condition-dependent with FLU. In vivo, CAS demonstrated the highest efficacy. Probiotic pre-treatment enhanced the therapeutic effect of AMB but showed limited impact on CAS and FLU.Conclusions: S. cerevisiae inhibited biofilm formation, reduced antifungal MIC values, and enhanced antifungal efficacy, particularly in combination with CAS and AMB. These findings support the potential role of probiotic adjunct strategies in the management of biofilm-associated candidiasis.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"20 9","pages":"1382-1392"},"PeriodicalIF":1.3,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149170855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic gaps in HCV RNA testing in the era of elimination: a single-center study. 消除时代HCV RNA检测的诊断差距：一项单中心研究

IF 1.3 4区医学

Journal of Infection in Developing Countries Pub Date : 2026-09-30 DOI: 10.3855/jidc.22370

Burcu Çalişkan Demirkiran, Neşe İnan, İrem Ataöv, Gülşen İskender, Duygu Mert, Semra Tunçbilek, Tuba Dal, Mustafa Ertek

{"title":"Diagnostic gaps in HCV RNA testing in the era of elimination: a single-center study.","authors":"Burcu Çalişkan Demirkiran, Neşe İnan, İrem Ataöv, Gülşen İskender, Duygu Mert, Semra Tunçbilek, Tuba Dal, Mustafa Ertek","doi":"10.3855/jidc.22370","DOIUrl":"https://doi.org/10.3855/jidc.22370","url":null,"abstract":"Introduction: It is essential to identify the current gaps in order to reach hepatitis C virus (HCV) elimination. This study focused on detecting undiagnosed HCV cases, to assess clinic awareness levels in the diagnostic process and explore strategies to decrease the number of undiagnosed cases.Methodology: Anti-HCV seropositive patients identified at the hospital between 1 January 2022, and 31 December 2023, were retrospectively reviewed. Anti-HCV seropositive patients who did not have an HCV ribonucleic acid (RNA) test done were invited to the hospital, and those who came underwent HCV RNA testing.Results: A total of 78,769 anti-HCV tests were conducted at the hospital, with 555 patients (0.7%) testing positive. HCV RNA testing was requested for 307 (55.3%) of the anti-HCV-positive patients during follow-up visits. The rate of HCV RNA test requests among anti-HCV-positive patients was significantly lower in surgical clinics compared to other clinics that requested HCV RNA testing (p < 0.001). Telephone calls were made to 248 patients who had not undergone HCV RNA testing, of whom 114 (46%) could not be reached. An anti-HCV signal-to-cutoff ratio (S/Co) ratio above 10.38 demonstrated 100% sensitivity and 89% specificity in predicting HCV RNA positivity (AUC: 0.95, p < 0.001).Conclusions: Raising awareness among surgical clinics about HCV diagnosis and developing reflex testing algorithms to enable diagnosis at the patient's first hospital visit will significantly support efforts to eliminate HCV.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"20 9","pages":"1376-1381"},"PeriodicalIF":1.3,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149167829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of biofilm activity, virulence genes, and antibiotic susceptibility profiles in clinical Proteus mirabilis isolates. 临床奇异变形杆菌分离株的生物膜活性、毒力基因和抗生素敏感性分析。

IF 1.3 4区医学

Journal of Infection in Developing Countries Pub Date : 2026-09-30 DOI: 10.3855/jidc.22641

