Journal of Infection in Developing Countries最新文献_第10页

Ventriculoperitoneal shunt in the treatment of cryptococcal meningitis with intracranial hypertension. 脑室-腹膜分流术治疗隐球菌性脑膜炎伴颅内高压。

IF 1.4 4区医学

Journal of Infection in Developing Countries Pub Date : 2024-12-30 DOI: 10.3855/jidc.19341

Cheng'an Cao, Lun Luo, Tengchao Huang, Wenhan Zheng, Cong Ling, Ying Guo

{"title":"Ventriculoperitoneal shunt in the treatment of cryptococcal meningitis with intracranial hypertension.","authors":"Cheng'an Cao, Lun Luo, Tengchao Huang, Wenhan Zheng, Cong Ling, Ying Guo","doi":"10.3855/jidc.19341","DOIUrl":"https://doi.org/10.3855/jidc.19341","url":null,"abstract":"Introduction: Cryptococcal meningitis (CM) combined with intracranial hypertension is associated with a poor prognosis. This study aimed to investigate the therapeutic efficacy and prognostic factors of ventriculoperitoneal (VP) shunt in non-human immunodeficiency virus (HIV) CM patients with intracranial hypertension.Methodology: A total of 136 non-HIV CM patients with intracranial hypertension treated in our hospital from July 2010 to December 2019 were retrospectively included. 57 patients underwent VP shunt placement (shunt group) and 79 patients received conservative therapy (conservative group). The clinical symptoms after treatment, cerebrospinal fluid (CSF) test results, and therapeutic outcomes were compared between the groups.Results: VP shunt significantly reduced the incidences of headache, vomiting, cranial nerve injury, intracranial pressure, and CSF leukocyte level in CM patients (all p < 0.05). The shunt group had a significantly higher curative rate, shorter seroconversion time, hospitalization time, and disease duration (all p < 0.001). However, no significant difference in the survival outcome was observed between the groups (p = 0.163). Cox proportional-hazard regression analysis showed that seroconversion time was the only independent factor associated with the survival outcome.Conclusions: Our results suggested that the VP shunt is an effective and safe treatment for non-HIV CM patients combined with intracranial hypertension. Seroconversion time was the only independent factor associated with the survival outcome.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"18 12","pages":"1949-1956"},"PeriodicalIF":1.4,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143014791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ongoing post-COVID-19 symptoms and complaints among healthcare professionals. 医疗保健专业人员中持续的covid -19后症状和投诉。

IF 1.4 4区医学

Journal of Infection in Developing Countries Pub Date : 2024-12-30 DOI: 10.3855/jidc.19368

Muhammet Burak Ozkan, Aysun Ozsahin, Nilufer Emre, Tamer Edirne, Yeşim Kınacı Çimen

{"title":"Ongoing post-COVID-19 symptoms and complaints among healthcare professionals.","authors":"Muhammet Burak Ozkan, Aysun Ozsahin, Nilufer Emre, Tamer Edirne, Yeşim Kınacı Çimen","doi":"10.3855/jidc.19368","DOIUrl":"https://doi.org/10.3855/jidc.19368","url":null,"abstract":"Introduction: Post-COVID-19 syndrome refers to the occurrence of symptoms lasting more than 4 weeks in individuals who have recovered from COVID-19. This study aims to investigate the post-COVID-19 symptoms in healthcare professionals.Methodology: This descriptive study included 166 healthcare professionals who had tested positive for COVID-19 via PCR at least four weeks prior and subsequently presented to the Family Medicine Clinic at Pamukkale University Training and Research Hospital. Participants` demographic data, medical history, COVID-19 history and ongoing or newly emerged complaints and symptoms were evaluated, and physical examinations were carried out and recorded on a patient information form. Blood tests were conducted, and the results were analyzed.Results: The most common post-COVID-19 symptoms and complaints observed in our study were difficulty in performing daily activities (32.5%; n = 54), fatigue (26.5%; n = 44), forgetfulness (25.9%; n = 43) and weakness (24.1%; n = 40), respectively. Smoking, alcohol use, hospitalization, the need for oxygen support and having comorbidities such as asthma, diabetes, hypertension and rheumatism were found to be associated with various post-acute symptoms. Post-acute symptoms were most frequently observed in individuals vaccinated with Sinovac (38.5%), followed by those who were unvaccinated (35.7%). Least symptoms were seen in individuals vaccinated with only Biontech (15.4%).Conclusions: The most common post-COVID-19 symptoms observed in our study were difficulty in performing daily activities, fatigue, forgetfulness and weakness. Having comorbidities was found to be associated with various post-COVID-19 symptoms.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"18 12","pages":"1846-1854"},"PeriodicalIF":1.4,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143014751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The immune exhaustion paradox: activated functionality during chronic bacterial infections. 免疫衰竭悖论：慢性细菌感染期间激活的功能。

