Journal of Infection in Developing Countries最新文献_第5页

Relationship between OprD porin downregulation and in-vitro interactions in Pseudomonas aeruginosa. 铜绿假单胞菌OprD孔蛋白下调与体外相互作用的关系。

IF 1.3 4区医学

Journal of Infection in Developing Countries Pub Date : 2026-07-31 DOI: 10.3855/jidc.22217

Tuba Müderris, Ufuk Akbayırlı, Rıza Durmaz, Selçuk Kaya, Tuba Dal, Ziya C Açıkgöz, Ayşegül Aksoy Gökmen

{"title":"Relationship between OprD porin downregulation and in-vitro interactions in Pseudomonas aeruginosa.","authors":"Tuba Müderris, Ufuk Akbayırlı, Rıza Durmaz, Selçuk Kaya, Tuba Dal, Ziya C Açıkgöz, Ayşegül Aksoy Gökmen","doi":"10.3855/jidc.22217","DOIUrl":"https://doi.org/10.3855/jidc.22217","url":null,"abstract":"Introduction: OprD porin plays a critical role in antibiotic uptake. However, the role of OprD in antimicrobial interactions is not yet fully understood. This study investigated the relationship between OprD downregulation and in vitro interactions of meropenem (MEM) with combinations of colistin (CT), ertapenem (ETP), and fosfomycin (FF) in Pseudomonas aeruginosa.Methodology: A total of 40 P. aeruginosa isolates were included in the study and divided into two groups (group-1, 20 isolates with confirmed OprD suppression; group-2; 20 isolates without OprD suppression). Antimicrobial interactions were examined using the checkerboard method.Results: The synergy rates of MEM/CT, MEM/ETP, and MEM/FF combinations in group-1/group-2 isolates were determined as 45%/30%, 5%/5%, and 15%/10% respectively. The minimum inhibitory concentration (MIC) of antimicrobials in combinations were examined for group-1 and group-2 isolates, and a decrease of 90%, 90% for MEM and 70%, 40% for CT was detected in the MEM/CT combination, 50%, 45% for MEM and 35%, 40% for ETP in the MEM/ETP combination, and 35%, 20% for MEM and 55%, 45% for FF in the MEM/FF combination, respectively.Conclusions: While significant synergy was observed between MEM/CT in OprD-deficient isolates, the limited synergistic effects observed with other combinations, such as MEM/ETP and MEM/FF, suggest that the impact of OprD downregulation on antimicrobial resistance is multifactorial and complex. The findings suggest that CT, when combined with MEM, may overcome certain resistance mechanisms mediated by OprD downregulation. Further investigations incorporating molecular diagnostics and in vivo validation are warranted to fully elucidate the therapeutic potential of these combinations.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"20 7","pages":"1031-1037"},"PeriodicalIF":1.3,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148690275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical characteristics and risk factors for prediction of severity in patients with COVID-19: a retrospective multicentre study. 预测COVID-19患者严重程度的临床特征和危险因素：一项回顾性多中心研究

IF 1.3 4区医学

Journal of Infection in Developing Countries Pub Date : 2026-07-31 DOI: 10.3855/jidc.21418

Maidina Abudouaini, Wenjuan Zeng, Shengtao Zeng, Bing Liu, Liang Dong, Amar Aynazar, Dilare Asimu, Jinquan Ma, Dongmei Lu

