Impact of Epstein-Barr virus infection on the development and prognosis of allergic purpura.

IF 1.2 4区医学 Q4 INFECTIOUS DISEASES

Journal of Infection in Developing Countries Pub Date : 2025-08-31 DOI:10.3855/jidc.21020

Zinian Zhao, Ying Zhang, Jing Han, Rong Ren, Guangming Li, Jinyu Yang

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Abstract

Introduction: This study aimed to examine the impact of Epstein-Barr virus (EBV) infection on the occurrence and prognosis of Henoch-Schönlein purpura (HSP).

Methodology: A total of 120 children diagnosed with HSP were selected as the experimental group, and 100 healthy children who underwent physical examinations were the control group. We compared renal function markers and quantified 24-hour urine protein in HSP children with different EBV infection statuses, and analyzed the association between EBV infection and Henoch-Schönlein purpura nephritis (HSPN).

Results: The detection rate of EBV-DNA load in the experimental group (30.83%) was significantly higher than that in the control group (10.00%) (p < 0.05). Among children with HSP, the detection rate of EBV-DNA load was significantly higher in those with abdominal involvement compared to those with joint or mixed types (p < 0.05). Serum levels of serum creatinine, blood urea nitrogen, and urine protein quantification were significantly higher in the EBV-positive group than in the EBV-negative group (p < 0.05). The detection rate of EBV-DNA load was significantly higher in the HSPN group compared to the non-HSPN group (p < 0.05). The detection rate of EBV-DNA load was significantly higher in the recurrence group than in the non-recurrence group (p < 0.05), and it was also higher in the relapse group compared to the non-relapse group (p < 0.05).

Conclusions: EBV infection is associated with the development of HSP; and gastrointestinal, joint, and renal damage. It is also an early warning sign for disease recurrence, which highlights its clinical significance.

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eb病毒感染对过敏性紫癜发展及预后的影响。

前言：本研究旨在探讨eb病毒（EBV）感染对Henoch-Schönlein紫癜（HSP）发生及预后的影响。方法：选取诊断为HSP的儿童120例为实验组，健康体检儿童100例为对照组。比较不同EBV感染状态HSP患儿肾功能指标及24小时尿蛋白定量，分析EBV感染与Henoch-Schönlein紫癜性肾炎（HSPN）的关系。结果：试验组EBV-DNA载量检出率（30.83%）显著高于对照组（10.00%）（p < 0.05）。在HSP患儿中，腹部受累组EBV-DNA载量检出率明显高于关节型和混合型（p < 0.05）。ebv阳性组血清肌酐、尿素氮、尿蛋白定量水平显著高于ebv阴性组（p < 0.05）。HSPN组EBV-DNA载量检出率显著高于非HSPN组（p < 0.05）。复发组EBV-DNA载量检出率显著高于未复发组（p < 0.05），复发组EBV-DNA载量检出率显著高于未复发组（p < 0.05）。结论：EBV感染与HSP的发生有关；以及胃肠道、关节和肾脏损伤。同时也是疾病复发的早期预警信号，凸显了其临床意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Infection in Developing Countries INFECTIOUS DISEASES-

CiteScore

3.70

自引率

5.30%

发文量

239

审稿时长

4-8 weeks

期刊介绍： The Journal of Infection in Developing Countries (JIDC) is an international journal, intended for the publication of scientific articles from Developing Countries by scientists from Developing Countries. JIDC is an independent, on-line publication with an international editorial board. JIDC is open access with no cost to view or download articles and reasonable cost for publication of research artcles, making JIDC easily availiable to scientists from resource restricted regions.