IF 1.4 4区医学

Journal of Infection in Developing Countries Pub Date : 2024-12-30 DOI: 10.3855/jidc.19754

María L Ruiz-de la Cruz, Mario César Salinas-Carmona

{"title":"The immune exhaustion paradox: activated functionality during chronic bacterial infections.","authors":"María L Ruiz-de la Cruz, Mario César Salinas-Carmona","doi":"10.3855/jidc.19754","DOIUrl":"https://doi.org/10.3855/jidc.19754","url":null,"abstract":"Co-inhibitory molecules, such as cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and programmed cell death protein 1 (PD-1), known as immune checkpoints, regulate the activity of T and myeloid cells during chronic viral infections and are well-established for their roles in cancer therapy. However, their involvement in chronic bacterial infections, particularly those caused by pathogens endemic to developing countries, such as Mycobacterium tuberculosis (Mtb), remains incompletely understood. Cytokine microenvironment determines the expression of co-inhibitory molecules in tuberculosis: Results indicate that the cytokine IL-12, in the presence of Mtb antigens, can enhance the expression of co-inhibitory molecules while preserving the effector and memory phenotypes of CD4+ T cells. Intersection of immune checkpoint inhibitors` role in cancer therapy and active tuberculosis: As discussed, co-inhibitory molecules` expression is crucial for effectively controlling inflammation during chronic bacterial infections. It has been suggested that monoclonal antibodies (mAbs) developed for cancer immunotherapy, known as immune checkpoint inhibitors (ICIs), may be associated with the reactivation of latent tuberculosis (LTB), though this occurrence has been rarely reported. Immune checkpoint molecules function as a \"brake\" to protect the host from the pathological effects of the immune response during chronic bacterial infections, which contrasts with the concept of exhaustion in the context of cancer. This means cells expressing co-inhibitory molecules on their surface can be paradoxically activated, as suggested in this review.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"18 12","pages":"1824-1836"},"PeriodicalIF":1.4,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143014755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An evaluation of clonal relationship by PFGE method in Acinetobacter baumannii isolates, examining integron presence and antibiotic resistance. 鲍曼不动杆菌分离株克隆关系的PFGE评价，检测整合子的存在和抗生素耐药性。

IF 1.4 4区医学

Journal of Infection in Developing Countries Pub Date : 2024-12-30 DOI: 10.3855/jidc.20021

Sedef Zeliha Öner, Hatice Er, Ahmet Çalışkan, Melek Demir, Hande Şenol, İlknur Kaleli

