Journal of Infection in Developing Countries最新文献

{"title":"Epidemiologic threats and outcome of evolving COVID-19-associated mucormycosis from a referral hospital in Egypt.","authors":"Safaa Elserougy, Muhammad Abdel-Ghaffar, Eman Medhat, Ahmed Heiba, Weam Shaheen, Elham Mostafa, Hala Mahfouz, Samah Abdel-Hafez, Mohammad S Mahfouz, Shimaa Afify, Omnia Ali, Enass El-Sayed, Ahmed M Mostafa, Ahmed M Salah, Anwar Elbatawy, Hanan M Elghoneimy, Amr A Elshafey, Ahmed Abou-ElFotouh, Tareq Abdul-Ghani, Fatma I Ibrahim, Sarah M Samy, Manal S Elhussini","doi":"10.3855/jidc.19897","DOIUrl":"https://doi.org/10.3855/jidc.19897","url":null,"abstract":"<p><strong>Introduction: </strong>The present study aimed to explore the epidemiologic threats and factors associated with the coronavirus disease 2019 (COVID-19)-associated mucormycosis (CAM) epidemic that emerged in Egypt during the second COVID-19 wave. The study also aimed to explore the diagnostic features and the role of surgical interventions of CAM on the outcome of the disease in a central referral hospital.</p><p><strong>Methodology: </strong>The study included 64 CAM patients from a referral hospital for CAM and a similar number of matched controls from COVID-19 patients who did not develop CAM.</p><p><strong>Results: </strong>The most frequent factors among CAM patients were the use of corticosteroids, older age, and diabetes. CAM patients presented with facial pain (98.4%), black coloring on nasal endoscopy examination (87.5%), orbital invasion (70.3%), and loss of vision (68.8%). Despite treatment, CAM led to the death of 30 patients and 34 patients survived until the end of the study. CAM patients with death outcomes had orbital invasion, disturbed consciousness level, referral to intensive care units, and invasive mechanical ventilation. The patients who survived received more surgical interventions than dead patients, including functional endoscopic sinus surgery (FESS) and maxillofacial surgery.</p><p><strong>Conclusions: </strong>CAM treatment requires complex, time-consuming, and expensive diagnostic approaches. Therefore, preventative measures should focus on early source control, strict glycemic control, and limiting steroids to COVID-19 patients especially older patients (> 40 years). Early antifungal treatment and surgical techniques such as FESS and necrotic tissue debridement were associated with better prognosis, indicating the efficiency of multidisciplinary medical and surgical teams.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"18 12.1","pages":"S369-S380"},"PeriodicalIF":1.4,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143042669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experiences of patients who retest positive for SARS-CoV-2 Omicron variant after discharge: a qualitative study.","authors":"Xin Liu, Ting Yun, Meimei Shang, Ronghua Kong, Yingtao Meng","doi":"10.3855/jidc.20234","DOIUrl":"https://doi.org/10.3855/jidc.20234","url":null,"abstract":"<p><strong>Introduction: </strong>In this study, we analyzed the psychological aspects of coronavirus disease 2019 (COVID-19) patients who were discharged from the hospitals in Shanghai, China, and later had positive nucleic acid retest results for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant infection (re-positive COVID-19). The purpose was to gain clarity on the patients' needs and to provide evidence for the medical staff to deliver scientific and targeted health care to the patients.</p><p><strong>Methodology: </strong>We screened patients who tested positive for SARS-CoV-2 Omicron variant infection by nucleic acid testing after having previously recovered from a COVID-19 infection and being discharged from Shanghai shelter hospitals or COVID-19-designated hospitals from April 3, 2022, to May 10, 2022. Purposive sampling and snowball sampling methods were applied. Semi-structured one-on-one interviews were performed online to collect the data, and the transcripts of the interviews were analyzed using Colaizzi's seven-step analytical method.</p><p><strong>Results: </strong>Fifteen patients were interviewed to reach saturation in this study. Four themes were generated, including negative emotions, positive emotions and self-growth, apparent effects on family life, and apparent effects on the social level. In addition, a lack of knowledge regarding re-positive COVID-19 was found.</p><p><strong>Conclusions: </strong>This study analyzed the psychological experiences of re-positive COVID-19 patients. Lack of knowledge of patients and the public about re-positive COVID-19 and irregular epidemic prevention measures in some communities were the leading causes of psychological stress in the patients. These findings can be used to optimize the management of patients in this setting.