İrem Unat, Tuğrul Hoşbul

{"title":"Evaluation of biofilm activity, virulence genes, and antibiotic susceptibility profiles in clinical Proteus mirabilis isolates.","authors":"İrem Unat, Tuğrul Hoşbul","doi":"10.3855/jidc.22641","DOIUrl":"https://doi.org/10.3855/jidc.22641","url":null,"abstract":"Introduction: Proteus mirabilis is a common opportunistic pathogen in wound and urinary tract infections (UTIs), whose clinical significance is driven by biofilm formation. This virulence-mediated process provides a shield against antimicrobials and host immunity, promoting difficult-to-treat infections. This study aimed to elucidate the relationship between biofilm-forming capacity, presence of virulence genes, and antibiotic resistance profiles in P. mirabilis isolates.Methodology: A total of 76 P. mirabilis isolates from urine and wound samples were analyzed. Isolates were identified using MALDI-TOF MS, antimicrobial susceptibility was tested via VITEK®2, biofilm formation was measured using the crystal violet method, and the presence of virulence genes (ureC, ireA, zapA, rsbA, flaA, atfA, ucaA, and hpmA) was analyzed by PCR.Results: Wound isolates showed significantly enhanced biofilm production and higher resistance rates to multiple antibiotics. Moderate-to-strong biofilm production was significantly associated with catheterization, the presence of the zapA, atfA, and ucaA genes, and increased resistance to ciprofloxacin and trimethoprim-sulfamethoxazole (TMP-SXT). The presence of the hpmA gene showed a borderline association with TMP-SXT resistance. The presence of the rsbA gene was significantly associated with a reduced likelihood of ertapenem resistance, suggesting a role in modulating porin-mediated antibiotic uptake.Conclusions: Biofilm-mediated resistance is a significant barrier to managing P. mirabilis infections, particularly in wounds and catheter-associated UTIs. The presence of specific genes in moderate-to-strong biofilm producers indicates their products are integral to the structural integrity and the functional capacity of the biofilm. The inverse relationship between rsbA and carbapenem resistance warrants further investigation as a biomarker for susceptibility.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"20 9","pages":"1351-1360"},"PeriodicalIF":1.3,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149167231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of carbapenem resistance genes in carbapenem-resistant Enterobacteriaceae isolates with GeneXpert® Carba-R panel. GeneXpert®碳青霉烯耐药肠杆菌科分离株碳青霉烯耐药基因的评价

IF 1.3 4区医学

Journal of Infection in Developing Countries Pub Date : 2026-09-30 DOI: 10.3855/jidc.22771

Canan Dizili Yelgin, Barış Gülhan, Halil Yazgı

{"title":"Evaluation of carbapenem resistance genes in carbapenem-resistant Enterobacteriaceae isolates with GeneXpert® Carba-R panel.","authors":"Canan Dizili Yelgin, Barış Gülhan, Halil Yazgı","doi":"10.3855/jidc.22771","DOIUrl":"https://doi.org/10.3855/jidc.22771","url":null,"abstract":"Introduction: Early detection of increases in carbapenem resistance among Enterobacteriaceae infections due to the widespread use of antibiotics is crucial. This study aimed to identify carbapenemase resistance genes in carbapenem-resistant Enterobacteriaceae isolates using the GeneXpert Carba-R Panel (Cepheid, Sunnyvale, USA).Methodology: A total of 120 carbapenem-resistant Enterobacteriaceae isolates collected between January and June 2022 at the Microbiology Laboratory of Erzincan Mengücek Gazi Training and Research Hospital were included. The samples were cultured, and then incubated at 37 °C for 24-48 hours. Species-level identification and carbapenem resistance were determined using the VITEK MS and VITEK 2 automated systems (bioMérieux, Marcy l'Étoile, France). Carbapenemase gene detection was performed using the GeneXpert Carba-R assay, and antibiotic susceptibility testing was conducted according to the European Committee on Antimicrobial Susceptibility Testing (EUCAST) guidelines (version 12.0, 2022) using the VITEK 2 system.Results: The most common carbapenemase genes detected were blaOXA-48 (65.0%), blaKPC (14.2%), blaNDM (4.2%), and blaVIM (1.7%). Additionally, combinations of resistance genes were observed in 3.3% (blaVIM + blaOXA-48 + blaKPC), 2.5% (blaOXA-48 + blaKPC), and 0.8% (blaVIM + blaKPC) of isolates. Klebsiella pneumoniae was the most frequently isolated species (116). All the isolates were resistant to ertapenem. The most effective antibiotics were colistin, imipenem, amikacin, and trimethoprim-sulfamethoxazole, in descending order of effectiveness.Conclusions: The findings provide essential insights into alternative treatment options and surveillance of resistance to carbapenem-resistant Enterobacteriaceae. The results may also serve as a reference for future comparative studies and aid in developing effective infection control strategies.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"20 9","pages":"1322-1330"},"PeriodicalIF":1.3,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149167680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A prospective observational study of cardiac involvement during dengue infection at a tertiary care hospital in Sri Lanka. 斯里兰卡一家三级保健医院登革热感染期间心脏受累的前瞻性观察研究。

IF 1.3 4区医学

Journal of Infection in Developing Countries Pub Date : 2026-09-30 DOI: 10.3855/jidc.22713