{"title":"Clinical characteristics and risk factors for prediction of severity in patients with COVID-19: a retrospective multicentre study.","authors":"Maidina Abudouaini, Wenjuan Zeng, Shengtao Zeng, Bing Liu, Liang Dong, Amar Aynazar, Dilare Asimu, Jinquan Ma, Dongmei Lu","doi":"10.3855/jidc.21418","DOIUrl":"10.3855/jidc.21418","url":null,"abstract":"Introduction: This study aimed to investigate the clinical characteristics of patients infected with coronavirus disease 2019 (COVID-19) and to identify risk factors associated with severe infection among Chinese patients.Methodology: We collected demographic data, clinical characteristics, and laboratory test results at admission for COVID-19 patients hospitalized in one of two designated tertiary hospitals in Yili Prefecture, Xinjiang Province, between July 2022 and October 2022. Patients were categorized into Group A (asymptomatic, mild, and moderate cases) and Group B (severe and critical cases) based on disease severity. Multivariate regression analysis was conducted to identify risk factors for severe disease, and a nomogram prediction model was developed using these factors. Additionally, stratified analyses were performed by comorbidity status.Results: Multivariate analysis indicated that older age, male sex, elevated urea nitrogen, higher D-dimer levels, and combined laboratory parameters at admission were positively associated with disease severity. The predictive performance of these factors, measured by area under the curve, was 0.872 (95% CI: 0.819-0.925), 0.613 (95% CI: 0.514-0.712), 0.813 (95% CI: 0.724-0.902), 0.790 (95% CI: 0.717-0.862), and 0.931 (95% CI: 0.891-0.971), respectively. Conversely, vaccination appeared to mitigate progression to severe disease to some extent.Conclusions: Patient age, sex, urea nitrogen, D-dimer, and serum creatinine levels at admission, as well as vaccination status and comorbidities, significantly influence disease progression in COVID-19 patients. Clinical management can be optimized by tailoring early warning systems and intervention strategies based on these patient-specific risk factors, thereby supporting informed decisions for diagnosis, treatment, prevention, and control.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"20 7","pages":"932-943"},"PeriodicalIF":1.3,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148690170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The quantitative evaluation of antibiotic utilization in community health centers during the COVID-19 pandemic: a cross-sectional multicenter study. COVID-19大流行期间社区卫生中心抗生素使用的定量评估：一项横断面多中心研究

IF 1.3 4区医学

Journal of Infection in Developing Countries Pub Date : 2026-07-31 DOI: 10.3855/jidc.22502

Zamharira Muslim, Angga Iw Effendi, Kartika Cdp Sari, Ayuk L Hariadini, Larasati A Kusumawardani

{"title":"The quantitative evaluation of antibiotic utilization in community health centers during the COVID-19 pandemic: a cross-sectional multicenter study.","authors":"Zamharira Muslim, Angga Iw Effendi, Kartika Cdp Sari, Ayuk L Hariadini, Larasati A Kusumawardani","doi":"10.3855/jidc.22502","DOIUrl":"10.3855/jidc.22502","url":null,"abstract":"Introduction: Uncertainty and rapid changes in treatment guidelines are influencing factors for medication use during the COVID-19 pandemic. Therefore, this study aimed to evaluate antibiotic utilization in Community Health Centers (CHCs) between 2020 and 2021.Methodology: Prescription data from adult outpatient visits (≥ 18 years) receiving prescription services at 35 CHCs in South Jakarta, Malang regency, and Bengkulu city, comprising 796,598 prescriptions, were examined using the ATC/DDD methodology and DU90% analysis. These regions were purposively selected to represent three distinct healthcare archetypes, namely metropolitan (South Jakarta), rural-urban continuum (Malang Regency), and regional cities outside Java (Bengkulu City). Wilcoxon signed-rank and Chi-square tests were used to determine statistical differences between years.Results: The proportion of adult patient visits receiving a minimum of one antibiotic prescription decreased by 1.56% in 2021 (p < 0.001). Malang Regency recorded the highest rates, decreasing by 2.24% in 2021. Furthermore, the highest DDD values for all antibiotics each year were recorded in South Jakarta, except for Cefadroxil, which peaked in Malang regency. Six antibiotics were constituted in the DU90% segment, with Amoxicillin accounting for over 50% of prescriptions and reaching 425 DDD/1000 patient visits/year in South Jakarta in 2020. In 2021, Azithromycin prescriptions increased significantly by 7.51%, as shown by a p of 0.0161. The average prescribing rate (14.57%) remained below the WHO optimal indicator (< 30%).Conclusions: Antibiotic use in CHCs declined during the pandemic, but there was a significant increase in Azithromycin prescriptions.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"20 7","pages":"954-961"},"PeriodicalIF":1.3,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148690231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploration of the diagnostic value and expression levels of IFN-γ and IL-2 in patients with lymph node tuberculosis. IFN-γ、IL-2在淋巴结结核诊断价值及表达水平探讨。

IF 1.3 4区医学

Journal of Infection in Developing Countries Pub Date : 2026-07-31 DOI: 10.3855/jidc.22313

