Journal of Infection in Developing Countries最新文献_第5页

Prevalence of genetic variants in SERPINB2 and PKNOX1 genes in erythema nodosum leprosum patients from southern Brazil. 巴西南部麻风结节性红斑患者SERPINB2和PKNOX1基因遗传变异的流行

IF 1.2 4区医学

Journal of Infection in Developing Countries Pub Date : 2025-07-28 DOI: 10.3855/jidc.20688

Simone Perazzoli, Miriãn Fm Fiuza, Paulo Cezar De Moraes, Renata Heck, Fernanda Sl Vianna, Renan R Bonamigo

{"title":"Prevalence of genetic variants in SERPINB2 and PKNOX1 genes in erythema nodosum leprosum patients from southern Brazil.","authors":"Simone Perazzoli, Miriãn Fm Fiuza, Paulo Cezar De Moraes, Renata Heck, Fernanda Sl Vianna, Renan R Bonamigo","doi":"10.3855/jidc.20688","DOIUrl":"10.3855/jidc.20688","url":null,"abstract":"Introduction: Erythema nodosum leprosum (ENL) is a humoral immune response to Mycobacterium leprae that is characterized by erythematous nodules, and may or may not be associated with systemic symptoms. Thalidomide is the primary treatment for ENL in Brazil, but peripheral neuropathy (PN) is a significant adverse effect. Genetic variants in SERPINB2 and PKNOX1 genes have been implicated in the predisposition to develop thalidomide-induced peripheral neuropathy (TiPN) in patients with multiple myeloma. This study evaluated the prevalence of the polymorphisms in SERPINB2 and PKNOX1 in ENL patients.Methodology: A cross-sectional study was conducted in a sample of ENL patients from southern Brazil to assess the presence of genetic variants of SERPINB2 and PKNOX1.Results: Forty-seven patients with ENL were included. The prevalence of SERPINB2 (rs6103) was 66% for the C allele and 34% for the G allele, and the prevalence of PKNOX1 (rs2839629) was 75% for the A allele and 25% for the G allele. There was significantly relevant presence of the PKNOX1 (rs2839629) A allele in patients with ENL (p < 0.001). In the case of patients with PN, the presence of the C genotype for rs6103 (SERPINB2) was 85% in homozygosity and 77.3% in heterozygosity; and the presence of the A genotype for rs2839629 (PKNOX1) was 84% in homozygosity and 80% in heterozygosity.Conclusions: Polymorphisms in SERPINB2 and PKNOX1 were identified in patients with ENL, with emphasis on PKNOX1. If confirmed by more robust future studies, these findings may guide clinical decisions and treatment guidelines for ENL.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 7","pages":"1083-1088"},"PeriodicalIF":1.2,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144734726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differences between COVID-19 and non-COVID-19 patients' bloodstream infections: a single-center retrospective study. COVID-19与非COVID-19患者血液感染的差异：单中心回顾性研究

IF 1.2 4区医学

Journal of Infection in Developing Countries Pub Date : 2025-07-28 DOI: 10.3855/jidc.20929

