Journal of Infection in Developing Countries最新文献_第5页

Efficacy and safety of cefiderocol in the treatment of infections caused by Gram-negative bacteria: a systematic review and meta-analysis. 头孢地罗治疗革兰氏阴性菌感染的有效性和安全性：系统综述和荟萃分析。

IF 1.4 4区医学

Journal of Infection in Developing Countries Pub Date : 2024-12-30 DOI: 10.3855/jidc.19875

Xiaocui Huang, Lin Su, Wenjie Zhou, Yiduo Zhang, Fan Yu, Chao Li

{"title":"Efficacy and safety of cefiderocol in the treatment of infections caused by Gram-negative bacteria: a systematic review and meta-analysis.","authors":"Xiaocui Huang, Lin Su, Wenjie Zhou, Yiduo Zhang, Fan Yu, Chao Li","doi":"10.3855/jidc.19875","DOIUrl":"https://doi.org/10.3855/jidc.19875","url":null,"abstract":"Objective: To assess the efficacy and safety of cefiderocol (CFDC) in the treatment of Gram-negative bacteria (GNB) infections.Methods: Relevant studies were collected from PubMed, Web of Science, Cochrane, and Embase databases, from inception to 15 October 2023. The search formula was as follow: \"cefiderocol\", \"S-649266\", \"Gram-Negative Bacteria\", \"Gram Negative Bacteria\", \"Klebsiella pneumoniae\", \"Hyalococcus pneumoniae\", and \"Bacterium pneumoniae proposal\". Stata 15.0 software was employed to pool data with risk ratios (RRs) and 95% confidence intervals (CIs). Data were pooled using a random- or a fixed-effects model.Results: After a comprehensive study selection, 11 studies (5 RCTs and 7 observational studies) were retrieved that compared the efficacy of CFDC with other regimens, e.g., imipenem/cilastatin. The clinical response (RR = 1.00, 95% CI 0.94-1.08, I2 = 0%) and microbiological response (RR = 0.95 95% CI = 0.80-1.14, I2 = 68.7%) of CFDC were comparable to the control group. No significant differences were observed in mortality and adverse events. Furthermore, subgroup analyses showed that CFDC enhanced microbiological eradication in the follow-up group (RR = 1.25, 95% CI 1.05-1.49) and patients with complicated urinary tract infections (cUTI) (RR = 1.32, 95% CI 1.11- 1.57).Conclusions: CFDC is a novel iron-carrying cephalosporin with the potential to effectively combat Gram-negative bacterial infections. Additional large and high-quality RCTs are required to further confirm the safety of CFDC.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"18 12","pages":"1815-1823"},"PeriodicalIF":1.4,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143014781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence, diversity, and antimicrobial resistance of Salmonella spp. isolated from river sediments in Northwest Mexico. 墨西哥西北部河流沉积物中沙门氏菌的流行、多样性和耐药性。

IF 1.4 4区医学

Journal of Infection in Developing Countries Pub Date : 2024-12-30 DOI: 10.3855/jidc.19938

José Andrés Medrano-Félix, Juan Carlos Guerra-Rodríguez, Vianey Araceli Verdugo Arredondo, Berenice González-Torres, Lennin Isaac Garrido-Palazuelos, Irvin González-López, Nohelia Castro-Del Campo, Osvaldo López-Cuevas, Cristóbal Chaidez Quiroz

