Journal of Infection in Developing Countries最新文献

{"title":"Pulmonary aspergillosis in patients with asthma.","authors":"Mihailo Stjepanovic, Aleksandra Barac, Aleksa Golubovic, Filip Markovic, Snježana Krajišnik, Jelena Jankovic","doi":"10.3855/jidc.20711","DOIUrl":"https://doi.org/10.3855/jidc.20711","url":null,"abstract":"<p><p>Asthma is a complex respiratory condition characterized by airway inflammation and hyper-responsiveness, and poses a significant global health burden, affecting millions worldwide. Its origins lie in interactions between genetic, environmental, and host factors. While typically manageable, asthma can lead to severe exacerbations and complications if left untreated. The association between asthma and fungal infections, particularly with Aspergillus species, has garnered attention due to its impact on disease severity and management. We aim to provide a comprehensive overview of this association focusing on its various clinical presentations, risk factors, diagnostic approaches, and treatment strategies. Allergic bronchopulmonary aspergillosis (ABPA) emerges as a prevalent form of aspergillosis in asthmatic individuals, presenting challenges in both diagnosis and management. We discuss the evolving diagnostic criteria for ABPA, emphasizing the importance of clinical suspicion, radiological findings, serological tests, and pulmonary function tests. Moreover, we address the therapeutic interventions, review the roles of systemic glucocorticoids, antifungal agents, and emerging novel therapeutic agents. Early detection and intervention in fungal infections in asthma patients, particularly ABPA, are essential to mitigate exacerbations, improve symptom control, and prevent severe complications. This review underscores the necessity for heightened awareness and proactive management of fungal infections in the context of asthma, aiming to enhance patient care and quality of life.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 6","pages":"804-811"},"PeriodicalIF":1.4,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144561744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disseminated paracoccidioidomycosis under biological therapy.","authors":"Jaime A Ibarra-Burgos, Simón Correa-Sierra, Sergio A Londoño-Tabares","doi":"10.3855/jidc.18939","DOIUrl":"https://doi.org/10.3855/jidc.18939","url":null,"abstract":"<p><strong>Introduction: </strong>Paracoccidioidomycosis is an endemic mycotic infection caused by Paracoccidioides spp., prevalent in Central and South American countries. Anti-tumor necrosis factor (TNF) alpha agents, commonly used for autoimmune diseases, increase the risk of severe infections. We present a case of anti-TNF alpha-related paracoccidioidomycosis in a 71-year-old male farmer from Colombia.</p><p><strong>Case presentation: </strong>The patient had oral lesions and chronic cough. A biopsy showed granulomatous inflammation with multinucleated giant cells but no microorganisms. Negative microbiological stains and tests for other infections prompted further investigations. A positive serum immunodiffusion test for Paracoccidioides antibodies at a 1:256 titer led to mediastinoscopy and lung biopsy, which revealed budding yeast in a \"captain's wheel\" formation. Treatment with liposomal amphotericin B and itraconazole was initiated.</p><p><strong>Conclusions: </strong>This case highlights the risk of opportunistic infections under anti-TNF alpha therapy and raises awareness of paracoccidioidomycosis associations. Early diagnosis and management are essential for better patient outcomes.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 6","pages":"987-989"},"PeriodicalIF":1.4,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144561708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibiotic stewardship program (ASP) implementation is more effective than the national action plan for rational drug use.","authors":"Cem Karaali, Huseyin Esin, Orhan Ureyen, Ozan Barıs Namdaroglu, Murat Can Kale, Mustafa Emiroglu, Savas Yakan, Enver Ilhan, Mehmet Burak Oztop, Sukran Kose","doi":"10.3855/jidc.20245","DOIUrl":"https://doi.org/10.3855/jidc.20245","url":null,"abstract":"<p><strong>Introduction: </strong>In this study, we investigated the long-term effects of different antibiotic stewardship programs on surgical prophylaxis (SP) and the continuation of SP at discharge prescription in two general surgery clinics.