Journal of Infection in Developing Countries最新文献_第4页

Trends of the incidence rate of Hepatitis C in Changsha, China, 2005 to 2023 and Its Prediction to 2025.

IF 1.4 4区医学

Journal of Infection in Developing Countries Pub Date : 2025-01-31 DOI: 10.3855/jidc.19790

Shuilian Chen, Ping Zeng, Kewei Yang, Xixing Zhang, Xuewen Yang, Yinzhu Zhou

{"title":"Trends of the incidence rate of Hepatitis C in Changsha, China, 2005 to 2023 and Its Prediction to 2025.","authors":"Shuilian Chen, Ping Zeng, Kewei Yang, Xixing Zhang, Xuewen Yang, Yinzhu Zhou","doi":"10.3855/jidc.19790","DOIUrl":"https://doi.org/10.3855/jidc.19790","url":null,"abstract":"Introduction: Hepatitis C is a globally distributed hepatic disease with a high chronicity rate, posing significant global public health concerns. This research aimed to predict the incidence trend of hepatitis C to guide disease prevention and control.Method: The quarterly incidence rates of hepatitis C in Changsha from the first quarter of 2005 to the third quarter of 2023 were collected. Curve-fitting method, grey model (GM (1,1)), Autoregressive Integrated Moving Average (ARIMA) model, and Back Propagation Neural Network (BPNN) model, were applied to simulate the incidence trend of hepatitis C.Results: The annual average reported incidence rate in Changsha was 12.518 per 100,000. The incidence rate of hepatitis C showed an upward trend from 1.102 per 100,000 in 2005 to 17.172 per 100,000 in 2013 and remained at a high level from 2014 to 2019. It has been steadily declining since 2020. The BPNN model exhibited the best forecasting performance (MAE = 0.394, MRE = 0.203). The prediction results from the BPNN model estimated the incidence rate of hepatitis C to be 9.991 per 100,000 in 2024 and 11.920 per 100,000 in 2025.Conclusions: The incidence of hepatitis C in the next two years is projected to be slightly higher than that during the COVID-19 epidemic. It is imperative to strengthen various measures to achieve the goal of hepatitis C elimination in China.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 1","pages":"140-145"},"PeriodicalIF":1.4,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143469774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of sample pooling for gene sequencing of SARS-CoV-2: a simulation study.

IF 1.4 4区医学

Journal of Infection in Developing Countries Pub Date : 2025-01-31 DOI: 10.3855/jidc.20348

Heng Chen, Yue Cheng, Xun He, Yuzhen Zhou, Wenjun Xie, Danyun Shen, Zhiqun He, Ruidan Li, Weixuan Liu, Liang Wang, Xuejun Zhang

{"title":"Evaluation of sample pooling for gene sequencing of SARS-CoV-2: a simulation study.","authors":"Heng Chen, Yue Cheng, Xun He, Yuzhen Zhou, Wenjun Xie, Danyun Shen, Zhiqun He, Ruidan Li, Weixuan Liu, Liang Wang, Xuejun Zhang","doi":"10.3855/jidc.20348","DOIUrl":"https://doi.org/10.3855/jidc.20348","url":null,"abstract":"Introduction: Coronavirus disease 2019 (COVID-19) continues to pose a significant public health threat, requiring epidemiological and genomic surveillance. Next generation sequencing (NGS) is commonly utilized for monitoring viral evolution at a high cost. This study evaluated pooled sequencing as a cost-effective tool for monitoring virus variants.Methodology: A simulation study was conducted to evaluate the efficacy of sample pooling for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequencing. In total, 72 original sets of raw data of gene sequencing with different genotypes were collected and combined to create 70 simulated samples based on five pooling strategies. A bioinformatics tool based on Freyja was utilized to analyze the variant composition of these 70 simulated pooled samples. The efficiency of recovering the correct genotypes of the original samples among different pooling strategies, result reports, and genotypes was evaluated with R software.Results: The genetic composition of the pooled samples mostly recovered the genotype compositions of the original samples, with discrepancies between the top X results (where X is the number of original samples in the pool) and the complete results (p < 0.05). Variability in identification efficiency of genotypes were observed in the reports for the top X results (p < 0.05) across the five pooling strategies, but not in the reports of complete results (p > 0.05). Some original samples of low quality were not accurately identified.Conclusions: Sample pooling coupled with streamlined genotyping offers a promising approach for cost-effective gene sequencing of SARS-CoV-2, which will aid in COVID-19 genomic surveillance.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 1","pages":"1-8"},"PeriodicalIF":1.4,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143469677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The evaluation of anti-diphtheria toxoid antibodies after 5 years with the primary Tetanus-Diphtheria vaccine in persons aged 6-25 years in Kon Tum, Vietnam: a follow-up study.

