Journal of Infection in Developing Countries最新文献_第9页

Molecular detection of Rickettsia felis in ticks and fleas from the environment in Hanoi and Phu Tho province, Vietnam. 越南河内市和富寿省环境中蜱和跳蚤立克次体分子检测。

IF 1.2 4区医学

Journal of Infection in Developing Countries Pub Date : 2026-05-31 DOI: 10.3855/jidc.21970

Huyen Ma Thi, Tuyen Tong Thi Kim, Hoa Tran Mai, Huong Dang Thi, Tien Vuong Quang, Mai Dao Thi Tuyet, Bach Dao Gia, Christina M Farris, Allen L Richards, Trung Nguyen Vu, Hoi Le Thi

{"title":"Molecular detection of Rickettsia felis in ticks and fleas from the environment in Hanoi and Phu Tho province, Vietnam.","authors":"Huyen Ma Thi, Tuyen Tong Thi Kim, Hoa Tran Mai, Huong Dang Thi, Tien Vuong Quang, Mai Dao Thi Tuyet, Bach Dao Gia, Christina M Farris, Allen L Richards, Trung Nguyen Vu, Hoi Le Thi","doi":"10.3855/jidc.21970","DOIUrl":"10.3855/jidc.21970","url":null,"abstract":"Introduction: Surveillance for Rickettsia spp. is necessary given the recent emergence and re-emergence of various rickettsioses in Vietnam. However, data on their circulation in off-host arthropods from natural environments remain limited. This study aimed to investigate the presence and distribution of Rickettsia species in ticks and fleas collected from the environment in Hanoi and Phu Tho provinces, northern Vietnam, between September and December 2021.Methodology: The ticks and fleas were collected using dragging, light traps, and carbon dioxide traps. Arthropods were identified morphologically and screened for Rickettsia species using real-time PCR targeting the 17kDa antigen gene. Positive samples were further analyzed using species-specific real-time PCR assays and multilocus sequence typing (MLST) for confirmation and phylogenetic analysis.Results: A total of 758 arthropods were collected, including 748 ticks (747 larval ticks grouped into 101 pools and 1 adult tick) and 10 fleas. The minimum field infection rate (MFIR) of Rickettsia spp. in ticks was 2.94% (22/748), while the prevalence in fleas was 50% (5/10). Rickettsia felis was detected in 9 larval tick pools and 2 individual fleas by species-specific real-time PCR and MLST. No other Rickettsia species were identified.Conclusions: This study provides the first evidence of Rickettsia spp. in off-host ticks and fleas from the natural environment in Vietnam. These findings indicate a potential risk of environmental exposure to Rickettsia and emphasize the need for integrated vector surveillance strategies.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"20 5","pages":"729-736"},"PeriodicalIF":1.2,"publicationDate":"2026-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148213074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 1.3 4区医学

Journal of Infection in Developing Countries Pub Date : 2026-05-31 DOI: 10.3855/jidc.21850

Raja A Aftab, Vincent Mal Mariadass, Syireen B Alwi, Baharudin B Ibrahim, Lim S Kun, Lam J Kai, Zirwa A Butt

{"title":"Catheter-related bloodstream infections in hemodialysis: a systematic review and meta-analysis of prevalence and risk.","authors":"Raja A Aftab, Vincent Mal Mariadass, Syireen B Alwi, Baharudin B Ibrahim, Lim S Kun, Lam J Kai, Zirwa A Butt","doi":"10.3855/jidc.21850","DOIUrl":"10.3855/jidc.21850","url":null,"abstract":"Introduction: This study aims to identify and systematically assess the prevalence of Catheter-related bloodstream infections (CRBSI) and identify risk factors of CRBSI in hemodialysis (HD) patients.Methodology: A comprehensive literature review was conducted to identify pertinent studies related to the prevalence of CRBSI and risk factors of CRBSI in HD patients. This involved searching widely recognized electronic databases with MeSH terms to retrieve relevant studies. Relevant articles were screened, duplicates were removed, eligibility criteria were applied, and studies that met the criteria were reviewed. Prevalence of CRBSI was pooled using a random effect model using Comprehensive Meta-Analysis (CMA) software.Results: From the initial search across four electronic databases, a total of 1850 studies were identified. After eliminating 1615 duplicate studies, 235 remained for screening. Of these, 180 were excluded due to the lack of relevant terms. Of the 55 studies left, 43 were not included due to a lack of relevant data. Finally, the pooled combined prevalence across these 12 studies was 22.8% (95% CI of 0.117 to 0.397), whereas the I-squared value obtained is 99.38%. Regionally, prevalence in Asia was 17.5% (95% CI of 0.046 to 0.483), while in Africa it was 30.4% (95% CI of 0.240 to 0.376). The most common risk factors identified were immunocompromised status, along with comorbidities such as hypertension and diabetes mellitus, previous catheter insertion, and prolonged hospital stays.Conclusions: The findings of this review indicate that CRBSI is a serious issue faced by HD patients, especially those with the commonly identified risk factors.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"20 5","pages":"614-623"},"PeriodicalIF":1.3,"publicationDate":"2026-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148213037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mycetoma caused by Streptomyces sudanensis. 苏丹链霉菌引起的足菌肿。