</p><p><strong>Methods: </strong>We retrospectively examined SP practices in the general surgery clinics of two hospitals. In Clinic A, a modified antibiotic stewardship program (mASP) was implemented, while in Clinic B, practices were conducted within the scope of the National Action Plan for Rational Drug Use (NAPRDU). A cross-sectional comparison was made by including quarterly data from both clinics for the years 2013, 2016, 2018, and 2023.</p><p><strong>Results: </strong>When the SP practices in clinics A and B were analyzed in detail according to year, we found that SP indication, SP use for > 24 hours, antibiotic use in prescription, and all stages of SP (prescription and non-prescription) improved for both clinics except for the time of SP administration (p < 0.05). Moreover, a significantly greater and faster improvement in these parameters was found in clinic A than in clinic B.</p><p><strong>Conclusions: </strong>Our study showed that the mASP and the NAPRDU have positive long-term effects on SP practices in general surgery clinics and the implementation of SP in discharge prescriptions. However, in clinics where mASP was applied, SP practices generally improved faster and more effectively, especially in terms of the antibiotics prescribed in discharge.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 6","pages":"890-895"},"PeriodicalIF":1.4,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144561695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HBeAg clearance in chronic Hepatitis B: is it predictable?","authors":"Tuba İlgar, Aybegüm Özşahin, Sudem Mahmutoğlu Çolak, İlknur Esen Yıldız, Uğur Kostakoğlu, Ayşe Ertürk","doi":"10.3855/jidc.20784","DOIUrl":"https://doi.org/10.3855/jidc.20784","url":null,"abstract":"<p><strong>Introduction: </strong>Prediction of HBeAg loss is crucial for understanding the prognosis of chronic hepatitis B (CHB) and determining when to discontinue treatment. We aimed to identify factors predicting HBeAg clearance in patients undergoing antiviral treatment for HBeAg-positive CHB.</p><p><strong>Methodology: </strong>This retrospective study included patients who started antiviral treatment for HBeAg-positive CHB from January 1, 2008, to December 31, 2022, with at least one year of follow-up. We evaluated age, platelet count, treatment duration, ALT × Upper limit of normal (ULN), AST × ULN, AST/ALT ratio, Albumin-Bilirubin grade (ALBI), Platelet-Albumin-Bilirubin grade (PALBI), AST-Platelet ratio index (APRI), and Fibrosis-4 (FIB-4) parameters. ROC analysis was used to assess these parameter's ability to predict HBeAg loss.</p><p><strong>Results: </strong>Ninety-four patients were included, 43 (45.7%) of whom were female. HBeAg clearance occurred in 32 (34%) patients. Treatment duration was significantly longer in patients with HBeAg clearance (p = 0.003). Patients with HBeAg clearance had significantly higher median age, fibrosis score (FS), APRI, and FIB-4 values (p = 0.028, p = 0.024, p = 0.008, and p = 0.003, respectively) and lower mean platelet count (p = 0.010) at treatment initiation. ROC analysis identified age, FS, APRI, FIB-4, and platelet count as significant predictors, with APRI having the highest area under the curve (AUC = 0.771, p = 0.007, sensitivity 65%, specificity 66.7% for the cut-off value of 0.71).</p><p><strong>Conclusions: </strong>This study highlights the potential of FIB-4, platelet count, and particularly APRI in predicting HBeAg clearance. These findings can aid clinicians in optimizing treatment strategies and improving patient outcomes.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 6","pages":"941-947"},"PeriodicalIF":1.4,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144561714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional annotation and identification of novel drug targets from uncharacterized proteome of Trichuris trichiura.","authors":"Kanchan Rauthan, Saranya Joshi, Lokesh Kumar, Sudhir Kumar","doi":"10.3855/jidc.19924","DOIUrl":"https://doi.org/10.3855/jidc.19924","url":null,"abstract":"<p><strong>Introduction: </strong>Trichuris trichiura, a soil-transmitted helminth, resides in the large intestine of humans, causing an asymptomatic disease known as trichuriasis. This global