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"18 12.1","pages":"S249-S259"},"PeriodicalIF":1.4,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143042868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge and behavior towards COVID-19 in the northern region of the state of Rio de Janeiro - Brazil.","authors":"Andre L Vargas, Larissa Pv Souza, Lauryne Mbr Paes, Raleigh P Dias, Thiago F Marotti, Thais Louvain de Souza, Inez Barcellos De Andrade","doi":"10.3855/jidc.20005","DOIUrl":"https://doi.org/10.3855/jidc.20005","url":null,"abstract":"<p><strong>Introduction: </strong>Despite efforts by health organizations to share evidence-based information, fake news hindered the promotion of social distancing and vaccination during the coronavirus disease 2019 (COVID-19) pandemic. This study analyzed COVID-19 knowledge and practices in a vulnerable area in northern Rio de Janeiro, acknowledging the influence of the complex social and economic landscape on public health perceptions.</p><p><strong>Methodology: </strong>This cross-sectional study was conducted in Novo Eldorado - a low-income, conflict-affected neighborhood in Campos dos Goytacazes - using a structured questionnaire, following the peak of COVID-19 deaths in Brazil (July-December 2021). Statistical tests were used to delineate profiles and evaluate knowledge and preventive behaviors associated with COVID-19.</p><p><strong>Results: </strong>This study involved a cohort of 156 participants, predominantly women (74%), with an average age of 53 years. Almost half of the participants were identified as single (48%), and more than half had not completed elementary school. Notably, 68% believed they were well-informed about COVID-19. The answers to the questionnaire revealed that the majority correctly identified severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as a virus (65%); 72% recognized fever or cough as the main symptoms; and 71% recognized the importance of wearing masks. The overall mean score of the study was 7.628 (SD 1.583047). Social networks, especially 'WhatsApp' (65%), were the primary information sources. Those using social media or WhatsApp had higher knowledge scores (8.000 vs. 7.000, p = 0.0064).</p><p><strong>Conclusions: </strong>Involving marginalized communities and using social media to disseminate accurate information and trust in science is necessary to tackle COVID-19 challenges.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"18 12.1","pages":"S282-S288"},"PeriodicalIF":1.4,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143042896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of hemoperfusion in critically ill COVID-19 patients: a case series from a single-center hospital in Indonesia.","authors":"Aldrich Kurniawan, Dwi Lestari Partiningrum, Ivona Olivera, Steffani Sanjaya, Josephine Djunarko, Nurul Hasanah Yusri, Kevin Tandarto","doi":"10.3855/jidc.19751","DOIUrl":"https://doi.org/10.3855/jidc.19751","url":null,"abstract":"<p><strong>Introduction: </strong>Hemoperfusion (HP), a blood filtration method targeting the removal of toxins and inflammatory elements, was investigated in this study. The objective was to present the observations in four individuals with confirmed COVID-19 who underwent several rounds of HP utilizing the HA330 cartridge at a hospital in Indonesia.</p><p><strong>Case studies: </strong>We report four cases of COVID-19 patients who underwent HP. The decision to start HP in COVID-19 patients hinges on severe illness and specific indications such as refractory hypercytokinemia or cytokine storm syndrome, despite conventional treatments. Inclusion criteria were evidence of organ dysfunction; particularly the lungs, kidneys, or liver; and significant inflammatory markers or laboratory abnormalities. The four cases described here received HP as a supplementary treatment for COVID-19. However, only two of these patients successfully finished three cycles of HP, and just one exhibited improvement and was eventually declared to have recovered.</p><p><strong>Conclusions: </strong>The rationale behind HP in COVID-19 patients lies in its potential to mitigate the cytokine storm, a hallmark of severe disease. COVID-19 is known to trigger an excessive inflammatory response, leading to organ damage and respiratory distress. HP, through the use of devices such as the HA330 cartridge, aims to remove inflammatory cytokines and toxins from blood circulation. Utilizing at least three sessions of HA-330 HP in addition to standard treatment in severe COVID-19 demonstrated a beneficial effect on decreasing inflammatory biomarkers, although it did not affect mortality rates.