IF 1.4 4区医学

Journal of Infection in Developing Countries Pub Date : 2025-01-31 DOI: 10.3855/jidc.19390

Tuan Van Le, Van Thi Tuyet Nguyen, Quan Hoang Nguyen, Huong Le Thien Tran, Son Dinh Tran, Chien Chinh Vien

{"title":"The evaluation of anti-diphtheria toxoid antibodies after 5 years with the primary Tetanus-Diphtheria vaccine in persons aged 6-25 years in Kon Tum, Vietnam: a follow-up study.","authors":"Tuan Van Le, Van Thi Tuyet Nguyen, Quan Hoang Nguyen, Huong Le Thien Tran, Son Dinh Tran, Chien Chinh Vien","doi":"10.3855/jidc.19390","DOIUrl":"https://doi.org/10.3855/jidc.19390","url":null,"abstract":"Introduction: Diphtheria is a serious infectious disease although being vaccine-preventable. 5-year follow-up study aimed to evaluate the persistence of IgG antibodies to diphtheria toxoid after Tetanus-diphtheria primary immunization for persons aged 6-25 years in Kon Tum, Viet Nam.Methodology: Blood samples were obtained from 128 healthy persons aged 6-25 years collected in 2021. Samples were tested for diphtheria toxoid antibodies by commercial Anti-Diphtheria Toxoid IgG Enzyme-Linked Immunosorbent Assay (ELISA).Results: One month after Td primary vaccination, 92.2% of participants were fully protected against diphtheria (> 0.1 IU/mL). GMCs increased from 0.04 to 0.91 IU/mL at one month, which were maintained in nearly 90% of vaccinees at 5 years. Among children aged 6-10 years, 97.3% had full protection at 1 month after primary vaccination, maintained in 94.6% at 5 years. Among adolescents and adults, 81.0% to 98.5% had full protection at 1 month after vaccination, which were maintained from 72.7% to 96.7% at 5 years. Although, the antibodies slightly declined approximately 5 years post-vaccination, but remained several-fold higher than pre-vaccination.Conclusions: Td vaccine provides long-lasting protective antibodies against diphtheria. These data may inform discussion of the need for Td booster vaccinations among high-risk persons.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 1","pages":"22-27"},"PeriodicalIF":1.4,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143469771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Contaminated faucets and sinks as a reservoir for antibiotic-resistant bacterial transmission in healthcare settings.

IF 1.4 4区医学

Journal of Infection in Developing Countries Pub Date : 2025-01-31 DOI: 10.3855/jidc.18907

Qiao Li, Honghui Ding, Zhongju Chen, Wenyuan Li, Kun Tan, Chuan Xu, Mingjun Zou, Xiao Wang, Li Tan

{"title":"Contaminated faucets and sinks as a reservoir for antibiotic-resistant bacterial transmission in healthcare settings.","authors":"Qiao Li, Honghui Ding, Zhongju Chen, Wenyuan Li, Kun Tan, Chuan Xu, Mingjun Zou, Xiao Wang, Li Tan","doi":"10.3855/jidc.18907","DOIUrl":"https://doi.org/10.3855/jidc.18907","url":null,"abstract":"Introduction: Multidrug-resistant bacterial infection has emerged as a global hygiene threat in hospitals, and outbreaks cause increased patient morbidity and mortality in the healthcare system. Mounting evidence points to faucets and sinks as the culprits in the outbreaks of multidrug-resistant bacterial infections. However, the mechanism and the route through which faucets and sinks contribute to antibiotic-resistant bacterial transmission are not fully understood.Methodology: We collected 455 surface samples from faucets and sinks in over 60 areas covering four environmental classes to comprehensively overview the prevalence and distribution of multidrug-resistant bacteria in the hospital.Results: We detected 32 carbapenem-resistant Acinetobacter samples, one methicillin-resistant staphylococcus aureus sample, and three carbapenem-resistant Klebsiella pneumoniae samples. Thirteen carbapenem-resistant Acinetobacter spp. and one Klebsiella spp. were identified in the 455 faucet samples.Conclusions: Some faucets in the hospital were contaminated with antibiotic-resistant Acinetobacter, suggesting the possibility that the contaminated faucets and sinks act as a reservoir of antibiotic-resistant bacterial transmission. The current study assessed the prevalence and distribution of multidrug-resistant bacteria on the faucets and sinks in the hospital. It revealed the potential of faucets and sinks as a carrier of antibiotic-resistant bacteria, assisting in spreading them. Improvement of hand hygiene facilities to prevent antibiotic resistance deserves better attention. This study can further instruct us on a surveillance strategy to be used in hospitals.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 1","pages":"98-106"},"PeriodicalIF":1.4,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143469614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the long-term outcomes of patients with hepatitis delta.

