Journal of Infection in Developing Countries最新文献

{"title":"Antibiogram and molecular insights into quinolone resistance in Salmonella spp. from food-producing animals in the Philippines.","authors":"Lawrence P Belotindos, Angel Mae C Magalong, Marvin Bryan S Salinas, Joel A Miguel, Marvin A Villanueva, Claro N Mingala, Chie Nakajima, Yasuhiko Suzuki","doi":"10.3855/jidc.21739","DOIUrl":"10.3855/jidc.21739","url":null,"abstract":"<p><strong>Introduction: </strong>The increasing quinolone resistance in food animals in the Philippines has been documented in previous studies. This study aims to investigate the prevalence and underlying molecular mechanisms responsible for quinolone non-susceptibility in Salmonella isolated from food-producing animals.</p><p><strong>Methodology: </strong>A total of 227 Salmonella isolates were obtained from food-producing animals and their derived food products in the Philippines. These isolates were subjected to antimicrobial susceptibility testing against 17 different agents. Quinolone non-susceptible isolates were screened for mutations in the quinolone resistance-determining region (QRDR) and plasmid-mediated quinolone resistance (PMQR) genes. QRDR- and PMQR-positive isolates were also screened for virulence genes and genotyped using the multilocus sequence typing (MLST) method.</p><p><strong>Results: </strong>Most isolates showed high resistance to tetracycline, ampicillin, streptomycin, sulfamethoxazole-trimethoprim, and nalidixic acid. About 68.3% of the isolates showed resistance to at least one antimicrobial agent, and 44.9% exhibited multidrug resistance. Out of the 74 quinolone non-susceptible isolates, 74.3% carried amino-acid substitutions in the QRDR of GyrA and ParC, 4.1% harbored PMQR genes, and 14.9% had both. High-level resistance was associated with double amino-acid substitutions in GyrA (Ser83Phe + Asp87Tyr) and ParC (Thr57Ser + Ser80Ile), while PMQR-positive isolates displayed variable low resistance. Moreover, 17 unique sequence types (STs) were identified, predominantly S. London ST155, S. Infantis ST32, and S. Anatum ST64. All Salmonella isolates exhibit QRDR mutations and/or PMQR genes that possess virulence factors invA and agfA.</p><p><strong>Conclusions: </strong>The findings highlight the widespread fluoroquinolone-resistant Salmonella in food-producing animals and their products, posing a significant threat to the effective treatment of Salmonella-related food-borne diseases.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"20 2","pages":"195-207"},"PeriodicalIF":1.2,"publicationDate":"2026-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147370132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pancytopenia associated with Weissella confusa septicemia.","authors":"Canan Akkus, Abdulhamid Arslan","doi":"10.3855/jidc.21449","DOIUrl":"10.3855/jidc.21449","url":null,"abstract":"<p><strong>Introduction: </strong>Weissella spp. are facultative gram-positive bacteria. They are also part of the human microbiota and can cause opportunistic infections. There are very few case reports in the literature describing bacteremia caused by W. confusa.</p><p><strong>Case presentation: </strong>A 74-year-old male patient presented to the Internal Medicine Department of Ankara Etlik City Hospital with complaints of fever, chills, nausea, and vomiting. Laboratory tests revealed pancytopenia. Etiological investigation identified W. confusa in blood cultures using MALDI-TOF MS, and other potential causes of pancytopenia were excluded. The patient had chronic kidney disease and was undergoing hemodialysis three times a week.</p><p><strong>Conclusions: </strong>W. confusa should be considered among opportunistic pathogens, especially in patients with end-stage renal disease. This case is presented as a rare clinical report due to the association of pancytopenia with W. confusa septicemia.