Journal of Infection in Developing Countries最新文献_第10页

Colopleurocutaneous fistula associated with empyema as a late complication of colorectal cancer. 结肠胸膜皮瘘与脓胸相关，是结直肠癌的晚期并发症。

IF 1.4 4区医学

Journal of Infection in Developing Countries Pub Date : 2025-05-31 DOI: 10.3855/jidc.19318

Milan Savic, Zeljko Garabinovic, Nikola Colic, Marko Kostic, Miljan Ceranic, Jovan Peric, Mihailo Stjepanovic

{"title":"Colopleurocutaneous fistula associated with empyema as a late complication of colorectal cancer.","authors":"Milan Savic, Zeljko Garabinovic, Nikola Colic, Marko Kostic, Miljan Ceranic, Jovan Peric, Mihailo Stjepanovic","doi":"10.3855/jidc.19318","DOIUrl":"10.3855/jidc.19318","url":null,"abstract":"Introduction: Pleurocutaneous fistula is a pathological communication of subcutaneous tissue with the pleural cavity, and can occur as a result of infectious, malignant processes and iatrogenic procedures. Colopleural fistula is rare and is mainly caused by processes in the abdomen. The appearance of empyema is usually described as a complication of colopleural fistulas that are the result of pathological processes in the abdomen.Case presentation: We report an extremely rare case of colopleurocutaneous fistula with pleural empyema present, 8 years after left hemicolectomy due to colon adenocarcinoma. Radiological diagnostic procedures performed confirmed the existence of colopleurocutaneous fistula. The patient was given antibiogram therapy and regular thoracocentesis for empyema, as well as a fistulous canal toilet.Conclusions: After achieving sterility of the fistulous canal and regression of empyema, the fistulous canal was closed with fibrin glue, and during the next 6 months follow-up, there was no reopening of the fistula, nor did the patient have any other complications.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 5","pages":"800-803"},"PeriodicalIF":1.4,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Observational study on Aspergillus infections in critically ill patients with coronavirus disease 2019 at a single medical center using sputum samples. 2019冠状病毒病危重患者痰液中曲霉感染的观察性研究

IF 1.4 4区医学

Journal of Infection in Developing Countries Pub Date : 2025-05-31 DOI: 10.3855/jidc.20072

Rui-Ming Xu, Xiao-Li Yuan, Qing-Qing Ge, Yan-Yun He, Qiu-Mei Cao

{"title":"Observational study on Aspergillus infections in critically ill patients with coronavirus disease 2019 at a single medical center using sputum samples.","authors":"Rui-Ming Xu, Xiao-Li Yuan, Qing-Qing Ge, Yan-Yun He, Qiu-Mei Cao","doi":"10.3855/jidc.20072","DOIUrl":"10.3855/jidc.20072","url":null,"abstract":"Objective: To explore Aspergillus infection's risks, treatment, and prognostic factors in critically ill COVID-19 patients.Methodology: Retrospective analysis of 50 critically ill COVID-19 patients' data. Patients were divided into Aspergillus infection group (10 cases) and non-Aspergillus infection group (40 cases) to examine risk factors and compare hospitalization length, expenses, and survival outcomes.Results: Logistic regression showed a significant correlation between Aspergillus infection and diabetes history, and steroid use duration in COVID-19 patients. Diabetes increased Aspergillus infection risk 9.708 times (not statistically significant). Each extra steroid use day raised infection risk by 25.6%. The Aspergillus infection group had longer hospital stays, and higher costs (p < 0.05) but surprisingly higher survival rate than the non-infection group (p < 0.05).Conclusions: The main risk factor for Aspergillus infection in critically ill COVID-19 patients is steroid use duration. The infection group had longer hospital stays and higher costs, and Aspergillus infection affected the survival duration of critically ill COVID-19 patients.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 5","pages":"677-682"},"PeriodicalIF":1.4,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

QuantiFERON-TB Gold Plus for screening and monitoring latent tuberculosis infection in spondyloarthritis patients. QuantiFERON-TB Gold Plus用于筛查和监测脊柱关节炎患者的潜伏结核感染。