IF 1.4 4区医学

Journal of Infection in Developing Countries Pub Date : 2025-01-31 DOI: 10.3855/jidc.20257

Muhammet Salih Tarhan, Habip Gedik, Kadriye Kart-Yasar

{"title":"Evaluation of the long-term outcomes of patients with hepatitis delta.","authors":"Muhammet Salih Tarhan, Habip Gedik, Kadriye Kart-Yasar","doi":"10.3855/jidc.20257","DOIUrl":"https://doi.org/10.3855/jidc.20257","url":null,"abstract":"Objective: To evaluate the long-term outcomes of hepatitis delta patients, including cirrhosis and hepatocellular carcinoma (HCC), based on clinical and laboratory data.Methodology: A retrospective evaluation was conducted on patients diagnosed with hepatitis delta. The patients were formed into four groups: no-treatment, pegylated interferon, oral antiviral, and combined treatment.Results: A total of 93 patients, 48 women and 45 men, were evaluated in the study. The mean follow-up time was 4.38 ± 2.7 years. Of those, 43 were in the no-treatment group, 22 received combination therapy including pegylated interferon and oral antiviral treatment for chronic hepatitis B (the combined treatment group), 19 received only oral antiviral treatment for chronic hepatitis B (the oral antiviral group), and nine received pegylated interferon (the pegylated interferon group). HDV-RNA negativity was observed in 67% (6/9) of patients in the pegylated interferon group and 33% (5/15) of patients in the combined treatment group. HDV-RNA became spontaneously negative in one of the two patients in the no-treatment group, while no patient in the oral antiviral group became HDV-RNA negative. Seven patients were diagnosed with cirrhosis and one with HCC. Three patients had undergone liver transplants. There were no fatalities among patients.Conclusions: Pegylated interferon therapy has been demonstrated to have partial efficacy in the treatment of delta hepatitis, while oral antivirals have been shown to offer no additional benefit. Although negative HDV-RNA was achieved in some patients treated with pegylated interferon, pegylated interferon treatment could not eliminate the risk of cirrhosis and HCC.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 1","pages":"146-154"},"PeriodicalIF":1.4,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143469693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Methicillin-resistant Staphylococcus aureus with Panton-Valentine leukocidin gene from a pediatric hospital in Morocco.

IF 1.4 4区医学

Journal of Infection in Developing Countries Pub Date : 2025-01-31 DOI: 10.3855/jidc.20319

Bahija Serray, Mohammed Sobh, Mohammed Timinouni, Mohamed El Azhari

{"title":"Methicillin-resistant Staphylococcus aureus with Panton-Valentine leukocidin gene from a pediatric hospital in Morocco.","authors":"Bahija Serray, Mohammed Sobh, Mohammed Timinouni, Mohamed El Azhari","doi":"10.3855/jidc.20319","DOIUrl":"https://doi.org/10.3855/jidc.20319","url":null,"abstract":"Introduction: Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of nosocomial and community infections. These infections are becoming increasingly difficult to combat, because of emerging resistance to all classes of antibiotics. Panton-Valentine leukocidin (PVL) is an important virulence factor in MRSA and causes white blood cell destruction, necrosis, and accelerated apoptosis. The aim of this study was to determine the frequency of pvl-positive MRSA in a pediatric hospital, in Marrakech, Morocco.Methodology: 53 isolates of MRSA were recovered in the hospital from December 2010 to May 2014, and confirmed with biochemical tests (coagulase, mannitol fermentation, and DNase). Then, polymerase chain reaction (PCR) was used to detect pvl.Results: Among the 259 Staphylococcus aureus isolates collected from various clinical specimens, 53 were identified as MRSA; and the presence of the PVL gene was investigated in them using PCR analysis. Out of the 53 MRSA isolates, only 1 (1.89%) was positive for pvl This pvl-positive MRSA isolate was characterized as staphylococcal cassette chromosome mec IV (SCCmec IV), a type commonly associated with community-acquired MRSA infections.Conclusions: The study revealed a relatively low prevalence of PVL-positive MRSA among pediatric patients at the University Hospital Center CHU Mohamed VI in Marrakech, with only 1.89% of MRSA isolates testing positive for pvl. Despite this low prevalence, the presence of PVL-positive strains accentuates a potential risk for severe infections in vulnerable children. These findings underscore the imperative need for sustained surveillance and rigorous infection control measures to mitigate the spread of MRSA and other resistant pathogens.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 1","pages":"34-39"},"PeriodicalIF":1.4,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143469716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Scrofuloderma: report of two cases.