Chun Zhang, Yu Chen, Jun Huang, Ying Liu, Hao Zhang, Tianxing Hang, Lili Huang, Jianqi Gao, Chunmei Hu

{"title":"Exploration of the diagnostic value and expression levels of IFN-γ and IL-2 in patients with lymph node tuberculosis.","authors":"Chun Zhang, Yu Chen, Jun Huang, Ying Liu, Hao Zhang, Tianxing Hang, Lili Huang, Jianqi Gao, Chunmei Hu","doi":"10.3855/jidc.22313","DOIUrl":"https://doi.org/10.3855/jidc.22313","url":null,"abstract":"Introduction: Lymph node tuberculosis (LNTB) is the most common form of extrapulmonary tuberculosis (TB). The symptoms of LNTB lack specificity, making diagnosis difficult and increasing the likelihood of missed or incorrect diagnoses. Along with IFN-γ Release Assay (IGRA), the detection method using enzyme-linked immunosorbent assay (ELISA) can simultaneously detect IFN-γ and interleukin-2 (IL-2). However, the diagnostic value and expression levels of IFN-γ and IL-2 in patients with LNTB remain unclear.Methodology: A total of 95 patients with enlarged lymph nodes were enrolled. Baseline data were collected, including age, gender, history of TB, histopathology, microbiology test results, and blood levels of IFN-γ and IL-2. Receiver operating characteristic (ROC) curve was used to investigate the diagnostic effect of the IFN-γ and IL-2. A double antibody sandwich ELISA was used to detect the concentrations of IFN-γ and IL-2 in culture supernatants.Results: Based on ROC curves, the cut-off values for IFN-γ/IL-2 for differentiating LNTB from non-TB-lymphadenopathy (LAP) were determined to be 58.267 and 12.207 pg/mL, respectively. In patients with LNTB and non-TB-LAP, the sensitivity of IFN-γ/IL-2 in parallel was 83.33% (95% CI: 71.71-90.99), significantly higher (p < 0.05) than that for IFN-γ alone. The highest specificity (93.10%) (95% CI: 75.78-98.8) was observed when IFN-γ and IL-2 were applied in tandem.Conclusions: The combined detection of IFN-γ and IL-2 showed good diagnostic efficacy in LNTB. In addition, in patients diagnosed with LNTB, the expression level of IL-2 may be related to the burden of MTB and the severity of TB infection.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"20 7","pages":"1049-1060"},"PeriodicalIF":1.3,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148690155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of knowledge, attitudes and behavior, perception, risk factors, practices, One Health, and interventions regarding Monkeypox in Pakistan. 评估巴基斯坦关于猴痘的知识、态度和行为、认知、风险因素、做法、同一健康和干预措施。

IF 1.3 4区医学

Journal of Infection in Developing Countries Pub Date : 2026-07-31 DOI: 10.3855/jidc.20285

Kainat Bibi, Huma Khan, Muhammad Sohail Afzal, Abid Ali, Haroon Ahmed

{"title":"Assessment of knowledge, attitudes and behavior, perception, risk factors, practices, One Health, and interventions regarding Monkeypox in Pakistan.","authors":"Kainat Bibi, Huma Khan, Muhammad Sohail Afzal, Abid Ali, Haroon Ahmed","doi":"10.3855/jidc.20285","DOIUrl":"10.3855/jidc.20285","url":null,"abstract":"Introduction: The monkeypox virus, a species of the Orthopoxvirus genus in the Poxviridae family, is the etiological agent of monkeypox, a rare but re-emerging zoonotic disease in non-endemic regions.Aim and objectives: This study assessed the knowledge, attitudes, and awareness, as well as the risk factors related to monkeypox, among the general population of Pakistan. It also investigated preventive practices, healthcare-seeking behavior, and One Health awareness to inform evidence-based strategies for reducing monkeypox incidence in Pakistan.Methodology: A cross-sectional study was conducted in Pakistan from June to December 2023 to evaluate knowledge, attitudes, perceptions, risk factors, practices, One Health, and interventions related to monkeypox. A standard, pre-validated questionnaire addressing critical questions about monkeypox was used, and 640 participants completed the study.Results: Among 640 study participants, the majority were male (56.6%). Overall, 75.6% of participants had poor knowledge of monkeypox. A positive attitude was reported in 58.8% of participants, and 74.8% expressed willingness to adopt precautionary measures. The chi-square test results showed significant associations between socio-demographic characteristics and knowledge, including gender (p < 0.033), education (p < 0.028), occupation (p < 0.038), and smoking status (p < 0.000). For attitudes, significant associations were observed with gender (p < 0.003), income (p < 0.003), occupation (p < 0.007), and smoking status (p < 0.000).Conclusions: Although most participants demonstrated insufficient knowledge and positive attitudes towards monkeypox. This underscores the need for a comprehensive public health education initiative aimed at preventing the emergence and transmission of monkeypox in Pakistan.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"20 7","pages":"1038-1048"},"PeriodicalIF":1.3,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148690175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors associated with the occurrence of various skin fungal infections in patients at Al-Qadisiyah Province, Iraq. 伊拉克Al-Qadisiyah省患者发生各种皮肤真菌感染的相关因素