IF 1.4 4区医学

Journal of Infection in Developing Countries Pub Date : 2025-05-31 DOI: 10.3855/jidc.21027

Zehra Ozsoy, Adem Ozdemir, Mustafa Ekici, Emre Bilgin, Asena Eken, Zeynep Saribas, Ahmet C Inkaya, Deniz Koksal, Burcin Sener, Ihsan Ertenli, Omer Karadag, Levent Kilic

{"title":"QuantiFERON-TB Gold Plus for screening and monitoring latent tuberculosis infection in spondyloarthritis patients.","authors":"Zehra Ozsoy, Adem Ozdemir, Mustafa Ekici, Emre Bilgin, Asena Eken, Zeynep Saribas, Ahmet C Inkaya, Deniz Koksal, Burcin Sener, Ihsan Ertenli, Omer Karadag, Levent Kilic","doi":"10.3855/jidc.21027","DOIUrl":"https://doi.org/10.3855/jidc.21027","url":null,"abstract":"Introduction: The optimal frequency of rescreening for latent tuberculosis infection (LTBI) in patients with inflammatory arthritis on biologic/targeted-synthetic disease modifying anti-rheumatic drugs (b/ts-DMARDs) is uncertain. We aimed to evaluate the impact of LTBI re-screening using the QuantiFERON-TB Gold Plus (QFT-Plus; QIAGEN, Germantown, USA) test method and to assess the frequency of re-screening in real-life spondyloarthritis (SpA) patients on b/ts-DMARDs.Methodology: This study focused on patients with SpA who were scheduled for b/ts-DMARDs therapy and underwent QFT-Plus testing to screen for LTBI. The study analyzed whether QFT-Plus test negative patients underwent sequential QFT-Plus tests during follow-up and the timing of these tests. Cases of tuberculosis (TB) reactivation were documented, and the clinical status of affected patients were recorded.Results: Of the 801 patients included in the study, the QFT-Plus tests were negative in 701 (87.5%), positive in 89 (11.1%), and indeterminate in 11 (1.3%) patients. The median follow-up of patients with initial QFT-Plus test negative was 33.6 months (min-max: 3-76.3). Follow-up tests were carried out on only 59 (8.4%) of these 701 patients. Of the rescreened 59 patients, 56 had negative results, 3 had positive results. TB was developed in only 2 (0.25%) of the 801 patients during follow-up.Conclusions: Assessment of LTBI in patients with SpA using interferon-gamma release assays (IGRAs) test is rational. Performance of annual testing of IGRAs in patients who were QFT negative was low in our SpA cohort. National and international guidelines may need to be updated to reflect real-world data and clinical practice.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 5","pages":"739-746"},"PeriodicalIF":1.4,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multidrug resistance efflux pump expression in uropathogenic Gram-negative bacteria in organ transplant recipients. 器官移植受者尿路致病性革兰氏阴性菌多药耐药外排泵表达。

IF 1.4 4区医学

Journal of Infection in Developing Countries Pub Date : 2025-05-31 DOI: 10.3855/jidc.20171

Aminah Alghamdi, Taghreed Hafiz, Reem Almaghrabi, Ahmed Al-Qahtani, Ehab Hammad, Dalia Obeid, Alwaleed Alaidan, Fatimah Alhamlan

