Journal of Infection in Developing Countries最新文献

{"title":"Commensal mouth bacteria are the main cause of dentoalveolar abscesses in the maxillofacial region.","authors":"Sinan Rusinovci, Milaim Sejdini, Sami Salihu, Naim Haliti, Doroteja P Jukić, Andrej Starc, David Stubljar, Tomislav Jukic","doi":"10.3855/jidc.20202","DOIUrl":"https://doi.org/10.3855/jidc.20202","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of this study was to investigate the bacterial strains that most commonly cause abscesses after failed endodontic treatment.</p><p><strong>Methodology: </strong>102 pus samples from dentoalveolar abscesses were examined for bacterial growth. Additionally, 102 samples of healthy gingiva from the same patients were swabbed for comparison of etiology. The swabs were inoculated on blood, chocolate, and Schaedler agar plates; and incubated aerobically and anaerobically. Isolated pathogenic bacteria were compared to healthy oral flora from 50 healthy individuals. Bacterial strains were identified using the matrix assisted laser desorption ionization-time of flight (MALDI-TOF) method and susceptibility was tested using VITEK 2.</p><p><strong>Results: </strong>The same microorganism was identified from the healthy and abscess side of the oral cavity in 50.0% of the cases. The most commonly identified healthy aerobic flora were coagulase-negative staphylococci, alpha-hemolytic Streptococcus, Enterococcus, and Klebsiella spp. The most identified anaerobes were Actinomyces, Lactobacillus, and Bacteroides spp. Identification of 6 vancomycin-resistant Enterococcus, 3 amoxiclav resistant Actinomyces spp., 1 extended-spectrum beta-lactamases (ESBL) E. coli, and 2 ESBL Klebsiella spp. were confirmed. A significant correlation was found between prescription of amoxiclav before surgery and isolation of amoxiclav-resistant Actinomyces spp. (p = 0.035).</p><p><strong>Conclusions: </strong>Common oral flora caused dental abscesses. Not much antimicrobial resistance was detected among the bacterial isolates. However, the dentists used antibiotics irresponsibly because a few cases were identified where the bacteria were resistant to antibiotics used prior to removal of dentoalveolar abscesses.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 1","pages":"107-116"},"PeriodicalIF":1.4,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143469382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Over-prescription of Watch antibiotics in primary healthcare settings in Sudan: results from routinely collected prescription data.","authors":"Enjy Abdou, Rayan Hayder, Mohamed Salaheldin, Elseddig Eltayeb","doi":"10.3855/jidc.20106","DOIUrl":"10.3855/jidc.20106","url":null,"abstract":"<p><strong>Introduction: </strong>Antimicrobial resistance represents a significant challenge in Sudan, further exacerbating the burden on healthcare systems already grappling with infectious disease epidemics. This study aims to examine the patterns of antibiotic prescription in primary healthcare settings (PHC) in Sudan and its compliance to the World Health Organization (WHO) Access, Watch and Reserve (AWaRe) antibiotic book.</p><p><strong>Methodology: </strong>We collected retrospective data on antibiotic prescriptions at 325 PHCs in five states in Sudan for 2022. We collected patient-level data only for prescriptions with at least one antimicrobial prescribed. We used descriptive analysis to identify patterns of antibiotic prescribing according to the WHO AWaRe classification and to calculate the compliance of antibiotic prescriptions against the WHO AWaRe antibiotic book.</p><p><strong>Results: </strong>A total of 52,274 antimicrobials were prescribed during 41,102 outpatient visits. Antibiotics accounted for 84.1% (n = 43,941) of prescriptions, of which 29.0% (n = 15,160) belonged to the Access antibiotics while 71.0% (n = 37,114) were from the Watch group. None of the prescribed antibiotics were from the Reserve group. Treatment of community-acquired pneumonia showed the highest compliance to the WHO AWaRe antibiotic book (40.1%, n = 447) followed by typhoid (31.5%, n = 53) and urinary tract infection (22.2%, n = 486). Though mostly caused by viral etiology, all patients with bronchitis received antibiotics.</p><p><strong>Conclusions: </strong>Over-prescribing Watch antibiotics in outpatient settings in Sudan necessitates adopting multifaceted approaches including context-specific antimicrobial stewardship programs and behavioral change interventions targeting patients and prescribers.