Journal of Infection in Developing Countries最新文献

{"title":"A retrospective study on factors related to in-hospital mortality among patients with COVID-19, March 2020 to November 2021.","authors":"Elisabetta Zinellu, Sara S Fois, Biagio Di Lorenzo, Stefano Zoroddu, Maria C Pau, Lorenzo Tassi, Barbara Piras, Alessandro G Fois, Ciriaco Carru, Arduino A Mangoni, Angelo Zinellu, Pietro Pirina","doi":"10.3855/jidc.20868","DOIUrl":"https://doi.org/10.3855/jidc.20868","url":null,"abstract":"<p><strong>Introduction: </strong>Four years since the pandemic was declared, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains an important cause of illness around the world. Although many countries were able to overcome the health crisis at its peak, there are still individuals at high risk of a severe course of coronavirus disease 2019 (COVID-19). Therefore, it is important to continue research on the factors that could predict disease severity and adverse outcomes.</p><p><strong>Methodology: </strong>We conducted a retrospective study on 171 consecutive hospitalized cases of COVID-19 from March 2020 to November 2021. Past medical history, drug history, clinical and laboratory parameters on admission, and the choice of treatment during hospital stay were obtained and associated with in-hospital mortality.</p><p><strong>Results: </strong>Older age was significantly associated with mortality. Non-survivors also showed a significantly lower PaO2/FiO2 (P/F) ratio at the time of hospital admission; a lower lymphocyte count; and increased levels of white blood cell count, C-reactive protein (CRP), lactate dehydrogenase (LDH), D-dimer, and creatinine. Significant differences were also observed with regards to both long-term medications and treatments administered during hospital stay.</p><p><strong>Conclusions: </strong>Our findings highlight the importance of age, clinical features, biochemical biomarkers, and therapeutic interventions in predicting COVID-19 disease severity and outcomes.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 4","pages":"467-475"},"PeriodicalIF":1.4,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143992313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Catheter-associated Urinary Tract Infections in a trauma care facility in India: trend over ten years.","authors":"Aparna Ningombam, Arpan Kumar Thakur, Ashish Kumar Srivastava, Sharin Varma, Madhavi Kirti, M Nizam Ahmed, Vanlal Tluanpuii, Kapil Dev Soni, Richa Aggarwal, Gyanendra Pal Singh, Ashish Bindra, Navdeep Sokhal, Keshav Goyal, Kamran Farooque, Purva Mathur","doi":"10.3855/jidc.20371","DOIUrl":"https://doi.org/10.3855/jidc.20371","url":null,"abstract":"<p><strong>Introduction: </strong>Catheter-associated urinary tract infections (CAUTIs) are one of the most common device-associated infections acquired in a hospital. Trauma patients are highly susceptible to CAUTI, as catheterization is a lifesaving measure often required for their management. This study focuses on the profile of CAUTI, the organism profile with antibiotic susceptibility patterns, and the clinical outcomes in the ICUs of a trauma care center.</p><p><strong>Methodology: </strong>A retrospective analysis of prospective surveillance data of patients in ICUs was done over a period of ten years (2010-2019) in a level 1 trauma center. A modified NHSN definition of CAUTI was used. Microbiological processing and antibiotic susceptibility profile was done based on standard guidelines. Clinical outcomes were considered for analysis.</p><p><strong>Results: </strong>A total of 10,732 patients were included in the study, accounting for 98,131 patient days and 78,126 urinary catheter days (UCD). Among 546 patients, 577 episodes of CAUTI were recorded, giving a CAUTI rate of 7.4/1,000 catheter days. The average length of stay (LOS) of patients was 19.9 days. There was a significant relationship between UCD and the development of CAUTI. Orthopedic and spinal injuries (91%) accounted for the maximum device utilization ratio, followed by polytrauma (90%), miscellaneous injuries (88%), and head injuries (69%). CAUTI episodes were the highest in head injury patients. Gram-negative organisms (53.4%) dominated the pathogen profile. The crude mortality was 25.1%.</p><p><strong>Conclusions: </strong>Surveillance of CAUTI with analysis of the organisms and the antibiotic susceptibility trend will help improve infection prevention practices and antibiotic stewardship programs in local hospital settings.