Çağla Keskin Sarıtaş, Halit Özsüt, Aysun Benli, Seniha Başaran

{"title":"Differences between COVID-19 and non-COVID-19 patients' bloodstream infections: a single-center retrospective study.","authors":"Çağla Keskin Sarıtaş, Halit Özsüt, Aysun Benli, Seniha Başaran","doi":"10.3855/jidc.20929","DOIUrl":"10.3855/jidc.20929","url":null,"abstract":"Introduction: This study aimed to examine the differences between coronavirus disease 2019 (COVID-19) and non-COVID-19 patients with intensive care unit (ICU)-associated bloodstream infections (BSIs), in terms of epidemiological, clinical, microbiological, and outcome data.Methodology: All patients who were followed up in the ICU of a university hospital between 18 March 2020 and 18 April 2022, and who had developed ICU-acquired BSI, based on the study criteria, were selected and divided into 2 groups: COVID-19 and non-COVID-19. Descriptive statistics were used to analyze differences between the groups. Logistic regression analysis was applied to determine mortality risk factors in BSI patients.Results: 234 patients were treated for ICU-acquired BSI, 127 COVID-19 and 107 non-COVID-19. Respiratory sources were significantly more common in COVID-19 patients compared to non-COVID-19 patients (43.3% vs. 26%, p = < 0.01). Among the causative pathogens, Acinetobacter baumannii (24.4% vs. 5.6%, p ≤ 0.01) and Gram-negative multidrug-resistant (MDR) bacteria (81.7% vs. 61.7%, p = 0.020) were detected more frequently in COVID-19 patients than in non-COVID-19 patients. The duration of antibiotic use in the hospital before BSI was longer in COVID-19 patients than in non-COVID-19 patients, and this was also associated with BSI in which Gram-negative MDR bacteria were active (p = < 0.01). Survival times after BSI were shorter in COVID-19 patients than in non-COVID-19 patients (p = 0.032).Conclusions: We demonstrated that MDR microorganisms were prevalent in COVID-19 patients with ICU-acquired BSI, and this was partly due to antibiotic use in the hospital prior to BSI.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 7","pages":"1015-1023"},"PeriodicalIF":1.2,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144734719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular characterization and diversity of carbapenemases in Gram-negative bacteria in Libyan hospitals. 利比亚医院革兰氏阴性菌碳青霉烯酶分子特征及多样性

IF 1.2 4区医学

Journal of Infection in Developing Countries Pub Date : 2025-07-28 DOI: 10.3855/jidc.18674

Khouloud Slimene, Salem K Almahjoub, Aldukali A Alkeskas, Ahmed I Elbousify, Elham O Omar, Allaaeddin A El Salabi, Elhussan A Mohamed, Mohammed I Hameid, Souad Alsanosi, Dhouha Miniaoui, Jean-Marc Rolain, Chedly Chouchani

{"title":"Molecular characterization and diversity of carbapenemases in Gram-negative bacteria in Libyan hospitals.","authors":"Khouloud Slimene, Salem K Almahjoub, Aldukali A Alkeskas, Ahmed I Elbousify, Elham O Omar, Allaaeddin A El Salabi, Elhussan A Mohamed, Mohammed I Hameid, Souad Alsanosi, Dhouha Miniaoui, Jean-Marc Rolain, Chedly Chouchani","doi":"10.3855/jidc.18674","DOIUrl":"10.3855/jidc.18674","url":null,"abstract":"Introduction: Antimicrobial resistance has become a major threat to public health, especially in developing countries, due to the uncontrolled consumption of antibiotics. This study aims to characterize antibiotic resistance genes in different bacteria recovered in different healthcare facilities in Libya.Methodology: 379 samples were recovered from various sources from different sites. 210 samples were able to grow on culture media. 133 Gram-negative carbapenem-resistant strains were recovered from clinical specimens (n = 64), and hospital environments (n = 69). Antibiotic susceptibility tests were performed to select carbapenem-resistant strains. Colistin resistance was tested by the UMIC method to determine the minimum inhibitory concentration. RT-PCR was conducted to detect the incidence of carbapenemases-encoding genes.Results: Gram-negative bacteria showed a low susceptibility to carbapenems. Molecular investigations indicated that NDM-1 was the most prevalent in Enterobacteriaceae isolated from patients and hospital environment (n = 26, n = 41), followed by blaOXA-48 (n = 16, n = 15) and blaVIM (n = 3) from patients and blaKPC (n = 1) from hospital environment. Concerning A. baumannii, blaOXA-23 was detected in strains isolated from patients (n = 8) and hospital environment (n = 6), followed by blaNDM (n = 9) from patients and one from hospital environment. Carbapenem resistance in P. aeruginosa was encoded by modification in OprD encoding gene, such as IS (ISpa26), polymorphism, and a premature stop codon.Conclusions: Several carbapenem resistant Gram-negative bacteria were identified by the expression of different carbapenemases and the alteration of OprD.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 7","pages":"1089-1099"},"PeriodicalIF":1.2,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144734724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rapid bedside testing for septic arthritis: evaluating cost-effective diagnostic tools. 脓毒性关节炎的快速床边检测：评估成本效益的诊断工具。

IF 1.2 4区医学

Journal of Infection in Developing Countries Pub Date : 2025-07-28 DOI: 10.3855/jidc.20882