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 1","pages":"91-97"},"PeriodicalIF":1.4,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143469746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical, epidemiological, and pathological findings of ovine gammaherpesvirus 2 infections in cattle from Southern Brazil.","authors":"Selwyn Arlington Headley, Juliana Torres Tomazi Fritzen, Érika Fernandes Lopes Maturana, Natali Araujo Correia Alves de Alvarenga, Rafael Vince Rodrigues, Ana Laura Paulino Leite Gomes, Maria Constanza Rodriguez, Maria Izabel Pedra Sogari, Ana Aparecida Correa Xavier, Flávia Helena Pereira Silva, Priscilla Fajardo Valente Pereira, Vitor Bruno Bianconi Rosa, Karina Keller Marques da Costa Flaiban, Giovana Wingeter Di Santis, Thais Helena Constantino Patelli, Júlio Augusto Naylor Lisbôa, Amauri Alcindo Alfieri","doi":"10.3855/jidc.19951","DOIUrl":"https://doi.org/10.3855/jidc.19951","url":null,"abstract":"<p><strong>Introduction: </strong>Sheep associated-malignant catarrhal fever is a frequently fatal, lymphoproliferative, and vascular disease caused by ovine gammaherpesvirus 2 (OvGHV2), a member of the malignant catarrhal fever virus (MCFV) complex. OvGHV2-related epidemics normally have reduced morbidity with elevated lethality.</p><p><strong>Methodology: </strong>This study investigated the causes of elevated morbidity, mortality, and lethality in cattle maintained on Brachiaria grass pastures and with neurological and enteric disease syndromes from nine farms in Paraná, Southern Brazil.</p><p><strong>Results: </strong>The principal histopathological findings included necrotizing lymphocytic vasculitis, proliferative vascular lesions, and toxic cholangiohepatitis. An immunohistochemical (IHC) assay utilizing the 15A monoclonal antibody (15A-MAb), which is specific for MCFV, revealed positive intracytoplasmic immunoreactivity within the epithelial cells of the lungs, intestine, liver, and kidneys in most animals, confirming infections by MCFV. PCR detected singular infections by OvGHV2 (n = 3) and bovine gammaherpesvirus 6 BoGHV6 (n = 3) in cattle with positive intracytoplasmic immunoreactivity by the 15A-MAb IHC assay. In one animal with positive immunoreactivity to the 15A-MAb IHC assay, neither Macavirus was identified through molecular testing.</p><p><strong>Conclusions: </strong>These findings suggested that these two Macavirus were associated with the positive IHC findings. Additionally, the non-detection of OvGHV2 and BoGHV6 in the organs of one animal, despite typical vascular lesions and with positive IHC results, suggests that another Macavirus may be involved. Moreover, the identification of BoGHV6 DNA in cattle not infected by OvGHV2 but containing MCFV antigens, indicates cross-reactivity of BoGHV6 with the 15A-MAb assay. The possibe role of Bracharia on the occurrence of these infections is discussed.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 1","pages":"124-139"},"PeriodicalIF":1.4,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143469448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Colistin and β-lactam resistance in Escherichia coli isolates from bovines, swine, and humans.","authors":"Nayla Kellen de O Ventura, Leslye R Freitas, Flaviana A Sousa, Marcus Vinicius C Cossi, Luis Augusto Nero, Ricardo S Yamatogi","doi":"10.3855/jidc.20143","DOIUrl":"https://doi.org/10.3855/jidc.20143","url":null,"abstract":"<p><strong>Introduction: </strong>Colistin and β-lactams are widely investigated because of their effectiveness in the treatment of human diseases. This study investigated the phenotypic and genotypic profiles of colistin- and β-lactam-resistant Escherichia coli (n = 235) obtained from bovines, swine, and workers from a mixed slaughterhouse in Brazil.</p><p><strong>Methodology: </strong>The disk diffusion method was used to test the resistance against β-lactams (amoxicillin, ampicillin, cefaclor, cefazolin, cefepime, cefotaxime, ceftazidime, ceftriaxone, imipenem, meropenem, and aztreonam). In order to test colistin resistance, the isolates were subjected to the minimum inhibitory concentration (MIC) technique using the broth microdilution method (BMD; 0.5 to 16 μg/mL) and polymerase chain reaction (PCR) assays targeting colistin- (mcr-1 to mcr-5) and β-lactam- (blaTEM, blaCTX-M, blaSHV, ampC) genes. The pmrAB mutation was further investigated.