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 4","pages":"590-596"},"PeriodicalIF":1.4,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144041645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of antimicrobial resistance and virulence of pathogens in dairy products from Egypt by whole genome sequencing.","authors":"Dina Saleh, Nora Mahmoud, Shymaa Enany, Samira Zakeer","doi":"10.3855/jidc.20845","DOIUrl":"https://doi.org/10.3855/jidc.20845","url":null,"abstract":"<p><strong>Introduction: </strong>Raw milk and dairy products can cause a variety of diseases due to environmental pollution. The objectives of this study were to identify the genetic variables, evaluate antibiotic resistance, and isolate microorganisms from raw milk and dairy products.</p><p><strong>Methodology: </strong>Three hundred samples of raw milk were collected from farmers and marketplaces in Gamasa, Mansoura, and Damietta cities in Egypt. Various bacterial species were isolated using selective culture media, of which 101 (33.6%) were Staphylococcus species, 11 (3.6%) were Escherichia coli, and 1 (0.3%) was Salmonella. The isolates were confirmed by biochemical tests. The disk diffusion method was used to test antibiotic susceptibility. Additionally, resistance genes and virulence factors in 4 randomly selected Staphylococcus species samples were identified through MinION nanopore sequencing (Oxford Nanopore Technologies, Oxford, UK).</p><p><strong>Results: </strong>Staphylococcus species showed resistance to antibiotics, including ampicillin (89%) and colistin (94%). Whole genome sequencing was used to identify the molecular traits of antibiotic-resistant Staphylococcus species. The genes associated with resistance to antibiotics in Staphylococcus species were examined. Four Staphylococcus samples were randomly selected for extracting DNA and nanopore sequencing. Staphylococcus species exhibited remarkable resistance to colistin because of the presence of putative serine protease proteins (colistinase) or resistance-nodulation-division (RND) efflux pumps (ACRB gene).</p><p><strong>Conclusions: </strong>The identification of resistant bacterial strains in unpasteurized milk and dairy products highlights the critical need for strict regulations to limit the overuse of antibacterial treatments in dairy herd management.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 4","pages":"544-552"},"PeriodicalIF":1.4,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144024270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic characterization of extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae collected from healthy turkeys.","authors":"Amel Romdhani, Sana Dhaouadi, Sarah Cheriet, Sana Lengliz, Ilhem Boutiba-Ben Boubaker, Ramzi Boubaker Landolsi, Mohamed Salah Abbassi","doi":"10.3855/jidc.18973","DOIUrl":"https://doi.org/10.3855/jidc.18973","url":null,"abstract":"<p><strong>Introduction: </strong>The spread of extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-En) from turkeys via food chain and environmental contamination is a human health concern.</p><p><strong>Methodology: </strong>Seventy fecal samples were collected from healthy turkeys and streaked on Tryptone Bile X-Glucoronide (TBX) supplemented with 2 mg/L of cefotaxime and on TBX supplemented with 1 mg/L of imipenem. ESBL production and susceptibility to antibiotics were studied according to CLSI guidelines. Genes encoding for ESBLs (SHV, CTX-M, TEM), carbapenemases (IMI, KPC, OXA48, NDM), tetracyclines (tetA, tetB, tetC), colistin (mcr-1 to mcr-5), sulphonamides (sul1, sul2), quinolones (qnr A/B/S, aac(6')-Ib-cr, qepA) resistance, and class 1 and 2 integrons were determined by PCR.</p><p><strong>Results: </strong>ESBL-En [n = 45 (64.3%): 41 E. coli and 4 K. pneumoniae] isolates were collected. In E. coli, blaCTX-M-1, blaCTX-M-14, blaCTX-M-15, blaCTX-M-27, and blaCTX-M-55 genes were identified in 23, 2, 5, 16, and one isolate, respectively. The blaCTX-M-15 gene was detected in two K. pneumoniae isolates, while each of blaCTX-M-1 and blaCTX-M-27 were detected in one isolate. Resistances to tetracyclines, sulfonamides, fluoroquinolones, and colistin were encoded by tetA (n = 21)/tetB (n = 1), sul1 (n = 8)/sul2 (n = 13), aac(6')-Ib-cr (n = 6), and mcr-1 (n = 2)/mcr-2 (n = 1) genes, respectively. Integrons of class 1 and class 2 were detected in 15 and six isolates, respectively. Five E. coli isolates belonged to the pandemic ST131 clone.</p><p><strong>Conclusions: </strong>Our findings highlight the high occurrence of MDR/ESBL-En and demonstrate the possible transfer of these strains to humans via the food chain or direct contact.