{"title":"Prevalence, diversity, and antimicrobial resistance of Salmonella spp. isolated from river sediments in Northwest Mexico.","authors":"José Andrés Medrano-Félix, Juan Carlos Guerra-Rodríguez, Vianey Araceli Verdugo Arredondo, Berenice González-Torres, Lennin Isaac Garrido-Palazuelos, Irvin González-López, Nohelia Castro-Del Campo, Osvaldo López-Cuevas, Cristóbal Chaidez Quiroz","doi":"10.3855/jidc.19938","DOIUrl":"https://doi.org/10.3855/jidc.19938","url":null,"abstract":"Introduction: Salmonella is a major foodborne pathogen widely distributed in the environment. Surface water, soil, and sediments may confer a protective effect on Salmonella against non-host conditions.Methodology: This study focused on determining the prevalence of Salmonella spp. in river sediments from Sinaloa central region by the Most Probable Number (MPN) technique and determining the antimicrobial resistance profile by Kirby-Bauer assay.Results: Results showed the prevalence of Salmonella from 37.5 to 62.5% of the samples, oscillating from 0.322 to 20 MPN/4g, with August being the month with the highest levels. In silico geno-serotyping reveals the presence of Salmonella serotypes Typhi, Javiana, Ohio, Montevideo, Oranienburg, Pomona, Agona, Livingstone, Weltevreden, Anatum, and Minnesota. The most prevalent serotypes in river sediments were Pomona, Montevideo, and Oranienburg. Almost all isolates showed resistance to erythromycin, rifampin, and penicillin.Conclusions: This study reveals the prevalence and distribution of Salmonella enterica in river sediments, which may represent a potential niche for establishment and survival in the environment and become a potential contamination source.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"18 12","pages":"1875-1882"},"PeriodicalIF":1.4,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143014753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Concerns on the mother-to-child transmission of hepatitis B virus reported in Ethiopia. 对埃塞俄比亚报告的乙型肝炎病毒母婴传播的关切。

IF 1.4 4区医学

Journal of Infection in Developing Countries Pub Date : 2024-11-30 DOI: 10.3855/jidc.19105

Jie Tang, Hong Zhao

{"title":"Concerns on the mother-to-child transmission of hepatitis B virus reported in Ethiopia.","authors":"Jie Tang, Hong Zhao","doi":"10.3855/jidc.19105","DOIUrl":"10.3855/jidc.19105","url":null,"abstract":"Introduction: Taye and colleagues reported that the rate of mother-to-child transmission (MTCT) of hepatitis B virus (HBV) was as high as 20.7% in Ethiopia based on their meta-analysis of three studies [1]. However, numerous studies demonstrate that the overall rate of MTCT is below 5% after timely neonatal administration of hepatitis B immunoglobulin (HBIG) and hepatitis B vaccine after birth.Concerns: The reports on which the meta-analysis was conducted appear to be problematic. The infants of HBV-infected mothers were not vaccinated against HBV at all, in one report. In another report, MTCT was defined based on positive hepatitis B surface antigen (HBsAg) in the umbilical cord blood, which is not correct because vast majority (> 95%) of positive HBsAg in umbilical cord blood is not infected with, but exposed to, HBV. Thus, MTCT of HBV calculated to be as high as 20.7% in this meta-analysis was overestimated, and much higher than the reported rate of 1-3% immunoprophylaxis failure in other parts of the world, including in Africa.Conclusions: The rate of MTCT of HBV in Ethiopia in this meta-analysis was overestimated. High-quality investigations are required to understand the real picture of immunoprophylaxis against MTCT of HBV in Ethiopia.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"18 11","pages":"1780-1781"},"PeriodicalIF":1.4,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142856177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidemiological trends and clinical characteristics of human leptospirosis in Wenzhou, Zhejiang Province, China, 2020-2022. 2020-2022年浙江省温州市人钩端螺旋体病流行趋势及临床特征

IF 1.4 4区医学

Journal of Infection in Developing Countries Pub Date : 2024-11-30 DOI: 10.3855/jidc.18434

YueYing Zhou, XianMin Wang, HuiJuan Li, Zhengxing Wu, Ning Pan, HongYe Ning, SaiDuo Liu, XinChun Ye, Chao-Chao Qiu, KaiJia Wu, JiChan Shi