health concern is particularly prevalent in low- or middle-income countries, representing a significant burden on public health as one of the most neglected tropical diseases. The diminishing effects of currently available anthelmintic drugs, attributed to escalating drug resistance, warrants an urgent need for alternative and more potent vaccines or drugs. A substantial portion of the proteins in the T. trichiura genome are uncharacterized and their annotation might offer insight into the parasite's invasion, interaction, and survival mechanisms inside the host. Hence, this study is aimed to provide functional annotations for the uncharacterized proteins identified in the proteome of T. trichiura.</p><p><strong>Methodology: </strong>The uncharacterized proteome of T. trichiura was subjected to physiological parameter computation, localization analysis, domain identification, homology, and druggability analysis. The programs used were evaluated using the Receiver Operating Characteristic (ROC) analysis.</p><p><strong>Results: </strong>Functional annotation was assigned to 165 out of the 1726 uncharacterized proteins. Out of these, 85 proteins were found to be non-homologous with the human host and considered to be potential novel drug targets. Two proteins were identified as essential proteins in the DEG database.</p><p><strong>Conclusions: </strong>Our study identified 165 new proteins from the uncharacterized proteome of the T. trichiura and several novel targets that can be further analyzed for drug designing and vaccine-related studies.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 6","pages":"948-961"},"PeriodicalIF":1.4,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144561712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of traditional Chinese medicine on the prognosis of COVID-19 in cancer patients: a questionnaire-based survey.","authors":"Man Yao, Shuhui Tang, Xiaowan Xu, Guo Chen, Min Liu, Yannan Xu, Shuang Xiang, Xuan Zhang, Xiaofeng Zhai, Hetong Zhao","doi":"10.3855/jidc.20064","DOIUrl":"https://doi.org/10.3855/jidc.20064","url":null,"abstract":"<p><strong>Introduction: </strong>The coronavirus disease 2019 (COVID-19) pandemic, exacerbated by the emergence of new variants such as Omicron, has posed significant challenges to healthcare systems worldwide. This study aimed to explore the potential effectiveness of long-term traditional Chinese medicine (TCM) use on COVID-19 infection and post-infection symptoms in cancer patients.</p><p><strong>Methodology: </strong>An anonymous online questionnaire was used to interview cancer patients who had used TCM (TCM group) and those who had never used TCM (non-TCM group) from March 31 to April 30,2023. A self-reported questionnaire was developed to investigate and analyze the patients' demography, underlying cancer types, treatment (TCM or non-TCM), clinical symptoms, and post-acute COVID-19 related symptoms.</p><p><strong>Results: </strong>A total of 996 cancer patients participated (607 TCM, 389 non-TCM). The non-TCM group had a higher infection rate (84.1% vs. 75.8%, p = 0.002). The TCM group reported significantly lower levels of post-COVID-19 symptoms at 3 months post-infection. Specifically, 98.0% of the TCM group reported no fatigue (91.7% in the non-TCM group, p < 0.001), and 98.7% reported no sleep difficulties (88.7% in the non-TCM group, p < 0.001). The median infection duration was 7 days in both groups, median body temperature was 38.2 °C in TCM and 38.3 °C in non-TCM group, and the fever duration was 2 days in both groups.</p><p><strong>Conclusions: </strong>There was a potential association between long-term TCM use and improved COVID-19 outcomes among cancer patients. Further research is essential to validate these findings and decipher the underlying mechanisms.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 6","pages":"850-860"},"PeriodicalIF":1.4,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144561715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge of sexually transmitted infections among health sciences students and teachers in southeastern Brazil.","authors":"Diego P Scotini, Pedro Hc Tomazelli, Michael S Miranda, Luiz G Elisei, Ehideé Ig La-Rotta, Leonardo A Dos Reis, Policardo G Da Silva","doi":"10.3855/jidc.20139","DOIUrl":"https://doi.org/10.3855/jidc.20139","url":null,"abstract":"<p><strong>Introduction: </strong>A cross-sectional study on the knowledge of sexually transmitted infections (STIs) was conducted. The objective was to assess the knowledge of STIs among health sciences students and teachers in a city in the southwest of Minas Gerais, Brazil.