Journal of Infection in Developing Countries最新文献_第5页

Effects of the COVID-19 pandemic on HIV care in people newly diagnosed with HIV infection. COVID-19大流行对新诊断艾滋病毒感染者艾滋病毒护理的影响

IF 1.4 4区医学

Journal of Infection in Developing Countries Pub Date : 2025-04-29 DOI: 10.3855/jidc.20276

Aysegul I Sezen, Yusuf E Ozdemir, Deniz Borcak, Esra Canbolat Unlu, Sevtap Senoğlu, Zuhal Yesilbag, Hayat Kumbasar Karaosmanoglu

{"title":"Effects of the COVID-19 pandemic on HIV care in people newly diagnosed with HIV infection.","authors":"Aysegul I Sezen, Yusuf E Ozdemir, Deniz Borcak, Esra Canbolat Unlu, Sevtap Senoğlu, Zuhal Yesilbag, Hayat Kumbasar Karaosmanoglu","doi":"10.3855/jidc.20276","DOIUrl":"https://doi.org/10.3855/jidc.20276","url":null,"abstract":"Introduction: This study was planned to understand the continuity of the follow-up and treatment of people newly diagnosed with HIV infection during the COVID-19 pandemic. We compared the pre-pandemic to the pandemic period, focusing on factors such as diagnosis, accessing treatment, staying on treatment, and viral suppression, as the pandemic had the potential to disrupt HIV care.Methodology: The one-year follow-up data of patients diagnosed in 2018 (pre-pandemic era) and 2020 (pandemic era) were compared. Each patient's age, gender, employment and educational status, sexual orientation, comorbidities, quantitative HIV RNA levels (qRT-PCR), and CD4+ cell counts during outpatient follow-up visits, regular use of the treatment, and regular visits to the outpatient clinic were investigated retrospectively.Results: We had 192 new patients during the pre-pandemic period in 2018 (Group A) and 118 new patients during the pandemic in 2020 (Group B). There was no difference between the two groups regarding patient age and gender. The number of newly diagnosed HIV patients during the pandemic period decreased compared to the previous period (p < 0.001). Compliance with treatment rates was similar in both periods. There was no statistical difference in HIV RNA between the two groups after one year of treatment.Conclusions: The COVID-19 pandemic has had the potential to disrupt the continuity of HIV care among individuals. Although the COVID pandemic had a statistically significant effect on attendance at HIV care programs, treatment compliance was not impaired due to rapid action on drug supply and correct policy implementation during the pandemic.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 4","pages":"476-481"},"PeriodicalIF":1.4,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144051767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A rapid method for Candida DNA preparation from sputum, and its clinical application. 痰液中念珠菌DNA的快速制备方法及其临床应用。

IF 1.4 4区医学

Journal of Infection in Developing Countries Pub Date : 2025-04-29 DOI: 10.3855/jidc.19625

