Journal of Infection in Developing Countries最新文献_第8页

Demographic and epidemiological characteristics of COVID-19 epidemic in Albania. 阿尔巴尼亚新冠肺炎疫情的人口统计学和流行病学特征

IF 1.4 4区医学

Journal of Infection in Developing Countries Pub Date : 2024-10-31 DOI: 10.3855/jidc.18636

Elona Gaxhja, Gjergji Koja, Brunilda Elezi, Elvin Rada, Shkelqim Hidri

{"title":"Demographic and epidemiological characteristics of COVID-19 epidemic in Albania.","authors":"Elona Gaxhja, Gjergji Koja, Brunilda Elezi, Elvin Rada, Shkelqim Hidri","doi":"10.3855/jidc.18636","DOIUrl":"10.3855/jidc.18636","url":null,"abstract":"Introduction: This study provides a general overview of the coronavirus disease 2019 (COVID-19) pandemic in Albania. The aim was to assess the spread of COVID-19 in the country by describing the demographic and epidemiological characteristics.Methodology: We performed a 12-month national observational, epidemiological study. The data were extracted from the national digital system of Infectious Diseases Information and included all reported COVID-19 cases. Demographic data, number of tests, number of confirmed positive cases, and number of deaths were analyzed to build a general overview of the pandemic in Albania.Results: The database comprised 251,139 tested individuals and 250,926 were reported as confirmed cases. The average age of the tested cases was 44.83 years; 19.8% of the studied individuals were 51-60 years old and this group had the highest proportion (51.7%) of females. The estimated prevalence of COVID-19 in Albania was 51.31% (110,397 cases). Tirana, the capital of Albania, had the highest percentage of COVID-19 positive cases (44.9%) with an incidence rate 3,879.02 individuals/100,000 inhabitants. The COVID-19 curve reached its peak in February 2021 with 54,046 cases. The mortality rate was 1.18/1000 inhabitants.Conclusions: This demographic and epidemiological analysis provides a better understanding of the COVID-19 pandemic, and. the findings can contribute towards perception and re-investigation of the spread of COVID-19 in Albania, However, further studies covering longer periods and deeper analysis are needed for developing an epidemiological mathematical model, as a tool to develop and implement specific strategies for monitoring future pandemics.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"18 10","pages":"1485-1493"},"PeriodicalIF":1.4,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating links between Trichomonas vaginalis, T. vaginalis virus, Mycoplasma hominis, and metronidazole resistance. 调查阴道毛滴虫、阴道滴虫病毒、人支原体和甲硝唑耐药性之间的联系。

IF 1.4 4区医学

Journal of Infection in Developing Countries Pub Date : 2024-10-31 DOI: 10.3855/jidc.17592

Rowen Govender, Nonkululeko Mabaso, Nathlee S Abbai

{"title":"Investigating links between Trichomonas vaginalis, T. vaginalis virus, Mycoplasma hominis, and metronidazole resistance.","authors":"Rowen Govender, Nonkululeko Mabaso, Nathlee S Abbai","doi":"10.3855/jidc.17592","DOIUrl":"https://doi.org/10.3855/jidc.17592","url":null,"abstract":"Introduction: Trichomonas vaginalis (TV) is the etiological agent of the common non-viral sexually transmitted infection (STI), trichomoniasis. TV can inherently harbour Mycoplasma hominis and Trichomonas vaginalis virus (TVV) species. Endosymbiosis of TV with M. hominis and TVV may contribute to metronidazole resistance in this pathogen. This study determined the prevalence of TVVs across clinical isolates of TV, as well as the symbiosis between TV, TVV, and M. hominis in relation to metronidazole resistance.Methodology: Twenty-one clinical isolates of TV were analysed in this study. The isolates were subjected to drug susceptibility assays using varying concentrations of metronidazole. Nucleic acids (RNA and DNA) were extracted from the isolates for molecular assays. The presence of intracellular M. hominis was determined by 16S rRNA polymerase chain reaction (PCR) with specific primers. The presence of the individual TVVs was determined by PCR using gene specific primers with template cDNA.Results: The prevalence of TVV and M. hominis were 76% (16/21) and 86% (18/21), respectively. No significant associations were observed between the presence of TVV and clinical symptoms. A significant association was noted between the coinfection of TVV4 and M. hominis (p = 0.014). The presence of any TVV was significantly associated with metronidazole susceptibility patterns (p = 0.012). No significant associations were noted between the coinfection of endosymbionts and metronidazole resistance.Conclusions: The information obtained displays the ability of TV to form an endosymbiotic relationship with several microorganisms, simultaneously. Based on these findings, both endosymbionts pose no significant influence on metronidazole resistance.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"18 10","pages":"1590-1600"},"PeriodicalIF":1.4,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142773811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of N-acetylcysteine on apoptosis and autophagy of macrophages infected with Mycobacterium tuberculosis. n -乙酰半胱氨酸对结核分枝杆菌感染巨噬细胞凋亡和自噬的影响。