IF 1.3 4区医学

Journal of Infection in Developing Countries Pub Date : 2026-07-31 DOI: 10.3855/jidc.22495

Saleem A Ajzan, Furqan M Al-Asady, Huda H Nema

{"title":"Factors associated with the occurrence of various skin fungal infections in patients at Al-Qadisiyah Province, Iraq.","authors":"Saleem A Ajzan, Furqan M Al-Asady, Huda H Nema","doi":"10.3855/jidc.22495","DOIUrl":"https://doi.org/10.3855/jidc.22495","url":null,"abstract":"Introduction: Fungal infections may damage the skin and become invasive with the possibility of spreading to other individuals. The goal of the current study was to detect the most common fungal agents causing skin infections, and to investigate the various factors associated with such infections.Methodology: The study involved 100 patients; who had suffered from various skin infections. All information related to the site of lesion, age, gender, date of collection, and history was recorded. Statistical analysis was carried out using SPSS version 27.Results: All the patients included in the study were diagnosed clinically and confirmed by laboratory diagnosis. The skin infections were caused by dermatophytes (72%), Trichophyton rubrum (56.9%), Microsporum canis (20.8%), and yeast (24%). Among the yeast infections, 54.2% were by Malassezia furfur, and 45.8% by Candida albicans. There was significant association between type of fungal infection and age group, and the majority of the patients with dermatophytes were ≤ 30 years old. Males constituted 62% and females 38%. There was a significant association between the type of fungal infection and family history of patients, and there was a positive association with households with animals.Conclusions: Dermatophytes (such as Trichophyton rubrum, Microsporum canis) were a crucial health problem. Males were more susceptible to fungal skin infections than females, with the majority of infections happening in the 11-40 years age group. Households with animals and family history of infection had significant association with the occurrence of fungal skin infections.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"20 7","pages":"1085-1092"},"PeriodicalIF":1.3,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148690135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Global burden of respiratory infections and tuberculosis attributable to risk factors, 1990-2021: demographic and SDI analysis. 风险因素导致的全球呼吸道感染和结核病负担，1990-2021年：人口统计和SDI分析

IF 1.3 4区医学

Journal of Infection in Developing Countries Pub Date : 2026-07-31 DOI: 10.3855/jidc.21667