{"title":"Multidrug resistance efflux pump expression in uropathogenic Gram-negative bacteria in organ transplant recipients.","authors":"Aminah Alghamdi, Taghreed Hafiz, Reem Almaghrabi, Ahmed Al-Qahtani, Ehab Hammad, Dalia Obeid, Alwaleed Alaidan, Fatimah Alhamlan","doi":"10.3855/jidc.20171","DOIUrl":"https://doi.org/10.3855/jidc.20171","url":null,"abstract":"Urinary tract infections (UTIs) are common in healthcare settings and communities; and are predominantly caused by Gram-negative bacteria, which account for > 70% of UTI cases. Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa are the most common bacterial agents responsible for UTIs. The emergence of antibiotic resistance poses a challenge for UTI treatment; and efflux pump overexpression contributes to Gram-negative bacterial resistance. This comprehensive review summarizes the current understanding of multidrug resistance (MDR) efflux pump expression in prevalent Gram-negative bacteria that demonstrate resistance to antibiotics predominantly used for UTI treatment. This review examines the available data, and offers insights into the role of efflux pumps in conferring MDR to UTI-causing bacteria. Understanding these resistance mechanisms is crucial for developing effective strategies to combat antibiotic resistance in UTI management. Furthermore, this review emphasizes the need to characterize efflux pump-mediated antimicrobial resistance in solid organ transplantation cases. Solid organ transplant recipients are particularly vulnerable to UTIs caused by MDR bacteria, posing a serious threat to their health and recovery. Identifying the efflux pump profiles of these bacterial strains can guide appropriate antibiotic choices and optimize treatment outcomes in transplant recipients. By consolidating existing knowledge on efflux pump expression in antibiotic-resistant Gram-negative bacteria associated with UTIs, this review acknowledges gaps and identifies the future scope of research that should address the growing challenge of MDR UTIs, particularly in high-risk populations such as solid organ transplant recipients.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 5","pages":"641-648"},"PeriodicalIF":1.4,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk factors for HCV infection in Georgia: A case-control study. 格鲁吉亚HCV感染的危险因素：一项病例对照研究

IF 1.4 4区医学

Journal of Infection in Developing Countries Pub Date : 2025-05-31 DOI: 10.3855/jidc.20658

Maia Butsashvili, Giorgi Kanchelashvili, Ketevan Galdavadze, Maia Tsereteli, Davit Baliashvili, Senad Handanagic, Paige A Armstrong, Shaun Shadaker, George Kamkamidze

{"title":"Risk factors for HCV infection in Georgia: A case-control study.","authors":"Maia Butsashvili, Giorgi Kanchelashvili, Ketevan Galdavadze, Maia Tsereteli, Davit Baliashvili, Senad Handanagic, Paige A Armstrong, Shaun Shadaker, George Kamkamidze","doi":"10.3855/jidc.20658","DOIUrl":"10.3855/jidc.20658","url":null,"abstract":"Introduction: Hepatitis C virus (HCV) infection is a leading cause of chronic liver disease, including cirrhosis and liver cancer. Prior studies in Georgia identified risk factors such as injection drug use (IDU), tattoos, dental cleanings, medical injections, and blood transfusion. This study explored risk factors associated with HCV seroconversion in Georgia.Methodology: A case-control study was conducted among adults aged ≥ 18 years. A total of 299 Cases (persons who seroconverted after ≥ 2 screenings) and 436 controls (persons with ≥ 2 negative anti-HCV test results dated 90 to 364 days apart) were randomly selected from the national HCV screening database from January 2019 to November 2020. Data were collected through telephone interviews and analyzed using descriptive statistics and logistic regression.Results: Among 206/299 (68.9%) cases and 229/436 (52.5%) controls who agreed to participate, 53.8% were female and 60.5% were aged > 40 years. After adjusting for covariates, independent predictors of HCV seroconversion were age > 40 years (adjusted odds ratio [aOR] = 2.47, 95% confidence interval [CI]: 1.52-4.01), male sex (aOR = 2.12, 95% CI: 1.34-3.34), IDU (aOR = 26.24, 95% CI: 3.27-210.43), history of invasive medical procedure (aOR = 3.19, 95% CI: 1.96-5.19), ≥ 24 hours of hospitalization (aOR = 2.01, 95% CI: 1.12-3.59), and occupational performance of any invasive medical procedure (aOR = 2.70, 95% CI: 1.12-6.53).Conclusions: Our findings suggest that HCV seroconversions in Georgia are associated with IDU, hospitalization, and invasive medical procedures. These identified risk factors provide opportunities to further improve the prevention of HCV infection in Georgia.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 5","pages":"792-796"},"PeriodicalIF":1.4,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12146773/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A fatal post-COVID-19 sino-orbital mucormycosis in an adult patient with diabetes mellitus: a case report and review of the literature. 成人糖尿病患者covid -19后致死性眶内毛霉菌病1例报告及文献复习