IF 1.4 4区医学

Journal of Infection in Developing Countries Pub Date : 2024-10-31 DOI: 10.3855/jidc.19372

Renchun Su, Min Qiao, Tianhui Gao, Jingtao Gao, Lihui Nie, Shanshan Li, Yufeng Wang, Yu Pang, Qi Li

{"title":"Effect of N-acetylcysteine on apoptosis and autophagy of macrophages infected with Mycobacterium tuberculosis.","authors":"Renchun Su, Min Qiao, Tianhui Gao, Jingtao Gao, Lihui Nie, Shanshan Li, Yufeng Wang, Yu Pang, Qi Li","doi":"10.3855/jidc.19372","DOIUrl":"https://doi.org/10.3855/jidc.19372","url":null,"abstract":"Introduction: The purpose of this study was to observe the effect of N-acetylcysteine (NAC) on oxidative stress (OS), intracellular Mycobacterium tuberculosis (MTB) load, apoptosis, and autophagy of macrophages infected with H37Rv MTB. In addition, we explored the possible mechanism of action, to provide a rationale for the use of NAC in the treatment of tuberculosis.Methodology: We divided THP-1 macrophages into four groups: control, control + NAC, H37Rv, and H37Rv + NAC. OS, apoptosis, autophagy and intracellular MTB colony-forming unit (CFU) indexes were measured at 0, 4, 24, and 48 hours, respectively. Then, various indicator changes were systematically compared.Results: The levels of reactive oxygen species (ROS), malondialdehyde (MDA), apoptosis rate, and LC3II/ β-actin ratio in the H37Rv group increased at 4 hours and reached their peak at 48 hours. The ROS and MDA in the H37Rv + NAC group were lower than those in the H37Rv group. CFU in the H37Rv + NAC group increased at 24 hours and decreased at 48 hours after treatment with NAC, relative to the H37Rv group. In addition, the H37Rv + NAC group showed a decrease in LC3II/β-actin ratio 48 hours after NAC treatment, compared to the H37Rv group.Conclusions: MTB infection can lead to an increase in macrophage OS, apoptosis, and autophagy levels. However, after treatment with NAC, the growth of MTB in macrophages is inhibited, and OS and autophagy levels are reduced. The antioxidant effect and inhibitory effect of NAC on MTB are related to MTB-mediated macrophage OS and autophagy.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"18 10","pages":"1566-1575"},"PeriodicalIF":1.4,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Umbilical abscess caused by Helcococcus kunzii: a case report and literature review. 昆紫斑螺致脐脓肿1例并文献复习。

IF 1.4 4区医学

Journal of Infection in Developing Countries Pub Date : 2024-10-31 DOI: 10.3855/jidc.18986

Jianfei E, Dengchao Wang, Wei Wei, Zongyao Chen

引用次数: 0

Assessment of perspectives, knowledge and attitude about antibiotic use and resistance in Sudanese population. 评估苏丹人口关于抗生素使用和耐药性的观点、知识和态度。

IF 1.4 4区医学

Journal of Infection in Developing Countries Pub Date : 2024-10-31 DOI: 10.3855/jidc.19147

Malik Suliman Mohamed, Mohamed Khalid, Mona Timan Idriss, Eyman Mohamed Eltayib, Tilal Elsaman, Magdi Awadalla Mohamed

