Decreased albumin to INR ratio is a prognostic marker of 30-day mortality in neonatal sepsis: a retrospective study.

IF 1.2 4区医学 Q4 INFECTIOUS DISEASES

Journal of Infection in Developing Countries Pub Date : 2025-09-30 DOI:10.3855/jidc.20968

Xiangwen Tu, Junkun Chen, Wen Liu

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引用次数: 0

Abstract

Introduction: Neonatal sepsis is a leading cause of neonatal mortality. This study aims to assess the clinical significance of the serum albumin (ALB) to international normalized ratio (INR) ratio (AIR) as a predictor for 30-day mortality in neonates with sepsis.

Methodology: Neonates diagnosed with sepsis between January 2019 and December 2022 were included. Admission data were collected, enabling the categorization of neonates into survival and non-survival groups. Logistic regression analyses and receiver operating characteristic (ROC) curves, were employed.

Results: A total of 195 neonates with sepsis were analyzed. The non-survival group exhibited significantly lower AIR compared to the survival group. Multivariate analysis identified low AIR as an independent risk factor (hazard ratio [HR]: 9.091, p < 0.001), achieving an area under the curve (AUC) of 0.746 for AIR. The sensitivity and specificity of AIR were 79.31% and 66.87%, respectively.

Conclusions: AIR serves as a cost-effective and easily obtainable marker in neonatal sepsis research. It emerges as an independent predictor of adverse outcomes in neonatal sepsis, demonstrating good predictive capabilities.

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白蛋白与INR比值降低是新生儿败血症30天死亡率的预后指标：一项回顾性研究。

新生儿败血症是新生儿死亡的主要原因。本研究旨在评估血清白蛋白（ALB）与国际标准化比值（INR）比值（AIR）作为脓毒症新生儿30天死亡率预测指标的临床意义。方法：纳入2019年1月至2022年12月期间诊断为败血症的新生儿。收集入院数据，将新生儿分为生存组和非生存组。采用Logistic回归分析和受试者工作特征（ROC）曲线。结果：对195例新生儿败血症进行分析。与生存组相比，非生存组表现出明显较低的AIR。多因素分析发现低空气是独立危险因素（风险比[HR]: 9.091, p < 0.001），空气的曲线下面积（AUC）为0.746。AIR的敏感性为79.31%，特异性为66.87%。结论：AIR在新生儿脓毒症研究中是一种成本效益高且易于获得的标志物。它是新生儿败血症不良结局的独立预测因子，显示出良好的预测能力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Infection in Developing Countries INFECTIOUS DISEASES-

CiteScore

3.70

自引率

5.30%

发文量

239

审稿时长

4-8 weeks

期刊介绍： The Journal of Infection in Developing Countries (JIDC) is an international journal, intended for the publication of scientific articles from Developing Countries by scientists from Developing Countries. JIDC is an independent, on-line publication with an international editorial board. JIDC is open access with no cost to view or download articles and reasonable cost for publication of research artcles, making JIDC easily availiable to scientists from resource restricted regions.