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"18 12.1","pages":"S206-S213"},"PeriodicalIF":1.4,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143042723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the rational use of the most commonly prescribed antibiotics at the Department of Health of Ramallah in Palestine.","authors":"Omar Al-Taweel, Costa Shubeita, Fairouz Zayed, Doaa Al-Hamed, Doaa Al-Tarifi, Mustafa Alnadi, Lina Adwan","doi":"10.3855/jidc.19794","DOIUrl":"https://doi.org/10.3855/jidc.19794","url":null,"abstract":"<p><strong>Introduction: </strong>Appropriate antibiotic use requires using the right antibiotic, at the right dose, for the right duration, and at the right time. Drug-resistant diseases cause numerous deaths globally a year, and antibiotic stewardship is a cornerstone in fighting antibiotic resistance. This study focuses on tracking the antibiotic prescribing practices in Palestine and improving future antibiotic prescribing.</p><p><strong>Methodology: </strong>Data from prescriptions of the most commonly prescribed antibiotics was collected from the Health Department of Ramallah and Al-Bireh clinics between January 1 to March 31, 2020. The prescriptions were divided into three categories according to the diagnosis status: unwritten, unspecific, and precise diagnosis. The precise prescriptions were further divided into two categories: appropriate or inappropriate indication. Only appropriate prescriptions were candidates for the assessment of dose and duration appropriateness.</p><p><strong>Results: </strong>The percentages of the three categories of diagnosis precise, unspecific, and unwritten were 23.4%, 20.4%, and 56.2%, respectively. The percentage of appropriate prescriptions was 16.2%. Azithromycin was the most over-utilized antibiotic, followed by co-amoxiclav (amoxicillin/clavulanic acid). Amoxicillin and co-trimoxazole (trimethoprim/sulfamethoxazole) were under-prescribed. All the prescriptions indicated for urinary tract infections (UTIs) were inappropriate.</p><p><strong>Conclusions: </strong>Most prescriptions were not candidates for analysis due to missing diagnosis. Amoxicillin, co-amoxiclav, cefuroxime, azithromycin, and ciprofloxacin were the most commonly prescribed antibiotics and were mostly indicated for pharyngitis. The duration of all sinusitis regimens was inappropriate. More rational antibiotic use in the Department of Health could be achieved by improving documentation, following updated guidelines, choosing cost-effective agents, and keeping track of local resistance patterns and antibiograms.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"18 12","pages":"1909-1915"},"PeriodicalIF":1.4,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143014776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatitis B and C infection in HIV-infected children and young adults attending HIV treatment centres in Calabar, Nigeria.","authors":"Joanah Ikobah, Kelechi Uhegbu, Atana Ewa, Imaobong Etuk, Emmanuel Ekanem","doi":"10.3855/jidc.19327","DOIUrl":"https://doi.org/10.3855/jidc.19327","url":null,"abstract":"<p><strong>Introduction: </strong>Globally, approximately 2.7 million and 2.3 million people living with HIV are co-infected with hepatitis B and C virus, respectively. Relatively, little is known regarding HBV or HCV co-infection in HIV-infected children in Calabar, Nigeria, though the routes of transmission of the three viruses are similar. This study aimed to determine the seroprevalence and risk factors for HBV and HCV among HIV-infected children and young adults attending Paediatric HIV Care and Treatment Centres in Calabar, Cross River State, Nigeria.</p><p><strong>Methodology: </strong>This was a cross sectional study involving 204 HIV-infected children and young adults aged 1-23 years attending four outpatient treatment centers. Blood samples were obtained and tested for hepatitis B surface antigen (HBsAg) and HCV antibody (anti-HCV antibodies). Seroprevalence and factors associated with HBsAg were analyzed using Chi-square test or Fisher's exact test. A p-value of < 0.05 was considered significant.</p><p><strong>Results: </strong>The mean age of the study participants was 13.20 ± 4.39 years. Overall, four study participants were positive for HBsAg, a seroprevalence of 2%, and none was positive for HCV-Ab. All positive study participants were females aged 11 years and above, and belonged to the low and middle socio-economic class, with no vaccination against HBV.</p><p><strong>Conclusions: </strong>The seroprevalence of hepatitis B infection in this study was low, none of those positive received vaccination against HBV. In view of the public health importance of HBV infection, vaccination against HBV should be extended to children and young adults above 14 weeks of age in Nigeria.