</p><p><strong>Results: </strong>The isolates presented resistance, especially to ampicillin (cattle: 14/106, swine: 62/100, humans: 10/29) and amoxicillin (cattle: 7/106, swine: 61/100, humans: 8/29). One swine isolate was characterized as extended spectrum β-lactamase (ESBL) producer. The isolates obtained from swine presented higher frequencies of colistin resistance (13/100) when compared to isolates from bovines (5/106) and humans (0/29). Molecular assays concluded that the isolates presented blaTEM (swine: 67/100, humans: 7/29), ampC (swine: 1/100), and blaCTXM (swine: 1/100). The pmrAB complex presented mutations (T31S, P42A, I128N, G144S, H2R, N358Y, D283G, K15I).</p><p><strong>Conclusions: </strong>This study highlights the presence of antimicrobial resistance and presents a method to verify these factors in the animal production chain.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 1","pages":"49-57"},"PeriodicalIF":1.4,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143469449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perceptions of hospital pharmacists regarding roles in preventing and minimizing prescribing cascades: a mixed-method study.","authors":"Mahnoor Asad, Waseem Ullah, Márió Gajdács, Melinda Madléna, Suresh Shanmugham, Sajesh K Veettil, Shazia Q Jamshed","doi":"10.3855/jidc.19554","DOIUrl":"https://doi.org/10.3855/jidc.19554","url":null,"abstract":"<p><strong>Introduction: </strong>A prescribing cascade occurs when new medications are prescribed to address an adverse drug reaction (ADR) associated with the preceding use of a medication, which may be mistaken as the onset of a novel disease or condition. The aim of this study was to evaluate the perceptions of hospital pharmacists regarding roles in preventing and minimizing prescribing cascades.</p><p><strong>Methodology: </strong>A qualitative, semi-structured interview, followed by a quantitative, questionnaire-based study, was carried out at the Shifa International Hospital (SIH; Islamabad, Pakistan). Discharge summaries of patients aged ≥ 60 years were collected to assess the prevalence of polypharmacy at SIH.</p><p><strong>Results: </strong>Discharge summaries of n = 350 patients were collected; 60.2% (n = 211) had comorbid conditions, and the co-occurrence of diabetes and hypertension were the most common. 37.8% (n = 132) were taking 8 or more medications. Eight (n = 8) hospital pharmacists participated in the qualitative study, and 4 major themes were identified in their perceptions regarding prescribing cascades. Fifty-two (n = 52) pharmacists were recruited in the quantitative phase. 86.5% (n = 45) of the participants reported long standing illness/chronic conditions; 67.3% (n = 35) noted the presence of comorbidities as a high risk, while 90.3% (n = 47) noted multiple prescribers, and 75.0% (n = 39) identified the ageing population as important risks factors for polypharmacy.</p><p><strong>Conclusions: </strong>The current research may inform the role and responsibilities of hospital pharmacists in outpatient and inpatient departments, and in interprofessional care teams, in preventing and minimizing prescribing cascades.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 1","pages":"58-66"},"PeriodicalIF":1.4,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143469688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immune response and leukocyte profile in patients infested with Sarcoptes scabiei in Duhok Province of Kurdistan region, Iraq.","authors":"Ahmed J Ahmed, Shamal A Al-Muffti, Malika K Najeeb","doi":"10.3855/jidc.19348","DOIUrl":"https://doi.org/10.3855/jidc.19348","url":null,"abstract":"<p><strong>Introduction: </strong>Scabies is a skin condition that affects humans and many other mammalian hosts. It is brought on by the major obligate parasite Sarcoptes scabiei, which lives and reproduces in the epidermis and causes significant morbidity in both humans and animals.</p><p><strong>Methodology: </strong>The current study aimed to determine the immunological responses of 60 patients who were clinically infested with scabies and who attended the Department of Dermatology at Azadi Teaching Hospital and the Gulan General Hospital at Akre. Serum samples were tested to measure the levels of total immunoglobulin E (IgE), interleukin 4 (IL-4), interleukin 5 (IL-5), complement protein 3 (C3), and complement protein 4 (C4) in all patients with scabies; and compared with non-infested healthy individuals as a control group. A fresh blood sample from each patient was tested for total white blood cell (WBC) count, lymphocytes, monocytes, neutrophils, eosinophils and basophils.</p><p><strong>Results: </strong>The present study showed a significant increase in the mean of total WBCs and absolute eosinophil counts in patients infested with scabies when compared with controls (p ≤ 0.05). There were significant differences (p ≤ 0.05) in the mean of total IgE, IL4, Il-5, C3, and C4 serum levels in patients infested with scabies when compared with the controls. Non-significant differences (p < 0.05) were recorded for the other parameters that were measured.