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"20 2","pages":"297-300"},"PeriodicalIF":1.2,"publicationDate":"2026-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147370503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid detection of carbapenem resistance genes using multiplex LAMP and melt curve analysis in clinical specimens.","authors":"Vaishnavi V Naik, Sumit Kumar, Tejal Thrimurthy, Vani Channareddy, Tushar Shaw","doi":"10.3855/jidc.21220","DOIUrl":"https://doi.org/10.3855/jidc.21220","url":null,"abstract":"<p><strong>Introduction: </strong>Carbapenem-resistant Enterobacteriaceae have become a major clinical and public health challenge due to the need for rapid administration of effective antimicrobials and implementation of supplemental infection control practices. Identifying genes associated with carbapenem resistance is crucial for managing these cases. The timely initiation of effective antimicrobial therapy and infection control interventions to prevent spreading are critical. Therefore, rapid diagnostic tests for detecting carbapenemase-producing carbapenem-resistant Enterobacteriaceae (CP-CRE) are necessary.</p><p><strong>Methodology: </strong>This study aimed to evaluate the use of LAMP and melting curve analysis in real-time polymerase chain reaction (RT-PCR) to identify carbapenem resistance genes New Delhi metallo-β-lactamase (NDM) and oxacillinase (OXA) in clinical specimens.</p><p><strong>Results: </strong>This study emphasized the benefits of the LAMP strategy in comparison to traditional methods, demonstrating its effectiveness and practicality. LAMP was proven to be more sensitive than RT-PCR and conventional multiplex PCR, with a detection rate of 96.7% and 91.6% respectively. While LAMP had a slightly lower specificity rate of 88.7%, it remains a promising method for rapid and accurate identification. Furthermore, the study found that LAMP could detect bacterial DNA even in low quantities, with a limit of detection of 102 CFU/mL for both K. pneumoniae and E. coli. This capability is crucial for early diagnosis and treatment in settings where multidrug-resistant (MDR) bacteria are prevalent.</p><p><strong>Conclusions: </strong>RT-PCR systems that combine melting curve analysis with LAMP offer promise for quick and precise identification of carbapenem resistance genes in clinical specimens. This approach can enhance the diagnosis and management of multidrug-resistant bacterial infections.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"20 2","pages":"246-252"},"PeriodicalIF":1.2,"publicationDate":"2026-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147370535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and drug resistance patterns of ESKAPE pathogens in Nigde, Türkiye.","authors":"Mohammed A Salim, Songül Budak Diler, Ramazan Köklü, Ali Öztrük, Fikriye Polat, Nooh Mohamed Hajhamed, Nouh Saad Mohamed","doi":"10.3855/jidc.21781","DOIUrl":"https://doi.org/10.3855/jidc.21781","url":null,"abstract":"<p><strong>Introduction: </strong>The escalating burden of antimicrobial resistance (AMR) presents a significant global health challenge. ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species), frequently exhibiting multidrug resistance (MDR), are especially alarming. This study evaluated the prevalence and antibiotic susceptibility profiles of ESKAPE infections in patients from Nigde, Türkiye.</p><p><strong>Methodology: </strong>This descriptive cross-sectional study was performed at Nigde Ömer Halisdemir University Training and Research Hospital from September 2022 to June 2024. Clinical specimens were collected and evaluated for antimicrobial susceptibility with the VITEK®2 compact system.</p><p><strong>Results: </strong>A total of 13,387 bacterial isolates were obtained from 7,438 patients. The majority of isolates were Gram-negative (9,671; 72.2%), of which 3,928 (39.6%) were ESKAPE. Gram-positive isolates accounted for 3,716 (27.8%), with 1,123 (30.2%) categorized as ESKAPE. Klebsiella pneumoniae (K. pneumoniae) was the most common Gram-negative ESKAPE pathogen (1,921; 19.9%), while Escherichia coli (E. coli) was the most frequent non-ESKAPE pathogen (4,747; 49.1%). Of the 5,051 ESKAPE isolates, 29.7% (1,501) were categorized as MDR and 30.9% (1,562) as extensively drug-resistant (XDR). MDR was widespread, with the highest prevalence observed in Enterococcus faecium (76.9%). Acinetobacter baumannii exhibited the highest prevalence of XDR isolates at 72.4%.</p><p><strong>Conclusions: </strong>This study emphasizes the substantial AMR burden linked to ESKAPE infections in Nigde, Türkiye, highlighting the necessity for effective infection management, antibiotic stewardship, and continuous research to track resistance patterns.