IF 1.2 4区医学

Journal of Infection in Developing Countries Pub Date : 2026-05-31 DOI: 10.3855/jidc.21134

Maria Alessandra Mattioli, Elisa Cinotti, Pietro Rubegni, Stefano Veraldi

引用次数: 0

Surveillance of multidrug-resistant bacterial isolates from bloodstream infections in Erbil, Iraq. 伊拉克埃尔比勒血液感染中多药耐药细菌分离株的监测。

IF 1.2 4区医学

Journal of Infection in Developing Countries Pub Date : 2026-05-31 DOI: 10.3855/jidc.22460

Safaa Th Aka

{"title":"Surveillance of multidrug-resistant bacterial isolates from bloodstream infections in Erbil, Iraq.","authors":"Safaa Th Aka","doi":"10.3855/jidc.22460","DOIUrl":"10.3855/jidc.22460","url":null,"abstract":"Introduction: When bacteria enter the bloodstream and grow, they produce toxins that cause systemic sickness; and this leads to bloodstream infections (BSIs). BSIs are a major contributor to morbidity and mortality in hospitals. Since infections produced by multidrug-resistant (MDR) organisms are linked to greater mortality rates, the situation becomes even more complicated. This study evaluated the bacterial agents found in Erbil septicemia patients and investigated how resistant they were to antibiotics.Methodology: Blood cultures were obtained from 81 patients at Maryamana Private Hospital who were suspected of having septicemia between March and October 2024. Automated laboratory equipment was used to identify the isolates and assess their susceptibility to antibiotics. Standard criteria were followed for classification into MDR, extensively drug-resistant (XDR), or pan-drug-resistant (PDR) categories.Results: Around 57 (70.3%) of the 81 blood samples had bacterial growth. Around 32 (56.1%) were male and 25 (43.9%) were female. The majority were in the 30-59 years age group. More Gram-negative organisms (59.7%) than Gram-positive species (40.3%) were isolated. Staphylococcus aureus (16.1%) and Burkholderia cepacia (17.9%) were the most common bacteria. Methicillin-resistant S. aureus (MRSA) strains made for more than half of the total (55.5%). PDR was found among the Gram-negative isolates; 65.5% were MDR and 34.5% XDR.Conclusions: The significant prevalence of resistant Gram-negative bacteria and MRSA highlights the critical need for quick diagnosis, careful antibiotic use, and improved infection control measures in healthcare environments.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"20 5","pages":"670-677"},"PeriodicalIF":1.2,"publicationDate":"2026-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148213166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A serological survey of hepatitis B among migrant workers at a construction site in Qingdao, China. 青岛某建筑工地农民工乙型肝炎血清学调查。

IF 1.2 4区医学

Journal of Infection in Developing Countries Pub Date : 2026-05-31 DOI: 10.3855/jidc.21901

Zhenzhu Liu, Yongling Hu, Tingting Xiao, Sitong Liu, Sicheng Hao, Feng Yang, Xuedan Li