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"18 12","pages":"1942-1948"},"PeriodicalIF":1.4,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143014748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibiotic Resistance Trends in ESKAPE Pathogens Isolated at a Health Practice and Research Hospital: A Five-Year Retrospective Study.","authors":"Zerife Orhan, Özlem Kirişci, Adem Doğaner, Mehzat Altun, Burak Küçük, Murat Aral","doi":"10.3855/jidc.19592","DOIUrl":"https://doi.org/10.3855/jidc.19592","url":null,"abstract":"<p><strong>Introduction: </strong>Antimicrobial resistance remains a global threat with increasing morbidity and mortality rates. The aim of this study was to identify the antimicrobial resistance trends among ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.) isolated from clinical samples at a Health Practice and Research Hospital over five years.</p><p><strong>Methodology: </strong>Microbiological diagnosis utilized classical culture methods and automated systems. Antimicrobial susceptibility analysis was conducted using BD Phoenix, adhering to European Committee on Antimicrobial Susceptibility Testing (EUCAST) standards.</p><p><strong>Results: </strong>A total of 15,272 clinical strains of ESKAPE pathogens were identified in this study. The most frequently isolated pathogens among ESKAPE were K. pneumoniae (3.938, 27.79%), Acinetobacter baumannii (3,013, 19.73%) and Enterococcus faecium (2,966, 19.24%). Bacterial strains were isolated predominantly from urine (3,263, 21.37%), followed by blood cultures (3,099, 20.29%). ESKAPE pathogens were most commonly found in internal intensive care units (4,758, 31.16%), followed by surgical intensive care units (4,000, 26.19%). Reduced resistance rates were observed for most antibiotics against Enterococcus faecium and Staphylococcus aureus. The vancomycin resistance rate for Enterococcus faecium was 18.48%, and the methicillin resistance rate for Staphylococcus aureus was 44.87%. A concerning trend of increasing antimicrobial resistance was noted in Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.</p><p><strong>Conclusions: </strong>The alarming rise in antimicrobial resistance among Pseudomonas aeruginosa, Acinetobacter baumannii, and Klebsiella pneumoniae is a significant concern. The high rates of antimicrobial resistance observed in ESKAPE pathogens underscore the urgent need for improvement in antimicrobial stewardship and infection prevention and control programs.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"18 12","pages":"1899-1908"},"PeriodicalIF":1.4,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143014775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A study of the risk factors for Ureaplasma urealyticum infection and the predictive role of immunoinflammation.","authors":"Yanhui Li, Jie Zheng, Junpeng Zhao, Wenjie Qi, Yuhong Yao, Dongxue Gao, Jinyin Yan","doi":"10.3855/jidc.19723","DOIUrl":"https://doi.org/10.3855/jidc.19723","url":null,"abstract":"<p><strong>Introduction: </strong>Despite increasing awareness on the prevention of Ureaplasma urealyticum (Uu) infection, the high-risk factors responsible for infection in female patients in China are yet to be determined.</p><p><strong>Methodology: </strong>The study included 3043 Chinese women. Cervical secretion samples were collected for Uu identification.</p><p><strong>Results: </strong>Higher age groups (25-30, 30-35, 35-40, and >40 years) had a higher risk of Uu infection (OR = 1.46; OR = 1.51; OR = 1.71; OR = 2.49, respectively). Being literate, and use of intrauterine device (IUD), or other contraceptive methods could reduce the risk of Uu infection (OR = 0.64; OR = 0.79; OR = 0.76, respectively). Women with low level of cleanliness or promiscuous behavior had a higher risk of Uu infection (OR = 1.42; OR = 1.41, respectively). Among the Uu-positive patients, 66.84%, 24.81%, and 8.35% were infected with biovars 1, 2, and coinfection. The predominant subtypes were S6 serotypes (28.91%) in biovar 1 and S2` subtypes (62.73%) in biovar 2. The possibility of S1 + S6 infection was lower than that in S1 patients (OR = 0.529). C-reactive protein (CRP) and systemic immune inflammation index (SII) could be used to predict Uu infection (area under curve, AUC = 0.55; AUC = 0.68, respectively).</p><p><strong>Conclusions: </strong>Uu-positive patients were infected with two biovars and multiple subtypes. Age, method of contraception, cleanliness, education level, promiscuity, and subtypes of Uu were factors influencing Uu infection. CRP and SII provide a new strategy for clinical diagnosis of Uu infection.