Qingqing Sun, Yun Xie, Hanbing Meng, Lina Zhang, Zhengxin He

{"title":"A rapid method for Candida DNA preparation from sputum, and its clinical application.","authors":"Qingqing Sun, Yun Xie, Hanbing Meng, Lina Zhang, Zhengxin He","doi":"10.3855/jidc.19625","DOIUrl":"https://doi.org/10.3855/jidc.19625","url":null,"abstract":"Introduction: The analysis and identification of Candida in sputum specimens is of significance in clinical settings. The aim of this study was to assess the feasibility of a previously validated rapid method for preparing Candida DNA in conjunction with pretreatment with Sputasol (Aiyan Biotechnology, Shanghai, China) for detecting Candida in sputum specimens.Methodology: The study included 181 patients with respiratory diseases who were hospitalized at the Bethune International Peace Hospital between 9 and 29 January 2020. Sputum specimens were collected retrospectively, and sputum culture results and related clinical information were extracted from electronic medical records. The sputum samples were pre-treated with Sputasol digest and subjected to rapid DNA sample preparation, and duplex polymerase chain reaction (PCR) for detecting Candida.Results: Out of the 181 sputum specimens, 65 tested positive for Candida through PCR, and 32 were positive through fungal culture. The samples that tested positive through fungal culture were also positive through PCR, and the identified species were completely consistent. Conversely, all samples that tested negative through PCR were also negative through fungal culture. The two assays showed moderate agreement, with a Kappa value of 0.554. The false-positive results of PCR Candida detection may be attributed to antifungal treatment and higher sensitivity.Conclusions: The rapid Candida DNA sample preparation technique combined with duplex PCR for Candida detection is a sensitive method for identifying Candida in sputum. It is necessary to combine PCR results with comprehensive clinical judgment for deriving conclusions. Further studies are needed to verify its clinical value.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 4","pages":"623-629"},"PeriodicalIF":1.4,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144027845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unlocking the mysteries of bacterial meningitis in Bosnia and Herzegovina: Predicting outcomes in developing country settings. 破解波斯尼亚和黑塞哥维那细菌性脑膜炎的奥秘：预测发展中国家的结果。

IF 1.4 4区医学

Journal of Infection in Developing Countries Pub Date : 2025-04-29 DOI: 10.3855/jidc.19721

Izeta Hamza, Rusmir Baljić, Amila Muratspahić, Meliha Šehić, Nejra Selak

{"title":"Unlocking the mysteries of bacterial meningitis in Bosnia and Herzegovina: Predicting outcomes in developing country settings.","authors":"Izeta Hamza, Rusmir Baljić, Amila Muratspahić, Meliha Šehić, Nejra Selak","doi":"10.3855/jidc.19721","DOIUrl":"https://doi.org/10.3855/jidc.19721","url":null,"abstract":"Introduction: Acute bacterial meningitis (ABM) is a serious infectious disease and medical emergency. Given the fact of its high mortality and morbidity, detecting prognostic factors is potentially useful in improving treatment strategies. This paper aims to determine prognostic factors of short-term outcomes of patients with ABM in a developing country - Bosnia and Herzegovina, measured by the Modified Rankin Scale (MRS) at discharge.Methodology: In this retrospective cohort study, 56 patients treated at the Clinic of Infectious Diseases, Clinical Center University of Sarajevo, for 11 years (2012-2022) were included. Statistical analysis was performed using IBM SPSS Statistics version 29.0.1.0.Results: The subjects' average age was 31.6 ± 27.7 years, with the youngest patient being 4 months and the oldest 75 years old. Among those, 31 were male and 25 were female. Unfavorable outcomes had 16 (28.6%) patients, including fatal outcomes in four patients and severe disabilities in 12 patients (MRS: 2-6), while 40 (71.4%) patients had favorable outcomes (MRS: 0-1). In the multivariate analysis, predictors of unfavorable outcomes included age older than 60 years, duration of symptoms longer than 24 hours, presence of neurological defects at admission, impaired consciousness, respiratory distress, and no corticosteroid use during treatment.Conclusions: There is certainly a window of opportunity for patients with ABM: The shorter the time between disease onset and treatment initiation, the better the disease outcome.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 4","pages":"528-536"},"PeriodicalIF":1.4,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144021837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship of serum hepatitis B Virus DNA levels with Hepcidin, Pentraxin-3, Zonulin, and Copeptin in chronic hepatitis B patients. 慢性乙型肝炎患者血清乙型肝炎病毒DNA水平与Hepcidin、pentaxin -3、Zonulin和Copeptin的关系

IF 1.4 4区医学

Journal of Infection in Developing Countries Pub Date : 2025-04-29 DOI: 10.3855/jidc.20918