</p><p><strong>Conclusions: </strong>Scabies infection increased the levels of eosinophils and other immunological parameters, including IL4, Il-5, C3, C4, and total IgE.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 1","pages":"162-167"},"PeriodicalIF":1.4,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143469697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibiotics in the treatment of scrub typhus: A network meta-analysis and cost-effectiveness analysis.","authors":"Chaoxin Chen, Tingting Chen, Dan Xue, Maobai Liu, Bin Zheng","doi":"10.3855/jidc.19228","DOIUrl":"https://doi.org/10.3855/jidc.19228","url":null,"abstract":"<p><strong>Introduction: </strong>A pharmacoeconomic analysis model was developed to evaluate the cost-effectiveness of antibiotics from a societal perspective in Korea and China. A network meta-analysis was conducted to evaluate the efficacy of antibiotics.</p><p><strong>Methodology: </strong>We conducted a systematic search for randomized controlled trials or quasi-randomized controlled trials on antibiotics employed as therapy in scrub typhus management. We performed a network meta-analysis to obtain their relative efficacy. The outcome measures for efficacy were cure rate and non-relapse rate. To evaluate their relative cost-effectiveness in Korea and China, a decision analytic model simulating a cohort of scrub typhus patients using antibiotics as therapy was constructed from a societal perspective over 8 weeks. The number of cure cases per 1000 patients and the incremental cost-effectiveness ratio (ICER) was calculated.</p><p><strong>Results: </strong>We identified 11 relevant articles for network meta-analysis. Of the seven comparisons (azithromycin, chloramphenicol, doxycycline, high-dose rifampin, low-dose rifampin, telithromycin, tetracycline) included in the network meta-analysis, tetracycline was the most effective drug for the treatment of scrub typhus, but the difference is not significant. In the cost-effectiveness analysis, all the treatments were dominated by tetracycline in Korea and China.</p><p><strong>Conclusions: </strong>Tetracycline is the most economic drug for the treatment of scrub typhus. Hence, tetracycline is recommended as the first choice for the treatment of scrub typhus without contraindications in China and Korea.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 1","pages":"67-75"},"PeriodicalIF":1.4,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143469268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical behavior of COVID-19 in a reference public hospital in Mexico City during SARS-CoV-2 epidemiological waves.","authors":"Alejandro Hernández-Solis, Pablo Álvarez-Maldonado, Yutzil M Velázquez Gachuz, León A Balderas-Salazar","doi":"10.3855/jidc.20076","DOIUrl":"https://doi.org/10.3855/jidc.20076","url":null,"abstract":"<p><strong>Introduction: </strong>The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic presented a unique behavior in each of the epidemiological waves in terms of clinical presentation, severity, and transmissibility; in Mexico, as in the rest of the world. The objective of this study was to describe the clinical severity and risk factors associated with mortality in patients hospitalized with coronavirus disease 2019 (COVID-19), by comparing each epidemiological wave in a reference public hospital in Mexico City.</p><p><strong>Methodology: </strong>The Kaplan-Meier and logistic regression analyses were performed to determine the mortality and odds ratio of 1,752 patients according to their specific comorbidity and during each epidemiological wave.</p><p><strong>Results: </strong>The average age of the patients was 54 years. Each patient presented at least one comorbidity; such as, diabetes mellitus (33.3%), systemic arterial hypertension (28.3%), chronic kidney disease (8.67%), chronic obstructive pulmonary disease (1.35%), and cancer (4.82%). The average length of hospital stay was 11.93 days. General mortality was 29%, with the percentage of deaths being higher in the first and second waves of COVID-19. Admission to the intensive care unit and mechanical ventilation were required in 21.6% and 5%, respectively.</p><p><strong>Conclusions: </strong>Chronic diseases such as diabetes mellitus and arterial hypertension were associated with a higher risk of death in patients hospitalized with COVID-19. This phenomenon was more evident during the first and second epidemiological waves of the pandemic in Mexico.