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 4","pages":"560-568"},"PeriodicalIF":1.4,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144021836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of post-COVID-19 syndrome: a meta-analysis.","authors":"Rulin Wang, Minghui Lin, Shangqiao Yu, Xijuan Xue, Xue Hu, Zhizhong Wang","doi":"10.3855/jidc.18574","DOIUrl":"https://doi.org/10.3855/jidc.18574","url":null,"abstract":"<p><strong>Introduction: </strong>Post Coronavirus Disease 2019 (COVID-19) Syndrome also known as long COVID-19 would affect survivors of various patients. At present, the evidence for predicting a poor prognosis of COVID-19 remains insufficient. This study aims to explore potential predictors of post-COVID-19 syndrome.</p><p><strong>Methodology: </strong>A systematic review process and meta-analysis method are applied to identify the predictors. Systematic searches were conducted without language restrictions from December 1, 2019, to February 28, 2022, on PubMed, Embase, Google Scholar, Web of Science, and Cochrane Library using specific keywords relevant to our targets. The Newcastle Ottawa Scale observational research tool was used to assess study quality and the R (4.1.1) package meta was used for statistical analysis.</p><p><strong>Results: </strong>Our meta-analysis of 14 studies showed that females (OR = 1.42, 95% CI: 1.19-1.70), the severity of patients (OR = 2.43, 95% CI: 1.26-4.68), comorbidity (OR = 2.08, 95% CI: 1.29-3.35), dyspnea (OR = 2.02, 95% CI: 1.34-3.04) associated with a higher risk of post-COVID-19 syndrome.</p><p><strong>Conclusions: </strong>Our study showed that females, the severity of COVID-19, comorbidity, and dyspnea were associated with a higher risk of post-COVID-19 syndrome. More attention should be paid to these factors to prevent and treat post-COVID-19 syndrome.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 4","pages":"490-497"},"PeriodicalIF":1.4,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144023943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of diagnostic efficacy of galactomannan lateral flow assay vs enzyme immunoassay: importance of storage conditions.","authors":"Enes Erbağcı, Ayşe Ö Mete, Handan H Şahin, Yasemin Zer, İlkay Karaoğlan","doi":"10.3855/jidc.20587","DOIUrl":"https://doi.org/10.3855/jidc.20587","url":null,"abstract":"<p><strong>Introduction: </strong>Galactomannan antigen is a valuable biomarker for diagnosing invasive aspergillosis. Traditional methods, such as enzyme immunoassays (EIA), require batch sampling, whereas lateral flow assays (LFA) provide a simpler and faster diagnostic process. This study aimed to compare the diagnostic efficacy of both testing methods.</p><p><strong>Methodology: </strong>This prospective case-control study involved 192 serum samples categorized according to the European Organization for Research and Treatment of Cancer/Mycoses Study Group (EORTC/MSG criteria). LFA were conducted following the manufacturer's instructions, utilizing a cube reader. Receiver operating characteristic (ROC) analysis was performed to determine the optimal LFA threshold, and concordance analysis was conducted for both assays.</p><p><strong>Results: </strong>The indicated sensitivity and specificity of LFA at the recommended galactomannan index threshold (GMI ≥ 0.5) were 15.3% (9/59) and 99% (132/133), respectively. Post-ROC analysis at a threshold of 0.4 revealed an area under the curve (AUC) of 0.685, with sensitivity, specificity, positive predictive value, and negative predictive value at 18%, 99%, 91%, and 73%, respectively. Qualitative agreement between the tests, assessed using the Kappa statistic, indicated a very low degree of agreement (κ = 0.18). In contrast, quantitative agreement, evaluated through Kendall's W-test, demonstrated a very high degree of agreement (W = 0.84).</p><p><strong>Conclusions: </strong>Despite previous literature suggesting the efficacy of LFA, our study found it unsuitable for screening due to its low sensitivity. We recommend exercising caution regarding the manufacturer's storage recommendations until further studies on sample storage conditions are conducted.