{"title":"An evaluation of clonal relationship by PFGE method in Acinetobacter baumannii isolates, examining integron presence and antibiotic resistance.","authors":"Sedef Zeliha Öner, Hatice Er, Ahmet Çalışkan, Melek Demir, Hande Şenol, İlknur Kaleli","doi":"10.3855/jidc.20021","DOIUrl":"https://doi.org/10.3855/jidc.20021","url":null,"abstract":"Introduction: This study aims to investigate the presence of class 1, 2, and 3 integrons in Acinetobacter baumannii isolates, evaluate the relationship between integrons and antibiotic resistance and determine the clonal relationship between isolates by PFGE method.Methodology: A total of 188 A. baumannii strains between February 2020 and March 2023 were included in the study. The antibiotic susceptibility was assessed per the recommendations of \"The European Committee on Antimicrobial Susceptibility Testing\". Integrons have been identified by polymerase chain reaction. The clonal relationship between isolates was evaluated with PFGE.Results: Integron carriage was observed in 45.7% of isolates. Of these, 44.1% carried class 0.5% carried class 2, and 2 (1.1%) carried both classes of integrons. Among the integron positive isolates, the rate of only class 1 integron was 96.5% (83/86), the rate of only class 2 was 1.2% (1/86), and the rate of only two integron classes together was 2.3% (2/86). In the presence of class 1 integrons, the MDR and XDR phenotypes were found to be high (p = 0.005, p = 0.029). PFGE method detected 26 clusters and 177 pulsotypes on the dendrogram. When the clusters are evaluated separately within themselves, in all of the isolates in the Y and Z clusters (100%), class 1 integron positivity was observed in cluster A at 52.2%, cluster J at 42.1%, and cluster N at 22.2%.Conclusions: Class 1 integron positivity observed in all of the isolates in the two clusters suggests the likelihood of clonal transfer alongside the horizontal transfer.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"18 12","pages":"1922-1929"},"PeriodicalIF":1.4,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143014774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bilateral facial nerve palsy in a patient with West Nile neuroinvasive disease. 西尼罗神经侵袭性疾病患者的双侧面神经麻痹。

IF 1.4 4区医学

Journal of Infection in Developing Countries Pub Date : 2024-12-30 DOI: 10.3855/jidc.19475

Nataša Nikolić, Ana Filipović, Nevena Todorović, Mirjana Jakšić Grgurović, Nikola Mitrović, Jovan Malinić, Ivana Milošević

{"title":"Bilateral facial nerve palsy in a patient with West Nile neuroinvasive disease.","authors":"Nataša Nikolić, Ana Filipović, Nevena Todorović, Mirjana Jakšić Grgurović, Nikola Mitrović, Jovan Malinić, Ivana Milošević","doi":"10.3855/jidc.19475","DOIUrl":"https://doi.org/10.3855/jidc.19475","url":null,"abstract":"Introduction: Bilateral facial nerve palsy (FNP) is a rare condition that is idiopathic in only 20%. FNP is the most common cranial neuropathy in West Nile neuroinvasive disease (WNND) but is usually unilateral and only a few cases of bilateral FNP have been reported.Case: We present a case of a 65-year-old woman with confirmed WNND and simultaneous bilateral FNP.Results: In August 2022, the patient presented with ataxia, gait instability, tremor, fever, and vomiting. Following admission, due to her cerebrospinal fluid analyses she was diagnosed with WNV encephalitis. Her initial symptoms subsided, but on the 17th day of the disease, right FNP was observed. Three days later bilateral FNP developed, predominantly on the right side, with bilateral otalgia. Further diagnostic was performed but no other aetiology that could contribute to FNP was found. The patient was treated with a 3-day metilprednisolone course, followed by 60 mg of prednisone with dose tapering for 12 days. One month later she was discharged with significant regression of the left and slight regression of the right FNP. Subsequent physical therapy was conducted. The patient's neurological status gradually improved and 4 months after the first symptoms onset, her neurological examination was normal.Conclusions: WNND should be included in the differential diagnosis of acquired bilateral FNP. It can result in full recovery, but unfavorable course is also possible.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"18 12","pages":"1957-1961"},"PeriodicalIF":1.4,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143014777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Detection of multidrug-resistant methicillin-resistant Staphylococcus aureus from healthy black Bengal goat in Bangladesh. 孟加拉健康黑孟加拉山羊中多重耐甲氧西林金黄色葡萄球菌的检测。

IF 1.4 4区医学

Journal of Infection in Developing Countries Pub Date : 2024-12-30 DOI: 10.3855/jidc.19701