{"title":"A serological survey of hepatitis B among migrant workers at a construction site in Qingdao, China.","authors":"Zhenzhu Liu, Yongling Hu, Tingting Xiao, Sitong Liu, Sicheng Hao, Feng Yang, Xuedan Li","doi":"10.3855/jidc.21901","DOIUrl":"10.3855/jidc.21901","url":null,"abstract":"Introduction: Migrant workers are a vulnerable population for hepatitis B virus (HBV) infection. The present study aimed to assess HBV prevalence and identify associated risk factors among migrant workers at a construction site in Qingdao, in order to inform prevention strategies.Methodology: A random sampling method was used to select 169 migrant workers from a construction site in Qingdao in 2022. Data were collected through questionnaire surveys, and venous blood samples were obtained for serological testing. The electrochemiluminescence method was employed for serological testing to determine the positivity rate of Hepatitis B surface antigen (HBsAg), surface antibody (HBsAb), and core antibody (HBcAb), as well as the overall infection rate of HBV. Multivariate logistic regression analysis was conducted to identify factors associated with HBV infection.Results: Among the 169 participants, the positivity rates of HBsAg, HBsAb, and HBcAb were 4.73%, 52.07%, and 43.20%, respectively, and the HBV infection rate was 46.75%. Multivariate logistic regression analysis revealed that being male, aged 41 years and above, having 2-5 years of working experience at construction sites, and residing in rural areas were risk factors for HBV infection, while a history of hepatitis B vaccination was a protective factor for HBV infection.Conclusions: The positivity rate of HBsAg was higher among migrant workers at a construction site in Qingdao. Several risk factors were identified in relation to HBV infection. Strengthening health education and promoting hepatitis B vaccination are recommended to reduce the infection and prevalence of hepatitis B.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"20 5","pages":"737-742"},"PeriodicalIF":1.2,"publicationDate":"2026-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148212997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of diarrhoeal cases and deaths associated with food-borne illnesses in India: a systematic review and meta-analysis. 印度与食源性疾病相关的腹泻病例和死亡流行率：系统回顾和荟萃分析

IF 1.2 4区医学

Journal of Infection in Developing Countries Pub Date : 2026-05-31 DOI: 10.3855/jidc.21106

Aaina Sharma, Poonam Khanna, Ravindra Khaiwal, Vivek Sagar, Savitesh Kushwaha, Ayushi Singh

{"title":"Prevalence of diarrhoeal cases and deaths associated with food-borne illnesses in India: a systematic review and meta-analysis.","authors":"Aaina Sharma, Poonam Khanna, Ravindra Khaiwal, Vivek Sagar, Savitesh Kushwaha, Ayushi Singh","doi":"10.3855/jidc.21106","DOIUrl":"10.3855/jidc.21106","url":null,"abstract":"Introduction: Foodborne illnesses are infections or intoxications caused by consuming contaminated food or beverages. This study aims to find the prevalence of diarrheal cases and deaths associated with food-borne illnesses in India.Methodology: A Search was performed on PubMed and other platforms from 2011 to 2022. Sensitivity and quality analyses were also performed. The pooled prevalence was reported with effect sizes, considering the random-effects and quality-effects models. A subgroup analysis was also performed based on the regions and age groups.Results: The prevalence of diarrheal cases due to foodborne illnesses in India was 18%. The prevalence was 22% in the North Eastern region, 20% in the Eastern region, 18% in the Southern region, 16% in the Western region, and 13% in the Northern region. Among the age groups, prevalence was 34% for 5-10 years, 22% for under 5, 13% for 20-60 years, 14% for 10-19 years, and 10% for more than 60 years.Conclusions: The prevalence of diarrhea is still on the higher side in India. Although programs like Intensified Diarrhea Control Fortnight are running, interventions and awareness, ensuring intake of safe food and water are necessary.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"20 5","pages":"624-636"},"PeriodicalIF":1.2,"publicationDate":"2026-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148213068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Donning gloves before patient contact, with or without prior hand hygiene. 在接触病人之前戴上手套，无论事先是否进行手部卫生。

IF 1.3 4区医学

Journal of Infection in Developing Countries Pub Date : 2026-05-31 DOI: 10.3855/jidc.22190