{"title":"Epidemiological trends and clinical characteristics of human leptospirosis in Wenzhou, Zhejiang Province, China, 2020-2022.","authors":"YueYing Zhou, XianMin Wang, HuiJuan Li, Zhengxing Wu, Ning Pan, HongYe Ning, SaiDuo Liu, XinChun Ye, Chao-Chao Qiu, KaiJia Wu, JiChan Shi","doi":"10.3855/jidc.18434","DOIUrl":"https://doi.org/10.3855/jidc.18434","url":null,"abstract":"Objective: To observe the clinical characteristics and epidemic trends of human leptospirosis in Wenzhou, Zhejiang Province, China, from 2020 to 2022 and to provide a scientific basis for prevention and control in this area.Methods: Descriptive epidemiological methods were used in Wenzhou, China, from 2020 to 2022. Leptospira antibodies were detected by a microscopic agglutination test (MAT), and laboratory tests were conducted to analyse the prevalence of Leptospira in the population.Results: From 2020 to 2022, a total of 41 cases of human leptospirosis were reported in Wenzhou, China, with no deaths and an average annual incidence of 0.1428/100,000. The highest incidence was in 2021 (30 cases, incidence rate: 0.31/100,000), and the lowest incidence was in 2022 (three cases, incidence rate: 0.04/100,000). The high-incidence season was from August to October, in which a total of 36 cases were reported, accounting for 87.80% of total cases, most of which were males. The main occupation was farming, which accounted for 70.7% of the total number of cases. 90.2% of cases had fever symptoms, and the body temperature was between 36.5 ℃ and 40.1 ℃. A total of 32 positive samples were detected by MAT in six main groups, mainly the Autumnalis serogroup.Conclusions: The incidence of leptospirosis in Wenzhou, China, was at a moderate level from 2020 to 2022. Localities should actively strengthen the monitoring of leptospirosis host animals and populations, understand the infection rate and floral changes and prevent leptospirosis outbreaks.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"18 11","pages":"1709-1714"},"PeriodicalIF":1.4,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142856212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of three rapigen biocredit point-of-care tests for malaria case management in Lagos, Nigeria. 在尼日利亚拉各斯评价用于疟疾病例管理的三种快速生物信贷护理点测试。

IF 1.4 4区医学

Journal of Infection in Developing Countries Pub Date : 2024-11-30 DOI: 10.3855/jidc.19314

Oluwagbemiga O Aina, Chimere O Agomo, Olusola Ajibaye, Celestina O Okoyenta, Nnenna Ogbulafor, Simon Ijezie, Akwaowo B Orok, Chinedum T Oparaugo, Samuel K Akindele, Damilare J Bamgbose, Susan A Holdbrooke, Olaide K Kareem, Yetunde A Olukosi, Isaac Ola

{"title":"Evaluation of three rapigen biocredit point-of-care tests for malaria case management in Lagos, Nigeria.","authors":"Oluwagbemiga O Aina, Chimere O Agomo, Olusola Ajibaye, Celestina O Okoyenta, Nnenna Ogbulafor, Simon Ijezie, Akwaowo B Orok, Chinedum T Oparaugo, Samuel K Akindele, Damilare J Bamgbose, Susan A Holdbrooke, Olaide K Kareem, Yetunde A Olukosi, Isaac Ola","doi":"10.3855/jidc.19314","DOIUrl":"https://doi.org/10.3855/jidc.19314","url":null,"abstract":"Introduction: Histidine-rich protein 2 (HRP2) antigen kits are widely used for malaria diagnosis in tropical regions due to their heat stability. The Plasmodium Lactate Dehydrogenase (pLDH) used in BIOCREDIT® malaria test kit is claimed to be heat-stable. This study aimed to evaluate the heat stability and field performance of three BIOCREDIT® kits.Methodology: A cross-sectional community survey of malaria infection was carried out in Agbowa and Ikosi communities in Lagos State. Finger-prick blood was used to assess the performance of three BIOCREDIT® kits: Kit 1 (PfpLDH), Kit 2 (PfLDH/HRP2), and Kit 3 (PfLDH/PvLDH). Malaria microscopy and a reference mRDT (SD BIOLINE® PfHRP2) were used as comparators. Heat stability testing was performed using Plasmodium falciparum panels after exposure to 35oC and 45oC for 60 days. A total of 834 participants were recruited.Results: The sensitivity of BIOCREDIT® kits were: Kit 1 (PfLDH) 88.4%; Kit 2 PfHRP2 92% and PfLDH 86.6%; Kit 3 (PfLDH) 88.4%. The specificity of kits was: Kit 1 (Pf LDH) 91.7%; Kit 2 (PfHRP2) 82.3%) and (PfLDH) 92.1%; Kit 3 (PfLDH) 91.6%. The sensitivity and specificity of the reference kit were 92.9% and 85.9%. The three BIOCREDIT® Kits were stable. No potential case of pfhrp2 gene deletion was observed.Conclusions: The sensitivities of the three BIOCREDIT® malaria test kits were similar to the reference kit (SD BIOLINE mRDT). However, the specificities of PfLDH kits were significantly higher than the specificities of PfHRP2 kits. The BIOCREDIT® kits are suitable to be deployed in malaria-endemic tropical regions.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"18 11","pages":"1764-1771"},"PeriodicalIF":1.4,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142856228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of colistin heteroresistance and the colistin resistance genes mcr-1 to mcr-5 in Escherichia coli and Klebsiella pneumoniae isolates in a tertiary hospital in Turkey. 土耳其某三级医院大肠杆菌和肺炎克雷伯菌分离株粘菌素异源耐药及耐药基因mcr-1 ~ mcr-5的调查