Burak Ezer, Mehmet Ozdemir

{"title":"Relationship of serum hepatitis B Virus DNA levels with Hepcidin, Pentraxin-3, Zonulin, and Copeptin in chronic hepatitis B patients.","authors":"Burak Ezer, Mehmet Ozdemir","doi":"10.3855/jidc.20918","DOIUrl":"https://doi.org/10.3855/jidc.20918","url":null,"abstract":"Introduction: This study aims to investigate the serum levels of hepcidin, pentraxin-3 (PTX-3), Zonulin, and Copeptin biomarkers, which can be detected by the more cost-effective and practical ELISA method compared to the quantitatively determined HBV DNA by molecular methods, and to contribute to studies on biomarkers that will facilitate the antiviral treatment management of chronic Hepatitis B patients.Methodology: Serum samples from 105 patients with HBsAg detected for more than 6 months and 35 control group individuals without any liver or chronic disease were included in the study. The serum HBV DNA levels of the patients were determined by the Real Time PCR (Anatolia, Turkey) method. Patients were divided into three different groups based on their HBV DNA levels (IU/mL): 35 patients with levels between 100-102, 35 patients with levels between 103-105, and 35 patients with levels between 106-108. These groups were evaluated as having mild, moderate, and severe viral loads.Results: A statistically significant difference was found in serum hepcidin levels between the control group and the group with severe viral load (p = 0.01). The difference in serum PTX-3 levels between the control group and the other three groups was statistically significant (p < 0.001). A statistically significant difference in Copeptin levels was determined between the group with severe viral load and moderate, mild, control groups (p = 0.007; p = 0.013; p = 0.036).Conclusions: Important clues have been obtained about markers that can give an idea about HBV DNA, but studies on larger populations are needed.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 4","pages":"615-622"},"PeriodicalIF":1.4,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144062610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The relationship between platelet parameters and bacterial types in patients with bacteremia: A retrospective observational study. 菌血症患者血小板参数与细菌类型之间的关系：回顾性观察研究

IF 1.4 4区医学

Journal of Infection in Developing Countries Pub Date : 2025-03-31 DOI: 10.3855/jidc.20548

Xiaoyan Liu, Guanqun Yi, Guoyang Zhang, Hongyun Liu, Ziyang Liang, Danian Nie, Liping Ma

{"title":"The relationship between platelet parameters and bacterial types in patients with bacteremia: A retrospective observational study.","authors":"Xiaoyan Liu, Guanqun Yi, Guoyang Zhang, Hongyun Liu, Ziyang Liang, Danian Nie, Liping Ma","doi":"10.3855/jidc.20548","DOIUrl":"10.3855/jidc.20548","url":null,"abstract":"Objective: To analyze the relationship between platelet parameters and bacterial types in patients with bacteremia.Methodology: Data from 265 patients with positive blood bacterial cultures were collected. Clinical parameters and procalcitonin (PCT) were recorded.Results: In 265 patients with bacteremia, gram-negative (G-) bacteria accounted for 56% of cases, and gram-positive (G +) bacteria accounted for 44% of cases. In patients with bacteremia, white blood cell counts (WBC), neutrophil counts (NEUT), the percentage of neutrophils (NEUT%), and PCT were increased, and lymphocyte counts (LYM) and the percentage of lymphocytes (LYM%) were decreased. The differences in plateletcrit values, NEUT%, LYM%, and PCT between the G- and the G + bacteria group were significantly different. The cutoff values of PCT, platelet, plateletcrit, and NEUT% were 1.31 ng/mL, 211 × 109/L, 0.205%, and 87.41%, respectively. The incidence of thrombocytopenia was 12%. There was no significant difference in WBC, NEUT%, PCT, platelet, platelet nadir, and days of thrombocytopenia between the G- and the G + bacteria among patients with thrombocytopenia.Conclusions: Platelet, plateletcrit, NEUT%, and PCT are helpful for the early identification of G- and G + bacteria. The combination of PCT and hemogram parameters is more conducive to the early differential diagnosis of bacterial classification.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 3","pages":"381-390"},"PeriodicalIF":1.4,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143765546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness of 14-day high-dose dual therapy for Helicobacter pylori infection in Vietnam. 越南幽门螺杆菌感染14天高剂量双重治疗的疗效。