Gülsüm Iclal Bayhan, Cansu Aydın Altuntaş, Nural Cevahir

{"title":"Donning gloves before patient contact, with or without prior hand hygiene.","authors":"Gülsüm Iclal Bayhan, Cansu Aydın Altuntaş, Nural Cevahir","doi":"10.3855/jidc.22190","DOIUrl":"10.3855/jidc.22190","url":null,"abstract":"Objective: Hand hygiene (HH) is a fundamental infection prevention measure in healthcare settings, playing a crucial role in reducing healthcare-associated infections (HAIs). Despite its importance, HH compliance remains suboptimal worldwide. A common error is omitting HH before donning gloves, specifically during WHO Moment 1 (\"Before touching a patient\"). This study investigates bacterial contamination associated with direct gloving and its potential implications for infection control.Methods: A randomized controlled trial included nurses and doctors preparing to touch patients in the pediatric cardiovascular surgery intensive care unit. Participants were divided into two groups: (1) \"HH prior to gloving\" (HH performed before donning gloves) and (2) \"direct gloving\" (no HH before gloves). For each group, 129 samples were collected. Bacterial counts on gloved hands were compared between groups and against bare hands.Results: The total bacterial colony counts on gloved hands were similar between the HH prior to gloving group and the direct gloving group (p = 0.559). However, bacterial colony counts on gloved hands in both groups were significantly lower compared to bare hands (p = 0.0001, p = 0.0001).Conclusions: Direct gloving did not increase bacterial contamination on gloves relative to HH before gloving. However, given the established benefits of HH in broader infection control practices, further research is needed to assess the impact of both or separate HH and gloving techniques across different clinical settings.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"20 5","pages":"750-754"},"PeriodicalIF":1.3,"publicationDate":"2026-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148213001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intravenous proton pump inhibitor uses for stress ulcer prophylaxis in the critically ill: a single-center study in Pakistan. 静脉注射质子泵抑制剂用于危重病人应激性溃疡预防：巴基斯坦的一项单中心研究。

IF 1.3 4区医学

Journal of Infection in Developing Countries Pub Date : 2026-05-31 DOI: 10.3855/jidc.22309

Saba Noureen, Waseem Ullah, Mahnoor Asad, Zita L Szabó, Márió Gajdács, Lua P Lin, Long C Ming, Suresh Shanmugham, Mian J Ahmed, Shazia Jamshed

{"title":"Intravenous proton pump inhibitor uses for stress ulcer prophylaxis in the critically ill: a single-center study in Pakistan.","authors":"Saba Noureen, Waseem Ullah, Mahnoor Asad, Zita L Szabó, Márió Gajdács, Lua P Lin, Long C Ming, Suresh Shanmugham, Mian J Ahmed, Shazia Jamshed","doi":"10.3855/jidc.22309","DOIUrl":"10.3855/jidc.22309","url":null,"abstract":"Introduction: Irrational use of intravenous (IV) proton pump inhibitors (PPIs) for stress ulcer prophylaxis (SUP) in critically ill patients increases the risk of adverse drug reactions (ADRs), and may lead to longer stays in the intensive care unit (ICU).Methodology: A single-center, retrospective, observational study was conducted to assess the practices with prescribing IV SUP in critically ill adult patients treated at ICUs between January 2020-December 2022. Data was collected from electronic medical records, using a pre-designed checklist. Appropriateness of SUP administration was determined using the American Society of Health-System Pharmacists (ASHP) recommendations.Results: Medical records of 1076 patients were analyzed; majority of patients (80.9%; n = 873) received IV SUP during their ICU stay, with the most commonly prescribed drug being omeprazole (99.2%). 75.5% of patients had no major or minor risk factors based on ASHP guidelines. The rationale of SUP was deemed appropriate in 51.7% of cases. Among patients treated at specific ICU wards, male patients were less likely (OR: 0.587 [95% CI: 0.345-0.998]; p = 0.048), while ventilated patients were more likely (OR: 2.525 [95% CI: 1.219-5.233]; p = 0.013) to receive SUP. Furthermore, ≥10 days of hospital stay corresponded to notable increase (OR: 4.076 [95% CI: 0.870-19.098]; p = 0.086) in the probability of receiving SUP.Conclusions: The results may provide a basis for developing protocols related to acid-suppressive therapy in critically ill adults, calling for heightened awareness and tailored interventions to optimize pharmacological care in ICU settings.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"20 5","pages":"717-728"},"PeriodicalIF":1.3,"publicationDate":"2026-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148213024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Direct MALDI-TOF MS identification from positive blood culture bottles: a time-saving approach to reduce diagnostic delays. 直接MALDI-TOF质谱鉴定阳性血培养瓶：一种节省时间的方法，以减少诊断延误。

IF 1.2 4区医学

Journal of Infection in Developing Countries Pub Date : 2026-05-31 DOI: 10.3855/jidc.21690