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 4","pages":"537-543"},"PeriodicalIF":1.4,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular characterization of carbapenemases production among environmental Gram-negative isolates at Addis Ababa, Ethiopia: first detection of NDM Producers in hospital environments.","authors":"Shemse Sebre, Aminu Seman, Tewachew Awoke, Woldaregay Erku Abegaz, Wude Mihret, Adane Mihret, Tamrat Abebe, Zelalem Desalegn","doi":"10.3855/jidc.20561","DOIUrl":"https://doi.org/10.3855/jidc.20561","url":null,"abstract":"<p><strong>Introduction: </strong>The Gram-Negative bacteria, particularly carbapenem-resistant strains (CR-GNB), pose a global health threat due to high morbidity and mortality. Detecting carbapenemase-encoding genes is essential for understanding their spread in hospital environments. This study investigated environmental colonization by CR-GNB in Ethiopian hospitals, including genetic characterization of resistance genes.</p><p><strong>Methodology: </strong>A cross-sectional study analyzed 103 environmental GNB isolates collected from inanimate surfaces at Tikur Anbessa Specialized Hospital (TASH) and ALERT Hospital (June-September 2021). Conventional microbiological methods identified the isolates, and antimicrobial susceptibility was tested using the Kirby-Bauer disk diffusion method. Carbapenemase production was screened using the Modified Hodge test (MHT) and combined disk test (CDT). Resistance genes (blaKPC, blaNDM, blaOXA-48) were detected via PCR in isolates with reduced meropenem susceptibility.</p><p><strong>Results: </strong>The predominant GNB were Acinetobacter baumannii (47%), Pseudomonas aeruginosa (33%), and E. coli (12%). Among 103 isolates, 62% showed reduced meropenem susceptibility. The most common CR-GNB was Acinetobacter baumannii (37.5%), followed by E. coli (18.8%) and Klebsiella pneumoniae (12.5%). Carbapenemase production was detected in 41.7% of isolates via PCR, with blaNDM being the most common (43 isolates). Linens (26.4%) and beds (21.4%) had the highest contamination rates. Most carbapenemase-producing isolates were multidrug-resistant (MDR).</p><p><strong>Conclusions: </strong>The presence of blaNDM and blaKPC genes highlights hospital surfaces as reservoirs for resistance genes, contributing to healthcare-associated infections. Routine surveillance and early detection of carbapenemase producers are crucial for infection control and antimicrobial resistance management.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 4","pages":"512-519"},"PeriodicalIF":1.4,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sexually Transmitted Infection knowledge and risky behaviours among Albanian university students: findings from a cross-sectional study.","authors":"Lumturi Merkuri, Erda Qorri, Xhini Rizaj, Busra Emir, Leidon Shapo","doi":"10.3855/jidc.20852","DOIUrl":"https://doi.org/10.3855/jidc.20852","url":null,"abstract":"<p><strong>Introduction: </strong>Sexually Transmitted Infections (STIs) pose a public health concern globally, especially among young adults. Despite efforts to address STIs transmission through sexual health education, risky behaviors persist among young adults. This study aims to assess knowledge and behaviors on STIs among university students, offering added evidence and insights for more targeted preventive interventions in the future.</p><p><strong>Methodology: </strong>Conducted between April - May 2023, our study surveyed 671 students using a structured questionnaire based on established guidelines. Data analysis utilized SPSS vs 25. Ethical considerations were adhered to, and limitations of self-reported data were acknowledged.</p><p><strong>Results: </strong>The findings revealed a disparity in students' knowledge and the presence of risky sexual behaviors related to STIs. We found that 72.2% of students reported they currently had sexual relations and 30.3% had multiple sexual partners. More than half did not use a condom (29.3%) or did not use a condom consistently (30.9%). Only 19.7% had been tested for STIs and almost all female students, 93.4%, had never had an HPV test.</p><p><strong>Conclusions: </strong>Our findings suggest that Albanian university students show limited knowledge of STIs and currently engage in risky sexual behaviors. There is a pressing need to coordinate a program of sexual health education, implement more preventive measures, and apply regular STI screening (for those at risk). Also, healthcare experts should spearhead educational initiatives to ensure the accuracy and reliability of information, addressing misconceptions among students. This study also highlights the importance of interventions to mitigate STIs transmission risks among young adults.