IF 1.4 4区医学

Journal of Infection in Developing Countries Pub Date : 2025-05-31 DOI: 10.3855/jidc.16526

Yousef Moghdam, Bahareh Arghavan, Firoozeh Kermani, Seyed Ali Jeddi, Shaghayegh Khojasteh, Tahereh Shokohi, Narges Aslani, Abolghasem Ebrahimi, Javad Javidnia

{"title":"A fatal post-COVID-19 sino-orbital mucormycosis in an adult patient with diabetes mellitus: a case report and review of the literature.","authors":"Yousef Moghdam, Bahareh Arghavan, Firoozeh Kermani, Seyed Ali Jeddi, Shaghayegh Khojasteh, Tahereh Shokohi, Narges Aslani, Abolghasem Ebrahimi, Javad Javidnia","doi":"10.3855/jidc.16526","DOIUrl":"10.3855/jidc.16526","url":null,"abstract":"Introduction: COVID-19 is associated with a broad spectrum of bacterial and fungal superinfections.Case presentation: We present a case of mucormycosis developing during post-COVID-19 therapeutic management. A 63-year-old diabetic female presented with COVID-19 and received combination therapy per institutional protocol, including dexamethasone, remdesivir, and ivermectin. Seven days post-discharge, the patient was readmitted with dyspnea and lethargy. On day 3 of readmission, the patient reported unilateral facial and orbital pain. Subsequent histopathological and mycological examination confirmed mucormycosis. Despite surgical debridement and treatment with amphotericin B (3 mg/kg/day), the patient succumbed to the infection.Results: Based on ITS rDNA sequencing, the fungus was identified as Rhizopus arrhizus. Antifungal susceptibility testing was performed according to the CLSI M38-A2 guideline, yielding minimum inhibitory concentration (MIC) values of 0.016 µg/mL for amphotericin B, 0.031 µg/mL for posaconazole, 0.25 µg/mL for isavuconazole, 1 µg/mL for itraconazole, and 8 µg/mL for voriconazole.Conclusions: Early diagnosis, prompt antifungal therapy, and appropriate surgical intervention are critical for improving mucormycosis outcomes, especially in COVID-19 patients.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 5","pages":"661-668"},"PeriodicalIF":1.4,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In-vitro antimicrobial susceptibility results of Brucella species; Single center study from Eastern Türkiye. 布鲁氏菌的体外药敏结果东部<s:1> rkiye的单中心研究。

IF 1.4 4区医学

Journal of Infection in Developing Countries Pub Date : 2025-05-31 DOI: 10.3855/jidc.20643

Merve Kılıç Tekin, Enes Erbağcı, Neşe İnal

{"title":"In-vitro antimicrobial susceptibility results of Brucella species; Single center study from Eastern Türkiye.","authors":"Merve Kılıç Tekin, Enes Erbağcı, Neşe İnal","doi":"10.3855/jidc.20643","DOIUrl":"https://doi.org/10.3855/jidc.20643","url":null,"abstract":"Introduction: Brucellosis is the most common zoonotic infection worldwide. The disease imposes significant economic burdens and public health challenges. Due to documented instances of treatment failures, relapses, and resistance, regular monitoring of antimicrobial susceptibility is essential. This study aimed to evaluate the sensitivity of Brucella spp. against antimicrobial agents.Methodology: The study was conducted at a tertiary state hospital from January 2023 to June 2024. Species level identification was performed using the VITEK-2 Compact system and 16S rRNA analysis. Isolated strains were cultured on Mueller-Hinton agar supplemented with 5% horse blood and β-Nicotinamide adenine dinucleotide (β-NAD), followed by testing with antibiotic discs. Antimicrobial susceptibility tests were performed according to the EUCAST 2024 version 14 recommendations. Zone diameters were categorized as susceptible, standard dosing regimen; susceptible, increased exposure and resistant.Results: 45 Brucella species isolated from blood culture were included in this study. Species level determination showed Brucella melitensis in 36 (80%) and Brucella abortus in 9 (20%) patients by 16S rRNA analysis. Antimicrobial susceptibilities were as follows: gentamicin, rifampicin, ceftriaxone, tetracycline, trimethoprim-sulfamethoxazole, and streptomycin all showed 100% susceptibility. Conversely, levofloxacin had a susceptibility rate of 15.5%, and ciprofloxacin had a rate of 4.4%. No resistance was detected for levofloxacin or ciprofloxacin, and there were no significant differences in susceptibility between Brucella melitensis and Brucella abortus.Conclusions: The study highlights increased exposure patterns for ciprofloxacin and levofloxacin, indicating potential future resistance issues. Regular monitoring of antimicrobial resistance in Brucella isolates is crucial for effective disease management and updating treatment guidelines.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 5","pages":"732-738"},"PeriodicalIF":1.4,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bronchoscopy procedures in diagnostics and treatment of endobronchial tuberculosis. 支气管镜检查在支气管内结核诊断和治疗中的应用。

