Observational study on Aspergillus infections in critically ill patients with coronavirus disease 2019 at a single medical center using sputum samples.

IF 1.2 4区医学 Q4 INFECTIOUS DISEASES

Journal of Infection in Developing Countries Pub Date : 2025-05-31 DOI:10.3855/jidc.20072

Rui-Ming Xu, Xiao-Li Yuan, Qing-Qing Ge, Yan-Yun He, Qiu-Mei Cao

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引用次数: 0

Abstract

Objective: To explore Aspergillus infection's risks, treatment, and prognostic factors in critically ill COVID-19 patients.

Methodology: Retrospective analysis of 50 critically ill COVID-19 patients' data. Patients were divided into Aspergillus infection group (10 cases) and non-Aspergillus infection group (40 cases) to examine risk factors and compare hospitalization length, expenses, and survival outcomes.

Results: Logistic regression showed a significant correlation between Aspergillus infection and diabetes history, and steroid use duration in COVID-19 patients. Diabetes increased Aspergillus infection risk 9.708 times (not statistically significant). Each extra steroid use day raised infection risk by 25.6%. The Aspergillus infection group had longer hospital stays, and higher costs (p < 0.05) but surprisingly higher survival rate than the non-infection group (p < 0.05).

Conclusions: The main risk factor for Aspergillus infection in critically ill COVID-19 patients is steroid use duration. The infection group had longer hospital stays and higher costs, and Aspergillus infection affected the survival duration of critically ill COVID-19 patients.

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2019冠状病毒病危重患者痰液中曲霉感染的观察性研究

目的：探讨COVID-19危重症患者曲霉感染的风险、治疗及预后因素。方法：回顾性分析50例COVID-19危重症患者资料。将患者分为曲霉感染组（10例）和非曲霉感染组（40例），检查危险因素，比较住院时间、费用和生存结局。结果：Logistic回归显示COVID-19患者曲霉感染与糖尿病史、类固醇使用时间有显著相关性。糖尿病使曲霉感染风险增加9.708倍（无统计学意义）。每多使用一天类固醇，感染风险就增加25.6%。曲霉感染组住院时间更长，费用更高（p < 0.05），但生存率明显高于未感染组（p < 0.05）。结论：COVID-19危重症患者曲霉感染的主要危险因素是类固醇使用时间。感染组住院时间更长，费用更高，曲霉感染影响COVID-19危重患者的生存时间。

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来源期刊

Journal of Infection in Developing Countries INFECTIOUS DISEASES-

CiteScore

3.70

自引率

5.30%

发文量

239

审稿时长

4-8 weeks

期刊介绍： The Journal of Infection in Developing Countries (JIDC) is an international journal, intended for the publication of scientific articles from Developing Countries by scientists from Developing Countries. JIDC is an independent, on-line publication with an international editorial board. JIDC is open access with no cost to view or download articles and reasonable cost for publication of research artcles, making JIDC easily availiable to scientists from resource restricted regions.