Investigation of the distribution and antifungal susceptibility of Candida species isolated from clinical specimens in central part of Turkey.

IF 1.2 4区医学 Q4 INFECTIOUS DISEASES

Journal of Infection in Developing Countries Pub Date : 2025-07-28 DOI:10.3855/jidc.20880

Burak Ezer, Selin Ugrakli, Enes Kasapoglu

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引用次数: 0

Abstract

Introduction: This study aimed to examine the distribution and antifungal susceptibility of Candida species in a university hospital and investigate the association of Candida species with age, gender, and clinical specimens.

Methodology: A total of 939 samples isolated Candida spp. from various clinical samples between 01.01.2019-06.08.2024 were included in the study. Between 01.01.2019-29.04.2022, Candida species and antifungal susceptibilities were determined using Vitek2 automated system. Between 30.04.2022-06.08.2024, Candida species were detected using the Phoenix automated system and MALDITOF-MS, and antifungal susceptibilities were determined by the gold standard method of broth microdilution.

Results: Candida albicans was detected in 511 (54.4%) and non-albicans candida species (NAC) in 428 (45.6%) of the samples with Candida spp. growth. The most frequently detected species were C. albicans in 511 (54.4%) samples, C. parapsilosis in 215 (22.9%) samples, and C. glabrata in 85 (9.1%) samples. The MIC values of all antifungals were statistically significantly higher in NAC species than in C. albicans (p < 0.001). C. tropicalis was isolated most frequently in CSF, C. albicans was isolated most frequently in ocular corneal fluid, C. tropicalis was isolated most frequently in pleural fluid and C. albicans was isolated in all vaginal discharge samples. The higher MIC values of caspofungin, micafungin, and anidulafungin in C. parapsilosis isolates were statistically significant compared to C. albicans and C. glabrata (p < 0.001).

Conclusions: Investigating the distribution and antifungal susceptibility of Candida species is vital to initiate appropriate and early empirical antifungal therapy. Each center should determine its species distribution and closely monitor antifungal resistance changes.

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土耳其中部地区假丝酵母菌临床分离株分布及抗真菌敏感性调查。

前言：本研究旨在调查念珠菌在某大学医院的分布和抗真菌药敏情况，并探讨念珠菌种类与年龄、性别和临床标本的关系。方法：选取2019年1月1日- 2024年6月8日期间从不同临床标本中分离到的念珠菌939例。2019年1月1日- 2022年4月29日，采用Vitek2自动化系统检测假丝酵母菌种类及抗真菌药物敏感性。在30.04.2022-06.08.2024期间，采用Phoenix自动化系统和MALDITOF-MS检测念珠菌菌种，采用微量肉汤稀释金标准法测定抗真菌药敏。结果：白色念珠菌511株（54.4%）检出，非白色念珠菌428株（45.6%）检出。检出最多的菌种分别为白色念珠菌511株（54.4%）、副枯枝念珠菌215株（22.9%）和光秃念珠菌85株（9.1%）。所有抗真菌药物的MIC值在NAC菌中均显著高于白色念珠菌（p < 0.001）。热带镰刀菌在脑脊液中最常见，白色镰刀菌在眼角膜液中最常见，热带镰刀菌在胸膜液中最常见，白色镰刀菌在阴道分泌物中最常见。caspofungin、micafungin和anidulafungin在假丝酵母菌分离株中的MIC值高于白色念珠菌和光秃念珠菌（p < 0.001）。结论：研究念珠菌的分布和抗真菌敏感性对早期开展适当的经验性抗真菌治疗至关重要。各中心应确定菌种分布，密切监测抗真菌药敏变化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Infection in Developing Countries INFECTIOUS DISEASES-

CiteScore

3.70

自引率

5.30%

发文量

239

审稿时长

4-8 weeks

期刊介绍： The Journal of Infection in Developing Countries (JIDC) is an international journal, intended for the publication of scientific articles from Developing Countries by scientists from Developing Countries. JIDC is an independent, on-line publication with an international editorial board. JIDC is open access with no cost to view or download articles and reasonable cost for publication of research artcles, making JIDC easily availiable to scientists from resource restricted regions.