IF 1.4 4区医学

Journal of Infection in Developing Countries Pub Date : 2024-11-30 DOI: 10.3855/jidc.19276

Erkut Afyoncu, Canan Eryıldız

{"title":"Investigation of colistin heteroresistance and the colistin resistance genes mcr-1 to mcr-5 in Escherichia coli and Klebsiella pneumoniae isolates in a tertiary hospital in Turkey.","authors":"Erkut Afyoncu, Canan Eryıldız","doi":"10.3855/jidc.19276","DOIUrl":"https://doi.org/10.3855/jidc.19276","url":null,"abstract":"Introduction: Heteroresistance is not detected by traditional antimicrobial susceptibility testing methods and may lead to treatment failures. Investigating the presence of plasmid-mediated colistin resistance genes is important because of the horizontal transmission of the relevant genes between bacterial species. This study aimed to investigate the presence of colistin heteroresistance and the colistin resistance genes mcr-1 to mcr-5 in Escherichia coli and Klebsiella pneumoniae isolates.Methodology: A total of 254 isolates, including 100 E. coli and 154 K. pneumoniae strains isolated from clinical samples, were included in the study. Colistin susceptibility was evaluated using the broth microdilution method for all strains. Heteroresistance screening was performed using the gradient strip test. Eight strains were evaluated for heteroresistance by population analysis profiling (PAP). The colistin resistance genes mcr-1 to mcr-5 were investigated by multiplex polymerase chain reaction (PCR) in colistin-resistant K. pneumoniae isolates. Multilocus sequence typing (MLST) analysis was performed on two K. pneumoniae strains.Results: Colistin resistance was not detected in the E. coli isolates and was detected in 16.23% (25/154) of the K. pneumoniae isolates. No heteroresistant bacteria were detected by the gradient strip test or by PAP. All colistin-resistant isolates were negative for the mcr genes. The two isolates analyzed by MLST were ST14 and ST2096.Conclusions: Periodic follow-up of colistin heteroresistance is useful for administering appropriate antibiotic therapy. In addition, the investigation of colistin resistance genes is important for infection control measures.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"18 11","pages":"1687-1694"},"PeriodicalIF":1.4,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142856362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Profile of co-occurring or secondary infections among COVID-19 patients with HBOT: a single-center retrospective study. COVID-19 HBOT患者并发或继发感染概况：一项单中心回顾性研究

IF 1.4 4区医学

Journal of Infection in Developing Countries Pub Date : 2024-11-30 DOI: 10.3855/jidc.20460

Peixia Yu, Hairu Wang, Ziyang Li, Junyan Zhang, Shuang Wei, Zhifeng Xue, Bozheng Zhang, Qi Mei, Zhengtao Wang, Yani Zhao, Qing Niu, Pingzhi Wang