Sarbani Biswas, Md Ariful Islam, Jahidul Islam, Mst Minara Khatun, Md Zaminur Rahman

{"title":"Detection of multidrug-resistant methicillin-resistant Staphylococcus aureus from healthy black Bengal goat in Bangladesh.","authors":"Sarbani Biswas, Md Ariful Islam, Jahidul Islam, Mst Minara Khatun, Md Zaminur Rahman","doi":"10.3855/jidc.19701","DOIUrl":"https://doi.org/10.3855/jidc.19701","url":null,"abstract":"Introduction: The emergence of livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) is a growing public health concern. The objective of this study was to determine the prevalence and multi-drug resistant (MDR) profiles of MRSA in goats in Bangladesh.Methodology: A total of 150 samples from goats comprised of rectal swab (n = 50), nasal swab (n = 50), and milk (n = 50) were collected. Isolation of S. aureus from samples was conducted onto mannitol salt agar (MSA). Identification of S. aureus was performed by cultural characteristics, Gram staining, biochemical tests (catalase, coagulase, indole, methyl red, and Voges-Proskaur), and nuc gene-specific PCR assay. The MRSA was identified by cefoxitin disc diffusion test and mecA gene-specific PCR assay. The MDR profiles of MRSA were performed against ampicillin, amoxicillin, gentamicin, cefoxitin, vancomycin, azithromycin, cefotaxime, ciprofloxacin and nalidixic acid by disc diffusion method.Results: The overall prevalence of S. aureus was 35.3% and MRSA was 7.3%. The prevalence of MRSA was 12% in rectal swabs, 8% in nasal swabs, and 2% in milk. The highest resistance of MRSA was against ampicillin (91%) followed by azithromycin (55%), amoxycillin (36%), nalidixic acid (27%), ciprofloxacin (18%) and cefotaxime (9%). Most MRSA isolates (90.9%) exhibited resistance to at least three classes of antibiotics and were MDR.Conclusions: This study shows that goats may harbor MDR-MRSA, posing a risk to public health.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"18 12","pages":"1891-1898"},"PeriodicalIF":1.4,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143014778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Detection of O25b-ST131 clone in extended spectrum beta-lactamase-producing E. coli from urinary tract infections in Mexico. 墨西哥尿路感染产β -内酰胺酶大肠杆菌O25b-ST131克隆的检测

IF 1.4 4区医学

Journal of Infection in Developing Countries Pub Date : 2024-12-30 DOI: 10.3855/jidc.18854

Josefina Duran-Bedolla, Juan Téllez-Sosa, Ana María González-Villoria, Humberto Barrios-Camacho

{"title":"Detection of O25b-ST131 clone in extended spectrum beta-lactamase-producing E. coli from urinary tract infections in Mexico.","authors":"Josefina Duran-Bedolla, Juan Téllez-Sosa, Ana María González-Villoria, Humberto Barrios-Camacho","doi":"10.3855/jidc.18854","DOIUrl":"https://doi.org/10.3855/jidc.18854","url":null,"abstract":"Introduction: Escherichia coli has emerged as an important pathogen in urinary tract infections (UTIs) due to the rapid acquisition of antibiotic resistance genes. This enhances the ability of E. coli to colonize and creates therapeutic challenges within the healthcare system. This study aimed to identify the extended spectrum beta-lactamase (ESBL) and O25b-ST131 pandemic clones in E. coli isolated from two hospitals in Mexico.Methodology: Bacterial identification and antibiotic susceptibility tests were conducted using the VITEK 2 system. The ESBL and plasmid-mediated quinolone resistance (PMQR) genes were identified by polymerase chain reaction (PCR). E. coli genotyping was carried out by the phylogenetic group analysis and O25b-ST131 identification.Results: A total of 103 unique E. coli clinical isolates were analyzed from a pool of 1,002 strains; 75% obtained from UTIs and vaginal secretions. Multi-resistant antibiotic profiles were observed. Notably, the presence of the aac(6`)lb-cr and qnr genes was associated with 100% ciprofloxacin resistance, when ESBL was present. Additionally, the B2 phylogenetic group was identified, with 23% of isolates belonging to the O25b-ST131 clone.Conclusions: Our research revealed a 10% prevalence of ESBL, in contrast to global prevalence rates. The resistance profiles suggest that the effectiveness of these commonly used antibiotics in treating E. coli-associated UTIs or vaginal infections has decreased significantly. Excessive use of antimicrobial agents contributes to the regional variation. Our results underscore the importance of monitoring the molecular epidemiology, antibiotic resistance, and transmission dynamics of the O25b-ST131 E. coli clone.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"18 12","pages":"1861-1866"},"PeriodicalIF":1.4,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143014779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of targeted care using a risk warning model on burn site infection. 使用风险预警模型的针对性护理对烧伤部位感染的影响。