Shareli Caikai, Jing Jiang, Yi Shi, Hongli Zhang, Sicheng Xu

{"title":"Global burden of respiratory infections and tuberculosis attributable to risk factors, 1990-2021: demographic and SDI analysis.","authors":"Shareli Caikai, Jing Jiang, Yi Shi, Hongli Zhang, Sicheng Xu","doi":"10.3855/jidc.21667","DOIUrl":"https://doi.org/10.3855/jidc.21667","url":null,"abstract":"Introduction: Respiratory infections and tuberculosis are leading causes of global morbidity and mortality; yet comprehensive research on their associated risk factors remains limited, hindering the development of effective preventive strategies.Methodology: The 2021 Global Burden of Disease data from 204 countries (1990-2021) was used to measure deaths, disability-adjusted life years (DALYs), and their age-standardized rates (ASMR and ASDR) tied to 9 risk factors. The trends were analyzed by age, gender, and socio-demographic index (SDI) regions, with annual and average annual percentage changes (APC, AAPC) used to track changes over time.Results: Globally, mortality rates (ASMR) for respiratory infections and tuberculosis linked to traditional risks-malnutrition, air pollution, and alcohol use-declined significantly; annual decreases of 4.46%, 3.18%, and 3.35%, respectively. Deaths attributed to metabolic risks like high BMI and blood sugar increased, despite falling ASMR. Geographic disparities were notable: Lesotho saw the sharpest rise in BMI-related mortality (3.92%), while Hungary had the steepest decline (-7.4%). Men faced a higher burden from behavioral risks, with tobacco-related mortality 3.6 times higher than in women. Children under 5 years were especially vulnerable to environmental risks, with unsafe water and sanitation contributing to a 4.55% annual decline in mortality rates.Conclusions: This study highlights the need for targeted actions, such as tobacco control in high-middle SDI regions, air quality improvements in South Asia, and nutrition programs in Sub-Saharan Africa. It offers a precise public health framework to reduce respiratory infections and tuberculosis, and promote global health equity by analyzing sociodemographic and time trends.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"20 7","pages":"974-989"},"PeriodicalIF":1.3,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148690212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predicting suitable spatial niches in the Philippines for Ascaris lumbricoides using bioclimatic envelope models. 利用生物气候包络模型预测菲律宾蛔虫适宜的空间生态位

IF 1.3 4区医学

Journal of Infection in Developing Countries Pub Date : 2026-07-31 DOI: 10.3855/jidc.21386

Loida M Recopuerto-Medina, Princess Anne T Dizon, Paulene Dg Dumo, Aya R El Oirdighi, Dana Patricia P Fernandez, Karla Sophia L Lumang, Nikki Heherson Dagamac

{"title":"Predicting suitable spatial niches in the Philippines for Ascaris lumbricoides using bioclimatic envelope models.","authors":"Loida M Recopuerto-Medina, Princess Anne T Dizon, Paulene Dg Dumo, Aya R El Oirdighi, Dana Patricia P Fernandez, Karla Sophia L Lumang, Nikki Heherson Dagamac","doi":"10.3855/jidc.21386","DOIUrl":"https://doi.org/10.3855/jidc.21386","url":null,"abstract":"Introduction: Recent studies on the spatial distribution of A. lumbricoides in the Philippines have used the data available from the nationwide parasitological survey in the early 2000s. This study developed an updated predictive map of the spatial distribution of ascariasis occurrences in the Philippines using data from 2000-2020 to identify high-risk areas for ascariasis.Methodology: Data were acquired from WorldClim and included 19 bioclimatic variables. Additionally, the geographical distribution of species occurrence records was obtained through literature and known medical reports for ascariasis cases. The spatial distribution was mapped using QGIS after running the occurrence and environmental layers in the software Maxent.Result: The predictive map revealed a high percentage of occurrences of ascariasis in Central Luzon, Calabarzon, Western Visayas, Bicol Region, and Central Visayas. The average training area under the receiver operating characteristic curve (AUC) for the replicate runs was 0.873. Analysis of variable contribution showed the highest percentage predictive contribution of the mean temperature during the warmest quarter (49.4%), annual range of temperature (10.9%), and mean temperature during the driest quarter (10.9%).Conclusions: The species predictive map generated in this study can identify bioclimatic variables associated with the high prevalence of A. lumbricoides. Since extensive parasitological surveys can be costly and time-consuming, predictions on A. lumbricoides distribution can fill the gap in areas lacking data. Consequently, a detailed understanding of the distribution of A. lumbricoides will assist in identifying high-risk areas for effective public health intervention, especially in underfunded regions in the Philippines.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"20 7","pages":"1068-1077"},"PeriodicalIF":1.3,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148690228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk factors and clinical characteristics of bloodstream infection caused by ESBL-producing Klebsiella pneumoniae. 产esbl肺炎克雷伯菌血流感染的危险因素及临床特征

IF 1.3 4区医学

Journal of Infection in Developing Countries Pub Date : 2026-07-31 DOI: 10.3855/jidc.22258