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"20 2","pages":"208-218"},"PeriodicalIF":1.2,"publicationDate":"2026-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147370571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nocardia farcinica infection after facial lipolysis injection in an immunocompetent patient.","authors":"Wei Xu, Fang Su, Youqi Ji, Mengyuan Chen, Xin Hong, Bingqian Zhuo, Yumei Ge","doi":"10.3855/jidc.20262","DOIUrl":"10.3855/jidc.20262","url":null,"abstract":"<p><strong>Introduction: </strong>Injection lipolysis is a widely used technique for the rapid reduction of localized fat deposits. Although complications such as non-tuberculous mycobacterial infections have been reported, Nocardia infections following this procedure remain rare.</p><p><strong>Case presentation: </strong>This report details a case of Nocardia infection in an immunocompetent patient after facial lipolytic agent administration. The patient exhibited amelioration of facial edema and resolution of chest rash following a course of amoxicillin-clavulanate treatment, ultimately achieving recovery and discharge.</p><p><strong>Conclusions: </strong>This case highlights the importance of considering Nocardia infection as a potential complication of lipolytic injections and provides valuable insights into its diagnosis and management.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"20 2","pages":"301-305"},"PeriodicalIF":1.2,"publicationDate":"2026-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147370530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic performance of ferritin in combination with CT-SS and NEWS, to predict ICU admission and mortality in COVID-19.","authors":"Murat Daş, Fatma Beyazıt, Okan Bardakcı, Ece Ünal Çetin, Gökhan Akdur, Canan Akman, Okhan Akdur, Yavuz Beyazıt","doi":"10.3855/jidc.21452","DOIUrl":"10.3855/jidc.21452","url":null,"abstract":"<p><strong>Introduction: </strong>The coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has created significant challenges in predicting severe disease outcomes. This study evaluates the combined prognostic performance of serum ferritin, national early warning score (NEWS), and computed tomography severity score (CT-SS) in predicting intensive care unit (ICU) admission and 30-day mortality.</p><p><strong>Methodology: </strong>This retrospective study included 693 COVID-19 patients with confirmed RT-PCR results and complete medical records. Demographic, clinical, and laboratory data, including ferritin levels, NEWS, and CT-SS, were analyzed. Statistical analyses were conducted to evaluate their individual and combined predictive capabilities.</p><p><strong>Results: </strong>Elevated ferritin levels, higher NEWS, and greater CT-SS were significantly associated with increased ICU admission and mortality risks. Receiver operating characteristic (ROC) analysis revealed excellent predictive accuracy for mortality: ferritin (area under the receiver operating characteristic curve [AUROC]: 0.916), NEWS (AUROC: 0.927), and CT-SS (AUROC: 0.881). Integrating ferritin into NEWS and CT-SS models enhanced predictive precision, with combined scoring systems yielding the highest odds ratios for adverse outcomes. Patients with a NEWS ≥ 5 and ferritin level ≥ 275.8 had a 151-fold increased risk of mortality, while those with a CT-SS ≥ 9 and ferritin level ≥ 275.8 had a 72-fold increased risk.</p><p><strong>Conclusions: </strong>Combining ferritin with NEWS and CT-SS improves the prognostic accuracy for predicting severe outcomes in COVID-19 patients. This study emphasizes the value of integrating laboratory markers with established scoring systems to optimize clinical decision-making. The findings can guide early interventions, reduce mortality, and improve resource utilization during pandemics.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"20 2","pages":"167-174"},"PeriodicalIF":1.2,"publicationDate":"2026-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147370513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Red cell distribution width and mean platelet volume as mortality markers in patients with COVID-19: a retrospective cohort study.","authors":"Jehat Kiliç, Ömer F Alakuş, İhsan Solmaz","doi":"10.3855/jidc.21878","DOIUrl":"10.3855/jidc.21878","url":null,"abstract":"<p><strong>Introduction: </strong>This study investigates RDW and MPV as simple, cost-effective markers linked to increased mortality in COVID-19, highlighting their potential prognostic value in viral infections.