</p><p><strong>Methodology: </strong>The data were collected through interviews of students enrolled in undergraduate health-related courses in two higher education institutions in Passos-MG. The questionnaire included questions about the demographics of the participants, as well as questions to assess knowledge about STIs.</p><p><strong>Results: </strong>The sample consisted of 690 individuals, including 470 women, 218 men, and 2 who identified themselves as the 'other gender'. Of these, 94.3% were students and 5.7% were teachers. Among the students, 284 were from private universities and 367 were from public universities. Of the teachers, 89.7% were from public universities. The mean (standard deviation) knowledge score (on a scale of 0 to 10) of the participants was 5.44 (1.59), with a median of 5. Males had a higher mean (5.77 ± 1.61), with a median of 6; compared to females (5.27 ± 1.56), with a median of 5 (p < 0.001). In addition, teachers had a higher mean (6.26 ± 1.61), with a median of 6; compared to students (5.39 ± 1.58) with a median of 5 (p < 0.002).</p><p><strong>Conclusions: </strong>There were gaps in the knowledge of students and teachers. This is a worrying situation, and it is necessary to improve academic training on STIs and promote protected sexual relations.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 6","pages":"934-940"},"PeriodicalIF":1.4,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144561740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and antimicrobial susceptibility of Salmonella enterica Typhi in febrile patients: a cross-sectional study.","authors":"Zainab Khattak, Roohul Aala, Nimra Sani, Sher A Khan, Sana Khan, Syed A Shah, Rubina Ansar, Mohsin Riaz, Hasnat Ahmed","doi":"10.3855/jidc.20373","DOIUrl":"https://doi.org/10.3855/jidc.20373","url":null,"abstract":"<p><strong>Introduction: </strong>Typhoid fever, caused by Salmonella Typhi, is a serious health problem, especially in developing countries like Pakistan where antibiotics are usually prescribed without susceptibility testing or epidemiological surveillance. Consequently, antibiotic-resistant typhoid bacteria appear, but are not reported to the authorities. There is limited research on the prevalence and antibiotic susceptibility patterns of S. Typhi among febrile patients in Swabi, Pakistan. This study aimed to address this gap at the Bacha Khan Medical Complex in Swabi.</p><p><strong>Methodology: </strong>Laboratory records of hospitalized patients who received a blood culture from September 2022 to August 2023 were reviewed in this retrospective, cross-sectional study. Every isolate of S. Typhi underwent antibiotic susceptibility test using modified Kirby-Bauer disk diffusion and agar-dilution methods to measure the isolates' minimum inhibitory concentration (MIC) for ciprofloxacin and azithromycin. The data were analyzed using SPSS version 24.0.</p><p><strong>Results: </strong>4.85% of febrile patients were positive for S. Typhi, with a higher prevalence in the 0-14 years age group. Male gender and seasonal variation were significant factors. The isolates were resistant to ampicillin, amoxicillin, cefotaxime, and ciprofloxacin; and sensitive to azithromycin, and carbapenems. The MICs for ciprofloxacin were between 0.06 to 16 µg/mL. Among the isolates, 1.094% were sensitive and 98.90% were resistant to ciprofloxacin; and 100% isolates were susceptible to azithromycin.</p><p><strong>Conclusions: </strong>Azithromycin and carbapenem were a suitable empirical therapy choice. However, the isolates were highly resistant to conventional first-line antibiotics (ampicillin, amoxicillin), second generation fluoroquinolones (ciprofloxacin), and third-generation cephalosporins (ceftriaxone, cefotaxime), that are considered vital in typhoid treatment.