Pranav Rajasekharan, Atmananda Hegde, Prajwal Mane, Chethan Shetty, Rishit Anand

{"title":"Rapid bedside testing for septic arthritis: evaluating cost-effective diagnostic tools.","authors":"Pranav Rajasekharan, Atmananda Hegde, Prajwal Mane, Chethan Shetty, Rishit Anand","doi":"10.3855/jidc.20882","DOIUrl":"10.3855/jidc.20882","url":null,"abstract":"Introduction: Diagnosing septic arthritis through synovial fluid culture and analysis can be time-consuming, and the limited accessibility of these tests in primary and secondary healthcare centers restricts their utility in emergency situations. Therefore, there is a pressing need for an alternative, rapid, and reliable test to significantly reduce morbidity. This study aimed to evaluate the efficacy of leucocyte esterase (LE) and glucose reagent strip tests for the early diagnosis of septic arthritis.Methodology: This cross-sectional study included 75 individuals presenting with atraumatic native joint effusion. Following arthrocentesis, bedside LE and glucose strip testing were performed, along with synovial fluid culture and analysis.Results: Out of the 75 cases, 25 (33.3%) were diagnosed with septic arthritis based on standard diagnostic tests. The LE strip test showed a sensitivity of 92%, specificity of 70%, positive predictive value (PPV) of 60%, and negative predictive value (NPV) of 94%. The glucose strip test demonstrated a sensitivity of 88%, specificity of 76%, PPV of 67%, and NPV of 93%. Combining the two tests resulted in a sensitivity of 84%, specificity of 88%, PPV of 77.8%, and NPV of 91.7%. The overall diagnostic accuracy was 80% for the glucose strip test, 77.3% for the LE strip test, and 86.7% for the combined results.Conclusions: The LE and glucose strip tests are cost-effective bedside assessments for the rapid diagnosis of septic arthritis. Combining the results from both strip tests yielded greater diagnostic accuracy than each one alone.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 7","pages":"1108-1114"},"PeriodicalIF":1.2,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144734728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Applying metagenomic next-generation sequencing to analyze infections in immunosuppressed patients with chronic kidney disease: A single-center retrospective study. 应用新一代宏基因组测序分析慢性肾病免疫抑制患者的感染：一项单中心回顾性研究

IF 1.2 4区医学

Journal of Infection in Developing Countries Pub Date : 2025-07-28 DOI: 10.3855/jidc.20713

Zhe Li, Shuhua Zhu, Jing Jiang, Yang Wang, Yuchao Zhou, Lixuan Lou, Shutian Xu, Shijun Li

{"title":"Applying metagenomic next-generation sequencing to analyze infections in immunosuppressed patients with chronic kidney disease: A single-center retrospective study.","authors":"Zhe Li, Shuhua Zhu, Jing Jiang, Yang Wang, Yuchao Zhou, Lixuan Lou, Shutian Xu, Shijun Li","doi":"10.3855/jidc.20713","DOIUrl":"10.3855/jidc.20713","url":null,"abstract":"Introduction: This retrospective study evaluated the diagnostic value and clinical application of metagenomic next-generation sequencing (mNGS) for detecting infections in immunosuppressed CKD patients.Methodology: Data from immunosuppressed CKD patients who were suspected of having an infection and admitted to Jinling Hospital from 2018-2022 were retrospectively analyzed. The patients were divided into the conventional microbiological testing (CMT)-confirmed infection group (Group I), clinically diagnosed infection group (Group II), and exclusion of infection group (Group III), and the efficiencies of microbiological detection with mNGS and CMT were compared.Results: In the 303 patients included in this study, 2 (1, 3) types of immunosuppressants were used for a median duration of 7 (2, 50) months. In Group I, 38.79% of the mNGS results were completely consistent with the CMT results, 27.88% were partially consistent, and 33.33% were inconsistent. In Group II, 57.69% of the infecting pathogens were detected by mNGS. Furthermore, 2 patients in Group III had positive NGS results. mNGS outperformed CMT in terms of the time to a positive test and the detection of mixed or rare microbial pathogens (p < 0.05). The sensitivity and accuracy of the detection of infectious pathogens were greater for mNGS than for CMT (p = 0.014).Conclusions: mNGS can improve the sensitivity and accuracy of infectious pathogen detection in immunosuppressed CKD patients. mNGS is a promising emerging technique for detecting pathogens in CKD patients, with potential benefits in speed and sensitivity, and may provide more diagnostic evidence for the detection of mixed, opportunistic, and rare infectious pathogens.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 7","pages":"1030-1038"},"PeriodicalIF":1.2,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144734716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular study of carbapenem-resistant Pseudomonas aeruginosa causing wound infection in an Egyptian tertiary hospital. 耐碳青霉烯铜绿假单胞菌引起埃及三级医院伤口感染的分子研究。