{"title":"Assessment of perspectives, knowledge and attitude about antibiotic use and resistance in Sudanese population.","authors":"Malik Suliman Mohamed, Mohamed Khalid, Mona Timan Idriss, Eyman Mohamed Eltayib, Tilal Elsaman, Magdi Awadalla Mohamed","doi":"10.3855/jidc.19147","DOIUrl":"https://doi.org/10.3855/jidc.19147","url":null,"abstract":"Introduction: The spread of multidrug-resistant pathogens is a major global health concern. A survey was conducted to evaluate the knowledge and attitudes towards antimicrobial use and resistance in Sudan.Methodology: A cross-sectional survey with a 39-item questionnaire was distributed via social media platforms to Sudanese residents in Khartoum state. Responses were collected anonymously from April to October 2022 and subjected to statistical analysis to assess associations between variables.Results: A total of 1,037 participants agreed to participate, with a 94.3% response rate. Two-thirds of participants reported using oral antibiotics in the past 12 months. Only a quarter obtained antibiotics with a prescription. Less than half (45.3%) of the participants underwent diagnostic tests before using antibiotics, and 30.2% adjusted or discontinued the antibiotic dosage. Forty-two percent correctly identified that antibiotics are ineffective against viral infections, but confusion regarding their use persisted. The mean knowledge score was 3.3 ± 1.7, indicating average knowledge levels. Significant variations in knowledge and attitudes were observed based on age, gender, marital status, and education. The mean score of the participants' attitude was 25.5 ± 3.97. Female, younger, and single participants exhibited more positive attitudes towards antibiotics use and resistance.Conclusions: The participants exhibited average knowledge levels and mixed attitudes towards antibiotic use and resistance. Misconceptions and inadequate indications for antibiotic use were identified. Gender, age, marital status, and education influenced participants` knowledge and attitudes. These findings can inform strategies to promote appropriate practices and combat the spread of antibiotic resistance across health and non-health sectors.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"18 10","pages":"1546-1558"},"PeriodicalIF":1.4,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142773998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of clinical and para-clinical characteristics between children and adults with the Omicron variant of COVID-19. 儿童和成人欧米克隆变异COVID-19的临床和准临床特征比较

IF 1.4 4区医学

Journal of Infection in Developing Countries Pub Date : 2024-10-31 DOI: 10.3855/jidc.18812

Yuchen Peng, Yufei Shi, Wentao Zhu, Xiaopeng Li, Jiwei Fu, Xincheng Wu, Pei Shi, Xiaoping Wu

{"title":"Comparison of clinical and para-clinical characteristics between children and adults with the Omicron variant of COVID-19.","authors":"Yuchen Peng, Yufei Shi, Wentao Zhu, Xiaopeng Li, Jiwei Fu, Xincheng Wu, Pei Shi, Xiaoping Wu","doi":"10.3855/jidc.18812","DOIUrl":"https://doi.org/10.3855/jidc.18812","url":null,"abstract":"Introduction: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant is associated with higher transmissibility, but lower disease severity, compared to some other variants. However, its exact pathogenicity among children is still largely unknown. This study was conducted to determine the differences in clinical characteristics between children and adults infected with this variant.Methodology: A total of 327 Omicron-infected patients admitted to the First Affiliated Hospital of Nanchang University, between 7 December 2022 and 10 March 2023 were retrospectively evaluated. They were divided into two groups: children (0-18 years, n = 149) and adults (> 18 years, n = 178). Differences in clinical classifications, symptoms, imaging features, biochemical markers, and positive nucleic acid test durations were compared between the groups.Results: Age had a significant impact on children in terms of clinical classifications (p < 0.05). Fever was the most common symptom among children (123/149), while coughing (151/178) was the most common among adults. The adults also had higher frequencies for pathological imaging features. The children had significantly higher white blood cell counts, and lymphocyte counts, while the adults had higher neutrophil percentages and C-reactive protein. Positive nucleic acid test durations were shorter among the children, compared to the adults. The children also had higher cumulative negative conversion and improvement rates (p < 0.05).Conclusions: Overall, children with Omicron had milder clinical classifications, significantly different symptoms and biochemical indices, as well as lower occurrence of pathological imaging features and shorter positive nucleic acid test durations, compared to adults.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"18 10","pages":"1494-1501"},"PeriodicalIF":1.4,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of inflammation on voriconazole levels in patients with invasive pulmonary aspergillosis. 炎症对侵袭性肺曲霉病患者伏立康唑水平的影响。

IF 1.4 4区医学

Journal of Infection in Developing Countries Pub Date : 2024-10-31 DOI: 10.3855/jidc.19290

Pinar Bakir Ekinci, Emre Kara, Ahmet G Er, Asli Pinar, Ahmet C Inkaya, Kutay Demirkan, Gokhan Metan, Omrum Uzun