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 6","pages":"904-912"},"PeriodicalIF":1.4,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144561743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetic foot osteomyelitis caused by Burkholderia pseudomallei: first case report from Türkiye and a review of literature.","authors":"Cumhur Özmen, Muhammed Soylar","doi":"10.3855/jidc.20687","DOIUrl":"10.3855/jidc.20687","url":null,"abstract":"<p><strong>Introduction: </strong>Burkholderia pseudomalleiis a non-fermenting, motile, Gram-negative, saprophytic bacillus that causes melioidosis. It is typically found as an endemic agent in South-eastern Asia and northern Australia. The primary transmission route is most likely percutaneous inoculation from wet soils or contaminated water. B. pseudomallei can cause a wide range of human diseases, including bacteremia, abscesses, osteomyelitis, and septic arthritis. Diabetes mellitus, renal disease, alcoholism, liver cirrhosis, and thalassemia are known predisposing factors. Mortality from melioidosis depends on clinical presentation, ranging from 2% (skin and soft tissue infections) to 21% (neurological disease).</p><p><strong>Case report: </strong>We reported a patient with a diabetic foot infection whose wound drainage yielded B. pseudomallei as the infecting agent. Due to the organism's rarity in our country, we searched with the keywords \"melioidosis\" and \"osteomyelitis\" in Pubmed on 09.07.2024. Among the 88 results displayed, there is a variety of case reports about septic arthritis, osteomyelitis, foot and splenic abscesses, acute cholangitis, pneumonia, pericarditis, and even cerebritis and subdural collections in patients with B. pseudomallei infections. These reports and studies mostly come from Middle Eastern and South Asian countries. There are also two previous reports of this microorganism from our country, but to our knowledge, this case is the first B. pseudomallei diabetic foot infection from Türkiye.</p><p><strong>Conclusions: </strong>This case signifies the appropriate sample collection practices for diabetic foot infections are important even in outpatient settings.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 6","pages":"982-986"},"PeriodicalIF":1.4,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144561707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive value of lactate levels for mortality in pneumonia: a systematic review and meta-analysis.","authors":"Ziyun Hu, Yanfei Qiang, Xiaolin Yan","doi":"10.3855/jidc.19898","DOIUrl":"10.3855/jidc.19898","url":null,"abstract":"<p><strong>Introduction: </strong>Lactate levels, a marker of tissue hypoxia and metabolic acidosis, have been suggested as a prognostic indicator for patient outcomes in pneumonia. This systematic review and meta-analysis aim to determine the predictive value of lactate levels for mortality in patients with pneumonia.</p><p><strong>Methods: </strong>A systematic literature search was done using CINAHL, SCOPUS, EMBASE, MEDLINE, Cochrane, Google Scholar, and ScienceDirect databases. Random-effect models were used to calculate pooled effect estimates, including sensitivity, specificity, and diagnostic odds ratios. Heterogeneity, publication bias, and meta-regression analyses were performed.</p><p><strong>Results: </strong>A total of 17 studies were included. The pooled diagnostic odds ratio for lactate levels in predicting mortality was 5 (95% CI: 3-8). The sensitivity and specificity were 61% (95% CI: 52 - 69%) and 78% (95% CI: 73 - 82%), respectively. The positive and negative likelihood ratios were 2.7 (95% CI: 2.1-3.4) and 0.51 (95% CI: 0.40-0.64). The area under the receiver operating characteristic curve was 0.77 (95% CI: 0.72-0.82). Subgroup analysis showed that studies with lactate cut-off values between 1.2 and 2 mmol/L had better sensitivity, while studies with cut-off values greater than 2 mmol/L had higher specificity.</p><p><strong>Conclusions: </strong>Lactate levels have moderate predictive value for mortality in patients with pneumonia. This indicator may potentially aid in risk stratification and clinical decision-making. Further research is needed to determine optimal lactate cut-off values and evaluate the potential benefits of incorporating lactate monitoring into pneumonia management strategies.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 6","pages":"883-889"},"PeriodicalIF":1.4,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144561742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}