IF 1.4 4区医学

Journal of Infection in Developing Countries Pub Date : 2025-03-31 DOI: 10.3855/jidc.20820

Nam T Phan, Long H Truong

{"title":"Effectiveness of 14-day high-dose dual therapy for Helicobacter pylori infection in Vietnam.","authors":"Nam T Phan, Long H Truong","doi":"10.3855/jidc.20820","DOIUrl":"10.3855/jidc.20820","url":null,"abstract":"Introduction: The eradication rates of Helicobacter pylori (H. pylori) in Vietnam, with both triple therapy and non-bismuth quadruple therapy, have significantly declined due to increasing antibiotic resistance. This prospective study aimed to evaluate the eradication efficacy of high-dose dual therapy (HDDT) with esomeprazole and amoxicillin in a region with high resistance rates to clarithromycin, metronidazole, and levofloxacin.Methodology: A total of 82 patients with active H. pylori infection, confirmed by either a rapid urease test or a ¹³C urea breath test, were enrolled at our hospital. All participants received esomeprazole (40 mg) and amoxicillin (1,000 mg), 3 times daily for 14 days. Treatment success was assessed using a ¹³C urea breath test 4-6 weeks post-treatment. Safety was evaluated based on reported adverse effects.Results: Gastritis, gastric ulcer, and duodenal ulcer were present in 80.5%, 10.4%, and 9.1% of cases, respectively. The eradication rates according to intention-to-treat (ITT) and per-protocol (PP) analyses were 76.8% (63/82) and 81.8% (63/77), respectively. In the PP analysis, the eradication rate was 86.0% (49/57) in first-line treatment, and 70.0% (14/20) in patients with prior H. pylori treatment failure. Mild side effects, including nausea, abdominal discomfort, pruritus, diarrhea, and fatigue, were reported in 22.1% (17/77) of patients.Conclusions: This study demonstrates that a 14-day HDDT regimen provides relatively high efficacy and a favorable safety profile for first-line H. pylori eradication. Given the widespread resistance to clarithromycin, levofloxacin, and metronidazole in Vietnam; HDDT may serve as an alternative first-line therapy for H. pylori eradication in this region.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 3","pages":"404-408"},"PeriodicalIF":1.4,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143765710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can Bacillus paranthracis cause bacteremia in a T-ALL patient? WGS-based diagnosis. 副嗜血杆菌能引起T-ALL患者的菌血症吗？WGS-based诊断。

IF 1.4 4区医学

Journal of Infection in Developing Countries Pub Date : 2025-03-31 DOI: 10.3855/jidc.20080

Serap Süzük Yıldız, Ayşegül Polat, Süleyman Yalçın, Mert Emre Ölmez, Tahir Darçın, Kerem Özdel, İpek Mumcuoğlu, Tuba Dal

{"title":"Can Bacillus paranthracis cause bacteremia in a T-ALL patient? WGS-based diagnosis.","authors":"Serap Süzük Yıldız, Ayşegül Polat, Süleyman Yalçın, Mert Emre Ölmez, Tahir Darçın, Kerem Özdel, İpek Mumcuoğlu, Tuba Dal","doi":"10.3855/jidc.20080","DOIUrl":"10.3855/jidc.20080","url":null,"abstract":"Introduction: Most of Bacillus spp. generally avirulent species in healthy patients, but if there is a fragile in the patient, especially their immune system, Bacillus spp. can be an agent for infections.Case report: In this case, we report that Bacillus paranthracis, diagnosed by whole genome sequencing, is responsible for bacteremia in a T-ALL patient. A 26-year-old male patient was diagnosed with T-cell acute lymphoblastic leukemia. Bacillus paranthracis was isolated from two sets of blood cultures obtained from a patient with febrile neutropenia.Results: The bacteria was identified as Bacillus cereus group in a routine microbiology laboratory by MALDI TOF MS. Then whole genome sequencing (WGS) confirmed its name as Bacillus paranthracis. The pathogenicity of the bacterium, especially in immunocompromised patients, has also been demonstrated by WGS.Conclusions: In a microbiology laboratory, the use of Whole Genome Sequencing (WGS) is important for diagnosing diseases, especially in immunocompromised patients. It will serve the management of these patients for infection control.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 3","pages":"458-461"},"PeriodicalIF":1.4,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143765702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Increase in quinolones prescriptions for children (0-10 years old) in Brazil. 巴西儿童（0-10岁）喹诺酮类药物处方增加。