IF 1.2 4区医学

Journal of Infection in Developing Countries Pub Date : 2025-07-28 DOI: 10.3855/jidc.19953

Nagwan Galal El Menofy, Mahmoud M Tawfick, Mona Shaban E M Badawy

{"title":"Molecular study of carbapenem-resistant Pseudomonas aeruginosa causing wound infection in an Egyptian tertiary hospital.","authors":"Nagwan Galal El Menofy, Mahmoud M Tawfick, Mona Shaban E M Badawy","doi":"10.3855/jidc.19953","DOIUrl":"10.3855/jidc.19953","url":null,"abstract":"Introduction: Pseudomonas aeruginosa is a bacterial pathogen that causes various acute and chronic human infections, including wound and burn infections, with serious consequences. This study aimed to determine the antimicrobial resistance profile of P. aeruginosa isolated from wound infections and investigate the molecular mechanism of carbapenem resistance.Methodology: Forty-nine P. aeruginosa wound infection isolates were collected from a tertiary care hospital in Cairo, Egypt, from September 2022 to September 2023. The resistance profile of P. aeruginosa isolates was determined by the disc diffusion method, minimum inhibitory concentration (MIC) of meropenem susceptibility, and detection of metallo‑β-lactamase (MBL) production by imipenem-EDTA combined disc test. Polymerase chain reaction (PCR) was utilized to identify the carbapenem resistance genes, blaKPC, blaNDM-1, and blaOXA-48 among carbapenem-resistant P. aeruginosa (CRPA) isolates. The ERIC-PCR was used to assess the genetic diversity and relatedness among CRPA isolates. The results were presented as descriptive statistics in percentages and relative frequencies.Results: The findings revealed that 44.9% (22/49) of P. aeruginosa isolates were multidrug-resistant (MDR), meropenem resistant, and MBL producers. PCR assays showed that out of 22 CRPA isolates, six isolates (6/22, 27.3%) harbored the blaNDM-1 gene, and three (3/22, 13.6%) carried the blaOXA-48 gene, while none of the isolates had the blaKPC. ERIC-PCR-based genotyping demonstrated a significant molecular heterogeneity, indicated by 16 ERIC-based patterns or fingerprints among 22 CRPA isolates.Conclusions: The resistance profile demonstrated by P. aeruginosa in wound infections suggests the need for effective hospital infection control and antibiotic policies in developing countries. The CRPA isolates were polyclonal, highlighted by their substantial genetic heterogeneity.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 7","pages":"997-1006"},"PeriodicalIF":1.2,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144734725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Iatrogenic infection by atypical mycobacteria: a case report of M. phlei infection in an immunocompetent patient simulating breast malignancy. 非典型分枝杆菌引起的医源性感染：一例模拟乳腺恶性肿瘤的免疫功能正常的患者的杆菌感染。

IF 1.2 4区医学

Journal of Infection in Developing Countries Pub Date : 2025-07-28 DOI: 10.3855/jidc.21174

Carlos Salomon Sáenz de-León, Rogelio de Jesus Treviño-Rangel, Ricardo Olvera Calderón, Diego Carrion-Álvarez, Carlos Alberto Calderón Díaz, Hiram Villanueva-Lozano