IF 1.4 4区医学

Journal of Infection in Developing Countries Pub Date : 2025-01-31 DOI: 10.3855/jidc.21136

Dusan Skiljevic, Maja Vilotijevic, Jelena Stojkovic Filipovic, Vesna Reljic, Marija Tomanovic, Jelena Peric

{"title":"Scrofuloderma: report of two cases.","authors":"Dusan Skiljevic, Maja Vilotijevic, Jelena Stojkovic Filipovic, Vesna Reljic, Marija Tomanovic, Jelena Peric","doi":"10.3855/jidc.21136","DOIUrl":"https://doi.org/10.3855/jidc.21136","url":null,"abstract":"Introduction: Tuberculosis (TB) is a chronic, granulomatous, infectious disease caused by the Mycobacterium tuberculosis complex. Cutaneous TB accounts for less than 1-2% of all TB cases. Scrofuloderma is a subcutaneous form of cutaneous TB, which results from direct spreading of infection from deeper tissues.Case reports: We present two patients with scrofuloderma who exhibited typical clinical features but posed significant diagnostic challenges. In the first case, diagnosis was confirmed by polymerase chain reaction (PCR) of a tissue specimen which detected M. tuberculosis. All other microbiological tests, including direct microscopy, acid-fast bacilli smear, mycobacterial cultures, and TB-PCR of caseous discharge, were negative. In the second case, M. tuberculosis was identified via PCR of an ulcer swab, while other tests were negative. Histopathological findings were consistent with cutaneous TB. Both patients were treated with four first-line antitubercular drugs. The first patient developed progressive leukopenia and neutropenia and the treatment was adjusted to exclude ethambutol. Both the patients showed significant clinical improvement shortly after starting therapy.Conclusions: Cutaneous TB is often misdiagnosed due to its rarity and the challenges of microbiological testing, especially in paucibacillary forms. Histopathological features, though suggestive, are not pathognomonic, contributing to diagnostic delays. Increased awareness among dermatologists can lead to earlier diagnosis and better outcomes.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 1","pages":"168-173"},"PeriodicalIF":1.4,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143469766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Seroprevalence and associated risk factors of HBV and HCV infections in the population of Ghudduwah Village, South Libya.

IF 1.4 4区医学

Journal of Infection in Developing Countries Pub Date : 2025-01-31 DOI: 10.3855/jidc.20088

Ahmed A Khalaf, Elloulu T BenDarif, Tarek M Gibreel, Abdulhamed J Alhadi, Mohamed O Abugalia, Ali E Mohamed, Nagi M Gebril, Fatma Jomaa, Ali O Daeki

{"title":"Seroprevalence and associated risk factors of HBV and HCV infections in the population of Ghudduwah Village, South Libya.","authors":"Ahmed A Khalaf, Elloulu T BenDarif, Tarek M Gibreel, Abdulhamed J Alhadi, Mohamed O Abugalia, Ali E Mohamed, Nagi M Gebril, Fatma Jomaa, Ali O Daeki","doi":"10.3855/jidc.20088","DOIUrl":"https://doi.org/10.3855/jidc.20088","url":null,"abstract":"Introduction: Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are serious public health concerns in Libya, particularly in the southern region. This study aimed to determine the prevalence and associated risk factors for HBV and HCV infections among the general population in Ghudduwah village, south Libya.Methodology: A cross-sectional study was carried out on 352 individuals from April to October 2018. Data on socio-demographic characteristics and suspected risk factors were obtained by a standard questionnaire. Serum samples were tested for HBV markers (HBsAg, HBcAb, HBeAg, HBeAb and HBsAb) and anti-HCV antibody (HCV-Ab).Results: The overall prevalence of HBsAg, HBcAb, and HCV-Ab was 2.8%, 21%, and 22.4%, respectively. The rates of HBsAg, HBcAb, and HCV-Ab were significantly higher in males (4.5 %, 25.8% and 26.2 %) than in females (0%, 12.9 %, and 16%, respectively). The high prevalence of HBcAb and HCV-Ab were significantly associated with individuals who had a history of blood transfusion (p = 0.037 and 0.035, respectively) and received dental treatment (p = 0.01 and 0.0001, respectively). In addition, a high prevalence of HCV infection was significantly associated with a family history of viral hepatitis and wet cupping (p = 0.05 and 0.0001, respectively).Conclusions: Ghudduwah village is an area of low-intermediate hepatitis B endemicity, whereas the local prevalence of hepatitis C infection is classified as high-endemicity. History of blood transfusion, dental treatment, family history of viral hepatitis and wet cupping were the most common risk factors for the transmission of HBV and HCV infection.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 1","pages":"117-123"},"PeriodicalIF":1.4,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143469769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness of homologous and heterologous BNT162b2 and CoronaVac booster vaccination against severe COVID-19 outcomes.