</p><p><strong>Methods: </strong>This retrospective observational study examined hospitalized COVID-19 patients from 2020 to 2022, assessing clinical outcomes such as ICU admission, hospital stay duration, and mortality. It focused on the prognostic value of Red Cell Distribution Width (RDW) and Mean Platelet Volume (MPV), investigating whether elevated levels of these markers could serve as accessible indicators of mortality risk.</p><p><strong>Results: </strong>The mean age at diagnosis among patients was 48.07 ± 17.33 years. The mean hospital stay was 5.82 ± 5.44 days. Among 1,810 patients, elevated Red Cell Distribution Width (RDW > 15%) and Mean Platelet Volume (MPV > 11.5 fL) were associated with significantly higher mortality rates (p < 0.01 and p = 0.014, respectively). Logistic regression analysis identified age, male sex, length of hospital stay, WBC count, RDW-CV, glucose, ferritin, and low albumin as independent predictors of mortality. Conversely, MPV, D-dimer, creatinine, calcium, and ALT were not significant mortality predictors. These findings suggest that routine markers, particularly RDW and WBC, may serve as accessible and cost-effective tools for early risk stratification in COVID-19 patients, while others, like MPV, may have limited independent prognostic value in this context.</p><p><strong>Conclusions: </strong>RDW and MPV, routinely available from blood tests, may help identify early clinical deterioration, supporting timely interventions to improve outcomes.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"20 2","pages":"160-166"},"PeriodicalIF":1.2,"publicationDate":"2026-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147370525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of in-hospital mortality and associated risk factors in hospitalized elderly patients with an Omicron infection.","authors":"Yan Liu, Jiao Liu, Ya-Nan Wang, Yu-Tong Zhao, Jie Zhang, Jing Cao","doi":"10.3855/jidc.20747","DOIUrl":"10.3855/jidc.20747","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of this study was to evaluate the in-hospital mortality rate and associated risk factors in elderly patients hospitalized with an Omicron coronavirus disease 2019 (COVID-19) infection.</p><p><strong>Methodology: </strong>This retrospective cohort study included 137 elderly patients with Omicron infection. The cases were divided into survival and mortality groups based on the discharge outcomes. The basic data were collected. A logistic regression model was used to analyze the risk factors for mortality.</p><p><strong>Results: </strong>The in-hospital mortality rate was 25.54% (102 survivors, 35 non-survivors). The mean age was higher in the mortality group. Shock and dyspnea were more common in the mortality group (p = 0.041). Multivariable logistic regression analysis concluded that advanced age (odds ratio, (OR) = 2.158, 95% confidence interval (CI): 1.183-3.368), shock (OR = 2.876, 95% CI: 1.538-8.304), high neutrophil-to-lymphocyte ratio (NLR; OR = 1.872, 95% CI: 1.060-2.424), radiographic pleural effusion (OR = 1.756, 95% CI: 1.592-3.662), and elevated fasting glucose (OR = 1.785, 95% CI: 1.263-3.821) were independent predictors of in-hospital mortality. The Hosmer-Lemeshow test showed that the proposed model had a good fit with observed values (χ2 = 4.681, p = 0.341). The receiver operating characteristic curve indicated that the proposed model had an area under the curve of 0.791 for predicting mortality, with a sensitivity of 83.9% and specificity of 61.5%.</p><p><strong>Conclusions: </strong>The in-hospital mortality rates were high in elderly patients with Omicron infection. Advanced age, glucose level, shock, NLR, and pleural effusion were identified as risk factors.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"20 2","pages":"153-159"},"PeriodicalIF":1.2,"publicationDate":"2026-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147370135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of sputum smear non-conversion after intensive phase treatment among pulmonary TB patients in southern Thailand.","authors":"Wilaiwan Buatong, Bhunyabhadh Chaimay, Somkiattiyos Woradet","doi":"10.3855/jidc.21793","DOIUrl":"10.3855/jidc.21793","url":null,"abstract":"<p><strong>Background: </strong>Tuberculosis remains a global health challenge, with sputum conversion serving as a critical indicator of treatment success during the intensive phase. This study aimed to identify factors associated with sputum smear non-conversion at the end of intensive phase treatment among patients with pulmonary tuberculosis.