{"title":"Iatrogenic infection by atypical mycobacteria: a case report of M. phlei infection in an immunocompetent patient simulating breast malignancy.","authors":"Carlos Salomon Sáenz de-León, Rogelio de Jesus Treviño-Rangel, Ricardo Olvera Calderón, Diego Carrion-Álvarez, Carlos Alberto Calderón Díaz, Hiram Villanueva-Lozano","doi":"10.3855/jidc.21174","DOIUrl":"10.3855/jidc.21174","url":null,"abstract":"Introduction: Atypical nontuberculous mycobacteria (NTM) constitute a diverse group of environmental organisms capable of causing infections in immunocompromised patients. Mycobacterium phlei has limited documentation of clinical disease in the literature.Case presentation: We present the case of a 68-year-old immunocompetent female with type II diabetes mellitus and a recent history of laparoscopic cholecystectomy. One month postoperatively, the patient developed localized wound complications followed by the appearance of a growing axillary mass. Imaging studies suggested possible malignancy (BIRADS-4), but histopathological evaluation revealed chronic granulomatous inflammation without malignant cells.Results: the diagnosis was a rare case of lymphadenitis due to M. phlei, confirmed by histology and molecular diagnostics. The patient responded favorably to combination antibiotic therapy.Conclusions: Through this report, we share our experience and expand the understanding of this entity, emphasizing the importance of considering this differential diagnosis and establishing appropriate guidelines for therapeutic decision-making, emphasizing in NTM.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 7","pages":"1138-1142"},"PeriodicalIF":1.2,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144734720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Shifts in hospital-associated pathogens and prevalence trends of carbapenem-resistant Escherichia coli infections, 2021-2023. 2021-2023年医院相关病原体的变化和耐碳青霉烯类大肠杆菌感染的流行趋势

IF 1.2 4区医学

Journal of Infection in Developing Countries Pub Date : 2025-07-28 DOI: 10.3855/jidc.20930

Luyao Liu, Shihui Liu, Zhenghai Yang, Fan Wang, Huiwen Yuan, Hao Xu, Jinguan Chen, Xiaoning Li

{"title":"Shifts in hospital-associated pathogens and prevalence trends of carbapenem-resistant Escherichia coli infections, 2021-2023.","authors":"Luyao Liu, Shihui Liu, Zhenghai Yang, Fan Wang, Huiwen Yuan, Hao Xu, Jinguan Chen, Xiaoning Li","doi":"10.3855/jidc.20930","DOIUrl":"10.3855/jidc.20930","url":null,"abstract":"Introduction: Carbapenem-resistant Escherichia coli (CREC) have emerged as a significant global health threat, particularly in hospital settings, due to their high resistance to critical antibiotics. This study aimed to evaluate the dynamics of pathogenic bacterial isolates in clinical specimens, characterize patients with CREC infections, and identify risk factors for co-infection; in order to strengthen surveillance and infection control measures.Methodology: Clinical specimens were collected from patients at a tertiary hospital in southern Anhui Province between 2021 and 2023. Strain identification and antibiotic susceptibility testing were performed using a time-of-flight mass spectrometry analyzer and the VITEK-2 compact system. Demographic and clinical data were analyzed using rigorous statistical methods.Results: The predominant bacterial species isolated included Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa, and Acinetobacter baumannii. Notably, the prevalence of CREC increased from 10.10% in 2021 to 16.36% in 2023. The predominant carbapenem-resistant Enterobacteriaceae (CRE) species were Enterobacter cloacae, Klebsiella pneumoniae, and Escherichia coli; with the proportion of CREC increasing significantly from 10.10% in 2021 to 16.36% in 2023. Of the 81 patients with CREC, 65.43% were over 60 years old. The most common specimen types were urine and sputum, with the highest proportion of patients in the intensive care unit (ICU; 32.10%). Analysis of the co-infected population revealed that ICU patients with tracheal intubation were significant risk factors. Co-infection with carbapenem-resistant Acinetobacter baumannii (CRAB) showed a concerning annual rise.Conclusions: There is urgent need for enhanced surveillance and stringent infection control measures to mitigate the spread of CREC and associated nosocomial infections.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 7","pages":"1100-1107"},"PeriodicalIF":1.2,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144734729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Infection dynamics and management in patients undergoing extracorporeal membrane oxygenation: a retrospective analysis. 接受体外膜氧合的患者感染动态和管理：回顾性分析。

IF 1.2 4区医学

Journal of Infection in Developing Countries Pub Date : 2025-07-28 DOI: 10.3855/jidc.20416