IF 1.4 4区医学

Journal of Infection in Developing Countries Pub Date : 2025-03-31 DOI: 10.3855/jidc.20177

Fernando S Del Fiol, Jéssica Cristina B Noguerol Andrade, Bianca G Belini, Silvio Barberato-Filho, Cristiane Bergamaschi Motta

{"title":"Increase in quinolones prescriptions for children (0-10 years old) in Brazil.","authors":"Fernando S Del Fiol, Jéssica Cristina B Noguerol Andrade, Bianca G Belini, Silvio Barberato-Filho, Cristiane Bergamaschi Motta","doi":"10.3855/jidc.20177","DOIUrl":"10.3855/jidc.20177","url":null,"abstract":"Introduction: Quinolones are frequently associated with adverse effects such as tendinopathies and joint damage. However, the safety of quinolone use in pediatric patients remains inadequately established, with limited recommended applications. This study aimed to investigate the escalating consumption of quinolones among Brazilian children aged 0-10 years.Methodology: An interrupted time series analysis was conducted to examine fluctuations in quinolone consumption within the pediatric population. Data were sourced from the Brazilian National Controlled Products Management System (SNGPC). Analysis of variance and joinpoint regression were employed to assess yearly variations in commercial unit sales of quinolones.Results: Brazil witnessed the consumption of approximately 93 million commercial units of quinolones by the entire population, with 1 million units prescribed for children (0-10years). The surge in quinolone utilization among children during this period exceeded 50% (p < 0.05), a statistically significant increase compared to the 24% growth observed in the entire population. Regression analysis indicated an annual linear growth of around 9% (year on year) in Brazil for quinolone use among children.Conclusions: Our study revealed a concerning rise in quinolone prescriptions for Brazilian children aged 0-10 years, underscoring the imperative for cautious use due to limited safety data and acknowledged risks, such as musculoskeletal damage. Healthcare providers should prioritize safer alternatives when possible, focusing on children`s well-being and combating antimicrobial resistance. Advocacy for prudent prescribing practices and increased awareness is crucial, along with further research to comprehensively understand long-term effects and establish evidence-based guidelines for quinolone use in pediatric populations.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 3","pages":"418-423"},"PeriodicalIF":1.4,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of anti-SARS-CoV-2 IgG positivity and long COVID-19 in pediatric age group. 小儿年龄段抗sars - cov -2 IgG阳性和长冠状病毒肺炎流行情况

IF 1.4 4区医学

Journal of Infection in Developing Countries Pub Date : 2025-03-31 DOI: 10.3855/jidc.19299

Nawfal R Hussein, Rojeen C Khalid, Tamara B Jamal, Sara A Mahdi, Abdullah S Mustafa, Bashar I Mohammed, Mateen A Shukri, Ibrahim A Naqid, Rashid M Ameen