{"title":"Effect of inflammation on voriconazole levels in patients with invasive pulmonary aspergillosis.","authors":"Pinar Bakir Ekinci, Emre Kara, Ahmet G Er, Asli Pinar, Ahmet C Inkaya, Kutay Demirkan, Gokhan Metan, Omrum Uzun","doi":"10.3855/jidc.19290","DOIUrl":"https://doi.org/10.3855/jidc.19290","url":null,"abstract":"Introduction: Voriconazole (VCZ) serum concentrations may be affected by many factors, such as drug-drug interactions, liver dysfunction, genetic polymorphism, and inflammation. This study aimed to determine the relationship between VCZ measured trough plasma levels and C-reactive protein levels in patients with coronavirus disease 2019 (COVID-19)-associated aspergillosis (CAPA) and invasive pulmonary aspergillosis (IPA).Methodology: Patients who were > 18 years of age, received VCZ treatment for IPA or CAPA in our hospital between March 2020 and April 2021, and had their VCZ level monitored, were included in this retrospective study.Results: A total of 85 patients (35 diagnosed with CAPA) were included in this study. Forty-three patients (50.6%) had VCZ levels in the therapeutic range, 4 (4.7%) were sub-therapeutic, and 38 (44.7%) were supra-therapeutic. Inflammatory markers were significantly higher in patients with supra-therapeutic levels (p < 0.05). Supra-therapeutic levels and VCZ-related adverse effects were significantly more frequent in CAPA patients than in IPA patients (p = 0.011 and p = 0.002, respectively).Conclusions: Patients diagnosed with CAPA were more prone to adverse effects and supra-therapeutic VCZ levels. More frequent therapeutic drug monitoring is recommended in this patient population.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"18 10","pages":"1617-1624"},"PeriodicalIF":1.4,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of virulence genes in Proteus strains isolated from diabetic foot infections and urinary tract infections. 糖尿病足和尿路感染分离的变形杆菌毒力基因评价。

IF 1.4 4区医学

Journal of Infection in Developing Countries Pub Date : 2024-10-31 DOI: 10.3855/jidc.18928

Ruth M Phiri, Mustafa Bülent Ertuğrul, Bülent Bozdoğan, Tuğrul Hoşbul

{"title":"Evaluation of virulence genes in Proteus strains isolated from diabetic foot infections and urinary tract infections.","authors":"Ruth M Phiri, Mustafa Bülent Ertuğrul, Bülent Bozdoğan, Tuğrul Hoşbul","doi":"10.3855/jidc.18928","DOIUrl":"https://doi.org/10.3855/jidc.18928","url":null,"abstract":"Introduction: Proteus species are frequently isolated from urinary tract infections (UTIs) and diabetic foot infections (DFIs). We aimed to evaluate the presence of virulence genes in P. mirabilis and P. vulgaris strains isolated from DFI and UTI.Methodology: A total of 78 Proteus isolates (57 P. mirabilis and 21 P. vulgaris) collected from patients were studied. The isolates were identified using matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometer. The presence of virulence-associated genes (hlyA, mrpA, atfA, pmfA, hmpA, ptaA, ureA, ureC, zapA, ireA, rsbA, flaA, and ucaA) was evaluated by polymerase chain reaction (PCR).Results: 46 isolates were obtained from wound cultures, and 32 were obtained from the midstream urine cultures. All virulence genes, except hlyA, were detected in the study. ureA was the most detected gene in both UTI (100%) and DFI isolates (84.8%). The distributions of ureC, flaA, hpmA, ireA, rsbA, pmfA, zapA, ucaA, ptaA, atfA, and mrpA genes in DFI and UTI isolates were as follows: 82.6% and 96.9%, 71.7% and 93.8%, 69.6% and 93.8%, 69.6% and 96.9%, 69.6% and 96.9, 67.4% and 81.3%, 65.2% and 43.8%, 54.3 and 71.9%, 34.8% and 96.9%, 26.1 and 93.8%, and 23.9% and 46.9%, respectively.Conclusions: We demonstrated that P. mirabilis and P. vulgaris express a variety of virulence genes related to pathogenicity. All virulence genes were found to be more frequent in UTI isolates except zapA. There is limited data on the virulence factors of Proteus species in DFIs. Further studies are needed to investigate virulence genes in wound isolates.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"18 10","pages":"1559-1565"},"PeriodicalIF":1.4,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expression and clinical significance of IL-8 and Wnt2 in Helicobacter pylori-infected gastric cancer patients. 幽门螺杆菌感染胃癌患者IL-8、Wnt2的表达及临床意义

IF 1.4 4区医学

Journal of Infection in Developing Countries Pub Date : 2024-10-31 DOI: 10.3855/jidc.20205