{"title":"Profile of co-occurring or secondary infections among COVID-19 patients with HBOT: a single-center retrospective study.","authors":"Peixia Yu, Hairu Wang, Ziyang Li, Junyan Zhang, Shuang Wei, Zhifeng Xue, Bozheng Zhang, Qi Mei, Zhengtao Wang, Yani Zhao, Qing Niu, Pingzhi Wang","doi":"10.3855/jidc.20460","DOIUrl":"https://doi.org/10.3855/jidc.20460","url":null,"abstract":"Introduction: This study was designed to describe the profile of co-occurring or secondary infections in hospitalized coronavirus disease 2019 (COVID-19) patients undergoing hyperbaric oxygen therapy (HBOT) and those without.Methodology: Out of 716 COVID-19 patients, 79 cases of co-occurring or secondary infections were included. These patients were categorized into two groups based on their usage of HBOT. The basic information and laboratory examinations, especially pathogen-related results were collected from the medical records. The rate of co-occurring or secondary infections, distribution of pathogens, infection sites, and results of antimicrobial susceptibility testing were analyzed.Results: Among the 79 COVID-19 patients examined, there were 73 cases of infections, including 58 co-occurring infections, 14 secondary infections, and 1 mixed infection in the non-HBOT group. There were 6 cases with co-occurring or secondary infections in the HBOT group. Influenza virus was predominant in the co-occurring or secondary infections of COVID-19 patients, but it was not detected in patients undergoing HBOT. Klebsiella pneumoniae, Corynebacterium striatum, and Acinetobacter baumannii were the main strains isolated among patients with HBOT. The multidrug-resistant organisms (MDROs) strains of Escherichia coli, Klebsiella aerogenes, Staphylococcus aureus, Pseudomonas aeruginosa, and Enterococcus faecium were detected from COVID-19 patients treated with HBOT.Conclusions: This study described the profile of in-hospital co-occurring or secondary infections in COVID-19 patients from North China. Management of the co-occurring or secondary infections, especially MDROs infections treated with HBOT, including but not limited to COVID-19, should be strengthened.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"18 11","pages":"1663-1670"},"PeriodicalIF":1.4,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142856381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Two rare cases of Brucella-induced endocarditis and myopericarditis: challenges in diagnosis. 罕见的布鲁氏菌性心内膜炎和心包炎2例：诊断的挑战。

IF 1.4 4区医学

Journal of Infection in Developing Countries Pub Date : 2024-11-30 DOI: 10.3855/jidc.19517

Dalila Šačić, Olga Petrović, Branislava Ivanović

{"title":"Two rare cases of Brucella-induced endocarditis and myopericarditis: challenges in diagnosis.","authors":"Dalila Šačić, Olga Petrović, Branislava Ivanović","doi":"10.3855/jidc.19517","DOIUrl":"https://doi.org/10.3855/jidc.19517","url":null,"abstract":"Introduction: Brucellosis is one of the most common zoonotic infections in the world. Cardiac complications of the disease are usually in the form of endocarditis, and, to a lesser extent, in the form of myopericarditis.Case: We report the case of a 34-year-old female admitted with signs of fever, nausea, and headache. The patient came from Libya, where she drank unpasteurized milk. Whright-Coombs test and blood confirmed Brucella species infection, while transoesophagal echocardiogram revealed a thrombotic mass on the tricuspid valve that required cardiac surgery and antibiotic treatment, leading to complete recovery. The second case was a 37-years-old male admitted with suspected acute coronary syndrome, where further diagnostics excluded occlusions of coronary arteries and found Brucella species infection and signs of myocardial and pericardial involvement that reacted well on treatment (combination of doxycycline and rifampicin).Discussion: Brucellosis is commonly seen in people working with farm animals or using unpasteurized milk but is still often misdiagnosed.Conclusions: Tricuspid valve endocarditis, as well as isolated myopericarditis, are rare complications of Brucellosis, which can be fatal if not diagnosed and treated on time.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"18 11","pages":"1782-1786"},"PeriodicalIF":1.4,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142856384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of the standard Q syphilis antibody rapid diagnostic test to gold standards for yaws detection in children. 标准Q梅毒抗体快速诊断试验与儿童雅司病检测金标准的比较。

IF 1.4 4区医学

Journal of Infection in Developing Countries Pub Date : 2024-11-30 DOI: 10.3855/jidc.17753