IF 1.4 4区医学

Journal of Infection in Developing Countries Pub Date : 2024-12-30 DOI: 10.3855/jidc.20291

Chenchen Sun, Xiaowu Wang, Dong Wu

{"title":"Effects of targeted care using a risk warning model on burn site infection.","authors":"Chenchen Sun, Xiaowu Wang, Dong Wu","doi":"10.3855/jidc.20291","DOIUrl":"https://doi.org/10.3855/jidc.20291","url":null,"abstract":"Introduction: Prevention and control of wound infection in burn patients is critical. This study aimed to establish an infection risk warning model based on the clinical characteristics of burn patients, by formulating targeted care programs according to the risk warning factors, and analyzing the effects of these programs on wound infection in burn patients.Methodology: Data of 73 burn patients admitted to the hospital between 2020 and 2022 who underwent microbial culture examinations were analyzed. The patients were categorized into infected (50) and uninfected (23) groups. The infected group was further divided into nosocomial and out-of-hospital infections. The patients' clinical characteristics and their relationships with infection were analyzed. An infection risk warning model was established and targeted care programs were developed on the basis of these characteristics. In 2023, 50 patients were randomly assigned to routine care or targeted care groups, to assess the effects of targeted care on burn site infection with use of the risk warning model.Results: Age, hypovolemic shock, and white blood cell counts were independent risk factors for wound infection in hospitalized patients with burn injuries. A degree III wound depth, hospitalization of ≥ 30 days, and duration from burn to first hospitalization of 3-72 hours were independent risk factors for nosocomial infection. Patients receiving targeted nursing care showed high wound healing efficiency, low nosocomial infection rates, and high satisfaction with nursing.Conclusions: Use of an early warning model and implementing a targeted nursing program can effectively decrease infection risk in burn patients.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"18 12","pages":"1916-1921"},"PeriodicalIF":1.4,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143014780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Knowledge and attitude towards Herpes Simplex Virus-2 in Al-Jouf region, Saudi Arabia. 沙特阿拉伯Al-Jouf地区对单纯疱疹病毒2型的认识和态度

IF 1.4 4区医学

Journal of Infection in Developing Countries Pub Date : 2024-12-30 DOI: 10.3855/jidc.20030

Amany A Ghazy, Mohammed A Albalawi, Omar K Alzarea, Sultan D Alanazi, Abdullah H Alruwaili, Ahmad Y ALmandil, Abdullah M Alfuhigi, Areej K Alsharari, Youssef A Shatara