Panpan Xu, Qingqing Chen, Yifeng Mao, Xijiang Zhang, Qin Si, Cheng Zheng

{"title":"Risk factors and clinical characteristics of bloodstream infection caused by ESBL-producing Klebsiella pneumoniae.","authors":"Panpan Xu, Qingqing Chen, Yifeng Mao, Xijiang Zhang, Qin Si, Cheng Zheng","doi":"10.3855/jidc.22258","DOIUrl":"https://doi.org/10.3855/jidc.22258","url":null,"abstract":"Introduction: The aim of this study was to analyze the clinical characteristics and risk factors of bloodstream infections (BSI) caused by extended-spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae (KP).Methodology: A retrospective study was conducted by enrolling clinically confirmed KP-BSI cases (2019-2023). Clinical data were collected and analyzed through review of the electronic medical records. Patients with ESBL-positive KP-BSI were compared to those with ESBL-negative KP-BSI. Multivariate logistic regression analysis was used to identify risk factors associated with ESBL-producing KP-BSI.Results: A total of 199 patients were included, among whom 47 (23.6%) had ESBL-producing KP-BSI. Univariate analysis revealed that the proportion of patients undergoing surgery within 48 hours before blood sampling was higher in the ESBL-positive group than in the ESBL-negative group (40.4% vs. 23.0%, p < 0.05). Regarding infection source, liver-origin infections were less frequent in the ESBL-positive group compared to the ESBL-negative group (6.4% vs. 24.3%, p < 0.05), while urinary tract-origin infections were significantly more frequent in the ESBL-positive group (38.3% vs. 18.4%, p < 0.05). Hospital-acquired infection was more common in the ESBL-positive group than in the ESBL-negative group (40.4% vs. 23.7%, p < 0.05). Multivariate analysis identified urinary tract origin (adjusted odds ratio [aOR], 2.162; 95% confidence interval [CI], 1.003-4.661) as an independent risk factor for ESBL-producing KP-BSI.Conclusions: Primary urinary tract infections constitute an independent risk factor for ESBL-producing KP-BSI. Given the therapeutic complexity of ESBL-producing strains, KP-BSI of urinary tract origin warrant heightened clinical vigilance among clinicians.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"20 7","pages":"1021-1030"},"PeriodicalIF":1.3,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148690234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treatment of infection caused by animal commensal pathogen Staphylococcus simulans. 动物共生致病菌拟象葡萄球菌感染的治疗。

IF 1.3 4区医学

Journal of Infection in Developing Countries Pub Date : 2026-07-31 DOI: 10.3855/jidc.22148

Thamer A Almangour, Abeer A Alanazi, Sarah T Al Dughaish, Fahad M Al Majid

{"title":"Treatment of infection caused by animal commensal pathogen Staphylococcus simulans.","authors":"Thamer A Almangour, Abeer A Alanazi, Sarah T Al Dughaish, Fahad M Al Majid","doi":"10.3855/jidc.22148","DOIUrl":"10.3855/jidc.22148","url":null,"abstract":"Introduction: Staphylococcus simulans is an animal pathogen belonging to the coagulase-negative staphylococci (CoNS) group that was occasionally identified in the skin of healthy people. Although it was suggested that S. simulans share some virulence factors with S. aureus, little is known about human infections, and clinical relevance is limited to a few reports. Herein, we report a case of bacteremia caused by S. simulans.Case presentation: A 39-year-old man was brought to the hospital due to heart attack. During the course of admission, his procalcitonin, C-reactive protein, and erythrocyte sedimentation rate were elevated. He was empirically started on vancomycin and meropenem. However, meropenem was discontinued after the identification of the fact that S. simulans was susceptible to oxacillin, as well as the identification of Streptococcus mitis in blood culture. Repeat blood culture a day after antibiotic initiation was persistently positive for S. simulans only, while the second repeat blood culture 3 days after antibiotic initiation was negative. The patient remained hemodynamically stable, and the laboratory values were back to normal. He continued the antibiotic course for a total of 14 days and was discharged in stable condition.Conclusions: CoNS should not be easily discarded as a sample contaminant and pathogen identification to species level is crucial. Clinicians should be aware of the virulence potential of S. simulans.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"20 7","pages":"1093-1098"},"PeriodicalIF":1.3,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148690317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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