IF 1.4 4区医学

Journal of Infection in Developing Countries Pub Date : 2025-05-31 DOI: 10.3855/jidc.20444

Spasoje Popevic, Nikola Maric, Slobodan Belic, Marija Karapandzic, Sanja Dimic Janjic, Branislav Ilic, Nikola Trboljevac, Drasko Dubljanin, Mihailo Stjepanovic

{"title":"Bronchoscopy procedures in diagnostics and treatment of endobronchial tuberculosis.","authors":"Spasoje Popevic, Nikola Maric, Slobodan Belic, Marija Karapandzic, Sanja Dimic Janjic, Branislav Ilic, Nikola Trboljevac, Drasko Dubljanin, Mihailo Stjepanovic","doi":"10.3855/jidc.20444","DOIUrl":"https://doi.org/10.3855/jidc.20444","url":null,"abstract":"Endobronchial tuberculosis is a rare form of tuberculosis that is characterized by the presence of tuberculous granuloma within the respiratory tract, usually in the trachea or main bronchi. Multiple key notes regarding this form make it difficult to detect and treat, which can lead to prolonged, lifelong even, problems that lead to a significant loss in quality of life. Even if the conventional treatment for tuberculosis is started on time, endobronchial tuberculosis can still develop. In those cases, a bronchoscopy should be performed to objectify the type of endobronchial tuberculosis and treat it in order to prevent permanent airway stenosis. In this paper, we will note the main characteristics of endobronchial tuberculosis, as well as bronchoscopy procedures used for its treatment such as balloon dilatation, laser, argon plasma coagulation, cryotherapy, and implementation of the stent. The main goal is to raise awareness of endobronchial tuberculosis to reduce the risk of complications of its mistreatment.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 5","pages":"636-640"},"PeriodicalIF":1.4,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Utility of neutrophil to lymphocyte ratio in the prediction of inflammation and COPD mortality. 中性粒细胞与淋巴细胞比值在预测炎症和慢性阻塞性肺病死亡率中的应用。

IF 1.4 4区医学

Journal of Infection in Developing Countries Pub Date : 2025-05-31 DOI: 10.3855/jidc.20466

Sanja Dimic-Janjic, Andrej Zecevic, Aleksa Golubovic, Ana Ratkovic, Ivan Milivojevic, Anka Postic, Mihailo Stjepanovic, Jelena Jankovic, Nikola Trboljevac, Aleksandra Barac, Spasoje Popevic, Ana Samardzic, Lidija Isovic, Branislava Milenkovic