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 1","pages":"17-21"},"PeriodicalIF":1.4,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143469444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of multiplex syndromic panel tests with conventional methods in the detection of gastroenteritis agents.","authors":"Özlem Aydemir, Hande Toptan, Elif Ö Şahin, Hüseyin A Terzi, Gökçen Ormanoğlu, Mehmet Köroğlu, Mustafa Altındiş","doi":"10.3855/jidc.19386","DOIUrl":"https://doi.org/10.3855/jidc.19386","url":null,"abstract":"<p><strong>Introduction: </strong>We aimed to evaluate the performance of multiplex polymerase chain reaction (PCR)-based FTD gastroenteritis kit (Fast-Track Diagnostics, Esch-sur-Alzette, Luxembourg) and QIAstat-Dx gastrointestinal panel (Q-GP; Hilden, Germany) in the detection of different enteric pathogens.</p><p><strong>Methodology: </strong>The molecular test results of 320 stool samples from patients with a preliminary diagnosis of infectious gastroenteritis between July 2019 and October 2023 were retrospectively examined, and compared with conventional test results.</p><p><strong>Results: </strong>A single pathogen was detected in 144 samples, and more than 1 pathogen was detected in 22 samples with FTD and QIAstat-Dx GP. Salmonella was isolated by culture in 30% samples that were detected as Salmonella-positive by PCR. Shigella, Campylobacter, verotoxin producing Escherichia coli, Shiga-like toxin producing E. coli, enteropathogenic E. coli, enteroaggregative E. coli, and enterotoxigenic E. coli were detected by molecular tests; but could not be isolated in stool culture. Rotavirus was detected by PCR in 11.1% samples; antigen test was positive in 20% samples that were adenovirus-positive based on molecular tests. Five percent of the samples in which C. difficile was detected by molecular tests were determined to be toxin A/B positive by immunochromatographic test. G. lamblia trophozoites were seen in direct microscopic evaluation in samples that were identified as G. lamblia positive by PCR.</p><p><strong>Conclusions: </strong>The multiplex gastrointestinal pathogen panel test is a simpler and faster test than traditional microbiology methods. However, the effect of these test results on the patient`s diagnosis and treatment needs to be investigated. More studies are needed to compare standard and molecular methods.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 1","pages":"76-82"},"PeriodicalIF":1.4,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143469611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"OXA-48-producing Enterobacteriaceae in North of Morocco: Data from regional hospital of Tangier.","authors":"Younes Mahrach, Nadira Mourabit, Mohamed Bakkali, Abdelhay Arakrak, Amine Laglaoui","doi":"10.3855/jidc.18564","DOIUrl":"https://doi.org/10.3855/jidc.18564","url":null,"abstract":"<p><strong>Introduction: </strong>This is a three-year retro-prospective study aimed at assessing the prevalence of carbapenem-resistant Enterobacteriaceae and to study three-year retrospective study aimed at determining the prevalence of carbapenem-resistant Enterobacteriaceae and analyzing the characteristics of OXA-48 producers.</p><p><strong>Methodology: </strong>Six thousand one hundred eighteen bacteriological samples were assessed at Mohamed V Regional Hospital microbiology laboratory in Tangier, Morocco.</p><p><strong>Results: </strong>Of the 1,228 identified Enterobacteriaceae, Escherichia coli was the most isolated bacteria (68%). Fifty-eight Enterobacteriaceae were resistant to carbapenem (4.7%). Klebsiella pneumoniae, Escherichia coli, and Enterobacter cloacae were the most common carbapenemase-producing isolates (43.1%, 27.5%, and 20.7%, respectively). All isolates were resistant to ertapenem, 62% to imipenem, whereas the lowest rate of resistance to carbapenems was against meropenem (51%). Among carbapenemase-producing isolates, 13.8% also produced extended-spectrum beta-lactamase. Most carbapenemase-producing Enterobacteriaceae isolates harbored the gene blaOXA-48 (84.5%).</p><p><strong>Conclusions: </strong>Our findings highlight the alarming situation of the probable misuse of antibiotics. Awareness-raising sessions about the appropriate use of antibiotics and improving hospital hygiene are highly needed.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 1","pages":"83-90"},"PeriodicalIF":1.4,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143469687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}