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"18 12","pages":"1883-1890"},"PeriodicalIF":1.4,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143014685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seroprevalence of peste des petits ruminants in sheep and goats managed under pastoral and agro-pastoral systems.","authors":"Julius Joseph Mwanandota, Gilbert Msuta, Daniel Mdetele, Raphael Sallu, George Paul Omondi, Augustino Chengula, Sharadhuli Kimera, Satya Parida, Gerald Misinzo","doi":"10.3855/jidc.19704","DOIUrl":"https://doi.org/10.3855/jidc.19704","url":null,"abstract":"<p><strong>Introduction: </strong>Peste des petits ruminants (PPR) is an infectious disease that imposes substantial economic burdens on small ruminants (SR) production. For Tanzania to develop efficient management and eradication plans, it is essential to comprehend the seroprevalence of PPR designated for global elimination by 2030.</p><p><strong>Methodology: </strong>This study investigated the prevalence of PPR in animals kept under pastoral and agropastoral communities in Tanzania. A total of 1,128 blood samples from SR were collected and analyzed for PPR-specific antibodies using the HPPR-b ELISA technique. Multivariate logistic regression was used to analyze the risk factors.</p><p><strong>Results: </strong>The overall seroprevalence was 10%. Higher seropositivity was observed in the Kiteto, Longido, and Simanjiro districts of the northern zone and the Mbarali district of the southern highlands, with the seroprevalence decreasing trend from the northern to southern zones. Multivariate logistic regression analysis for risk factors identified significant differences in seroprevalence across disease surveillance zones, with odds ratios (OR) ranging from 2 to 3.</p><p><strong>Conclusions: </strong>Agropastoral production systems exhibited lower PPR seroprevalence compared to pastoral systems. The increasing seropositivity in the Mbarali district suggests a southward spread of PPR, increasing a threat to Tanzania`s southern regions and neighboring countries. The disease`s dissemination is closely linked to livestock trading infrastructure, highlighting the need for periodic seromonitoring. Control efforts should prioritize highly affected northern zones and implement strict regulations on animal movement to protect less-affected southern areas.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"18 12","pages":"1867-1874"},"PeriodicalIF":1.4,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143014754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of anti-infective therapy on patients undergoing warfarin treatment.","authors":"Linlin Fu, Huimin Yao, Wei Xu, Li Li, Baoyan Wang","doi":"10.3855/jidc.19802","DOIUrl":"https://doi.org/10.3855/jidc.19802","url":null,"abstract":"<p><strong>Introduction: </strong>The combination of antibiotics and warfarin is used frequently in clinical practice. However, the impact of this combination on the anticoagulant efficacy of warfarin remains uncertain, posing challenges to clinical decision-making. This study aimed to evaluate the influence of various antibiotics on the international normalized ratio (INR) values in hospitalized patients who were concurrently administered warfarin.</p><p><strong>Methodology: </strong>This retrospective cohort study enrolled patients who received concomitant warfarin and antibiotic therapy at the Nanjing Drum Tower Hospital, between January 2013 and December 2022. The patients were categorized into 8 groups based on the type of antibiotics they were received. The demographic characteristics were recorded, and the clinical outcomes were focused on changes in INR values after combining antibiotics in warfarin users.</p><p><strong>Results: </strong>A total of 623 patients were enrolled in this study. Based on analysis of covariance (ANCOVA), the maximum INR values of the combinations were as follows: 2.72 for oxazolidinones, 2.86 for β-lactams, 2.86 for carbapenems, 2.91 for glycopeptides, 2.91 for macrolides, 3.77 for quinolones, 4.13 for sulfonamides, and 4.37 for antifungal agents. Pairwise comparisons revealed that quinolones, sulfonamides, and antifungal agents manifested the most substantial elevation in INR values when co-administered with warfarin. β-lactams, glycopeptides, oxazolidinones, macrolides, and carbapenems demonstrated a comparatively weaker impact on INR values.</p><p><strong>Conclusions: </strong>Co-administration of warfarin with antibiotics led to an elevation in INR values in patients. Quinolones, sulfonamides, and antifungal agents had the most pronounced impact.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"18 12","pages":"1930-1936"},"PeriodicalIF":1.4,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143014790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}