{"title":"Utility of neutrophil to lymphocyte ratio in the prediction of inflammation and COPD mortality.","authors":"Sanja Dimic-Janjic, Andrej Zecevic, Aleksa Golubovic, Ana Ratkovic, Ivan Milivojevic, Anka Postic, Mihailo Stjepanovic, Jelena Jankovic, Nikola Trboljevac, Aleksandra Barac, Spasoje Popevic, Ana Samardzic, Lidija Isovic, Branislava Milenkovic","doi":"10.3855/jidc.20466","DOIUrl":"https://doi.org/10.3855/jidc.20466","url":null,"abstract":"Introduction: The Neutrophil-to-Lymphocyte Ratio (NLR) has been utilized to predict clinical outcomes in cardiovascular diseases, infectious diseases, and solid tumors and it has a potential association with the severity of Chronic Obstructive Pulmonary Disease (COPD). This study aimed to determine whether NLR is a possible predictor of inflammation severity and mortality in COPD.Methodology: A prospective analysis of NLR in 70 COPD patients, and its relation with biochemical, lung function parameters, and mortality was assessed.Results: NLR was negatively associated with oxygen saturation (p < 0.05) and positively related to C-reactive protein (CRP) (p < 0.05), matrix metalloproteinase-9 (MMP-9) (p ≤ 0.001), tissue inhibitor of metalloproteinase-1 (TIMP-1) (p < 0.05), MMP-9/TIMP-1 ratio (p < 0.05), and the modified Medical Research Council dyspnea scale (mMRC) score (p < 0.05). Deceased patients had significantly higher NLR (p < 0.05). Older age and lower levels of saturation were independently associated with higher mortality in COPD patients (p < 0.05).Conclusions: NLR in COPD correlates with inflammation and protease/antiprotease balance, with elevated NLR detected in deceased patients. These findings suggest that NLR can be a helpful clinical marker in COPD.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 5","pages":"776-781"},"PeriodicalIF":1.4,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phenotypic and molecular analysis of Pseudomonas aeruginosa virulence and association with antibiotic resistance in Egypt. 埃及铜绿假单胞菌毒力的表型和分子分析及其与抗生素耐药性的关系。

IF 1.4 4区医学

Journal of Infection in Developing Countries Pub Date : 2025-05-31 DOI: 10.3855/jidc.20957

Salah Ai Ali, Aya A Ghamry, Amal M Soliman, Abdullah M Abdo, Nagwan G El-Menofy, Manal M Al-Gerby, Haytham K Mahrous

{"title":"Phenotypic and molecular analysis of Pseudomonas aeruginosa virulence and association with antibiotic resistance in Egypt.","authors":"Salah Ai Ali, Aya A Ghamry, Amal M Soliman, Abdullah M Abdo, Nagwan G El-Menofy, Manal M Al-Gerby, Haytham K Mahrous","doi":"10.3855/jidc.20957","DOIUrl":"https://doi.org/10.3855/jidc.20957","url":null,"abstract":"Introduction: Pseudomonas aeruginosa is a common nosocomial pathogen with multidrug resistance (MDR) and virulence factors (VFs). This study assessed the VFs and their associations with MDR and non-MDR isolates.Methodology: One hundred clinical isolates were analyzed for 12 VFs, encoding genes, and phenotypic traits. Antibiotic resistance patterns and correlations between VFs and MDR were investigated.Results: Aztreonam showed the highest resistance rate among MDR (94.7%) and ceftazidime showed the highest resistance rate among non-MDR isolates (44.2%). Carbapenems demonstrated the greatest susceptibility. VF positivity rates included 91% for algD, 90% for lasB, 86% for toxA, 82% for exoS, 19% for exoU, 78% for aprA, 75% for plcH, 94% for pigment production, 93% for biofilm formation, 72% for hemolysin, 65% for lipase, and 36% for DNase. Strong biofilm formation correlated with algD and lasB (93%). Pigment production was linked with lasB and toxA (94%). Strong biofilm formation was significantly higher in MDR isolates and resistant strains, than non-MDR isolates. No significant differences in VFs were observed between susceptible and resistant strains for lasB, algD, toxA, plcH, exoU, or general biofilm production; except for strong biofilm formation. Certain VFs correlated with susceptible isolates: exoS with tobramycin, aprA with aztreonam and piperacillin-tazobactam, pigment production with imipenem, DNase with aztreonam and norfloxacin, and lipase with tobramycin and ceftazidime.Conclusions: P. aeruginosa isolates displayed diverse VFs, biofilm-forming abilities, and MDR profiles; with strong biofilm formation closely linked to MDR. Targeting biofilm-related genes (algD, lasB) could offer effective therapeutic interventions, helping mitigate MDR infections and improve clinical outcomes.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 5","pages":"712-722"},"PeriodicalIF":1.4,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0