Lumal Soysa, Harindra Karunathilake, Nandana Dikmadugoda

{"title":"A prospective observational study of cardiac involvement during dengue infection at a tertiary care hospital in Sri Lanka.","authors":"Lumal Soysa, Harindra Karunathilake, Nandana Dikmadugoda","doi":"10.3855/jidc.22713","DOIUrl":"10.3855/jidc.22713","url":null,"abstract":"Introduction: Dengue virus infection causes high mortality and morbidity and imposes an economic burden in Sri Lanka. Currently, there is insufficient data on the prevalence and associated factors of cardiac involvement in dengue viral infection in Sri Lanka.Methodology: A total of 220 patients admitted with dengue viral infection to the National Hospital of Sri Lanka, between July and September 2025, participated in this study. Patients were evaluated for cardiac involvement based on highly sensitive Troponin I positivity and dynamic Electrocardiogram (ECG) changes. Cardiac involvement was stratified into subgroups: Troponin I positivity only, ECG changes only, and both.Results: Out of the 220 patients enrolled in the study, 126 (57.27%) were male, and 94 (42.73%) were female. The mean age was 35.02 (± 14.84 SD). Troponin I positivity only was seen in 11 (5.00%) patients, and ECG changes only were seen in 28 (12.73%) of patients. 8 (3.63%) had both changes. In total, 47 patients (21.36%) had ECG changes and/or Troponin I positivity. Patients with these changes had significantly higher AST (p = 0.0287), lower platelet counts (p = 0.003), a higher proportion of diabetes mellitus (p = 0.041), and hypertension (p = 0.0074).Conclusions: In this study, 21.36% of the population had evidence of cardiac involvement, as indicated by ECG changes or Troponin I positivity. Higher AST levels, lower platelet counts, dengue hemorrhagic fever and the presence of comorbidities such as diabetes mellitus and hypertension were recognized as possible associated factors of cardiac involvement by this study.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"20 9","pages":"1368-1375"},"PeriodicalIF":1.3,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149170962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnosis and treatment of four cases of pulmonary cryptococcosis: case report and literature review. 肺隐球菌病4例诊治报告并文献复习。

IF 1.3 4区医学

Journal of Infection in Developing Countries Pub Date : 2026-09-30 DOI: 10.3855/jidc.20737

Shan Song, Tai Guo, Tiebin You, Ping Wang

{"title":"Diagnosis and treatment of four cases of pulmonary cryptococcosis: case report and literature review.","authors":"Shan Song, Tai Guo, Tiebin You, Ping Wang","doi":"10.3855/jidc.20737","DOIUrl":"10.3855/jidc.20737","url":null,"abstract":"Introduction: Cryptococcosis has attracted global attention due to its high mortality rate, unique geographical distribution, and tendency to cause severe and rapid disease progression. Metagenomic next-generation sequencing (mNGS) is a novel detection technology that provides diagnostic insights for identifying pathogens, particularly rare ones. The present article describes 4 individuals diagnosed with pulmonary cryptococcosis (PC) using mNGS of bronchoalveolar lavage fluid (BALF).Case presentation: Among these patients, 3 had cancer, 1 had sarcoidosis and diabetes, and 2 were exposed to pigeons and/or pigeon droppings. These patients experienced symptoms, including fever, cough, and chest pain. They were diagnosed with PC after mNGS of BALF. The patient was diagnosed based on mNGS test results. Subsequently, the patient was treated with fluconazole, and the patient's chest computed tomography scan showed significant absorption of the lung lesions.Conclusions: mNGS of BALF can quickly diagnose PC. This diagnostic method has minimal trauma to the body and is worthy of clinical promotion. Fluconazole remains the preferred and best therapeutic drug for PC treatment.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"20 9","pages":"1408-1414"},"PeriodicalIF":1.3,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149168446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The greatest threat to mpox control is institutional amnesia. 对麻疹控制的最大威胁是制度性失忆。

IF 1.3 4区医学

Journal of Infection in Developing Countries Pub Date : 2026-08-31 DOI: 10.3855/jidc.23755

Henry Kyobe Bosa, Ritah Atugonza, Ingrid Ampeire, Brenda Nakafeero, Annet Kisakye, Wilber Sabiiti, Misaki Wayengera

引用次数: 0