Zhu Yuan, Shili Zhong, Qiqi Tang, Yunting Liu, Zhen Wang, Hong Xiao

{"title":"Infection dynamics and management in patients undergoing extracorporeal membrane oxygenation: a retrospective analysis.","authors":"Zhu Yuan, Shili Zhong, Qiqi Tang, Yunting Liu, Zhen Wang, Hong Xiao","doi":"10.3855/jidc.20416","DOIUrl":"10.3855/jidc.20416","url":null,"abstract":"Introduction: The aim of this study was to summarize the infection situation of patients during extracorporeal membrane oxygenation (ECMO) treatment, and analyze the relevant infectious indexes before and after ECMO treatment; so as to provide clinical evidence for the control of infection after ECMO treatment.Methodology: A retrospective analysis was conducted from May 2014 to January 2024 on 66 patients treated with ECMO at the Department of Intensive Care Medicine, Daping Hospital, Army Medical University. The patients' general clinical data were collected, focusing on infection types, pathogenic bacteria, anti-infective regimens, infection markers, and coagulation function. Additionally, risk factors for infection in intensive care unit (ICU) patients undergoing ECMO treatment were analyzed.Results: Pulmonary infections were the most common among the patients in this study, and Gram-negative bacilli were the predominant pathogens. Significant reductions were observed in white blood cell count (p < 0.05, n = 57), platelet count (p < 0.05, n = 56), and fibrinogen levels (p < 0.05, n = 57) 48 hours after ECMO treatment. Of the 66 ECMO patients, 30 survived. The length of stay in the ICU was identified as an independent risk factor for adverse events following ECMO treatment.Conclusions: Controlling infection during ECMO is the cornerstone of survival and prognosis of patients. Mechanical ventilation time, continuous renal replacement therapy, central venous catheterization time, and antibiotic treatment time may be related to infection after ECMO. Early bacterial culture; and prophylactic, empirical, and targeted antimicrobials contribute to infection control.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 7","pages":"1039-1045"},"PeriodicalIF":1.2,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144734721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Silent spread of pathogens in hospital settings: a one-week molecular epidemiologic study. 病原体在医院环境中的无声传播：一项为期一周的分子流行病学研究

IF 1.2 4区医学

Journal of Infection in Developing Countries Pub Date : 2025-07-28 DOI: 10.3855/jidc.20812

Elif S Tanriverdi, Yusuf Yakupogullari, Deste Ceylan, Yucel Duman, Baris Otlu

{"title":"Silent spread of pathogens in hospital settings: a one-week molecular epidemiologic study.","authors":"Elif S Tanriverdi, Yusuf Yakupogullari, Deste Ceylan, Yucel Duman, Baris Otlu","doi":"10.3855/jidc.20812","DOIUrl":"10.3855/jidc.20812","url":null,"abstract":"Introduction: Molecular fingerprinting analyses of the pathogens isolated from healthcare-associated infections (HAIs) in an off-outbreak period can provide important data which cannot be obtained by prospective surveillance. Such data may indicate unnoticed breaks in infection control measures and guide in determining targeted interventions or reinforcements. The study aimed to analyze the clonal relatedness of pathogens isolated from HAIs during a period when the facility}'s HAI rate remained stable.Methodology: A prospective cross-sectional study was conducted in a university hospital. A total of 105 bacterial pathogens isolated from HAIs in a one-week period were genotyped using pulsed-field gel electrophoresis.Results: All 12 enterococci isolates belonged to one of the genotypes that infected more than one patient. There was an epidemic clone in Staphylococcus aureus responsible for 7 out of 12 HAIs caused by this species. Among the Gram-negative bacteria, Acinetobacter baumannii showed the highest clonality, with 3 genotypes responsible for 13 out of 16 HAIs caused by this species. Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa showed the lowest clonality, and their spreads involved a pair of patients in a total of 7 events.Conclusions: This study showed that almost half of HAIs were due to clonal spread that was not detected by active surveillance. Enterococci, S. aureus, and A. baumannii had the highest clonality, suggesting that a significant proportion of HAIs could be prevented in healthcare facilities where these pathogens predominate. Repeating comprehensive studies in hospitals at regular intervals will be useful to identify unnoticed breaks in infection control measures.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 7","pages":"1066-1073"},"PeriodicalIF":1.2,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144734730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0