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 4","pages":"553-559"},"PeriodicalIF":1.4,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143994714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seroprevalence of IgM antibodies against cytomegalovirus (CMV) in HIV patients: single center study.","authors":"Deema I Fallatah, Hafeez A Adekola, Musa Mohammed, Hajar AlQadeeb","doi":"10.3855/jidc.20552","DOIUrl":"https://doi.org/10.3855/jidc.20552","url":null,"abstract":"<p><strong>Introduction: </strong>The presence of cytomegalovirus (CMV) immunoglobulin M (IgM) in human immunodeficiency virus (HIV)-positive individuals indicates an active infection or reactivation of the virus.</p><p><strong>Methodology: </strong>This study investigated the seroprevalence of CMV IgM antibodies among HIV-positive individuals attending the Ahmadu Bello University Teaching Hospital in Nigeria.</p><p><strong>Results: </strong>Fifty nine out of 92 participants who were tested with an enzyme-linked immunosorbent assay (ELISA) were positive for CMV IgM, resulting in a prevalence rate of 64.1%. Analysis of sociodemographic variables revealed a statistically significant association between CMV IgM seropositivity, and both gender and residence of the participants. Clinical variables also indicated a significant association between CMV IgM seropositivity and the duration of HIV infection. Multivariate analysis showed that participants in the 18-29 years age group, those with a secondary education level, the unemployed, and those who had been infected with HIV for 1-3 years were most likely to test positive for CMV infection. Joint and muscle pain were the most commonly reported symptoms among participants.</p><p><strong>Conclusions: </strong>The high seroprevalence of CMV IgM antibodies found in this study suggests that CMV infection is widespread in the study area. Therefore, it is essential to regularly screen HIV-positive individuals for CMV during routine antiretroviral therapy visits to enable early detection and improve treatment outcomes.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 4","pages":"608-614"},"PeriodicalIF":1.4,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144048463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seven-year evaluation of Stenotrophomonas maltophilia bacteremia in a university-affiliated hospital.","authors":"Aysegul I Sezen, Yusuf E Ozdemir, Zuhal Yeşilbağ, Deniz Borcak, Esra Canbolat Ünlü, Fatma Bayrak Erdem, Zeynep Çizmeci, Enes Topcu, Kadriye Kart Yasar","doi":"10.3855/jidc.20243","DOIUrl":"https://doi.org/10.3855/jidc.20243","url":null,"abstract":"<p><strong>Introduction: </strong>Stenotrophomonas maltophilia is the only opportunistic human pathogen in the genus Stenotrophomonas. These bacteria can be isolated from healthcare settings, possibly resulting in bacterial colonization of medical devices, which cause nosocomial infections. S. maltophilia bacteremia results in high mortality and morbidity. This study aimed to determine the outcomes of S. maltophilia bacteremia and its associated mortality risk factors.</p><p><strong>Methodology: </strong>This was a retrospective study conducted at the University of Medical Sciences, Bakirkoy Dr. Sadi Konuk Training and Research Hospital (Istanbul, Turkey) from December 2015 to December 2022. Medical records, demographic information, clinical conditions, laboratory data, antimicrobial susceptibility, and clinical outcomes were retrospectively analyzed for the period between December 2015 and December 2022.</p><p><strong>Results: </strong>Data from 87 patients (median age 61 years) with bacteremia were included in this study. The most common underlying conditions were diabetes mellitus (DM; 32.2%), hypertension (29.9%), and malignancies (19.5%). The most common sources of bacteremia were central venous catheters (CVCs; 44%), primary blood infection (32%), respiratory tract infection (20.7%), and wound site/abscess infection (2.3%). Seventy-eight percent of the patients were admitted to the intensive care unit (ICU) when bacteremia was detected. The 28-day mortality rate was 55%. The mortality rate was significantly higher in the ICU (p < 0.001). Elevated values of procalcitonin and C-reactive protein, and the presence of CVC were significant risk factors for mortality in those with S. maltophilia bacteremia.</p><p><strong>Conclusions: </strong>S. maltophilia bacteremia should be carefully monitored in patients with CVCs. Timely removal of CVCs can result in decreased mortality.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 4","pages":"498-503"},"PeriodicalIF":1.4,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144051605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}