{"title":"Prevalence of anti-SARS-CoV-2 IgG positivity and long COVID-19 in pediatric age group.","authors":"Nawfal R Hussein, Rojeen C Khalid, Tamara B Jamal, Sara A Mahdi, Abdullah S Mustafa, Bashar I Mohammed, Mateen A Shukri, Ibrahim A Naqid, Rashid M Ameen","doi":"10.3855/jidc.19299","DOIUrl":"10.3855/jidc.19299","url":null,"abstract":"Introduction: This study aimed to determine the prevalence and associated factors of coronavirus disease 2019 (COVID-19) and long COVID-19 in children in Duhok province and Zakho city in the Kurdistan region.Methodology: The study was conducted as a cross-sectional study and included children aged 5-12 years in Duhok and Zakho, two major neighboring cities in the Bahdenan region of northern Iraq. A total of 330 participants were included and the study was conducted between October 2022 and April 2023. The children were tested for the presence of anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunoglobulin G (IgG) antibodies. A questionnaire was used to collect demographic and personal data, and symptoms of each participant to determine the prevalence of long COVID-19.Results: Out of 330 participants, 302 (91.5%) were positive for IgG, and 156 (51.7%) of them were male. Only 4 participants (1.3%) had pneumonia, and 282 (93.4%) were asymptomatic. Fourteen out of 302 (4.6%) participants had long COVID-19. There were significant associations between long COVID-19 and history of previous COVID-19 episodes (p = 0.001), presence of pneumonia (p = 0.001), and family history of COVID-19 (p = 0.005).Conclusions: There was a high prevalence of COVID-19 among children in Duhok province and Zakho city, and 4.6% of them experienced long COVID-19. Factors such as prior COVID-19, pneumonia, and family history of COVID-19 were associated with long COVID-19. Continued monitoring, education, vaccination, preventive measures, and supportive care are recommended to effectively address the impact of COVID-19 on the pediatric population.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 3","pages":"335-341"},"PeriodicalIF":1.4,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143765509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic value of TNF-α, PCT, IL-8, and HBP, combined with APACHE II score in patients with sepsis. 脓毒症患者TNF-α、PCT、IL-8和HBP与APACHE II评分的预后价值。

IF 1.4 4区医学

Journal of Infection in Developing Countries Pub Date : 2025-03-31 DOI: 10.3855/jidc.20383

Shuping Guo, Chunyan Liao, Qinghong Liu

{"title":"Prognostic value of TNF-α, PCT, IL-8, and HBP, combined with APACHE II score in patients with sepsis.","authors":"Shuping Guo, Chunyan Liao, Qinghong Liu","doi":"10.3855/jidc.20383","DOIUrl":"10.3855/jidc.20383","url":null,"abstract":"Introduction: This study evaluated the prognostic value of serum cytokines tumor necrosis factor-alpha (TNF-α), procalcitonin (PCT), interleukin-8 (IL-8), and heparin binding protein (HBP); combined with acute physiology and chronic health evaluation II (APACHE II) score in sepsis patients.Methodology: Patients were divided into sepsis and septic shock groups based on sepsis-3 criteria, with non-sepsis individuals as controls. Serum TNF-α, PCT, IL-8, and HBP levels; and APACHE II scores were recorded upon intensive care unit (ICU) admission. The diagnostic value was evaluated using receiver operating characteristic (ROC) curves and areas under the curves (AUCs).Results: Correlation analysis revealed that serum TNF-α (r = 0.701), PCT (r = 0.623), IL-8 (r = 0.617), and HBP (r = 0.721) were positively correlated with the APACHE II score (p < 0.05). Serum TNF-α, PCT, IL-8, HBP levels, and APACHE II scores were significantly higher in non-survivors than survivors (p < 0.05). The AUC for combined indicators in predicting mortality was 0.913 (confidence interval, CI: 0.861-0.912), significantly higher than individual indicators. HBP showed AUC of 0.798 (CI: 0.707-0.879) and APACHE II 0.769 (CI: 0.782-0.892). The combined prediction demonstrated 96.21% sensitivity and 79.34% specificity.Conclusions: Serum TNF-α, PCT, IL-8, and HBP levels influenced sepsis patient prognosis, and their combined detection with APACHE II score provided a high predictive value for patient outcomes.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"19 3","pages":"439-445"},"PeriodicalIF":1.4,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143765525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0