Jyotsna Agarwal, Nikhil Raj, Vikramjeet Singh, Avneesh Sharma, Anupam Das, Manodeep Sen

{"title":"Direct MALDI-TOF MS identification from positive blood culture bottles: a time-saving approach to reduce diagnostic delays.","authors":"Jyotsna Agarwal, Nikhil Raj, Vikramjeet Singh, Avneesh Sharma, Anupam Das, Manodeep Sen","doi":"10.3855/jidc.21690","DOIUrl":"10.3855/jidc.21690","url":null,"abstract":"Introduction: Bloodstream infections are a leading cause of mortality worldwide, necessitating prompt identification and treatment to improve patient outcomes. Conventional methods are time-consuming, often delaying appropriate antimicrobial therapy. Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) has emerged as a revolutionary tool for rapid microbial identification. This study aimed to evaluate the utility of direct microbial identification from positive blood cultures using MALDI-TOF MS in reducing diagnostic delays and improving pathogen detection for effective clinical management.Methodology: This prospective study analyzed 416 monomicrobial positive blood cultures obtained between October 2022 and October 2024 from a tertiary care teaching hospital in North India. After Gram staining and initial processing, direct microbial identification was performed using MALDI-TOF MS. Conventional subculture-based methods were employed as the gold standard for comparison.Results: Of the 416 isolates, 89% were correctly identified at the species level using the direct method. Among 204 Gram positive cocci, 91.6% were correctly identified, with species-specific rates of 100% for Staphylococcus aureus and Staphylococcus ureilyticus. Out of 160 Gram negative bacilli, 88.1% were accurately identified, with Acinetobacter baumannii showing 97.5% accuracy. Candida species showed a correct identification rate of 80.8%, with 100% identification for Candida albicans and Candida krusei.Conclusions: Direct microbial identification using MALDI-TOF MS is a rapid, cost-effective alternative to conventional methods, enabling faster pathogen detection and supporting antimicrobial stewardship.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"20 5","pages":"687-692"},"PeriodicalIF":1.2,"publicationDate":"2026-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148213004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mortality rates among adults with sepsis and septic shock in Indonesia: a systematic review and meta-analysis. 印度尼西亚成人败血症和感染性休克的死亡率：一项系统回顾和荟萃分析

IF 1.3 4区医学

Journal of Infection in Developing Countries Pub Date : 2026-05-31 DOI: 10.3855/jidc.21943

Muhammad Ramadhan Ghifari, Lisa L Dewi, Alindina Anjani

{"title":"Mortality rates among adults with sepsis and septic shock in Indonesia: a systematic review and meta-analysis.","authors":"Muhammad Ramadhan Ghifari, Lisa L Dewi, Alindina Anjani","doi":"10.3855/jidc.21943","DOIUrl":"10.3855/jidc.21943","url":null,"abstract":"Introduction: Sepsis and septic shock represent a critical global health challenge, accounting for a substantial proportion of patient fatalities worldwide. Despite this, Indonesia lacks a comprehensive, nationwide analysis of the mortality rates associated with these conditions. This study aimed to systematically evaluate the burden of sepsis and septic shock mortality across Indonesia, addressing a crucial gap in the existing healthcare data, which may aid clinical and policy considerations.Methodology: We searched PubMed, Scopus, DOAJ, and citation lists for studies with sepsis and septic shock mortality rate , focusing on 28-day and in-hospital mortality. Study quality was assessed using the Newcastle-Ottawa Scale, and the protocol was registered with PROSPERO (CRD42025645312).Results: Overall, 47 studies were included in this review , revealing a pooled 28-day mortality rate of 55.9% (95% CI, 48.7%-63.0%; I2 = 79.5%) among patients with sepsis and septic shock, as determined by the Sepsis-3, Sepsis 2, and Not-Mentioned criteria. Additionally, the in-hospital mortality rates for the same cohort were higher at 67.4% (95% CI, 62.9%-72.0%; I2 = 95.02%). Notably, among patients with septic shock specifically, in-hospital mortality reached 77.5% (95% CI, 67.3%-87.8%; I2 = 91.18%).Conclusions: Sepsis and septic shock mortality rates in Indonesian adults remain high. These findings underscore the need for enhanced sepsis management protocols, effective resource allocation, and targeted interventions for vulnerable patients.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"20 5","pages":"601-613"},"PeriodicalIF":1.3,"publicationDate":"2026-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148213011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0