Li Lin, Ruiyu Tao, Yonggang Cai, Qiang Zhao, Ke Yang, Wenjuan Yang, Fengxia Guo

{"title":"Expression and clinical significance of IL-8 and Wnt2 in Helicobacter pylori-infected gastric cancer patients.","authors":"Li Lin, Ruiyu Tao, Yonggang Cai, Qiang Zhao, Ke Yang, Wenjuan Yang, Fengxia Guo","doi":"10.3855/jidc.20205","DOIUrl":"https://doi.org/10.3855/jidc.20205","url":null,"abstract":"Introduction: We assessed the expression levels of interleukin-8 (IL-8) and Wnt2 in Helicobacter pylori-infected gastric cancer (GC) patients, and investigated the association of these proteins with prognosis.Methodology: Seventy-two GC patients, including 40 cases with H. pylori infection and 32 cases without H. pylori infection, were enrolled. Tumor and para-tumor normal tissues were collected. H. pylori infection was determined using the rapid urease test and Warthin-Starry silver staining. The expressions of IL-8 and Wnt2 were assessed using immunohistochemistry. The association between H. pylori infection, IL-8, Wnt2, and pathological and clinical data was analyzed. The relationship between H. pylori, IL-8, Wnt2, and prognosis was assessed using survival curves and regression analyses.Results: The expression levels of IL-8 and Wnt2 in GC tissue significantly exceeded that in normal mucosa. The expression levels of IL-8 and Wnt2 were significantly higher in patients with H. pylori infection, than in those without H. pylori infection; and a positive correlation was observed between IL-8 and Wnt2 expressions. The positivity rate of IL-8 and Wnt2 in early-stage GC without lymph node metastasis markedly differed from that in advanced-stage GC with lymph node metastasis. Additionally, the survival rate of GC patients with positive IL-8 and Wnt2 expressions was significantly lower than in patients without such expression patterns. Clinical stage and Wnt2 were identified as independent prognostic factors of GC.Conclusions: IL-8 and Wnt2 were prognostic indicators for GC. H. pylori and IL-8 were not independent prognostic factors, whereas Wnt2 could independently serve as a prognostic factor for GC.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"18 10","pages":"1512-1521"},"PeriodicalIF":1.4,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fungal sinusitis due to mucormycosis in a diabetic immunosuppressed patient with acute myeloid leukemia (AML). 糖尿病免疫抑制合并急性髓性白血病（AML）患者因毛霉病引起的真菌性鼻窦炎。

IF 1.4 4区医学

Journal of Infection in Developing Countries Pub Date : 2024-10-31 DOI: 10.3855/jidc.19724

Gulfem Ece, Ejder Ciger, Celal Acar, Seckin Cagirgan, Ogulcan Cetin

{"title":"Fungal sinusitis due to mucormycosis in a diabetic immunosuppressed patient with acute myeloid leukemia (AML).","authors":"Gulfem Ece, Ejder Ciger, Celal Acar, Seckin Cagirgan, Ogulcan Cetin","doi":"10.3855/jidc.19724","DOIUrl":"https://doi.org/10.3855/jidc.19724","url":null,"abstract":"Introduction: Mucormycosis is an acute onset, invasive, fungal infection, characterized by organ involvement, and caused by Mucor, Rhizopus, or Absidia. Our aim was to present a case of mucormycotic infection and emphasize its importance in a diabetic immunosuppressed patient with acute myeloid leukemia (AML).Case presentation: A 68-year-old hypertensive and diabetic male patient with a diagnosis of AML developed respiratory failure and exhibited diffuse bilateral consolidation in high-resolution computed tomography (HRCT). The treatment plan involved chemotherapy with cytarabine (200 mg/m2/day for 7 days) and daunorubicin (60 mg/m2/day for 3 days) starting on 20 July 2022. Posaconazole prophylactic treatment was initiated on 23 July 2022, to prevent fungal infections. Five days later there was a black necrotic appearance on the left wing of the nose. The patient underwent excision of the left wing of the nose. Mucor was detected in the excision tissue both histopathologically and in culture. A culture under lactophenol cotton blue (LFCB) staining displaying hyphal structures of Mucor was obtained. The patient died of progressive pneumonia and sepsis.Conclusions: Mucormycosis is an infection with high mortality, and should be considered in the early stages of diagnosis when dealing with immunosuppression patients.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"18 10","pages":"1636-1639"},"PeriodicalIF":1.4,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0