IF 1.4 4区医学

Journal of Infection in Developing Countries Pub Date : 2025-01-31 DOI: 10.3855/jidc.18946

Masliyana Husin, Peter Seah Keng Tok, Jing Lian Suah, Boon Hwa Tng, Thevesh Thevananthan, Kalaiarasu M Peariasamy, Sheamini Sivasampu

{"title":"Effectiveness of homologous and heterologous BNT162b2 and CoronaVac booster vaccination against severe COVID-19 outcomes.","authors":"Masliyana Husin, Peter Seah Keng Tok, Jing Lian Suah, Boon Hwa Tng, Thevesh Thevananthan, Kalaiarasu M Peariasamy, Sheamini Sivasampu","doi":"10.3855/jidc.18946","DOIUrl":"https://doi.org/10.3855/jidc.18946","url":null,"abstract":"Introduction: Evidence of the waning immunity of coronavirus disease 2019 (COVID-19) primary vaccination, and immune evasion by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants has led to the rollout of booster vaccination in many countries. Assessing the effectiveness of booster vaccination against severe COVID-19 outcomes is crucial during the transition to endemicity.Methodology: We conducted a population-based, matched case-control study in Malaysia to estimate the marginal vaccine effectiveness (mVE) of homologous and heterologous BNT162b2 and CoronaVac booster vaccination against COVID-19 related intensive care unit (ICU) admission and death in Delta-predominant and Omicron-predominant periods.Results: Receipt of a booster vaccination - either homologous or heterologous for CoronaVac, and homologous for BNT162b2 - demonstrated mVE estimates of at least 70% against ICU admission and at least 80% against death, compared to BNT162b2 primary vaccination, in both periods. Overall, the mVE estimates were 10-20 percentage points lower in the Omicron-predominant period than in the Delta-predominant period.Conclusions: Our study reaffirms that the administration of booster vaccination increases protection against severe COVID-19 outcomes for BNT162b2 and CoronaVac primary vaccination recipients.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 1","pages":"9-12"},"PeriodicalIF":1.4,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143469664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term predictions of COVID-19 waves in China based on an improved SEIRS-Q model of antibody failure.

IF 1.4 4区医学

Journal of Infection in Developing Countries Pub Date : 2025-01-31 DOI: 10.3855/jidc.19058

Mengxuan Lin, Pengyuan Nie, Qunjiao Yan, Xinying Du, Jinquan Chen, Yaqing Jin, Ligui Wang, Lei Wang

{"title":"Long-term predictions of COVID-19 waves in China based on an improved SEIRS-Q model of antibody failure.","authors":"Mengxuan Lin, Pengyuan Nie, Qunjiao Yan, Xinying Du, Jinquan Chen, Yaqing Jin, Ligui Wang, Lei Wang","doi":"10.3855/jidc.19058","DOIUrl":"https://doi.org/10.3855/jidc.19058","url":null,"abstract":"Introduction: China had already experienced two COVID-19 epidemics since the promulgation of 10 new prevention and control measures in December 2022.Methodology: In response to the current frequent epidemics of severe acute respiratory syndrome coronavirus 2 variants in China and the gradual relaxation of prevention and control policies, we built and ran a susceptible-exposed-infective-removed-susceptible-quarantined model incorporating self-isolation to predict future cases of COVID-19.Results: Four waves of outbreaks were predicted to occur in November 2023, and in April, July, and November 2024. The first two waves were predicted to be more severe, with the maximum number of infected cases reaching 18.97% (269 million) and 8.77% (124 million) of the country's population, respectively, while the rest were predicted to affect a maximum of < 3%.Conclusions: Future outbreaks are expected to occur at shorter intervals but last for longer durations. COVID-19 epidemics in China are expected to subside after November 2024.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 1","pages":"13-16"},"PeriodicalIF":1.4,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143469701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0