</p><p><strong>Methodology: </strong>This case-control study utilized data from the National Tuberculosis Information Program (NTIP) Registry database between 2014 and 2019. Newly diagnosed pulmonary tuberculosis patients were included. The study comprised 322 cases of sputum smear non-conversion and 644 controls who achieved sputum smear conversion. Descriptive statistics and multiple logistic regression were used to analyze the data.</p><p><strong>Results: </strong>Factors significantly associated with sputum smear non-conversion included male sex (Adjusted Odds Ratio [AOR] = 1.57, 95% CI: 1.10-2.25), age 35-59 years (AOR = 1.75, 95% CI: 1.19-2.59), age ≥ 60 years (AOR = 1.72, 95% CI: 1.09-2.71), sputum AFB smear grading of 2+ (AOR = 2.74, 95% CI: 1.20-6.28) and 3+ (AOR = 4.72, 95% CI: 2.14-10.43), and receiving treatment at a private hospital (AOR = 4.94, 95% CI: 2.34-10.44). In contrast, patients weighing ≥ 50 kg at baseline treatment were less likely to experience non-conversion (AOR = 0.72, 95% CI: 0.54-0.96).</p><p><strong>Conclusions: </strong>Patients' sex, age, sputum acid-fast bacilli [AFB] smear grading, and private hospital access were significant risk factors for sputum smear non-conversion, while higher baseline weight appeared protective. Enhanced monitoring of high-risk groups could improve treatment outcomes.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"20 2","pages":"175-182"},"PeriodicalIF":1.2,"publicationDate":"2026-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147370266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and molecular identification of protozoan parasites in cancer patients in Jordan.","authors":"Rashed Almashakbeh, Nawal Hijjawi, Haya Abu Suilike, Maher Sughayer, Ali Al-Radaideh","doi":"10.3855/jidc.21561","DOIUrl":"10.3855/jidc.21561","url":null,"abstract":"<p><strong>Introduction: </strong>Parasitic infections are prevalent in developing countries, and cancer patients with weakened immune systems are particularly vulnerable. This study examined the prevalence of protozoan parasites among cancer patients.</p><p><strong>Methodology: </strong>A total of 300 stool and heparinized plasma samples were collected from cancer patients at the King Hussien Cancer Center (KHCC). Cryptosporidium, Giardia duodenalis, and Blastocystis were detected by microscopy. Immunodiagnostic tests included electrochemiluminescence immunoassay (ECLIA) for Toxoplasma gondii IgG and IgM antibodies in plasma samples, and the ImmunoCard STAT Cryptosporidium/Giardia Kit for G. duodenalis and Cryptosporidium detection in stool. DNA extraction from stool samples was followed by nested polymerase chain reaction (PCR) to confirm the presence of intestinal parasites.</p><p><strong>Results: </strong>Toxoplasma gondii, Cryptosporidium, G. duodenalis, and Blastocystis were detected. T. gondii was found in 22% of patients via IgG antibodies and in 2.7% via IgM, with the highest IgG seropositivity in multiple myeloma and uterine cancer patients (50%), and the highest IgM seropositivity in multiple myeloma patients (12.5%). The prevalence of Cryptosporidium varied depending on the detection method: 8.3% by microscopy, 11% by immunodiagnostic tests, and 12.3% by PCR. The highest infection rate was among colorectal cancer (CRC) patients. Giardia duodenalis was detected at rates of 1.7% by microscopy, 2.0% by immunodiagnostic testing, and 0.7% by PCR. Blastocystis was most prevalent in CRC patients, with detection rates of 31.0% by microscopy and 48.3% by PCR.</p><p><strong>Conclusions: </strong>This study highlights the significance of protozoan parasitic infections among cancer patients, emphasizing the need for screening and management to improve patient outcomes.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"20 2","pages":"278-286"},"PeriodicalIF":1.2,"publicationDate":"2026-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147370579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}