Yudo Irawan, Astuti Giantini, Nevi Yasnova

{"title":"Comparison of the standard Q syphilis antibody rapid diagnostic test to gold standards for yaws detection in children.","authors":"Yudo Irawan, Astuti Giantini, Nevi Yasnova","doi":"10.3855/jidc.17753","DOIUrl":"https://doi.org/10.3855/jidc.17753","url":null,"abstract":"Introduction: Yaws remains a public health problem in Indonesia, and it is the largest contributor to Yaws cases in Southeast Asia. Yaws is caused by bacterial infection of Treponema pallidum subspecies pertenue, mainly affecting the skin and bones. An estimated 75% of new cases were found in children under 15. The diagnosis of yaws is based on clinical findings with serological confirmation. Rapid diagnostic tests (RDT) have been developed to diagnose Yaws faster and simpler and can thus be used in areas with limited resources.Methodology: In this study, sensitivity and specificity of the solid phase immunochromatographic assay of Standard Q Syphilis Antibody (Ab) RDT was performed compared to Treponema Pallidum Haemagglutination Assay (TPHA Plasmatec®) and Rapid Plasma Reagin (RPR) in 195 children with yaws age 2-15 years in Halmahera Barat, Maluku.Results: There were 116 children with clinical symptoms representative of yaws, but only 13 were serologically positive. The scar was the most commonly found lesion, and the most affected regions were the legs. The sensitivity and specificity of RDT compared to TPHA were 93.3% and 99.4%, respectively. The sensitivity and specificity of RDT compared to RPR were 100% and 98.4%, respectively.Conclusions: Based on the excellent performance of this test, this study suggests that Standard Q Syphilis Ab RDT examination can be used as a screening test. However, unusual clinical findings, like scars in RDT reactive patients, indicated that RPR is still required to confirm the diagnosis of yaws.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"18 11","pages":"1734-1738"},"PeriodicalIF":1.4,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142856066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuropathy among drug resistant HIV Patients treated in Jakarta. 雅加达治疗耐药HIV患者的神经病变。

IF 1.4 4区医学

Journal of Infection in Developing Countries Pub Date : 2024-11-30 DOI: 10.3855/jidc.19756

Ibnu A Ariyanto, Fitri Octaviana, Churi Wardah, Ekawati Beti, Silvia Widyaningtyas, Budiman Bela, Patricia Price, Amin Soebandrio

{"title":"Neuropathy among drug resistant HIV Patients treated in Jakarta.","authors":"Ibnu A Ariyanto, Fitri Octaviana, Churi Wardah, Ekawati Beti, Silvia Widyaningtyas, Budiman Bela, Patricia Price, Amin Soebandrio","doi":"10.3855/jidc.19756","DOIUrl":"https://doi.org/10.3855/jidc.19756","url":null,"abstract":"Introduction: Some people living with HIV (PLWH) receiving ART in Indonesia display poor clearance of replicating virus. This has been associated with HIV-associated sensory neuropathy. Here we assess whether treatment failure reflects the presence of drug resistance mutations.Methodology: PLWH were stratified by HIV RNA levels using a ≥ 1000 copies/mL cut-off after 5.3 (2-7.5) years on ART. Drug-resistance mutations were analyzed in seven of ten cases with a detectable viral load. The HIV pol gene was screened for mutations affecting resistance to nucleoside inhibitors (NRTI), non-nucleoside inhibitors (NNRTI) and protease inhibitors (PI). We recorded co-infections, transmission routes, and neuropathy based on the Brief Peripheral Neuropathy Screen Tool.Results: The primary HIV subtype was HIV-1 CRF01_AE, but one patient had subtype G. Polymorphisms affecting NRTI or NNRTI (6/7 cases) and protease inhibitors (1/7 cases) were identified. Three mutations affecting NRTI (M184V, M4IL, T215F), two for NNRTI (K103N, G190A) and five for protease inhibitors (M46I, I50V, I54V, V82A, N88NDGS) were evident. Subjects with resistance mutations were mostly intra-venous drug users (4/7) and had a higher risk of neuropathy (p = 0.016).Conclusions: Drug resistance mutations were present in most cases of treatment failure examined and were therefore indirectly a risk factor for peripheral neuropathy.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"18 11","pages":"1640-1644"},"PeriodicalIF":1.4,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142856375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0