{"title":"Knowledge and attitude towards Herpes Simplex Virus-2 in Al-Jouf region, Saudi Arabia.","authors":"Amany A Ghazy, Mohammed A Albalawi, Omar K Alzarea, Sultan D Alanazi, Abdullah H Alruwaili, Ahmad Y ALmandil, Abdullah M Alfuhigi, Areej K Alsharari, Youssef A Shatara","doi":"10.3855/jidc.20030","DOIUrl":"https://doi.org/10.3855/jidc.20030","url":null,"abstract":"Introduction: Herpes simplex virus type-2 (HSV-2) infection is a sexually transmitted disease (STD) that causes genital ulcers. The prevalence of HSV-2 increases because of its asymptomatic shedding. This study aimed to evaluate community knowledge and attitude toward HSV-2 infection in Al-Jouf region.Methodology: 410 participants were enrolled in the study and they filled out a questionnaire on HSV-2 and its complications.Results: Of the 410 participants, 106 individuals were excluded from the study because they resided outside Al-Jouf. Of the remaining 304 participants, 56% were females, 44% were aged between 21-30 years, 84% were university graduates, 56% were single, and 40% were married. Only 58% of participants knew that HSV-2 is an STD, and less than 50% knew that HSV-2 infection can occur many times and can be transmitted from asymptomatic individuals. Regarding their attitude, only 32.5% participants agreed to use a condom if they had sores, 27% agreed to use the condom if they had more than one wife, and more than half of participants responded that they did not know.Conclusions: A considerable proportion of the youth (21-30 years old) did not know that HSV-2 infection is an STD that can occur many times, may remain asymptomatic, and is transmitted from asymptomatic partners or from the mother to her fetus. They were also not aware how to protect themselves from this infectious disease. Thus, educational and health awareness campaigns are required to raise the level of knowledge on HSV-2 infection, including its prevention, and control.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"18 12","pages":"1937-1941"},"PeriodicalIF":1.4,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143014749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy and safety of cefiderocol in the treatment of infections caused by Gram-negative bacteria: a systematic review and meta-analysis. 头孢地罗治疗革兰氏阴性菌感染的有效性和安全性：系统综述和荟萃分析。

IF 1.4 4区医学

Journal of Infection in Developing Countries Pub Date : 2024-12-30 DOI: 10.3855/jidc.19875

Xiaocui Huang, Lin Su, Wenjie Zhou, Yiduo Zhang, Fan Yu, Chao Li

{"title":"Efficacy and safety of cefiderocol in the treatment of infections caused by Gram-negative bacteria: a systematic review and meta-analysis.","authors":"Xiaocui Huang, Lin Su, Wenjie Zhou, Yiduo Zhang, Fan Yu, Chao Li","doi":"10.3855/jidc.19875","DOIUrl":"https://doi.org/10.3855/jidc.19875","url":null,"abstract":"Objective: To assess the efficacy and safety of cefiderocol (CFDC) in the treatment of Gram-negative bacteria (GNB) infections.Methods: Relevant studies were collected from PubMed, Web of Science, Cochrane, and Embase databases, from inception to 15 October 2023. The search formula was as follow: \"cefiderocol\", \"S-649266\", \"Gram-Negative Bacteria\", \"Gram Negative Bacteria\", \"Klebsiella pneumoniae\", \"Hyalococcus pneumoniae\", and \"Bacterium pneumoniae proposal\". Stata 15.0 software was employed to pool data with risk ratios (RRs) and 95% confidence intervals (CIs). Data were pooled using a random- or a fixed-effects model.Results: After a comprehensive study selection, 11 studies (5 RCTs and 7 observational studies) were retrieved that compared the efficacy of CFDC with other regimens, e.g., imipenem/cilastatin. The clinical response (RR = 1.00, 95% CI 0.94-1.08, I2 = 0%) and microbiological response (RR = 0.95 95% CI = 0.80-1.14, I2 = 68.7%) of CFDC were comparable to the control group. No significant differences were observed in mortality and adverse events. Furthermore, subgroup analyses showed that CFDC enhanced microbiological eradication in the follow-up group (RR = 1.25, 95% CI 1.05-1.49) and patients with complicated urinary tract infections (cUTI) (RR = 1.32, 95% CI 1.11- 1.57).Conclusions: CFDC is a novel iron-carrying cephalosporin with the potential to effectively combat Gram-negative bacterial infections. Additional large and high-quality RCTs are required to further confirm the safety of CFDC.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"18 12","pages":"1815-1823"},"PeriodicalIF":1.4,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143014781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0